Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AGD4_LEIIN

TriTrypDb:

LINF_120009800

Length:

784

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGD4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	279	283	PF00656	0.695
CLV_C14_Caspase3-7	389	393	PF00656	0.697
CLV_C14_Caspase3-7	545	549	PF00656	0.664
CLV_C14_Caspase3-7	706	710	PF00656	0.828
CLV_NRD_NRD_1	106	108	PF00675	0.763
CLV_NRD_NRD_1	185	187	PF00675	0.663
CLV_NRD_NRD_1	252	254	PF00675	0.734
CLV_NRD_NRD_1	367	369	PF00675	0.753
CLV_NRD_NRD_1	595	597	PF00675	0.640
CLV_NRD_NRD_1	684	686	PF00675	0.679
CLV_NRD_NRD_1	738	740	PF00675	0.706
CLV_PCSK_KEX2_1	106	108	PF00082	0.758
CLV_PCSK_KEX2_1	185	187	PF00082	0.663
CLV_PCSK_KEX2_1	252	254	PF00082	0.734
CLV_PCSK_KEX2_1	366	368	PF00082	0.771
CLV_PCSK_KEX2_1	595	597	PF00082	0.640
CLV_PCSK_KEX2_1	684	686	PF00082	0.679
CLV_PCSK_KEX2_1	738	740	PF00082	0.703
CLV_PCSK_PC7_1	248	254	PF00082	0.729
CLV_PCSK_PC7_1	591	597	PF00082	0.639
CLV_PCSK_SKI1_1	110	114	PF00082	0.759
CLV_PCSK_SKI1_1	525	529	PF00082	0.763
CLV_PCSK_SKI1_1	60	64	PF00082	0.747
CLV_PCSK_SKI1_1	637	641	PF00082	0.660
DEG_Kelch_Keap1_1	501	506	PF01344	0.753
DEG_Nend_UBRbox_3	1	3	PF02207	0.723
DEG_SCF_FBW7_1	473	480	PF00400	0.746
DEG_SPOP_SBC_1	269	273	PF00917	0.621
DEG_SPOP_SBC_1	695	699	PF00917	0.692
DEG_SPOP_SBC_1	96	100	PF00917	0.714
DOC_ANK_TNKS_1	594	601	PF00023	0.580
DOC_CDC14_PxL_1	187	195	PF14671	0.721
DOC_CKS1_1	144	149	PF01111	0.682
DOC_CKS1_1	265	270	PF01111	0.701
DOC_CKS1_1	399	404	PF01111	0.606
DOC_CKS1_1	474	479	PF01111	0.782
DOC_CYCLIN_RxL_1	106	115	PF00134	0.724
DOC_CYCLIN_yClb3_PxF_3	259	265	PF00134	0.700
DOC_MAPK_gen_1	106	113	PF00069	0.757
DOC_MAPK_gen_1	757	764	PF00069	0.689
DOC_MAPK_JIP1_4	107	113	PF00069	0.710
DOC_PP2B_LxvP_1	119	122	PF13499	0.641
DOC_PP2B_LxvP_1	198	201	PF13499	0.784
DOC_PP2B_LxvP_1	527	530	PF13499	0.762
DOC_PP4_FxxP_1	265	268	PF00568	0.789
DOC_PP4_FxxP_1	4	7	PF00568	0.646
DOC_USP7_MATH_1	112	116	PF00917	0.754
DOC_USP7_MATH_1	122	126	PF00917	0.642
DOC_USP7_MATH_1	153	157	PF00917	0.678
DOC_USP7_MATH_1	169	173	PF00917	0.568
DOC_USP7_MATH_1	201	205	PF00917	0.783
DOC_USP7_MATH_1	209	213	PF00917	0.643
DOC_USP7_MATH_1	268	272	PF00917	0.667
DOC_USP7_MATH_1	491	495	PF00917	0.727
DOC_USP7_MATH_1	515	519	PF00917	0.711
DOC_USP7_MATH_1	695	699	PF00917	0.665
DOC_USP7_MATH_1	740	744	PF00917	0.758
DOC_USP7_MATH_1	745	749	PF00917	0.751
DOC_USP7_MATH_1	75	79	PF00917	0.694
DOC_USP7_MATH_1	760	764	PF00917	0.687
DOC_USP7_MATH_1	84	88	PF00917	0.600
DOC_USP7_MATH_1	91	95	PF00917	0.531
DOC_WW_Pin1_4	140	145	PF00397	0.841
DOC_WW_Pin1_4	246	251	PF00397	0.773
DOC_WW_Pin1_4	26	31	PF00397	0.715
DOC_WW_Pin1_4	264	269	PF00397	0.564
DOC_WW_Pin1_4	270	275	PF00397	0.647
DOC_WW_Pin1_4	282	287	PF00397	0.556
DOC_WW_Pin1_4	293	298	PF00397	0.604
DOC_WW_Pin1_4	299	304	PF00397	0.587
DOC_WW_Pin1_4	310	315	PF00397	0.548
DOC_WW_Pin1_4	398	403	PF00397	0.776
DOC_WW_Pin1_4	426	431	PF00397	0.767
DOC_WW_Pin1_4	432	437	PF00397	0.685
DOC_WW_Pin1_4	44	49	PF00397	0.572
DOC_WW_Pin1_4	473	478	PF00397	0.849
DOC_WW_Pin1_4	712	717	PF00397	0.781
DOC_WW_Pin1_4	97	102	PF00397	0.719
LIG_14-3-3_CanoR_1	19	27	PF00244	0.682
LIG_14-3-3_CanoR_1	192	198	PF00244	0.726
LIG_14-3-3_CanoR_1	231	236	PF00244	0.753
LIG_14-3-3_CanoR_1	252	257	PF00244	0.691
LIG_14-3-3_CanoR_1	332	340	PF00244	0.783
LIG_14-3-3_CanoR_1	366	372	PF00244	0.753
LIG_14-3-3_CanoR_1	405	414	PF00244	0.722
LIG_14-3-3_CanoR_1	441	449	PF00244	0.810
LIG_14-3-3_CanoR_1	450	456	PF00244	0.671
LIG_14-3-3_CanoR_1	525	530	PF00244	0.700
LIG_14-3-3_CanoR_1	60	67	PF00244	0.741
LIG_14-3-3_CanoR_1	672	681	PF00244	0.739
LIG_14-3-3_CanoR_1	685	691	PF00244	0.596
LIG_14-3-3_CanoR_1	757	763	PF00244	0.757
LIG_Actin_WH2_2	671	686	PF00022	0.580
LIG_BIR_III_2	662	666	PF00653	0.703
LIG_BRCT_BRCA1_1	297	301	PF00533	0.648
LIG_BRCT_BRCA1_1	724	728	PF00533	0.699
LIG_BRCT_BRCA1_1	760	764	PF00533	0.684
LIG_BRCT_BRCA1_2	724	730	PF00533	0.700
LIG_CtBP_PxDLS_1	664	668	PF00389	0.567
LIG_deltaCOP1_diTrp_1	537	546	PF00928	0.598
LIG_FHA_1	23	29	PF00498	0.691
LIG_FHA_1	232	238	PF00498	0.704
LIG_FHA_1	265	271	PF00498	0.655
LIG_FHA_1	394	400	PF00498	0.619
LIG_FHA_1	521	527	PF00498	0.692
LIG_FHA_1	654	660	PF00498	0.767
LIG_FHA_2	566	572	PF00498	0.513
LIG_FHA_2	687	693	PF00498	0.726
LIG_LIR_Apic_2	3	7	PF02991	0.642
LIG_LIR_Apic_2	429	434	PF02991	0.765
LIG_LIR_Apic_2	538	544	PF02991	0.729
LIG_LIR_Apic_2	618	623	PF02991	0.672
LIG_LIR_Nem_3	298	304	PF02991	0.655
LIG_LIR_Nem_3	522	527	PF02991	0.667
LIG_MYND_1	101	105	PF01753	0.715
LIG_PTAP_UEV_1	210	215	PF05743	0.622
LIG_SH2_CRK	431	435	PF00017	0.770
LIG_SH2_CRK	524	528	PF00017	0.739
LIG_SH2_GRB2like	606	609	PF00017	0.529
LIG_SH2_NCK_1	431	435	PF00017	0.770
LIG_SH2_STAP1	233	237	PF00017	0.561
LIG_SH2_STAP1	288	292	PF00017	0.718
LIG_SH2_STAP1	451	455	PF00017	0.655
LIG_SH2_STAP1	771	775	PF00017	0.681
LIG_SH2_STAT5	233	236	PF00017	0.559
LIG_SH2_STAT5	371	374	PF00017	0.735
LIG_SH2_STAT5	431	434	PF00017	0.738
LIG_SH3_2	101	106	PF14604	0.716
LIG_SH3_3	141	147	PF00018	0.717
LIG_SH3_3	208	214	PF00018	0.721
LIG_SH3_3	24	30	PF00018	0.687
LIG_SH3_3	253	259	PF00018	0.764
LIG_SH3_3	289	295	PF00018	0.588
LIG_SH3_3	305	311	PF00018	0.573
LIG_SH3_3	353	359	PF00018	0.648
LIG_SH3_3	396	402	PF00018	0.615
LIG_SH3_3	478	484	PF00018	0.700
LIG_SH3_3	710	716	PF00018	0.784
LIG_SH3_3	746	752	PF00018	0.715
LIG_SH3_3	8	14	PF00018	0.603
LIG_SH3_3	98	104	PF00018	0.692
LIG_SUMO_SIM_par_1	638	644	PF11976	0.712
LIG_TRAF2_1	778	781	PF00917	0.631
LIG_WRC_WIRS_1	1	6	PF05994	0.644
LIG_WRC_WIRS_1	378	383	PF05994	0.673
LIG_WRC_WIRS_1	543	548	PF05994	0.597
LIG_WW_3	103	107	PF00397	0.713
LIG_WW_3	338	342	PF00397	0.604
LIG_WW_3	480	484	PF00397	0.603
MOD_CDC14_SPxK_1	249	252	PF00782	0.759
MOD_CDC14_SPxK_1	480	483	PF00782	0.603
MOD_CDK_SPxK_1	246	252	PF00069	0.757
MOD_CDK_SPxK_1	477	483	PF00069	0.633
MOD_CDK_SPxxK_3	246	253	PF00069	0.693
MOD_CDK_SPxxK_3	398	405	PF00069	0.709
MOD_CK1_1	138	144	PF00069	0.760
MOD_CK1_1	18	24	PF00069	0.716
MOD_CK1_1	246	252	PF00069	0.807
MOD_CK1_1	293	299	PF00069	0.765
MOD_CK1_1	302	308	PF00069	0.642
MOD_CK1_1	37	43	PF00069	0.519
MOD_CK1_1	370	376	PF00069	0.803
MOD_CK1_1	406	412	PF00069	0.736
MOD_CK1_1	453	459	PF00069	0.657
MOD_CK1_1	475	481	PF00069	0.773
MOD_CK1_1	648	654	PF00069	0.763
MOD_CK1_1	696	702	PF00069	0.787
MOD_CK1_1	758	764	PF00069	0.821
MOD_CK1_1	767	773	PF00069	0.611
MOD_CK1_1	87	93	PF00069	0.676
MOD_CK2_1	220	226	PF00069	0.698
MOD_CK2_1	686	692	PF00069	0.720
MOD_CK2_1	712	718	PF00069	0.818
MOD_CK2_1	738	744	PF00069	0.842
MOD_GlcNHglycan	114	117	PF01048	0.789
MOD_GlcNHglycan	129	132	PF01048	0.661
MOD_GlcNHglycan	198	201	PF01048	0.794
MOD_GlcNHglycan	21	24	PF01048	0.720
MOD_GlcNHglycan	211	214	PF01048	0.643
MOD_GlcNHglycan	237	240	PF01048	0.675
MOD_GlcNHglycan	336	339	PF01048	0.764
MOD_GlcNHglycan	348	351	PF01048	0.596
MOD_GlcNHglycan	372	375	PF01048	0.711
MOD_GlcNHglycan	414	417	PF01048	0.770
MOD_GlcNHglycan	426	429	PF01048	0.608
MOD_GlcNHglycan	443	446	PF01048	0.632
MOD_GlcNHglycan	465	468	PF01048	0.760
MOD_GlcNHglycan	497	500	PF01048	0.719
MOD_GlcNHglycan	517	520	PF01048	0.699
MOD_GlcNHglycan	55	58	PF01048	0.661
MOD_GlcNHglycan	616	620	PF01048	0.690
MOD_GlcNHglycan	647	650	PF01048	0.692
MOD_GlcNHglycan	7	10	PF01048	0.731
MOD_GlcNHglycan	70	73	PF01048	0.569
MOD_GlcNHglycan	723	727	PF01048	0.828
MOD_GlcNHglycan	729	733	PF01048	0.728
MOD_GlcNHglycan	740	743	PF01048	0.605
MOD_GlcNHglycan	77	80	PF01048	0.625
MOD_GlcNHglycan	776	779	PF01048	0.511
MOD_GlcNHglycan	89	92	PF01048	0.576
MOD_GSK3_1	15	22	PF00069	0.665
MOD_GSK3_1	231	238	PF00069	0.736
MOD_GSK3_1	240	247	PF00069	0.678
MOD_GSK3_1	264	271	PF00069	0.693
MOD_GSK3_1	282	289	PF00069	0.604
MOD_GSK3_1	295	302	PF00069	0.575
MOD_GSK3_1	306	313	PF00069	0.583
MOD_GSK3_1	346	353	PF00069	0.690
MOD_GSK3_1	366	373	PF00069	0.727
MOD_GSK3_1	377	384	PF00069	0.568
MOD_GSK3_1	405	412	PF00069	0.742
MOD_GSK3_1	422	429	PF00069	0.535
MOD_GSK3_1	430	437	PF00069	0.645
MOD_GSK3_1	459	466	PF00069	0.645
MOD_GSK3_1	473	480	PF00069	0.822
MOD_GSK3_1	487	494	PF00069	0.647
MOD_GSK3_1	515	522	PF00069	0.738
MOD_GSK3_1	525	532	PF00069	0.679
MOD_GSK3_1	533	540	PF00069	0.544
MOD_GSK3_1	561	568	PF00069	0.518
MOD_GSK3_1	61	68	PF00069	0.678
MOD_GSK3_1	644	651	PF00069	0.783
MOD_GSK3_1	672	679	PF00069	0.571
MOD_GSK3_1	694	701	PF00069	0.750
MOD_GSK3_1	760	767	PF00069	0.775
MOD_GSK3_1	86	93	PF00069	0.675
MOD_GSK3_1	95	102	PF00069	0.649
MOD_N-GLC_1	127	132	PF02516	0.762
MOD_N-GLC_1	282	287	PF02516	0.743
MOD_N-GLC_1	406	411	PF02516	0.740
MOD_N-GLC_1	463	468	PF02516	0.630
MOD_N-GLC_1	607	612	PF02516	0.524
MOD_NEK2_1	235	240	PF00069	0.678
MOD_NEK2_1	244	249	PF00069	0.646
MOD_NEK2_1	377	382	PF00069	0.721
MOD_NEK2_1	403	408	PF00069	0.762
MOD_NEK2_1	58	63	PF00069	0.613
MOD_NEK2_1	673	678	PF00069	0.635
MOD_NEK2_1	722	727	PF00069	0.666
MOD_NEK2_1	728	733	PF00069	0.663
MOD_NEK2_1	764	769	PF00069	0.682
MOD_PIKK_1	332	338	PF00454	0.771
MOD_PIKK_1	475	481	PF00454	0.740
MOD_PIKK_1	686	692	PF00454	0.707
MOD_PIKK_1	733	739	PF00454	0.704
MOD_PK_1	252	258	PF00069	0.685
MOD_PKA_1	252	258	PF00069	0.717
MOD_PKA_1	366	372	PF00069	0.753
MOD_PKA_1	684	690	PF00069	0.705
MOD_PKA_1	738	744	PF00069	0.649
MOD_PKA_2	169	175	PF00069	0.628
MOD_PKA_2	18	24	PF00069	0.697
MOD_PKA_2	191	197	PF00069	0.698
MOD_PKA_2	252	258	PF00069	0.709
MOD_PKA_2	322	328	PF00069	0.676
MOD_PKA_2	366	372	PF00069	0.753
MOD_PKA_2	409	415	PF00069	0.736
MOD_PKA_2	645	651	PF00069	0.627
MOD_PKA_2	684	690	PF00069	0.794
MOD_PKA_2	738	744	PF00069	0.796
MOD_PKA_2	758	764	PF00069	0.754
MOD_PKB_1	441	449	PF00069	0.687
MOD_Plk_1	153	159	PF00069	0.626
MOD_Plk_1	458	464	PF00069	0.639
MOD_Plk_1	537	543	PF00069	0.665
MOD_Plk_1	615	621	PF00069	0.661
MOD_Plk_1	722	728	PF00069	0.763
MOD_Plk_2-3	160	166	PF00069	0.790
MOD_Plk_4	367	373	PF00069	0.746
MOD_Plk_4	537	543	PF00069	0.665
MOD_Plk_4	760	766	PF00069	0.675
MOD_ProDKin_1	140	146	PF00069	0.841
MOD_ProDKin_1	246	252	PF00069	0.776
MOD_ProDKin_1	26	32	PF00069	0.715
MOD_ProDKin_1	264	270	PF00069	0.565
MOD_ProDKin_1	282	288	PF00069	0.558
MOD_ProDKin_1	293	299	PF00069	0.605
MOD_ProDKin_1	310	316	PF00069	0.552
MOD_ProDKin_1	398	404	PF00069	0.775
MOD_ProDKin_1	426	432	PF00069	0.768
MOD_ProDKin_1	44	50	PF00069	0.573
MOD_ProDKin_1	473	479	PF00069	0.848
MOD_ProDKin_1	712	718	PF00069	0.778
MOD_ProDKin_1	97	103	PF00069	0.719
TRG_DiLeu_BaLyEn_6	522	527	PF01217	0.700
TRG_DiLeu_BaLyEn_6	669	674	PF01217	0.673
TRG_ENDOCYTIC_2	524	527	PF00928	0.740
TRG_ER_diArg_1	105	107	PF00400	0.760
TRG_ER_diArg_1	185	187	PF00400	0.663
TRG_ER_diArg_1	366	368	PF00400	0.671
TRG_ER_diArg_1	594	596	PF00400	0.637
TRG_ER_diArg_1	683	685	PF00400	0.682
TRG_ER_diArg_1	738	740	PF00400	0.703
TRG_ER_diArg_1	756	759	PF00400	0.761

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I9B3	Leishmania donovani	100%	100%
A4H707	Leishmania braziliensis	59%	100%
E9ANX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QGP6	Leishmania major	83%	100%