TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat/TPR repeat - putative

Species:

Leishmania infantum

UniProt:

E9AGE8_LEIIN

TriTrypDb:

LINF_120011300

Length:

1013

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Show entries

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0000152	nuclear ubiquitin ligase complex	3	1
GO:0005680	anaphase-promoting complex	4	1
GO:0005737	cytoplasm	2	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

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Expansion

Sequence features

E9AGE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGE8

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007088	regulation of mitotic nuclear division	6	1
GO:0007091	metaphase/anaphase transition of mitotic cell cycle	5	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.653
CLV_NRD_NRD_1	10	12	PF00675	0.580
CLV_NRD_NRD_1	740	742	PF00675	0.537
CLV_NRD_NRD_1	904	906	PF00675	0.762
CLV_PCSK_KEX2_1	10	12	PF00082	0.580
CLV_PCSK_KEX2_1	270	272	PF00082	0.702
CLV_PCSK_KEX2_1	575	577	PF00082	0.492
CLV_PCSK_KEX2_1	740	742	PF00082	0.537
CLV_PCSK_KEX2_1	903	905	PF00082	0.764
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.702

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H6L1	Leishmania donovani	100%	100%
A4H6X4	Leishmania braziliensis	80%	100%
E9ANY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QGN2	Leishmania major	91%	100%

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