LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Glutathione S-transferase - N-terminal domain containing protein - putative
Species:
Leishmania infantum
UniProt:
E9AGC3_LEIIN
TriTrypDb:
LINF_120008700
Length:
370

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized LINJ.12.0310

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AGC3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGC3

Function

Biological processes
Term Name Level Count
GO:0006414 translational elongation 5 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009059 macromolecule biosynthetic process 4 1
GO:0009987 cellular process 1 1
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016740 transferase activity 2 1
GO:0003676 nucleic acid binding 3 3
GO:0003746 translation elongation factor activity 4 3
GO:0005488 binding 1 3
GO:0008135 translation factor activity, RNA binding 3 3
GO:0045182 translation regulator activity 1 3
GO:0090079 translation regulator activity, nucleic acid binding 2 3
GO:0097159 organic cyclic compound binding 2 3
GO:1901363 heterocyclic compound binding 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 118 122 PF00656 0.471
CLV_NRD_NRD_1 166 168 PF00675 0.407
CLV_NRD_NRD_1 265 267 PF00675 0.741
CLV_NRD_NRD_1 359 361 PF00675 0.361
CLV_PCSK_KEX2_1 166 168 PF00082 0.480
CLV_PCSK_KEX2_1 265 267 PF00082 0.741
CLV_PCSK_SKI1_1 136 140 PF00082 0.514
CLV_PCSK_SKI1_1 154 158 PF00082 0.471
CLV_PCSK_SKI1_1 16 20 PF00082 0.279
CLV_PCSK_SKI1_1 333 337 PF00082 0.376
CLV_PCSK_SKI1_1 348 352 PF00082 0.230
DEG_APCC_DBOX_1 300 308 PF00400 0.536
DEG_SCF_FBW7_1 276 283 PF00400 0.651
DOC_CYCLIN_RxL_1 233 246 PF00134 0.517
DOC_CYCLIN_yCln2_LP_2 351 357 PF00134 0.473
DOC_MAPK_gen_1 233 243 PF00069 0.519
DOC_MAPK_gen_1 345 355 PF00069 0.506
DOC_MAPK_gen_1 360 367 PF00069 0.295
DOC_MAPK_MEF2A_6 348 355 PF00069 0.469
DOC_MAPK_MEF2A_6 360 367 PF00069 0.313
DOC_MAPK_MEF2A_6 76 84 PF00069 0.501
DOC_MAPK_NFAT4_5 348 356 PF00069 0.498
DOC_MAPK_NFAT4_5 360 368 PF00069 0.435
DOC_MIT_MIM_1 162 172 PF04212 0.357
DOC_PP1_RVXF_1 128 134 PF00149 0.400
DOC_PP2B_LxvP_1 351 354 PF13499 0.455
DOC_USP7_MATH_1 260 264 PF00917 0.693
DOC_USP7_MATH_1 267 271 PF00917 0.608
DOC_USP7_MATH_1 280 284 PF00917 0.521
DOC_USP7_UBL2_3 144 148 PF12436 0.413
DOC_WW_Pin1_4 276 281 PF00397 0.606
DOC_WW_Pin1_4 8 13 PF00397 0.419
LIG_14-3-3_CanoR_1 188 198 PF00244 0.672
LIG_14-3-3_CanoR_1 213 218 PF00244 0.515
LIG_14-3-3_CanoR_1 281 285 PF00244 0.621
LIG_14-3-3_CanoR_1 289 293 PF00244 0.613
LIG_Actin_WH2_2 157 174 PF00022 0.432
LIG_Actin_WH2_2 319 335 PF00022 0.537
LIG_deltaCOP1_diTrp_1 121 126 PF00928 0.331
LIG_eIF4E_1 13 19 PF01652 0.355
LIG_eIF4E_1 346 352 PF01652 0.522
LIG_FHA_1 15 21 PF00498 0.482
LIG_FHA_2 116 122 PF00498 0.399
LIG_FHA_2 127 133 PF00498 0.312
LIG_FHA_2 190 196 PF00498 0.612
LIG_FHA_2 244 250 PF00498 0.509
LIG_FHA_2 311 317 PF00498 0.442
LIG_LIR_Gen_1 121 131 PF02991 0.327
LIG_LIR_Nem_3 121 126 PF02991 0.331
LIG_LIR_Nem_3 135 141 PF02991 0.354
LIG_LIR_Nem_3 343 347 PF02991 0.494
LIG_Rb_LxCxE_1 322 343 PF01857 0.496
LIG_SH2_CRK 23 27 PF00017 0.410
LIG_SH2_CRK 347 351 PF00017 0.538
LIG_SH2_NCK_1 218 222 PF00017 0.573
LIG_SH2_STAP1 134 138 PF00017 0.457
LIG_SH2_STAT3 134 137 PF00017 0.442
LIG_SH2_STAT5 13 16 PF00017 0.355
LIG_SH2_STAT5 134 137 PF00017 0.461
LIG_SH2_STAT5 170 173 PF00017 0.495
LIG_SH2_STAT5 63 66 PF00017 0.279
LIG_SH2_STAT5 73 76 PF00017 0.279
LIG_SH3_3 98 104 PF00018 0.615
LIG_SUMO_SIM_anti_2 77 83 PF11976 0.496
LIG_TRAF2_1 192 195 PF00917 0.561
LIG_UBA3_1 240 245 PF00899 0.517
MOD_CDK_SPK_2 276 281 PF00069 0.606
MOD_CK1_1 184 190 PF00069 0.663
MOD_CK1_1 206 212 PF00069 0.547
MOD_CK1_1 270 276 PF00069 0.613
MOD_CK1_1 287 293 PF00069 0.663
MOD_CK1_1 294 300 PF00069 0.557
MOD_CK2_1 110 116 PF00069 0.371
MOD_CK2_1 189 195 PF00069 0.567
MOD_CK2_1 243 249 PF00069 0.486
MOD_GlcNHglycan 181 184 PF01048 0.571
MOD_GlcNHglycan 276 279 PF01048 0.581
MOD_GlcNHglycan 286 289 PF01048 0.551
MOD_GlcNHglycan 293 296 PF01048 0.475
MOD_GlcNHglycan 84 87 PF01048 0.671
MOD_GlcNHglycan 89 92 PF01048 0.689
MOD_GSK3_1 110 117 PF00069 0.480
MOD_GSK3_1 179 186 PF00069 0.554
MOD_GSK3_1 209 216 PF00069 0.524
MOD_GSK3_1 261 268 PF00069 0.670
MOD_GSK3_1 270 277 PF00069 0.563
MOD_GSK3_1 280 287 PF00069 0.533
MOD_N-GLC_1 38 43 PF02516 0.297
MOD_NEK2_1 1 6 PF00069 0.392
MOD_NEK2_1 114 119 PF00069 0.479
MOD_NEK2_1 126 131 PF00069 0.482
MOD_NEK2_1 274 279 PF00069 0.697
MOD_NEK2_1 319 324 PF00069 0.487
MOD_NEK2_1 64 69 PF00069 0.318
MOD_PIKK_1 115 121 PF00454 0.408
MOD_PK_1 213 219 PF00069 0.585
MOD_PK_1 265 271 PF00069 0.601
MOD_PKA_1 244 250 PF00069 0.564
MOD_PKA_1 265 271 PF00069 0.729
MOD_PKA_2 206 212 PF00069 0.513
MOD_PKA_2 265 271 PF00069 0.645
MOD_PKA_2 280 286 PF00069 0.453
MOD_PKA_2 288 294 PF00069 0.638
MOD_PKA_2 363 369 PF00069 0.365
MOD_Plk_1 115 121 PF00069 0.464
MOD_Plk_2-3 38 44 PF00069 0.410
MOD_Plk_4 1 7 PF00069 0.352
MOD_Plk_4 110 116 PF00069 0.452
MOD_Plk_4 119 125 PF00069 0.410
MOD_Plk_4 152 158 PF00069 0.371
MOD_Plk_4 213 219 PF00069 0.552
MOD_Plk_4 280 286 PF00069 0.695
MOD_Plk_4 294 300 PF00069 0.657
MOD_Plk_4 346 352 PF00069 0.498
MOD_Plk_4 363 369 PF00069 0.440
MOD_ProDKin_1 276 282 PF00069 0.605
MOD_ProDKin_1 8 14 PF00069 0.419
TRG_ENDOCYTIC_2 23 26 PF00928 0.410
TRG_ENDOCYTIC_2 347 350 PF00928 0.461
TRG_ER_diArg_1 166 168 PF00400 0.508
TRG_ER_diArg_1 224 227 PF00400 0.609
TRG_ER_diArg_1 265 267 PF00400 0.741
TRG_Pf-PMV_PEXEL_1 176 180 PF00026 0.512

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HY02 Leptomonas seymouri 69% 99%
A0A1X0NNU8 Trypanosomatidae 36% 92%
A0A3R7MZA1 Trypanosoma rangeli 35% 100%
A0A3S7WRV8 Leishmania donovani 100% 100%
A4H6V1 Leishmania braziliensis 83% 100%
C9ZQA1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9ANW3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 99%
Q4QGQ7 Leishmania major 98% 100%
V5DE18 Trypanosoma cruzi 39% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS