LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AGE2_LEIIN
TriTrypDb:
LINF_120010700
Length:
167

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005741 mitochondrial outer membrane 5 1
GO:0016020 membrane 2 1
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0098588 bounding membrane of organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AGE2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGE2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 144 146 PF00675 0.605
CLV_NRD_NRD_1 45 47 PF00675 0.597
CLV_PCSK_KEX2_1 133 135 PF00082 0.620
CLV_PCSK_PC1ET2_1 133 135 PF00082 0.527
CLV_PCSK_SKI1_1 3 7 PF00082 0.684
DOC_PP1_RVXF_1 100 107 PF00149 0.478
DOC_PP1_RVXF_1 78 85 PF00149 0.457
DOC_USP7_UBL2_3 153 157 PF12436 0.593
DOC_USP7_UBL2_3 19 23 PF12436 0.548
DOC_WW_Pin1_4 106 111 PF00397 0.625
DOC_WW_Pin1_4 121 126 PF00397 0.513
DOC_WW_Pin1_4 148 153 PF00397 0.612
LIG_14-3-3_CanoR_1 143 152 PF00244 0.546
LIG_14-3-3_CanoR_1 7 17 PF00244 0.509
LIG_BRCT_BRCA1_1 17 21 PF00533 0.555
LIG_BRCT_BRCA1_2 17 23 PF00533 0.527
LIG_LIR_Gen_1 155 165 PF02991 0.580
LIG_LIR_Nem_3 155 161 PF02991 0.559
LIG_NRP_CendR_1 164 167 PF00754 0.560
LIG_Pex14_2 17 21 PF04695 0.493
LIG_Pex14_2 9 13 PF04695 0.493
LIG_SH3_3 115 121 PF00018 0.474
LIG_SH3_3 146 152 PF00018 0.516
LIG_SH3_3 156 162 PF00018 0.618
LIG_SH3_3 67 73 PF00018 0.631
LIG_WRC_WIRS_1 10 15 PF05994 0.487
LIG_WW_1 162 165 PF00397 0.615
LIG_WW_3 161 165 PF00397 0.586
MOD_CDK_SPK_2 148 153 PF00069 0.607
MOD_CK1_1 11 17 PF00069 0.672
MOD_CK1_1 35 41 PF00069 0.607
MOD_CK1_1 50 56 PF00069 0.603
MOD_Cter_Amidation 131 134 PF01082 0.521
MOD_GlcNHglycan 35 38 PF01048 0.751
MOD_GlcNHglycan 50 53 PF01048 0.583
MOD_GlcNHglycan 65 68 PF01048 0.689
MOD_GSK3_1 11 18 PF00069 0.527
MOD_GSK3_1 144 151 PF00069 0.734
MOD_GSK3_1 35 42 PF00069 0.659
MOD_NEK2_1 1 6 PF00069 0.526
MOD_NEK2_1 144 149 PF00069 0.541
MOD_NEK2_1 32 37 PF00069 0.633
MOD_NEK2_1 9 14 PF00069 0.507
MOD_NEK2_2 39 44 PF00069 0.621
MOD_PIKK_1 144 150 PF00454 0.537
MOD_PKA_2 144 150 PF00069 0.543
MOD_Plk_4 39 45 PF00069 0.641
MOD_ProDKin_1 106 112 PF00069 0.627
MOD_ProDKin_1 121 127 PF00069 0.510
MOD_ProDKin_1 148 154 PF00069 0.608
MOD_SUMO_for_1 152 155 PF00179 0.604
MOD_SUMO_rev_2 151 159 PF00179 0.573

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4JMJ7 Bodo saltans 47% 100%
A0A3S7WRX5 Leishmania donovani 99% 100%
E9ANY2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4QGN8 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS