DUF866 domain protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic protein of unknown function (DUF866) - putative

Species:

Leishmania infantum

UniProt:

E9AGC9_LEIIN

TriTrypDb:

LINF_120009300

Length:

161

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized LINJ.12.0370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGC9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_ODPH_VHL_1	19	31	PF01847	0.246
DOC_MAPK_gen_1	103	112	PF00069	0.324
DOC_MAPK_gen_1	23	31	PF00069	0.268
DOC_MAPK_JIP1_4	106	112	PF00069	0.324
DOC_MAPK_MEF2A_6	103	112	PF00069	0.324
DOC_PP2B_LxvP_1	77	80	PF13499	0.333
DOC_USP7_MATH_1	144	148	PF00917	0.385
DOC_USP7_MATH_1	149	153	PF00917	0.368
DOC_USP7_MATH_1	6	10	PF00917	0.337
DOC_USP7_UBL2_3	157	161	PF12436	0.495
LIG_BRCT_BRCA1_1	151	155	PF00533	0.378
LIG_BRCT_BRCA1_2	151	157	PF00533	0.324
LIG_FHA_1	71	77	PF00498	0.265
LIG_LIR_Gen_1	113	121	PF02991	0.378
LIG_LIR_Nem_3	113	119	PF02991	0.378
LIG_LIR_Nem_3	132	138	PF02991	0.285
LIG_Pex14_1	27	31	PF04695	0.326
LIG_SH2_GRB2like	45	48	PF00017	0.272
LIG_SH2_SRC	138	141	PF00017	0.314
LIG_SH2_STAT3	45	48	PF00017	0.272
LIG_SH2_STAT5	45	48	PF00017	0.247
LIG_SUMO_SIM_par_1	106	111	PF11976	0.349
LIG_TRAF2_1	87	90	PF00917	0.384
MOD_CK2_1	32	38	PF00069	0.290
MOD_CK2_1	6	12	PF00069	0.370
MOD_CK2_1	84	90	PF00069	0.387
MOD_GlcNHglycan	38	42	PF01048	0.278
MOD_GlcNHglycan	86	89	PF01048	0.341
MOD_GSK3_1	6	13	PF00069	0.371
MOD_GSK3_1	80	87	PF00069	0.326
MOD_N-GLC_1	46	51	PF02516	0.288
MOD_NEK2_1	155	160	PF00069	0.451
MOD_NEK2_2	6	11	PF00069	0.324
MOD_PIKK_1	129	135	PF00454	0.324
MOD_PIKK_1	139	145	PF00454	0.220
TRG_DiLeu_BaEn_3	38	44	PF01217	0.369
TRG_ER_diLys_1	157	161	PF00400	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P365	Leptomonas seymouri	59%	99%
A0A0S4JVB0	Bodo saltans	40%	100%
A0A1X0NMW8	Trypanosomatidae	45%	100%
A0A3Q8IHN7	Leishmania donovani	100%	100%
A0A422MXW1	Trypanosoma rangeli	48%	100%
A1Z9A2	Drosophila melanogaster	31%	99%
A4H6V7	Leishmania braziliensis	82%	99%
A7SJ66	Nematostella vectensis	31%	100%
C9ZIQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	99%
E9ANW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O74797	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q290L7	Drosophila pseudoobscura pseudoobscura	31%	99%
Q32P66	Bos taurus	30%	100%
Q3B8G0	Xenopus laevis	27%	100%
Q498R7	Rattus norvegicus	30%	100%
Q55C72	Dictyostelium discoideum	28%	100%
Q8BHG2	Mus musculus	31%	100%
Q9BI88	Caenorhabditis elegans	30%	96%
Q9NWV4	Homo sapiens	30%	100%