Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AGD2_LEIIN

TriTrypDb:

LINF_120009600

Length:

651

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGD2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.561
CLV_C14_Caspase3-7	208	212	PF00656	0.689
CLV_C14_Caspase3-7	264	268	PF00656	0.691
CLV_C14_Caspase3-7	333	337	PF00656	0.662
CLV_C14_Caspase3-7	366	370	PF00656	0.657
CLV_C14_Caspase3-7	484	488	PF00656	0.504
CLV_NRD_NRD_1	276	278	PF00675	0.688
CLV_NRD_NRD_1	3	5	PF00675	0.581
CLV_NRD_NRD_1	408	410	PF00675	0.621
CLV_NRD_NRD_1	471	473	PF00675	0.484
CLV_NRD_NRD_1	508	510	PF00675	0.642
CLV_NRD_NRD_1	625	627	PF00675	0.649
CLV_NRD_NRD_1	629	631	PF00675	0.642
CLV_NRD_NRD_1	644	646	PF00675	0.622
CLV_NRD_NRD_1	72	74	PF00675	0.517
CLV_NRD_NRD_1	75	77	PF00675	0.523
CLV_PCSK_FUR_1	403	407	PF00082	0.587
CLV_PCSK_FUR_1	626	630	PF00082	0.717
CLV_PCSK_KEX2_1	12	14	PF00082	0.541
CLV_PCSK_KEX2_1	2	4	PF00082	0.587
CLV_PCSK_KEX2_1	226	228	PF00082	0.606
CLV_PCSK_KEX2_1	276	278	PF00082	0.688
CLV_PCSK_KEX2_1	402	404	PF00082	0.626
CLV_PCSK_KEX2_1	405	407	PF00082	0.631
CLV_PCSK_KEX2_1	408	410	PF00082	0.639
CLV_PCSK_KEX2_1	470	472	PF00082	0.481
CLV_PCSK_KEX2_1	508	510	PF00082	0.653
CLV_PCSK_KEX2_1	627	629	PF00082	0.651
CLV_PCSK_KEX2_1	644	646	PF00082	0.622
CLV_PCSK_KEX2_1	71	73	PF00082	0.501
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.541
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.587
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.606
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.561
CLV_PCSK_PC1ET2_1	627	629	PF00082	0.651
CLV_PCSK_PC7_1	403	409	PF00082	0.585
CLV_PCSK_PC7_1	68	74	PF00082	0.491
CLV_PCSK_SKI1_1	3	7	PF00082	0.577
CLV_PCSK_SKI1_1	390	394	PF00082	0.629
CLV_PCSK_SKI1_1	458	462	PF00082	0.504
CLV_PCSK_SKI1_1	52	56	PF00082	0.402
CLV_PCSK_SKI1_1	645	649	PF00082	0.617
DEG_APCC_DBOX_1	469	477	PF00400	0.514
DEG_Nend_UBRbox_1	1	4	PF02207	0.564
DEG_SCF_FBW7_1	230	236	PF00400	0.678
DEG_SPOP_SBC_1	235	239	PF00917	0.596
DEG_SPOP_SBC_1	448	452	PF00917	0.677
DOC_CDC14_PxL_1	118	126	PF14671	0.555
DOC_CDC14_PxL_1	565	573	PF14671	0.549
DOC_CKS1_1	230	235	PF01111	0.679
DOC_MAPK_gen_1	316	323	PF00069	0.583
DOC_USP7_MATH_1	205	209	PF00917	0.664
DOC_USP7_MATH_1	233	237	PF00917	0.718
DOC_USP7_MATH_1	281	285	PF00917	0.629
DOC_USP7_MATH_1	326	330	PF00917	0.600
DOC_USP7_MATH_1	355	359	PF00917	0.411
DOC_USP7_MATH_1	446	450	PF00917	0.740
DOC_USP7_MATH_1	463	467	PF00917	0.393
DOC_USP7_MATH_1	527	531	PF00917	0.680
DOC_USP7_MATH_1	540	544	PF00917	0.699
DOC_USP7_MATH_1	592	596	PF00917	0.637
DOC_USP7_MATH_1	80	84	PF00917	0.570
DOC_USP7_MATH_1	90	94	PF00917	0.568
DOC_WW_Pin1_4	122	127	PF00397	0.638
DOC_WW_Pin1_4	156	161	PF00397	0.612
DOC_WW_Pin1_4	229	234	PF00397	0.712
DOC_WW_Pin1_4	236	241	PF00397	0.675
DOC_WW_Pin1_4	279	284	PF00397	0.765
DOC_WW_Pin1_4	322	327	PF00397	0.593
DOC_WW_Pin1_4	328	333	PF00397	0.674
DOC_WW_Pin1_4	392	397	PF00397	0.675
DOC_WW_Pin1_4	444	449	PF00397	0.693
DOC_WW_Pin1_4	453	458	PF00397	0.552
DOC_WW_Pin1_4	474	479	PF00397	0.568
DOC_WW_Pin1_4	551	556	PF00397	0.740
DOC_WW_Pin1_4	608	613	PF00397	0.688
LIG_14-3-3_CanoR_1	142	148	PF00244	0.521
LIG_14-3-3_CanoR_1	16	24	PF00244	0.528
LIG_14-3-3_CanoR_1	247	255	PF00244	0.619
LIG_14-3-3_CanoR_1	306	310	PF00244	0.769
LIG_14-3-3_CanoR_1	379	384	PF00244	0.471
LIG_14-3-3_CanoR_1	390	395	PF00244	0.642
LIG_14-3-3_CanoR_1	481	489	PF00244	0.508
LIG_14-3-3_CanoR_1	535	540	PF00244	0.661
LIG_14-3-3_CanoR_1	547	553	PF00244	0.712
LIG_14-3-3_CanoR_1	89	99	PF00244	0.605
LIG_Actin_WH2_2	466	483	PF00022	0.460
LIG_APCC_ABBA_1	383	388	PF00400	0.614
LIG_BRCT_BRCA1_1	255	259	PF00533	0.557
LIG_BRCT_BRCA1_1	27	31	PF00533	0.543
LIG_BRCT_BRCA1_1	284	288	PF00533	0.695
LIG_BRCT_BRCA1_1	544	548	PF00533	0.715
LIG_deltaCOP1_diTrp_1	252	259	PF00928	0.602
LIG_EVH1_2	160	164	PF00568	0.483
LIG_FHA_1	157	163	PF00498	0.521
LIG_FHA_1	189	195	PF00498	0.589
LIG_FHA_1	457	463	PF00498	0.517
LIG_FHA_1	475	481	PF00498	0.466
LIG_FHA_1	559	565	PF00498	0.683
LIG_FHA_2	247	253	PF00498	0.638
LIG_FHA_2	262	268	PF00498	0.538
LIG_FHA_2	289	295	PF00498	0.573
LIG_FHA_2	340	346	PF00498	0.616
LIG_FHA_2	482	488	PF00498	0.518
LIG_FHA_2	582	588	PF00498	0.547
LIG_LIR_Gen_1	291	300	PF02991	0.548
LIG_LIR_Gen_1	39	50	PF02991	0.401
LIG_LIR_Nem_3	168	173	PF02991	0.432
LIG_LIR_Nem_3	256	262	PF02991	0.628
LIG_LIR_Nem_3	291	295	PF02991	0.609
LIG_LIR_Nem_3	39	45	PF02991	0.421
LIG_MYND_1	122	126	PF01753	0.532
LIG_NRBOX	129	135	PF00104	0.477
LIG_Pex14_2	288	292	PF04695	0.683
LIG_SH2_CRK	187	191	PF00017	0.500
LIG_SH2_CRK	42	46	PF00017	0.379
LIG_SH2_SRC	498	501	PF00017	0.507
LIG_SH2_STAT3	394	397	PF00017	0.667
LIG_SH2_STAT5	173	176	PF00017	0.398
LIG_SH3_1	227	233	PF00018	0.682
LIG_SH3_3	199	205	PF00018	0.679
LIG_SH3_3	227	233	PF00018	0.723
LIG_SH3_3	320	326	PF00018	0.567
LIG_SH3_3	451	457	PF00018	0.634
LIG_SH3_3	585	591	PF00018	0.618
LIG_SUMO_SIM_anti_2	305	314	PF11976	0.574
LIG_SxIP_EBH_1	89	102	PF03271	0.506
LIG_TRAF2_1	291	294	PF00917	0.571
MOD_CDK_SPK_2	236	241	PF00069	0.646
MOD_CDK_SPK_2	453	458	PF00069	0.669
MOD_CDK_SPxxK_3	474	481	PF00069	0.546
MOD_CK1_1	148	154	PF00069	0.590
MOD_CK1_1	192	198	PF00069	0.740
MOD_CK1_1	236	242	PF00069	0.657
MOD_CK1_1	27	33	PF00069	0.607
MOD_CK1_1	282	288	PF00069	0.636
MOD_CK1_1	305	311	PF00069	0.607
MOD_CK1_1	34	40	PF00069	0.532
MOD_CK1_1	425	431	PF00069	0.587
MOD_CK1_1	449	455	PF00069	0.765
MOD_CK1_1	456	462	PF00069	0.570
MOD_CK1_1	521	527	PF00069	0.653
MOD_CK1_1	611	617	PF00069	0.678
MOD_CK1_1	85	91	PF00069	0.535
MOD_CK2_1	246	252	PF00069	0.652
MOD_CK2_1	288	294	PF00069	0.626
MOD_CK2_1	339	345	PF00069	0.729
MOD_CK2_1	581	587	PF00069	0.538
MOD_CK2_1	80	86	PF00069	0.563
MOD_DYRK1A_RPxSP_1	229	233	PF00069	0.679
MOD_DYRK1A_RPxSP_1	453	457	PF00069	0.598
MOD_GlcNHglycan	149	153	PF01048	0.603
MOD_GlcNHglycan	165	168	PF01048	0.530
MOD_GlcNHglycan	18	21	PF01048	0.567
MOD_GlcNHglycan	191	194	PF01048	0.786
MOD_GlcNHglycan	220	223	PF01048	0.662
MOD_GlcNHglycan	255	258	PF01048	0.663
MOD_GlcNHglycan	284	287	PF01048	0.656
MOD_GlcNHglycan	33	36	PF01048	0.604
MOD_GlcNHglycan	369	373	PF01048	0.623
MOD_GlcNHglycan	374	378	PF01048	0.511
MOD_GlcNHglycan	444	447	PF01048	0.612
MOD_GlcNHglycan	544	547	PF01048	0.764
MOD_GlcNHglycan	613	616	PF01048	0.709
MOD_GlcNHglycan	82	85	PF01048	0.703
MOD_GSK3_1	188	195	PF00069	0.583
MOD_GSK3_1	218	225	PF00069	0.709
MOD_GSK3_1	229	236	PF00069	0.669
MOD_GSK3_1	23	30	PF00069	0.589
MOD_GSK3_1	261	268	PF00069	0.677
MOD_GSK3_1	305	312	PF00069	0.745
MOD_GSK3_1	322	329	PF00069	0.622
MOD_GSK3_1	442	449	PF00069	0.694
MOD_GSK3_1	542	549	PF00069	0.746
MOD_GSK3_1	556	563	PF00069	0.621
MOD_GSK3_1	80	87	PF00069	0.580
MOD_N-GLC_1	205	210	PF02516	0.682
MOD_N-GLC_1	355	360	PF02516	0.503
MOD_N-GLC_1	409	414	PF02516	0.541
MOD_N-GLC_1	518	523	PF02516	0.646
MOD_N-GLC_2	344	346	PF02516	0.518
MOD_NEK2_1	18	23	PF00069	0.531
MOD_NEK2_1	255	260	PF00069	0.640
MOD_NEK2_1	265	270	PF00069	0.678
MOD_NEK2_1	31	36	PF00069	0.565
MOD_NEK2_1	461	466	PF00069	0.442
MOD_NEK2_1	480	485	PF00069	0.486
MOD_NEK2_1	548	553	PF00069	0.602
MOD_PIKK_1	461	467	PF00454	0.442
MOD_PKA_2	246	252	PF00069	0.604
MOD_PKA_2	265	271	PF00069	0.511
MOD_PKA_2	305	311	PF00069	0.574
MOD_PKA_2	480	486	PF00069	0.472
MOD_PKA_2	493	499	PF00069	0.528
MOD_PKA_2	534	540	PF00069	0.729
MOD_PKA_2	546	552	PF00069	0.607
MOD_PKB_1	407	415	PF00069	0.593
MOD_Plk_1	205	211	PF00069	0.684
MOD_Plk_1	355	361	PF00069	0.593
MOD_Plk_1	46	52	PF00069	0.381
MOD_Plk_1	518	524	PF00069	0.621
MOD_Plk_4	205	211	PF00069	0.660
MOD_Plk_4	27	33	PF00069	0.499
MOD_Plk_4	355	361	PF00069	0.551
MOD_Plk_4	46	52	PF00069	0.381
MOD_Plk_4	54	60	PF00069	0.402
MOD_Plk_4	560	566	PF00069	0.614
MOD_ProDKin_1	122	128	PF00069	0.634
MOD_ProDKin_1	156	162	PF00069	0.605
MOD_ProDKin_1	229	235	PF00069	0.712
MOD_ProDKin_1	236	242	PF00069	0.671
MOD_ProDKin_1	279	285	PF00069	0.763
MOD_ProDKin_1	322	328	PF00069	0.592
MOD_ProDKin_1	392	398	PF00069	0.672
MOD_ProDKin_1	444	450	PF00069	0.691
MOD_ProDKin_1	453	459	PF00069	0.543
MOD_ProDKin_1	474	480	PF00069	0.558
MOD_ProDKin_1	551	557	PF00069	0.739
MOD_ProDKin_1	608	614	PF00069	0.690
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.546
TRG_ENDOCYTIC_2	42	45	PF00928	0.385
TRG_ER_diArg_1	184	187	PF00400	0.454
TRG_ER_diArg_1	227	230	PF00400	0.685
TRG_ER_diArg_1	3	5	PF00400	0.581
TRG_ER_diArg_1	403	406	PF00400	0.641
TRG_ER_diArg_1	407	409	PF00400	0.605
TRG_ER_diArg_1	469	472	PF00400	0.466
TRG_ER_diArg_1	508	510	PF00400	0.704
TRG_ER_diArg_1	626	629	PF00400	0.719
TRG_ER_diArg_1	71	73	PF00400	0.515
TRG_NLS_Bipartite_1	626	645	PF00514	0.632
TRG_NLS_MonoCore_2	401	406	PF00514	0.571
TRG_NLS_MonoCore_2	626	631	PF00514	0.715
TRG_NLS_MonoExtC_3	225	230	PF00514	0.599
TRG_NLS_MonoExtC_3	401	406	PF00514	0.595
TRG_NLS_MonoExtC_3	639	644	PF00514	0.725
TRG_NLS_MonoExtC_3	72	77	PF00514	0.538
TRG_NLS_MonoExtN_4	626	631	PF00514	0.646
TRG_NLS_MonoExtN_4	640	645	PF00514	0.625
TRG_NLS_MonoExtN_4	71	77	PF00514	0.499
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2D5	Leptomonas seymouri	38%	100%
A0A3S7WRY8	Leishmania donovani	100%	100%
A4H6V9	Leishmania braziliensis	69%	100%
E9ANX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QGP8	Leishmania major	87%	100%