Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AGE3_LEIIN

TriTrypDb:

LINF_120010800

Length:

499

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.611
CLV_NRD_NRD_1	119	121	PF00675	0.468
CLV_NRD_NRD_1	156	158	PF00675	0.482
CLV_NRD_NRD_1	18	20	PF00675	0.457
CLV_PCSK_KEX2_1	119	121	PF00082	0.468
CLV_PCSK_KEX2_1	18	20	PF00082	0.457
CLV_PCSK_KEX2_1	491	493	PF00082	0.499
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.499
CLV_PCSK_PC7_1	487	493	PF00082	0.497
CLV_PCSK_SKI1_1	119	123	PF00082	0.481
CLV_PCSK_SKI1_1	467	471	PF00082	0.487
CLV_Separin_Metazoa	413	417	PF03568	0.628
CLV_Separin_Metazoa	468	472	PF03568	0.494
DEG_APCC_KENBOX_2	270	274	PF00400	0.688
DEG_SCF_FBW7_1	166	173	PF00400	0.582
DEG_SPOP_SBC_1	170	174	PF00917	0.599
DOC_CYCLIN_RxL_1	467	477	PF00134	0.456
DOC_MAPK_FxFP_2	422	425	PF00069	0.588
DOC_MAPK_gen_1	145	153	PF00069	0.452
DOC_PP4_FxxP_1	296	299	PF00568	0.658
DOC_PP4_FxxP_1	422	425	PF00568	0.588
DOC_USP7_MATH_1	170	174	PF00917	0.599
DOC_USP7_MATH_1	189	193	PF00917	0.480
DOC_USP7_MATH_1	198	202	PF00917	0.590
DOC_USP7_MATH_1	207	211	PF00917	0.525
DOC_USP7_MATH_1	232	236	PF00917	0.646
DOC_USP7_MATH_1	310	314	PF00917	0.631
DOC_USP7_MATH_1	334	338	PF00917	0.688
DOC_USP7_MATH_1	347	351	PF00917	0.574
DOC_USP7_MATH_1	389	393	PF00917	0.581
DOC_USP7_MATH_1	456	460	PF00917	0.546
DOC_USP7_UBL2_3	143	147	PF12436	0.600
DOC_USP7_UBL2_3	271	275	PF12436	0.686
DOC_WW_Pin1_4	166	171	PF00397	0.575
DOC_WW_Pin1_4	213	218	PF00397	0.657
DOC_WW_Pin1_4	233	238	PF00397	0.503
DOC_WW_Pin1_4	255	260	PF00397	0.660
DOC_WW_Pin1_4	295	300	PF00397	0.749
DOC_WW_Pin1_4	364	369	PF00397	0.697
DOC_WW_Pin1_4	371	376	PF00397	0.685
LIG_14-3-3_CanoR_1	19	25	PF00244	0.599
LIG_14-3-3_CanoR_1	244	248	PF00244	0.646
LIG_14-3-3_CanoR_1	338	348	PF00244	0.684
LIG_14-3-3_CanoR_1	384	390	PF00244	0.635
LIG_AP2alpha_2	420	422	PF02296	0.600
LIG_BRCT_BRCA1_1	171	175	PF00533	0.607
LIG_CSL_BTD_1	318	321	PF09270	0.630
LIG_EVH1_1	424	428	PF00568	0.612
LIG_FHA_1	135	141	PF00498	0.452
LIG_FHA_1	385	391	PF00498	0.594
LIG_FHA_1	69	75	PF00498	0.440
LIG_FHA_2	112	118	PF00498	0.475
LIG_FHA_2	447	453	PF00498	0.620
LIG_LIR_Apic_2	226	231	PF02991	0.637
LIG_LIR_Apic_2	295	299	PF02991	0.657
LIG_LIR_Apic_2	420	425	PF02991	0.596
LIG_LIR_Gen_1	25	34	PF02991	0.318
LIG_LIR_Gen_1	436	442	PF02991	0.573
LIG_LIR_Gen_1	9	17	PF02991	0.452
LIG_LIR_Nem_3	25	30	PF02991	0.455
LIG_LIR_Nem_3	436	441	PF02991	0.575
LIG_LIR_Nem_3	488	493	PF02991	0.495
LIG_NRBOX	469	475	PF00104	0.455
LIG_SH2_CRK	222	226	PF00017	0.641
LIG_SH2_CRK	228	232	PF00017	0.592
LIG_SH2_CRK	438	442	PF00017	0.571
LIG_SH2_CRK	490	494	PF00017	0.502
LIG_SH2_STAP1	27	31	PF00017	0.436
LIG_SH2_STAP1	385	389	PF00017	0.651
LIG_SH2_STAT5	385	388	PF00017	0.651
LIG_SH3_3	253	259	PF00018	0.655
LIG_SH3_3	314	320	PF00018	0.629
LIG_SH3_3	422	428	PF00018	0.661
LIG_SH3_CIN85_PxpxPR_1	421	426	PF14604	0.604
LIG_SUMO_SIM_anti_2	313	319	PF11976	0.597
LIG_TRAF2_1	102	105	PF00917	0.515
LIG_TRAF2_1	48	51	PF00917	0.426
LIG_UBA3_1	469	476	PF00899	0.454
LIG_WRC_WIRS_1	293	298	PF05994	0.590
MOD_CDK_SPxxK_3	213	220	PF00069	0.625
MOD_CDK_SPxxK_3	299	306	PF00069	0.639
MOD_CK1_1	168	174	PF00069	0.591
MOD_CK1_1	212	218	PF00069	0.749
MOD_CK1_1	235	241	PF00069	0.645
MOD_CK1_1	245	251	PF00069	0.564
MOD_CK1_1	289	295	PF00069	0.615
MOD_CK1_1	3	9	PF00069	0.521
MOD_CK1_1	333	339	PF00069	0.685
MOD_CK1_1	341	347	PF00069	0.624
MOD_CK1_1	371	377	PF00069	0.639
MOD_CK1_1	81	87	PF00069	0.532
MOD_CK2_1	111	117	PF00069	0.474
MOD_CK2_1	233	239	PF00069	0.647
MOD_CK2_1	255	261	PF00069	0.661
MOD_CK2_1	266	272	PF00069	0.595
MOD_CK2_1	3	9	PF00069	0.521
MOD_CK2_1	427	433	PF00069	0.574
MOD_CK2_1	45	51	PF00069	0.415
MOD_GlcNHglycan	124	129	PF01048	0.470
MOD_GlcNHglycan	209	212	PF01048	0.685
MOD_GlcNHglycan	299	302	PF01048	0.605
MOD_GlcNHglycan	312	315	PF01048	0.571
MOD_GlcNHglycan	332	335	PF01048	0.538
MOD_GlcNHglycan	349	352	PF01048	0.556
MOD_GlcNHglycan	387	390	PF01048	0.636
MOD_GlcNHglycan	429	432	PF01048	0.629
MOD_GlcNHglycan	452	456	PF01048	0.624
MOD_GlcNHglycan	458	461	PF01048	0.502
MOD_GlcNHglycan	75	78	PF01048	0.505
MOD_GlcNHglycan	80	83	PF01048	0.494
MOD_GlcNHglycan	91	94	PF01048	0.480
MOD_GSK3_1	107	114	PF00069	0.485
MOD_GSK3_1	164	171	PF00069	0.568
MOD_GSK3_1	209	216	PF00069	0.617
MOD_GSK3_1	242	249	PF00069	0.646
MOD_GSK3_1	288	295	PF00069	0.654
MOD_GSK3_1	326	333	PF00069	0.672
MOD_GSK3_1	334	341	PF00069	0.637
MOD_GSK3_1	364	371	PF00069	0.664
MOD_GSK3_1	385	392	PF00069	0.663
MOD_GSK3_1	436	443	PF00069	0.619
MOD_GSK3_1	447	454	PF00069	0.527
MOD_GSK3_1	84	91	PF00069	0.540
MOD_NEK2_1	107	112	PF00069	0.344
MOD_NEK2_1	243	248	PF00069	0.646
MOD_NEK2_1	45	50	PF00069	0.410
MOD_NEK2_1	78	83	PF00069	0.501
MOD_NEK2_1	89	94	PF00069	0.568
MOD_PIKK_1	198	204	PF00454	0.631
MOD_PIKK_1	215	221	PF00454	0.535
MOD_PIKK_1	336	342	PF00454	0.685
MOD_PIKK_1	391	397	PF00454	0.701
MOD_PIKK_1	45	51	PF00454	0.415
MOD_PKA_2	107	113	PF00069	0.399
MOD_PKA_2	134	140	PF00069	0.455
MOD_PKA_2	243	249	PF00069	0.645
MOD_PKA_2	383	389	PF00069	0.623
MOD_PKA_2	78	84	PF00069	0.530
MOD_PKA_2	96	102	PF00069	0.441
MOD_Plk_1	275	281	PF00069	0.624
MOD_Plk_1	289	295	PF00069	0.555
MOD_Plk_1	3	9	PF00069	0.521
MOD_Plk_1	84	90	PF00069	0.534
MOD_Plk_2-3	266	272	PF00069	0.619
MOD_Plk_4	223	229	PF00069	0.576
MOD_Plk_4	292	298	PF00069	0.654
MOD_Plk_4	433	439	PF00069	0.630
MOD_ProDKin_1	166	172	PF00069	0.580
MOD_ProDKin_1	213	219	PF00069	0.656
MOD_ProDKin_1	233	239	PF00069	0.504
MOD_ProDKin_1	255	261	PF00069	0.661
MOD_ProDKin_1	295	301	PF00069	0.745
MOD_ProDKin_1	364	370	PF00069	0.697
MOD_ProDKin_1	371	377	PF00069	0.684
TRG_ENDOCYTIC_2	21	24	PF00928	0.439
TRG_ENDOCYTIC_2	27	30	PF00928	0.399
TRG_ENDOCYTIC_2	438	441	PF00928	0.574
TRG_ENDOCYTIC_2	490	493	PF00928	0.499
TRG_ER_diArg_1	118	120	PF00400	0.465
TRG_ER_diArg_1	17	19	PF00400	0.460
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	471	475	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WS06	Leishmania donovani	99%	100%
E9ANY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QGN7	Leishmania major	90%	100%