LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AGD5_LEIIN
TriTrypDb:
LINF_120009900 *
Length:
749

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized LINJ.12.0430

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGD5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGD5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 131 135 PF00656 0.775
CLV_C14_Caspase3-7 298 302 PF00656 0.656
CLV_NRD_NRD_1 153 155 PF00675 0.743
CLV_NRD_NRD_1 185 187 PF00675 0.806
CLV_NRD_NRD_1 188 190 PF00675 0.773
CLV_NRD_NRD_1 199 201 PF00675 0.589
CLV_NRD_NRD_1 246 248 PF00675 0.758
CLV_NRD_NRD_1 262 264 PF00675 0.641
CLV_NRD_NRD_1 464 466 PF00675 0.644
CLV_PCSK_FUR_1 186 190 PF00082 0.720
CLV_PCSK_KEX2_1 185 187 PF00082 0.809
CLV_PCSK_KEX2_1 188 190 PF00082 0.770
CLV_PCSK_KEX2_1 199 201 PF00082 0.586
CLV_PCSK_KEX2_1 245 247 PF00082 0.768
CLV_PCSK_KEX2_1 262 264 PF00082 0.636
CLV_PCSK_KEX2_1 464 466 PF00082 0.644
CLV_PCSK_PC1ET2_1 185 187 PF00082 0.759
CLV_PCSK_PC1ET2_1 245 247 PF00082 0.757
CLV_PCSK_SKI1_1 246 250 PF00082 0.745
CLV_PCSK_SKI1_1 40 44 PF00082 0.576
CLV_PCSK_SKI1_1 434 438 PF00082 0.772
CLV_PCSK_SKI1_1 448 452 PF00082 0.758
DEG_APCC_DBOX_1 543 551 PF00400 0.568
DEG_MDM2_SWIB_1 549 557 PF02201 0.574
DEG_SCF_FBW7_1 370 377 PF00400 0.622
DEG_SCF_TRCP1_1 270 275 PF00400 0.746
DEG_SPOP_SBC_1 324 328 PF00917 0.653
DEG_SPOP_SBC_1 7 11 PF00917 0.554
DOC_CKS1_1 507 512 PF01111 0.688
DOC_CKS1_1 699 704 PF01111 0.614
DOC_CYCLIN_RxL_1 240 252 PF00134 0.691
DOC_CYCLIN_yCln2_LP_2 401 407 PF00134 0.637
DOC_CYCLIN_yCln2_LP_2 474 480 PF00134 0.589
DOC_MAPK_gen_1 154 164 PF00069 0.726
DOC_MAPK_MEF2A_6 576 585 PF00069 0.706
DOC_MIT_MIM_1 161 171 PF04212 0.590
DOC_PP2B_LxvP_1 248 251 PF13499 0.602
DOC_PP2B_LxvP_1 401 404 PF13499 0.729
DOC_PP2B_LxvP_1 583 586 PF13499 0.691
DOC_PP4_FxxP_1 94 97 PF00568 0.590
DOC_PP4_MxPP_1 584 587 PF00568 0.567
DOC_USP7_MATH_1 114 118 PF00917 0.824
DOC_USP7_MATH_1 128 132 PF00917 0.578
DOC_USP7_MATH_1 181 185 PF00917 0.801
DOC_USP7_MATH_1 195 199 PF00917 0.586
DOC_USP7_MATH_1 256 260 PF00917 0.732
DOC_USP7_MATH_1 317 321 PF00917 0.764
DOC_USP7_MATH_1 323 327 PF00917 0.743
DOC_USP7_MATH_1 36 40 PF00917 0.614
DOC_USP7_MATH_1 46 50 PF00917 0.766
DOC_USP7_MATH_1 531 535 PF00917 0.756
DOC_USP7_MATH_1 555 559 PF00917 0.575
DOC_USP7_MATH_1 60 64 PF00917 0.713
DOC_USP7_MATH_1 674 678 PF00917 0.684
DOC_USP7_MATH_1 717 721 PF00917 0.693
DOC_USP7_MATH_1 733 737 PF00917 0.506
DOC_USP7_UBL2_3 151 155 PF12436 0.738
DOC_WW_Pin1_4 136 141 PF00397 0.727
DOC_WW_Pin1_4 281 286 PF00397 0.732
DOC_WW_Pin1_4 3 8 PF00397 0.656
DOC_WW_Pin1_4 370 375 PF00397 0.748
DOC_WW_Pin1_4 473 478 PF00397 0.696
DOC_WW_Pin1_4 506 511 PF00397 0.710
DOC_WW_Pin1_4 698 703 PF00397 0.778
DOC_WW_Pin1_4 706 711 PF00397 0.766
DOC_WW_Pin1_4 9 14 PF00397 0.652
LIG_14-3-3_CanoR_1 120 124 PF00244 0.719
LIG_14-3-3_CanoR_1 149 154 PF00244 0.746
LIG_14-3-3_CanoR_1 167 172 PF00244 0.565
LIG_14-3-3_CanoR_1 189 195 PF00244 0.754
LIG_14-3-3_CanoR_1 257 262 PF00244 0.714
LIG_14-3-3_CanoR_1 286 291 PF00244 0.720
LIG_14-3-3_CanoR_1 40 48 PF00244 0.593
LIG_14-3-3_CanoR_1 464 471 PF00244 0.765
LIG_14-3-3_CanoR_1 544 550 PF00244 0.753
LIG_14-3-3_CanoR_1 576 581 PF00244 0.600
LIG_14-3-3_CanoR_1 650 656 PF00244 0.743
LIG_AP2alpha_1 94 98 PF02296 0.587
LIG_AP2alpha_2 96 98 PF02296 0.764
LIG_BIR_III_4 421 425 PF00653 0.598
LIG_BRCT_BRCA1_1 545 549 PF00533 0.695
LIG_BRCT_BRCA1_1 708 712 PF00533 0.627
LIG_CtBP_PxDLS_1 565 569 PF00389 0.742
LIG_FHA_1 213 219 PF00498 0.737
LIG_FHA_1 311 317 PF00498 0.697
LIG_FHA_1 361 367 PF00498 0.728
LIG_FHA_1 435 441 PF00498 0.738
LIG_FHA_1 477 483 PF00498 0.680
LIG_FHA_1 594 600 PF00498 0.551
LIG_FHA_1 692 698 PF00498 0.777
LIG_FHA_1 739 745 PF00498 0.573
LIG_FHA_2 175 181 PF00498 0.747
LIG_FHA_2 229 235 PF00498 0.761
LIG_FHA_2 99 105 PF00498 0.714
LIG_Integrin_RGD_1 641 643 PF01839 0.659
LIG_LIR_Gen_1 207 216 PF02991 0.601
LIG_LIR_Gen_1 469 478 PF02991 0.603
LIG_LIR_Gen_1 538 547 PF02991 0.698
LIG_LIR_Gen_1 657 666 PF02991 0.671
LIG_LIR_Gen_1 715 725 PF02991 0.566
LIG_LIR_Nem_3 469 474 PF02991 0.614
LIG_LIR_Nem_3 538 542 PF02991 0.698
LIG_LIR_Nem_3 657 661 PF02991 0.661
LIG_LIR_Nem_3 715 721 PF02991 0.668
LIG_MYND_3 396 400 PF01753 0.730
LIG_PCNA_PIPBox_1 88 97 PF02747 0.597
LIG_Pex14_2 549 553 PF04695 0.702
LIG_Pex14_2 712 716 PF04695 0.600
LIG_Pex14_2 94 98 PF04695 0.587
LIG_SH2_NCK_1 591 595 PF00017 0.555
LIG_SH2_STAP1 335 339 PF00017 0.778
LIG_SH2_STAT5 307 310 PF00017 0.708
LIG_SH2_STAT5 601 604 PF00017 0.718
LIG_SH3_3 14 20 PF00018 0.635
LIG_SH3_3 208 214 PF00018 0.787
LIG_SH3_3 603 609 PF00018 0.645
LIG_SH3_3 696 702 PF00018 0.643
LIG_SH3_3 704 710 PF00018 0.810
LIG_SUMO_SIM_anti_2 360 368 PF11976 0.644
LIG_SUMO_SIM_anti_2 694 701 PF11976 0.696
LIG_SUMO_SIM_anti_2 741 746 PF11976 0.505
LIG_SUMO_SIM_par_1 362 368 PF11976 0.729
LIG_SUMO_SIM_par_1 435 443 PF11976 0.740
LIG_SUMO_SIM_par_1 740 746 PF11976 0.507
LIG_TRAF2_1 343 346 PF00917 0.718
LIG_TRAF2_1 410 413 PF00917 0.688
LIG_TRAF2_1 612 615 PF00917 0.707
LIG_WRC_WIRS_1 206 211 PF05994 0.604
LIG_WRC_WIRS_1 690 695 PF05994 0.735
MOD_CDK_SPK_2 281 286 PF00069 0.657
MOD_CDK_SPxK_1 370 376 PF00069 0.712
MOD_CK1_1 119 125 PF00069 0.748
MOD_CK1_1 174 180 PF00069 0.727
MOD_CK1_1 193 199 PF00069 0.693
MOD_CK1_1 241 247 PF00069 0.689
MOD_CK1_1 268 274 PF00069 0.684
MOD_CK1_1 284 290 PF00069 0.576
MOD_CK1_1 293 299 PF00069 0.688
MOD_CK1_1 3 9 PF00069 0.684
MOD_CK1_1 303 309 PF00069 0.541
MOD_CK1_1 326 332 PF00069 0.789
MOD_CK1_1 334 340 PF00069 0.678
MOD_CK1_1 360 366 PF00069 0.756
MOD_CK1_1 382 388 PF00069 0.690
MOD_CK1_1 460 466 PF00069 0.737
MOD_CK1_1 476 482 PF00069 0.540
MOD_CK1_1 491 497 PF00069 0.616
MOD_CK1_1 51 57 PF00069 0.698
MOD_CK1_1 512 518 PF00069 0.735
MOD_CK1_1 567 573 PF00069 0.628
MOD_CK1_1 593 599 PF00069 0.641
MOD_CK1_1 63 69 PF00069 0.632
MOD_CK1_1 654 660 PF00069 0.710
MOD_CK1_1 706 712 PF00069 0.816
MOD_CK1_1 720 726 PF00069 0.460
MOD_CK2_1 155 161 PF00069 0.744
MOD_CK2_1 174 180 PF00069 0.516
MOD_CK2_1 204 210 PF00069 0.785
MOD_CK2_1 230 236 PF00069 0.663
MOD_CK2_1 381 387 PF00069 0.777
MOD_CK2_1 406 412 PF00069 0.725
MOD_CK2_1 535 541 PF00069 0.676
MOD_GlcNHglycan 116 119 PF01048 0.777
MOD_GlcNHglycan 123 126 PF01048 0.672
MOD_GlcNHglycan 130 133 PF01048 0.534
MOD_GlcNHglycan 157 160 PF01048 0.760
MOD_GlcNHglycan 270 273 PF01048 0.819
MOD_GlcNHglycan 381 384 PF01048 0.778
MOD_GlcNHglycan 421 425 PF01048 0.686
MOD_GlcNHglycan 485 488 PF01048 0.764
MOD_GlcNHglycan 514 517 PF01048 0.752
MOD_GlcNHglycan 53 56 PF01048 0.702
MOD_GlcNHglycan 533 536 PF01048 0.750
MOD_GlcNHglycan 553 556 PF01048 0.722
MOD_GlcNHglycan 557 560 PF01048 0.704
MOD_GlcNHglycan 561 564 PF01048 0.669
MOD_GlcNHglycan 592 595 PF01048 0.572
MOD_GlcNHglycan 62 65 PF01048 0.769
MOD_GlcNHglycan 647 650 PF01048 0.712
MOD_GlcNHglycan 735 738 PF01048 0.673
MOD_GSK3_1 110 117 PF00069 0.797
MOD_GSK3_1 149 156 PF00069 0.800
MOD_GSK3_1 167 174 PF00069 0.513
MOD_GSK3_1 189 196 PF00069 0.807
MOD_GSK3_1 224 231 PF00069 0.751
MOD_GSK3_1 252 259 PF00069 0.738
MOD_GSK3_1 268 275 PF00069 0.601
MOD_GSK3_1 284 291 PF00069 0.543
MOD_GSK3_1 3 10 PF00069 0.652
MOD_GSK3_1 311 318 PF00069 0.679
MOD_GSK3_1 323 330 PF00069 0.668
MOD_GSK3_1 345 352 PF00069 0.772
MOD_GSK3_1 353 360 PF00069 0.652
MOD_GSK3_1 36 43 PF00069 0.608
MOD_GSK3_1 370 377 PF00069 0.592
MOD_GSK3_1 379 386 PF00069 0.639
MOD_GSK3_1 453 460 PF00069 0.762
MOD_GSK3_1 469 476 PF00069 0.539
MOD_GSK3_1 47 54 PF00069 0.752
MOD_GSK3_1 531 538 PF00069 0.738
MOD_GSK3_1 545 552 PF00069 0.702
MOD_GSK3_1 55 62 PF00069 0.732
MOD_GSK3_1 555 562 PF00069 0.651
MOD_GSK3_1 566 573 PF00069 0.650
MOD_GSK3_1 586 593 PF00069 0.457
MOD_GSK3_1 600 607 PF00069 0.570
MOD_GSK3_1 650 657 PF00069 0.726
MOD_GSK3_1 706 713 PF00069 0.808
MOD_GSK3_1 716 723 PF00069 0.527
MOD_LATS_1 292 298 PF00433 0.742
MOD_N-GLC_1 110 115 PF02516 0.666
MOD_N-GLC_2 279 281 PF02516 0.709
MOD_NEK2_1 110 115 PF00069 0.740
MOD_NEK2_1 288 293 PF00069 0.783
MOD_NEK2_1 364 369 PF00069 0.732
MOD_NEK2_1 42 47 PF00069 0.737
MOD_NEK2_1 457 462 PF00069 0.755
MOD_NEK2_1 48 53 PF00069 0.571
MOD_NEK2_1 482 487 PF00069 0.767
MOD_NEK2_1 488 493 PF00069 0.671
MOD_NEK2_1 549 554 PF00069 0.573
MOD_NEK2_1 575 580 PF00069 0.734
MOD_NEK2_1 71 76 PF00069 0.817
MOD_NEK2_1 712 717 PF00069 0.598
MOD_NEK2_1 8 13 PF00069 0.608
MOD_NEK2_2 571 576 PF00069 0.640
MOD_PIKK_1 463 469 PF00454 0.751
MOD_PIKK_1 69 75 PF00454 0.797
MOD_PK_1 576 582 PF00069 0.544
MOD_PKA_1 199 205 PF00069 0.748
MOD_PKA_2 119 125 PF00069 0.717
MOD_PKA_2 153 159 PF00069 0.788
MOD_PKA_2 166 172 PF00069 0.584
MOD_PKA_2 199 205 PF00069 0.748
MOD_PKA_2 256 262 PF00069 0.716
MOD_PKA_2 463 469 PF00069 0.758
MOD_PKA_2 543 549 PF00069 0.752
MOD_PKA_2 575 581 PF00069 0.586
MOD_Plk_1 311 317 PF00069 0.736
MOD_Plk_1 434 440 PF00069 0.790
MOD_Plk_1 674 680 PF00069 0.678
MOD_Plk_4 12 18 PF00069 0.583
MOD_Plk_4 167 173 PF00069 0.593
MOD_Plk_4 249 255 PF00069 0.727
MOD_Plk_4 303 309 PF00069 0.685
MOD_Plk_4 311 317 PF00069 0.636
MOD_Plk_4 360 366 PF00069 0.784
MOD_Plk_4 545 551 PF00069 0.595
MOD_Plk_4 576 582 PF00069 0.778
MOD_Plk_4 586 592 PF00069 0.646
MOD_Plk_4 720 726 PF00069 0.680
MOD_ProDKin_1 136 142 PF00069 0.726
MOD_ProDKin_1 281 287 PF00069 0.733
MOD_ProDKin_1 3 9 PF00069 0.655
MOD_ProDKin_1 370 376 PF00069 0.751
MOD_ProDKin_1 473 479 PF00069 0.695
MOD_ProDKin_1 506 512 PF00069 0.711
MOD_ProDKin_1 698 704 PF00069 0.781
MOD_ProDKin_1 706 712 PF00069 0.768
MOD_SUMO_rev_2 234 241 PF00179 0.667
TRG_DiLeu_BaLyEn_6 244 249 PF01217 0.607
TRG_ENDOCYTIC_2 631 634 PF00928 0.699
TRG_ER_diArg_1 186 189 PF00400 0.772
TRG_ER_diArg_1 246 248 PF00400 0.664
TRG_ER_diArg_1 261 263 PF00400 0.588
TRG_ER_diArg_1 501 504 PF00400 0.672
TRG_NLS_MonoCore_2 184 189 PF00514 0.714
TRG_NLS_MonoExtC_3 184 189 PF00514 0.751
TRG_NLS_MonoExtN_4 151 158 PF00514 0.733
TRG_NLS_MonoExtN_4 185 191 PF00514 0.756

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8I993 Leishmania donovani 99% 100%
A4H6X0 Leishmania braziliensis 53% 98%
E9ANX5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 99%
Q4QGP5 Leishmania major 79% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS