LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
WW domain containing protein - putative
Species:
Leishmania infantum
UniProt:
E9AGD9_LEIIN
TriTrypDb:
LINF_120010400
Length:
969

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized LINJ.12.0470

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AGD9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGD9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 198 202 PF00656 0.776
CLV_C14_Caspase3-7 268 272 PF00656 0.571
CLV_C14_Caspase3-7 299 303 PF00656 0.597
CLV_C14_Caspase3-7 434 438 PF00656 0.672
CLV_C14_Caspase3-7 950 954 PF00656 0.719
CLV_NRD_NRD_1 107 109 PF00675 0.706
CLV_NRD_NRD_1 279 281 PF00675 0.610
CLV_NRD_NRD_1 292 294 PF00675 0.499
CLV_NRD_NRD_1 349 351 PF00675 0.610
CLV_NRD_NRD_1 373 375 PF00675 0.541
CLV_NRD_NRD_1 465 467 PF00675 0.616
CLV_NRD_NRD_1 554 556 PF00675 0.729
CLV_NRD_NRD_1 599 601 PF00675 0.761
CLV_NRD_NRD_1 723 725 PF00675 0.471
CLV_NRD_NRD_1 736 738 PF00675 0.439
CLV_NRD_NRD_1 742 744 PF00675 0.356
CLV_NRD_NRD_1 894 896 PF00675 0.656
CLV_NRD_NRD_1 925 927 PF00675 0.671
CLV_NRD_NRD_1 943 945 PF00675 0.772
CLV_NRD_NRD_1 956 958 PF00675 0.627
CLV_PCSK_FUR_1 365 369 PF00082 0.549
CLV_PCSK_KEX2_1 106 108 PF00082 0.707
CLV_PCSK_KEX2_1 264 266 PF00082 0.559
CLV_PCSK_KEX2_1 279 281 PF00082 0.393
CLV_PCSK_KEX2_1 291 293 PF00082 0.503
CLV_PCSK_KEX2_1 349 351 PF00082 0.599
CLV_PCSK_KEX2_1 367 369 PF00082 0.506
CLV_PCSK_KEX2_1 554 556 PF00082 0.729
CLV_PCSK_KEX2_1 742 744 PF00082 0.613
CLV_PCSK_KEX2_1 756 758 PF00082 0.618
CLV_PCSK_KEX2_1 894 896 PF00082 0.568
CLV_PCSK_KEX2_1 925 927 PF00082 0.707
CLV_PCSK_KEX2_1 943 945 PF00082 0.772
CLV_PCSK_KEX2_1 956 958 PF00082 0.627
CLV_PCSK_PC1ET2_1 106 108 PF00082 0.707
CLV_PCSK_PC1ET2_1 264 266 PF00082 0.607
CLV_PCSK_PC1ET2_1 291 293 PF00082 0.541
CLV_PCSK_PC1ET2_1 349 351 PF00082 0.503
CLV_PCSK_PC1ET2_1 367 369 PF00082 0.548
CLV_PCSK_PC1ET2_1 756 758 PF00082 0.538
CLV_PCSK_SKI1_1 102 106 PF00082 0.592
CLV_PCSK_SKI1_1 231 235 PF00082 0.805
CLV_PCSK_SKI1_1 387 391 PF00082 0.525
CLV_PCSK_SKI1_1 600 604 PF00082 0.720
CLV_PCSK_SKI1_1 634 638 PF00082 0.464
CLV_PCSK_SKI1_1 65 69 PF00082 0.462
CLV_PCSK_SKI1_1 804 808 PF00082 0.473
CLV_PCSK_SKI1_1 85 89 PF00082 0.464
DEG_APCC_DBOX_1 554 562 PF00400 0.757
DEG_APCC_KENBOX_2 77 81 PF00400 0.646
DEG_SCF_FBW7_1 656 662 PF00400 0.722
DEG_SCF_FBW7_1 87 92 PF00400 0.721
DEG_SPOP_SBC_1 232 236 PF00917 0.679
DEG_SPOP_SBC_1 760 764 PF00917 0.568
DOC_ANK_TNKS_1 709 716 PF00023 0.575
DOC_ANK_TNKS_1 934 941 PF00023 0.733
DOC_CKS1_1 656 661 PF01111 0.730
DOC_CYCLIN_RxL_1 62 71 PF00134 0.459
DOC_CYCLIN_yCln2_LP_2 684 687 PF00134 0.798
DOC_MAPK_gen_1 551 560 PF00069 0.659
DOC_PP2B_LxvP_1 26 29 PF13499 0.449
DOC_PP2B_LxvP_1 684 687 PF13499 0.807
DOC_PP4_FxxP_1 642 645 PF00568 0.556
DOC_PP4_FxxP_1 700 703 PF00568 0.680
DOC_PP4_FxxP_1 843 846 PF00568 0.560
DOC_USP7_MATH_1 180 184 PF00917 0.737
DOC_USP7_MATH_1 204 208 PF00917 0.667
DOC_USP7_MATH_1 36 40 PF00917 0.329
DOC_USP7_MATH_1 385 389 PF00917 0.585
DOC_USP7_MATH_1 661 665 PF00917 0.709
DOC_USP7_MATH_1 668 672 PF00917 0.705
DOC_USP7_MATH_1 847 851 PF00917 0.685
DOC_USP7_MATH_1 867 871 PF00917 0.605
DOC_USP7_MATH_1 89 93 PF00917 0.781
DOC_USP7_UBL2_3 102 106 PF12436 0.764
DOC_USP7_UBL2_3 477 481 PF12436 0.557
DOC_USP7_UBL2_3 529 533 PF12436 0.546
DOC_USP7_UBL2_3 74 78 PF12436 0.601
DOC_WW_Pin1_4 13 18 PF00397 0.408
DOC_WW_Pin1_4 225 230 PF00397 0.730
DOC_WW_Pin1_4 567 572 PF00397 0.714
DOC_WW_Pin1_4 637 642 PF00397 0.396
DOC_WW_Pin1_4 643 648 PF00397 0.603
DOC_WW_Pin1_4 655 660 PF00397 0.641
DOC_WW_Pin1_4 664 669 PF00397 0.727
DOC_WW_Pin1_4 85 90 PF00397 0.730
DOC_WW_Pin1_4 879 884 PF00397 0.657
DOC_WW_Pin1_4 913 918 PF00397 0.739
DOC_WW_Pin1_4 928 933 PF00397 0.725
LIG_14-3-3_CanoR_1 182 188 PF00244 0.750
LIG_14-3-3_CanoR_1 554 559 PF00244 0.680
LIG_14-3-3_CanoR_1 605 609 PF00244 0.744
LIG_14-3-3_CanoR_1 761 769 PF00244 0.490
LIG_14-3-3_CanoR_1 774 778 PF00244 0.410
LIG_14-3-3_CanoR_1 804 809 PF00244 0.476
LIG_14-3-3_CanoR_1 848 852 PF00244 0.566
LIG_14-3-3_CanoR_1 925 931 PF00244 0.695
LIG_Actin_WH2_2 462 479 PF00022 0.619
LIG_Actin_WH2_2 621 636 PF00022 0.518
LIG_BIR_III_2 201 205 PF00653 0.672
LIG_BRCT_BRCA1_1 378 382 PF00533 0.595
LIG_BRCT_BRCA1_1 395 399 PF00533 0.315
LIG_BRCT_BRCA1_1 696 700 PF00533 0.733
LIG_Clathr_ClatBox_1 805 809 PF01394 0.511
LIG_FHA_1 128 134 PF00498 0.669
LIG_FHA_1 14 20 PF00498 0.385
LIG_FHA_1 628 634 PF00498 0.492
LIG_FHA_1 834 840 PF00498 0.489
LIG_FHA_1 898 904 PF00498 0.563
LIG_FHA_2 511 517 PF00498 0.563
LIG_FHA_2 580 586 PF00498 0.721
LIG_FHA_2 604 610 PF00498 0.781
LIG_FHA_2 652 658 PF00498 0.728
LIG_FHA_2 774 780 PF00498 0.572
LIG_FHA_2 957 963 PF00498 0.738
LIG_IRF3_LxIS_1 145 152 PF10401 0.628
LIG_LIR_Apic_2 54 59 PF02991 0.324
LIG_LIR_Apic_2 640 645 PF02991 0.529
LIG_LIR_Apic_2 697 703 PF02991 0.706
LIG_LIR_Apic_2 841 847 PF02991 0.524
LIG_LIR_Apic_2 962 967 PF02991 0.684
LIG_LIR_Gen_1 419 426 PF02991 0.485
LIG_LIR_Nem_3 419 424 PF02991 0.485
LIG_LIR_Nem_3 43 49 PF02991 0.321
LIG_LIR_Nem_3 61 67 PF02991 0.444
LIG_PCNA_yPIPBox_3 535 548 PF02747 0.694
LIG_PCNA_yPIPBox_3 622 634 PF02747 0.573
LIG_Pex14_2 395 399 PF04695 0.578
LIG_REV1ctd_RIR_1 841 845 PF16727 0.540
LIG_RPA_C_Fungi 165 177 PF08784 0.640
LIG_SH2_CRK 865 869 PF00017 0.722
LIG_SH2_GRB2like 46 49 PF00017 0.321
LIG_SH2_PTP2 726 729 PF00017 0.534
LIG_SH2_STAP1 326 330 PF00017 0.509
LIG_SH2_STAP1 403 407 PF00017 0.503
LIG_SH2_STAT3 255 258 PF00017 0.559
LIG_SH2_STAT5 46 49 PF00017 0.321
LIG_SH2_STAT5 726 729 PF00017 0.534
LIG_SH2_STAT5 941 944 PF00017 0.670
LIG_SH3_1 653 659 PF00018 0.732
LIG_SH3_3 653 659 PF00018 0.732
LIG_SH3_4 120 127 PF00018 0.685
LIG_SUMO_SIM_anti_2 556 562 PF11976 0.769
LIG_SUMO_SIM_par_1 358 364 PF11976 0.453
LIG_SUMO_SIM_par_1 804 809 PF11976 0.586
LIG_TRAF2_1 381 384 PF00917 0.555
LIG_TRAF2_1 536 539 PF00917 0.550
LIG_TRAF2_1 607 610 PF00917 0.759
LIG_TRAF2_1 705 708 PF00917 0.457
LIG_TRAF2_1 776 779 PF00917 0.523
LIG_UBA3_1 359 367 PF00899 0.376
LIG_UBA3_1 543 551 PF00899 0.674
LIG_UBA3_1 805 810 PF00899 0.484
LIG_WW_3 845 849 PF00397 0.714
MOD_CDC14_SPxK_1 228 231 PF00782 0.742
MOD_CDK_SPK_2 567 572 PF00069 0.710
MOD_CDK_SPxK_1 225 231 PF00069 0.739
MOD_CDK_SPxK_1 664 670 PF00069 0.764
MOD_CDK_SPxxK_3 928 935 PF00069 0.671
MOD_CK1_1 109 115 PF00069 0.638
MOD_CK1_1 178 184 PF00069 0.697
MOD_CK1_1 186 192 PF00069 0.693
MOD_CK1_1 553 559 PF00069 0.673
MOD_CK1_1 646 652 PF00069 0.724
MOD_CK1_1 664 670 PF00069 0.596
MOD_CK1_1 833 839 PF00069 0.487
MOD_CK1_1 850 856 PF00069 0.707
MOD_CK1_1 928 934 PF00069 0.707
MOD_CK2_1 109 115 PF00069 0.684
MOD_CK2_1 224 230 PF00069 0.776
MOD_CK2_1 416 422 PF00069 0.610
MOD_CK2_1 510 516 PF00069 0.551
MOD_CK2_1 603 609 PF00069 0.723
MOD_CK2_1 651 657 PF00069 0.749
MOD_CK2_1 702 708 PF00069 0.477
MOD_CK2_1 773 779 PF00069 0.530
MOD_CK2_1 887 893 PF00069 0.630
MOD_Cter_Amidation 722 725 PF01082 0.444
MOD_GlcNHglycan 307 310 PF01048 0.619
MOD_GlcNHglycan 396 399 PF01048 0.497
MOD_GlcNHglycan 458 461 PF01048 0.422
MOD_GlcNHglycan 495 498 PF01048 0.650
MOD_GlcNHglycan 579 582 PF01048 0.711
MOD_GlcNHglycan 609 613 PF01048 0.691
MOD_GlcNHglycan 663 666 PF01048 0.743
MOD_GlcNHglycan 670 673 PF01048 0.723
MOD_GlcNHglycan 689 692 PF01048 0.569
MOD_GlcNHglycan 696 699 PF01048 0.634
MOD_GlcNHglycan 825 829 PF01048 0.726
MOD_GlcNHglycan 869 872 PF01048 0.721
MOD_GlcNHglycan 99 102 PF01048 0.753
MOD_GSK3_1 145 152 PF00069 0.672
MOD_GSK3_1 171 178 PF00069 0.755
MOD_GSK3_1 182 189 PF00069 0.712
MOD_GSK3_1 550 557 PF00069 0.683
MOD_GSK3_1 563 570 PF00069 0.681
MOD_GSK3_1 573 580 PF00069 0.630
MOD_GSK3_1 604 611 PF00069 0.694
MOD_GSK3_1 651 658 PF00069 0.674
MOD_GSK3_1 659 666 PF00069 0.699
MOD_GSK3_1 687 694 PF00069 0.666
MOD_GSK3_1 85 92 PF00069 0.703
MOD_GSK3_1 879 886 PF00069 0.715
MOD_GSK3_1 909 916 PF00069 0.702
MOD_GSK3_1 921 928 PF00069 0.763
MOD_GSK3_1 943 950 PF00069 0.710
MOD_N-GLC_1 830 835 PF02516 0.598
MOD_N-GLC_2 830 832 PF02516 0.653
MOD_NEK2_1 149 154 PF00069 0.754
MOD_NEK2_1 176 181 PF00069 0.702
MOD_NEK2_1 224 229 PF00069 0.673
MOD_NEK2_1 476 481 PF00069 0.557
MOD_NEK2_1 510 515 PF00069 0.520
MOD_NEK2_1 573 578 PF00069 0.792
MOD_NEK2_1 603 608 PF00069 0.769
MOD_NEK2_1 675 680 PF00069 0.721
MOD_NEK2_1 741 746 PF00069 0.547
MOD_NEK2_1 791 796 PF00069 0.510
MOD_PIKK_1 376 382 PF00454 0.557
MOD_PIKK_1 476 482 PF00454 0.556
MOD_PIKK_1 501 507 PF00454 0.641
MOD_PIKK_1 517 523 PF00454 0.414
MOD_PIKK_1 791 797 PF00454 0.520
MOD_PIKK_1 909 915 PF00454 0.731
MOD_PK_1 129 135 PF00069 0.727
MOD_PKA_1 106 112 PF00069 0.694
MOD_PKA_1 554 560 PF00069 0.759
MOD_PKA_1 925 931 PF00069 0.699
MOD_PKA_1 943 949 PF00069 0.767
MOD_PKA_1 956 962 PF00069 0.615
MOD_PKA_2 106 112 PF00069 0.681
MOD_PKA_2 553 559 PF00069 0.741
MOD_PKA_2 604 610 PF00069 0.695
MOD_PKA_2 675 681 PF00069 0.687
MOD_PKA_2 741 747 PF00069 0.516
MOD_PKA_2 760 766 PF00069 0.344
MOD_PKA_2 773 779 PF00069 0.398
MOD_PKA_2 791 797 PF00069 0.420
MOD_PKA_2 847 853 PF00069 0.695
MOD_PKA_2 925 931 PF00069 0.655
MOD_PKA_2 942 948 PF00069 0.456
MOD_PKA_2 956 962 PF00069 0.703
MOD_Plk_1 715 721 PF00069 0.570
MOD_Plk_1 824 830 PF00069 0.610
MOD_Plk_1 897 903 PF00069 0.507
MOD_Plk_2-3 416 422 PF00069 0.476
MOD_Plk_2-3 57 63 PF00069 0.526
MOD_Plk_2-3 708 714 PF00069 0.636
MOD_Plk_4 150 156 PF00069 0.675
MOD_Plk_4 183 189 PF00069 0.672
MOD_Plk_4 416 422 PF00069 0.476
MOD_Plk_4 51 57 PF00069 0.412
MOD_Plk_4 556 562 PF00069 0.739
MOD_Plk_4 898 904 PF00069 0.509
MOD_ProDKin_1 13 19 PF00069 0.405
MOD_ProDKin_1 225 231 PF00069 0.731
MOD_ProDKin_1 567 573 PF00069 0.715
MOD_ProDKin_1 637 643 PF00069 0.404
MOD_ProDKin_1 655 661 PF00069 0.640
MOD_ProDKin_1 664 670 PF00069 0.728
MOD_ProDKin_1 85 91 PF00069 0.731
MOD_ProDKin_1 879 885 PF00069 0.653
MOD_ProDKin_1 913 919 PF00069 0.743
MOD_ProDKin_1 928 934 PF00069 0.601
MOD_SUMO_for_1 304 307 PF00179 0.414
MOD_SUMO_for_1 68 71 PF00179 0.537
MOD_SUMO_for_1 755 758 PF00179 0.466
MOD_SUMO_rev_2 112 121 PF00179 0.636
MOD_SUMO_rev_2 314 320 PF00179 0.621
MOD_SUMO_rev_2 325 331 PF00179 0.438
MOD_SUMO_rev_2 388 395 PF00179 0.575
MOD_SUMO_rev_2 434 441 PF00179 0.557
MOD_SUMO_rev_2 470 479 PF00179 0.624
MOD_SUMO_rev_2 512 520 PF00179 0.528
TRG_DiLeu_BaEn_1 708 713 PF01217 0.448
TRG_DiLeu_BaEn_3 538 544 PF01217 0.645
TRG_DiLeu_BaEn_4 813 819 PF01217 0.587
TRG_DiLeu_BaLyEn_6 14 19 PF01217 0.557
TRG_DiLeu_BaLyEn_6 801 806 PF01217 0.468
TRG_ENDOCYTIC_2 46 49 PF00928 0.321
TRG_ENDOCYTIC_2 64 67 PF00928 0.439
TRG_ENDOCYTIC_2 726 729 PF00928 0.534
TRG_ENDOCYTIC_2 865 868 PF00928 0.724
TRG_ER_diArg_1 278 280 PF00400 0.590
TRG_ER_diArg_1 717 720 PF00400 0.491
TRG_ER_diArg_1 741 743 PF00400 0.605
TRG_ER_diArg_1 818 821 PF00400 0.590
TRG_ER_diArg_1 894 896 PF00400 0.575
TRG_ER_diArg_1 942 944 PF00400 0.766
TRG_ER_diArg_1 955 957 PF00400 0.626
TRG_NLS_Bipartite_1 279 295 PF00514 0.526
TRG_NLS_MonoCore_2 104 109 PF00514 0.698
TRG_NLS_MonoExtC_3 105 110 PF00514 0.700
TRG_NLS_MonoExtC_3 287 292 PF00514 0.611
TRG_NLS_MonoExtN_4 102 109 PF00514 0.722
TRG_NLS_MonoExtN_4 288 295 PF00514 0.610
TRG_Pf-PMV_PEXEL_1 143 147 PF00026 0.746
TRG_Pf-PMV_PEXEL_1 250 254 PF00026 0.641
TRG_Pf-PMV_PEXEL_1 710 714 PF00026 0.545
TRG_Pf-PMV_PEXEL_1 894 898 PF00026 0.495

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IL16 Leptomonas seymouri 55% 93%
A0A3R7KNZ4 Trypanosoma rangeli 31% 100%
A0A3S7WRX9 Leishmania donovani 99% 100%
A4H6W6 Leishmania braziliensis 84% 100%
E9ANX9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4QGP1 Leishmania major 94% 100%
V5AMQ0 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS