LeishMANIAdb
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Sulfatase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Sulfatase domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AGE7_LEIIN
TriTrypDb:
LINF_120011200
Length:
518

Annotations

Annotations by Jardim et al.

Phosphatase, alkaline phosphatase Uncharacterized LINJ.12.0550

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

E9AGE7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGE7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0008484 sulfuric ester hydrolase activity 4 1
GO:0016787 hydrolase activity 2 2
GO:0016788 hydrolase activity, acting on ester bonds 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 332 336 PF00656 0.448
CLV_C14_Caspase3-7 433 437 PF00656 0.233
CLV_NRD_NRD_1 286 288 PF00675 0.621
CLV_NRD_NRD_1 496 498 PF00675 0.585
CLV_PCSK_KEX2_1 215 217 PF00082 0.542
CLV_PCSK_KEX2_1 439 441 PF00082 0.590
CLV_PCSK_KEX2_1 496 498 PF00082 0.526
CLV_PCSK_PC1ET2_1 215 217 PF00082 0.567
CLV_PCSK_PC1ET2_1 439 441 PF00082 0.558
CLV_PCSK_PC7_1 492 498 PF00082 0.524
CLV_PCSK_SKI1_1 215 219 PF00082 0.612
CLV_PCSK_SKI1_1 440 444 PF00082 0.587
CLV_PCSK_SKI1_1 449 453 PF00082 0.431
CLV_PCSK_SKI1_1 49 53 PF00082 0.471
CLV_Separin_Metazoa 259 263 PF03568 0.412
DEG_APCC_KENBOX_2 395 399 PF00400 0.300
DEG_Nend_Nbox_1 1 3 PF02207 0.727
DEG_ODPH_VHL_1 444 456 PF01847 0.371
DEG_SPOP_SBC_1 419 423 PF00917 0.425
DOC_MAPK_DCC_7 74 82 PF00069 0.312
DOC_MAPK_gen_1 215 224 PF00069 0.393
DOC_MAPK_gen_1 393 402 PF00069 0.302
DOC_MAPK_MEF2A_6 218 226 PF00069 0.349
DOC_MAPK_MEF2A_6 396 404 PF00069 0.370
DOC_MAPK_MEF2A_6 74 82 PF00069 0.305
DOC_USP7_MATH_1 149 153 PF00917 0.435
DOC_USP7_MATH_1 177 181 PF00917 0.318
DOC_USP7_MATH_1 204 208 PF00917 0.343
DOC_USP7_MATH_1 232 236 PF00917 0.364
DOC_USP7_MATH_1 239 243 PF00917 0.367
DOC_USP7_MATH_1 278 282 PF00917 0.405
DOC_USP7_MATH_1 34 38 PF00917 0.704
DOC_USP7_MATH_1 471 475 PF00917 0.350
DOC_USP7_UBL2_3 52 56 PF12436 0.634
DOC_WW_Pin1_4 102 107 PF00397 0.453
DOC_WW_Pin1_4 183 188 PF00397 0.388
DOC_WW_Pin1_4 25 30 PF00397 0.727
DOC_WW_Pin1_4 288 293 PF00397 0.396
DOC_WW_Pin1_4 483 488 PF00397 0.397
LIG_14-3-3_CanoR_1 352 358 PF00244 0.398
LIG_14-3-3_CanoR_1 391 400 PF00244 0.400
LIG_14-3-3_CanoR_1 440 445 PF00244 0.333
LIG_14-3-3_CanoR_1 449 458 PF00244 0.208
LIG_BRCT_BRCA1_1 236 240 PF00533 0.324
LIG_BRCT_BRCA1_1 72 76 PF00533 0.515
LIG_eIF4E_1 375 381 PF01652 0.329
LIG_FHA_1 21 27 PF00498 0.755
LIG_FHA_1 306 312 PF00498 0.300
LIG_FHA_1 433 439 PF00498 0.298
LIG_FHA_1 471 477 PF00498 0.388
LIG_FHA_2 164 170 PF00498 0.427
LIG_FHA_2 22 28 PF00498 0.701
LIG_FHA_2 330 336 PF00498 0.465
LIG_FHA_2 431 437 PF00498 0.346
LIG_FHA_2 450 456 PF00498 0.275
LIG_FHA_2 55 61 PF00498 0.640
LIG_FHA_2 96 102 PF00498 0.517
LIG_HP1_1 106 110 PF01393 0.281
LIG_LIR_Gen_1 119 129 PF02991 0.311
LIG_LIR_Gen_1 397 404 PF02991 0.325
LIG_LIR_Gen_1 462 471 PF02991 0.380
LIG_LIR_Nem_3 119 124 PF02991 0.293
LIG_LIR_Nem_3 179 185 PF02991 0.363
LIG_LIR_Nem_3 313 318 PF02991 0.305
LIG_LIR_Nem_3 397 402 PF02991 0.282
LIG_LIR_Nem_3 462 466 PF02991 0.374
LIG_LIR_Nem_3 73 79 PF02991 0.432
LIG_Pex14_2 342 346 PF04695 0.344
LIG_SH2_GRB2like 203 206 PF00017 0.320
LIG_SH2_GRB2like 94 97 PF00017 0.440
LIG_SH2_SRC 357 360 PF00017 0.292
LIG_SH2_SRC 6 9 PF00017 0.661
LIG_SH2_STAP1 268 272 PF00017 0.335
LIG_SH2_STAP1 434 438 PF00017 0.369
LIG_SH2_STAT3 320 323 PF00017 0.400
LIG_SH2_STAT3 370 373 PF00017 0.285
LIG_SH2_STAT5 171 174 PF00017 0.323
LIG_SH2_STAT5 21 24 PF00017 0.650
LIG_SH2_STAT5 357 360 PF00017 0.458
LIG_SH2_STAT5 370 373 PF00017 0.305
LIG_SH2_STAT5 375 378 PF00017 0.248
LIG_SH2_STAT5 387 390 PF00017 0.375
LIG_SH2_STAT5 434 437 PF00017 0.279
LIG_SH2_STAT5 6 9 PF00017 0.696
LIG_SH2_STAT5 94 97 PF00017 0.426
LIG_SH3_3 126 132 PF00018 0.409
LIG_SH3_3 289 295 PF00018 0.403
LIG_SUMO_SIM_anti_2 452 459 PF11976 0.349
LIG_SUMO_SIM_par_1 109 114 PF11976 0.322
LIG_TRAF2_1 256 259 PF00917 0.372
MOD_CDK_SPK_2 102 107 PF00069 0.386
MOD_CDK_SPK_2 183 188 PF00069 0.310
MOD_CDK_SPxxK_3 25 32 PF00069 0.607
MOD_CK1_1 151 157 PF00069 0.455
MOD_CK1_1 180 186 PF00069 0.314
MOD_CK1_1 196 202 PF00069 0.383
MOD_CK1_1 321 327 PF00069 0.463
MOD_CK1_1 423 429 PF00069 0.341
MOD_CK1_1 508 514 PF00069 0.383
MOD_CK2_1 163 169 PF00069 0.392
MOD_CK2_1 183 189 PF00069 0.314
MOD_CK2_1 2 8 PF00069 0.662
MOD_CK2_1 21 27 PF00069 0.702
MOD_CK2_1 253 259 PF00069 0.424
MOD_CK2_1 261 267 PF00069 0.443
MOD_CK2_1 363 369 PF00069 0.394
MOD_CK2_1 391 397 PF00069 0.350
MOD_CK2_1 418 424 PF00069 0.419
MOD_CK2_1 47 53 PF00069 0.618
MOD_CK2_1 54 60 PF00069 0.599
MOD_CK2_1 97 103 PF00069 0.408
MOD_GlcNHglycan 116 119 PF01048 0.567
MOD_GlcNHglycan 126 129 PF01048 0.659
MOD_GlcNHglycan 165 169 PF01048 0.592
MOD_GlcNHglycan 172 175 PF01048 0.476
MOD_GlcNHglycan 182 185 PF01048 0.480
MOD_GlcNHglycan 299 302 PF01048 0.645
MOD_GlcNHglycan 38 41 PF01048 0.448
MOD_GlcNHglycan 472 476 PF01048 0.586
MOD_GlcNHglycan 508 511 PF01048 0.501
MOD_GlcNHglycan 63 67 PF01048 0.501
MOD_GlcNHglycan 8 11 PF01048 0.500
MOD_GSK3_1 147 154 PF00069 0.417
MOD_GSK3_1 176 183 PF00069 0.338
MOD_GSK3_1 2 9 PF00069 0.712
MOD_GSK3_1 21 28 PF00069 0.707
MOD_GSK3_1 222 229 PF00069 0.366
MOD_GSK3_1 419 426 PF00069 0.389
MOD_GSK3_1 479 486 PF00069 0.448
MOD_GSK3_1 505 512 PF00069 0.394
MOD_N-GLC_1 163 168 PF02516 0.618
MOD_N-GLC_1 193 198 PF02516 0.549
MOD_N-GLC_1 204 209 PF02516 0.535
MOD_N-GLC_1 363 368 PF02516 0.535
MOD_N-GLC_1 480 485 PF02516 0.657
MOD_N-GLC_1 95 100 PF02516 0.653
MOD_NEK2_1 116 121 PF00069 0.289
MOD_NEK2_1 124 129 PF00069 0.359
MOD_NEK2_1 137 142 PF00069 0.422
MOD_NEK2_1 2 7 PF00069 0.720
MOD_NEK2_1 222 227 PF00069 0.313
MOD_NEK2_1 277 282 PF00069 0.370
MOD_NEK2_1 318 323 PF00069 0.492
MOD_NEK2_1 337 342 PF00069 0.329
MOD_NEK2_1 430 435 PF00069 0.275
MOD_NEK2_2 177 182 PF00069 0.348
MOD_OFUCOSY 276 282 PF10250 0.518
MOD_PIKK_1 137 143 PF00454 0.399
MOD_PIKK_1 149 155 PF00454 0.241
MOD_PIKK_1 241 247 PF00454 0.300
MOD_PIKK_1 319 325 PF00454 0.459
MOD_PIKK_1 391 397 PF00454 0.390
MOD_PIKK_1 449 455 PF00454 0.367
MOD_PKA_2 261 267 PF00069 0.431
MOD_PKB_1 389 397 PF00069 0.390
MOD_Plk_1 337 343 PF00069 0.294
MOD_Plk_1 423 429 PF00069 0.390
MOD_Plk_1 471 477 PF00069 0.377
MOD_Plk_4 116 122 PF00069 0.320
MOD_Plk_4 177 183 PF00069 0.275
MOD_Plk_4 198 204 PF00069 0.413
MOD_Plk_4 2 8 PF00069 0.761
MOD_Plk_4 222 228 PF00069 0.378
MOD_Plk_4 310 316 PF00069 0.394
MOD_Plk_4 337 343 PF00069 0.328
MOD_Plk_4 353 359 PF00069 0.380
MOD_Plk_4 456 462 PF00069 0.290
MOD_ProDKin_1 102 108 PF00069 0.445
MOD_ProDKin_1 183 189 PF00069 0.392
MOD_ProDKin_1 25 31 PF00069 0.729
MOD_ProDKin_1 288 294 PF00069 0.399
MOD_ProDKin_1 483 489 PF00069 0.390
TRG_NES_CRM1_1 455 470 PF08389 0.350
TRG_Pf-PMV_PEXEL_1 56 60 PF00026 0.447

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I453 Leptomonas seymouri 64% 99%
A0A1X0NM85 Trypanosomatidae 36% 87%
A0A3Q8IHP7 Leishmania donovani 100% 100%
A0A422NA33 Trypanosoma rangeli 36% 97%
A4H6X3 Leishmania braziliensis 80% 100%
E9ANY7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4QGN3 Leishmania major 93% 100%
V5AZS1 Trypanosoma cruzi 36% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS