Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AGC8_LEIIN

TriTrypDb:

LINF_120009200

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGC8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	48	52	PF00656	0.679
CLV_NRD_NRD_1	101	103	PF00675	0.740
CLV_NRD_NRD_1	138	140	PF00675	0.610
CLV_NRD_NRD_1	276	278	PF00675	0.663
CLV_PCSK_KEX2_1	276	278	PF00082	0.663
CLV_PCSK_SKI1_1	184	188	PF00082	0.796
CLV_PCSK_SKI1_1	296	300	PF00082	0.828
DEG_Nend_Nbox_1	1	3	PF02207	0.703
DEG_ODPH_VHL_1	176	188	PF01847	0.729
DEG_SCF_FBW7_1	396	402	PF00400	0.712
DEG_SCF_FBW7_2	348	355	PF00400	0.745
DEG_SPOP_SBC_1	16	20	PF00917	0.766
DOC_CKS1_1	305	310	PF01111	0.706
DOC_CKS1_1	396	401	PF01111	0.714
DOC_CYCLIN_yCln2_LP_2	388	394	PF00134	0.757
DOC_PP1_RVXF_1	236	243	PF00149	0.739
DOC_PP4_FxxP_1	106	109	PF00568	0.741
DOC_USP7_MATH_1	143	147	PF00917	0.700
DOC_USP7_MATH_1	16	20	PF00917	0.766
DOC_USP7_MATH_1	266	270	PF00917	0.761
DOC_USP7_MATH_1	381	385	PF00917	0.731
DOC_WW_Pin1_4	107	112	PF00397	0.756
DOC_WW_Pin1_4	129	134	PF00397	0.760
DOC_WW_Pin1_4	155	160	PF00397	0.818
DOC_WW_Pin1_4	197	202	PF00397	0.835
DOC_WW_Pin1_4	250	255	PF00397	0.853
DOC_WW_Pin1_4	301	306	PF00397	0.832
DOC_WW_Pin1_4	348	353	PF00397	0.823
DOC_WW_Pin1_4	382	387	PF00397	0.762
DOC_WW_Pin1_4	395	400	PF00397	0.620
DOC_WW_Pin1_4	85	90	PF00397	0.604
LIG_14-3-3_CanoR_1	197	201	PF00244	0.792
LIG_14-3-3_CanoR_1	25	29	PF00244	0.664
LIG_14-3-3_CanoR_1	72	81	PF00244	0.648
LIG_AP_GAE_1	93	99	PF02883	0.664
LIG_BIR_III_2	282	286	PF00653	0.761
LIG_BIR_III_4	51	55	PF00653	0.661
LIG_BRCT_BRCA1_1	324	328	PF00533	0.775
LIG_Clathr_ClatBox_1	8	12	PF01394	0.709
LIG_EH_1	325	329	PF12763	0.678
LIG_eIF4E_1	180	186	PF01652	0.664
LIG_eIF4E_1	361	367	PF01652	0.594
LIG_FHA_1	152	158	PF00498	0.638
LIG_FHA_1	221	227	PF00498	0.651
LIG_FHA_1	305	311	PF00498	0.754
LIG_FHA_1	387	393	PF00498	0.759
LIG_FHA_2	368	374	PF00498	0.784
LIG_FHA_2	46	52	PF00498	0.647
LIG_IRF3_LxIS_1	56	63	PF10401	0.758
LIG_LIR_Apic_2	105	109	PF02991	0.740
LIG_LIR_Gen_1	93	104	PF02991	0.742
LIG_LIR_Nem_3	93	99	PF02991	0.741
LIG_NRBOX	4	10	PF00104	0.689
LIG_RPA_C_Fungi	67	79	PF08784	0.675
LIG_SH2_CRK	86	90	PF00017	0.640
LIG_SH2_GRB2like	150	153	PF00017	0.759
LIG_SH2_STAT5	361	364	PF00017	0.787
LIG_SH3_3	130	136	PF00018	0.756
LIG_SH3_3	227	233	PF00018	0.735
LIG_SH3_3	302	308	PF00018	0.839
LIG_SH3_3	318	324	PF00018	0.560
LIG_SUMO_SIM_anti_2	181	190	PF11976	0.722
LIG_SUMO_SIM_par_1	153	158	PF11976	0.735
LIG_SUMO_SIM_par_1	181	190	PF11976	0.722
LIG_SUMO_SIM_par_1	365	371	PF11976	0.700
LIG_SUMO_SIM_par_1	6	12	PF11976	0.704
LIG_TRAF2_1	352	355	PF00917	0.739
LIG_WW_3	79	83	PF00397	0.742
MOD_CDC14_SPxK_1	200	203	PF00782	0.849
MOD_CDK_SPK_2	85	90	PF00069	0.686
MOD_CDK_SPxK_1	197	203	PF00069	0.839
MOD_CDK_SPxK_1	395	401	PF00069	0.618
MOD_CDK_SPxxK_3	132	139	PF00069	0.615
MOD_CK1_1	135	141	PF00069	0.782
MOD_CK1_1	18	24	PF00069	0.818
MOD_CK1_1	199	205	PF00069	0.730
MOD_CK1_1	26	32	PF00069	0.716
MOD_CK2_1	122	128	PF00069	0.737
MOD_CK2_1	266	272	PF00069	0.681
MOD_CK2_1	70	76	PF00069	0.798
MOD_GlcNHglycan	194	197	PF01048	0.704
MOD_GlcNHglycan	220	223	PF01048	0.652
MOD_GlcNHglycan	258	261	PF01048	0.787
MOD_GlcNHglycan	268	271	PF01048	0.628
MOD_GlcNHglycan	28	31	PF01048	0.767
MOD_GlcNHglycan	355	359	PF01048	0.739
MOD_GlcNHglycan	72	75	PF01048	0.794
MOD_GSK3_1	15	22	PF00069	0.804
MOD_GSK3_1	151	158	PF00069	0.661
MOD_GSK3_1	168	175	PF00069	0.640
MOD_GSK3_1	192	199	PF00069	0.754
MOD_GSK3_1	24	31	PF00069	0.708
MOD_GSK3_1	300	307	PF00069	0.724
MOD_GSK3_1	382	389	PF00069	0.826
MOD_GSK3_1	395	402	PF00069	0.615
MOD_GSK3_1	66	73	PF00069	0.779
MOD_N-GLC_1	151	156	PF02516	0.732
MOD_N-GLC_1	218	223	PF02516	0.714
MOD_NEK2_1	121	126	PF00069	0.835
MOD_NEK2_1	299	304	PF00069	0.843
MOD_NEK2_1	328	333	PF00069	0.719
MOD_NEK2_1	60	65	PF00069	0.756
MOD_NEK2_1	70	75	PF00069	0.631
MOD_NEK2_1	92	97	PF00069	0.630
MOD_NEK2_2	143	148	PF00069	0.692
MOD_PIKK_1	231	237	PF00454	0.773
MOD_PK_1	341	347	PF00069	0.601
MOD_PKA_2	196	202	PF00069	0.789
MOD_PKA_2	24	30	PF00069	0.663
MOD_Plk_1	151	157	PF00069	0.734
MOD_Plk_1	92	98	PF00069	0.664
MOD_Plk_4	3	9	PF00069	0.634
MOD_ProDKin_1	107	113	PF00069	0.759
MOD_ProDKin_1	129	135	PF00069	0.758
MOD_ProDKin_1	155	161	PF00069	0.820
MOD_ProDKin_1	197	203	PF00069	0.839
MOD_ProDKin_1	250	256	PF00069	0.855
MOD_ProDKin_1	301	307	PF00069	0.833
MOD_ProDKin_1	348	354	PF00069	0.822
MOD_ProDKin_1	382	388	PF00069	0.765
MOD_ProDKin_1	395	401	PF00069	0.621
MOD_ProDKin_1	85	91	PF00069	0.599
TRG_DiLeu_BaEn_1	181	186	PF01217	0.797
TRG_DiLeu_LyEn_5	181	186	PF01217	0.797
TRG_ER_diArg_1	236	239	PF00400	0.734
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.742
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H6K7	Leishmania donovani	99%	100%
A4H6V6	Leishmania braziliensis	62%	97%
E9ANW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	95%
Q4QGQ2	Leishmania major	89%	100%