TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AGE4_LEIIN

TriTrypDb:

LINF_120010900

Length:

1369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Show entries

Cellular components
Term	Name	Level	Count
GO:0000127	transcription factor TFIIIC complex	4	1
GO:0005667	transcription regulator complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0090576	RNA polymerase III transcription regulator complex	3	1

Previous1Next

Expansion

Sequence features

E9AGE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGE4

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006351	DNA-templated transcription	7	7
GO:0006383	transcription by RNA polymerase III	8	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009059	macromolecule biosynthetic process	4	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7

Previous1 2 3Next

Could not find GO molecular_function term for this entry.

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1019	1023	PF00656	0.625
CLV_C14_Caspase3-7	502	506	PF00656	0.396
CLV_C14_Caspase3-7	852	856	PF00656	0.711
CLV_C14_Caspase3-7	861	865	PF00656	0.624
CLV_NRD_NRD_1	1103	1105	PF00675	0.512
CLV_NRD_NRD_1	1150	1152	PF00675	0.382
CLV_NRD_NRD_1	1231	1233	PF00675	0.526
CLV_NRD_NRD_1	161	163	PF00675	0.407
CLV_NRD_NRD_1	24	26	PF00675	0.658
CLV_NRD_NRD_1	478	480	PF00675	0.515

Previous1 2 3 4 5…46Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y2	Leptomonas seymouri	65%	100%
A0A3S7WS10	Leishmania donovani	100%	100%
A4H6W5	Leishmania braziliensis	85%	100%
E9ANY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QGN6	Leishmania major	95%	100%

Previous1Next