Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CCR4-NOT transcription complex subunit 2 - putative

Species:

Leishmania infantum

UniProt:

E9AGC2_LEIIN

TriTrypDb:

LINF_120008600

Length:

561

Annotations

Annotations by Jardim et al.

Transcription, CCR4-NOT transcription complex subunit 2

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0030015	CCR4-NOT core complex	3	5
GO:0032991	protein-containing complex	1	5
GO:0140535	intracellular protein-containing complex	2	5
GO:0000932	P-body	5	1
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AGC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGC2

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	5
GO:0009889	regulation of biosynthetic process	4	5
GO:0010468	regulation of gene expression	5	5
GO:0010556	regulation of macromolecule biosynthetic process	5	5
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	5
GO:0019222	regulation of metabolic process	3	5
GO:0031323	regulation of cellular metabolic process	4	5
GO:0031326	regulation of cellular biosynthetic process	5	5
GO:0050789	regulation of biological process	2	5
GO:0050794	regulation of cellular process	3	5
GO:0051171	regulation of nitrogen compound metabolic process	4	5
GO:0051252	regulation of RNA metabolic process	5	5
GO:0060255	regulation of macromolecule metabolic process	4	5
GO:0065007	biological regulation	1	5
GO:0080090	regulation of primary metabolic process	4	5
GO:1903506	regulation of nucleic acid-templated transcription	7	5
GO:2001141	regulation of RNA biosynthetic process	6	5
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	8	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	339	343	PF00656	0.561
CLV_C14_Caspase3-7	468	472	PF00656	0.483
CLV_NRD_NRD_1	67	69	PF00675	0.593
CLV_PCSK_KEX2_1	446	448	PF00082	0.283
CLV_PCSK_KEX2_1	67	69	PF00082	0.593
CLV_PCSK_PC1ET2_1	446	448	PF00082	0.283
CLV_PCSK_SKI1_1	426	430	PF00082	0.335
CLV_PCSK_SKI1_1	474	478	PF00082	0.335
CLV_PCSK_SKI1_1	68	72	PF00082	0.597
DEG_COP1_1	319	326	PF00400	0.664
DOC_MAPK_gen_1	124	132	PF00069	0.599
DOC_MAPK_JIP1_4	400	406	PF00069	0.535
DOC_MAPK_MEF2A_6	309	317	PF00069	0.623
DOC_PP2B_LxvP_1	130	133	PF13499	0.595
DOC_PP2B_LxvP_1	49	52	PF13499	0.574
DOC_PP4_FxxP_1	25	28	PF00568	0.764
DOC_PP4_FxxP_1	390	393	PF00568	0.389
DOC_USP7_MATH_1	256	260	PF00917	0.730
DOC_USP7_MATH_1	265	269	PF00917	0.666
DOC_USP7_MATH_1	378	382	PF00917	0.582
DOC_USP7_MATH_1	541	545	PF00917	0.763
DOC_USP7_MATH_1	552	556	PF00917	0.631
DOC_USP7_MATH_1	557	561	PF00917	0.589
DOC_USP7_UBL2_3	305	309	PF12436	0.570
DOC_USP7_UBL2_3	398	402	PF12436	0.535
DOC_WW_Pin1_4	240	245	PF00397	0.738
DOC_WW_Pin1_4	317	322	PF00397	0.743
DOC_WW_Pin1_4	553	558	PF00397	0.753
LIG_14-3-3_CanoR_1	101	109	PF00244	0.674
LIG_14-3-3_CanoR_1	400	405	PF00244	0.535
LIG_BIR_II_1	1	5	PF00653	0.722
LIG_eIF4E_1	302	308	PF01652	0.560
LIG_FHA_1	318	324	PF00498	0.736
LIG_FHA_1	328	334	PF00498	0.635
LIG_FHA_1	350	356	PF00498	0.628
LIG_FHA_1	374	380	PF00498	0.567
LIG_FHA_1	477	483	PF00498	0.535
LIG_FHA_2	466	472	PF00498	0.483
LIG_FHA_2	59	65	PF00498	0.653
LIG_LIR_Apic_2	23	28	PF02991	0.712
LIG_LIR_Apic_2	383	388	PF02991	0.565
LIG_LIR_Apic_2	389	393	PF02991	0.389
LIG_LIR_Apic_2	394	399	PF02991	0.501
LIG_LIR_Gen_1	345	355	PF02991	0.540
LIG_LIR_Gen_1	408	417	PF02991	0.535
LIG_LIR_Gen_1	477	485	PF02991	0.535
LIG_LIR_Nem_3	345	351	PF02991	0.543
LIG_LIR_Nem_3	380	385	PF02991	0.636
LIG_LIR_Nem_3	408	412	PF02991	0.535
LIG_LIR_Nem_3	415	421	PF02991	0.488
LIG_LIR_Nem_3	477	483	PF02991	0.535
LIG_LIR_Nem_3	487	491	PF02991	0.467
LIG_MYND_1	233	237	PF01753	0.593
LIG_PCNA_yPIPBox_3	195	206	PF02747	0.613
LIG_SH2_CRK	396	400	PF00017	0.572
LIG_SH2_CRK	422	426	PF00017	0.535
LIG_SH2_PTP2	385	388	PF00017	0.552
LIG_SH2_SRC	322	325	PF00017	0.655
LIG_SH2_STAP1	382	386	PF00017	0.580
LIG_SH2_STAT3	173	176	PF00017	0.586
LIG_SH2_STAT5	322	325	PF00017	0.655
LIG_SH2_STAT5	385	388	PF00017	0.552
LIG_SH2_STAT5	419	422	PF00017	0.535
LIG_SH2_STAT5	480	483	PF00017	0.535
LIG_SH3_3	266	272	PF00018	0.685
LIG_SH3_3	307	313	PF00018	0.586
LIG_SH3_3	318	324	PF00018	0.569
LIG_SH3_3	326	332	PF00018	0.715
LIG_SH3_3	479	485	PF00018	0.628
LIG_SH3_4	398	405	PF00018	0.535
LIG_SUMO_SIM_anti_2	106	111	PF11976	0.571
LIG_TRAF2_1	513	516	PF00917	0.564
LIG_WRC_WIRS_1	406	411	PF05994	0.535
LIG_WW_2	313	316	PF00397	0.641
MOD_CK1_1	405	411	PF00069	0.535
MOD_CK1_1	555	561	PF00069	0.701
MOD_CK2_1	100	106	PF00069	0.615
MOD_CK2_1	322	328	PF00069	0.649
MOD_CK2_1	360	366	PF00069	0.558
MOD_CK2_1	458	464	PF00069	0.535
MOD_CK2_1	58	64	PF00069	0.619
MOD_GlcNHglycan	102	105	PF01048	0.715
MOD_GlcNHglycan	228	231	PF01048	0.671
MOD_GlcNHglycan	259	262	PF01048	0.671
MOD_GlcNHglycan	324	327	PF01048	0.673
MOD_GlcNHglycan	333	336	PF01048	0.627
MOD_GlcNHglycan	505	510	PF01048	0.589
MOD_GlcNHglycan	537	540	PF01048	0.783
MOD_GlcNHglycan	550	553	PF01048	0.623
MOD_GlcNHglycan	557	560	PF01048	0.649
MOD_GSK3_1	175	182	PF00069	0.637
MOD_GSK3_1	208	215	PF00069	0.594
MOD_GSK3_1	327	334	PF00069	0.667
MOD_GSK3_1	369	376	PF00069	0.605
MOD_GSK3_1	474	481	PF00069	0.535
MOD_GSK3_1	548	555	PF00069	0.653
MOD_N-GLC_1	146	151	PF02516	0.601
MOD_N-GLC_1	156	161	PF02516	0.455
MOD_N-GLC_1	257	262	PF02516	0.828
MOD_N-GLC_1	346	351	PF02516	0.542
MOD_N-GLC_1	553	558	PF02516	0.749
MOD_NEK2_1	225	230	PF00069	0.673
MOD_NEK2_1	346	351	PF00069	0.540
MOD_NEK2_1	370	375	PF00069	0.551
MOD_NEK2_1	463	468	PF00069	0.543
MOD_NEK2_1	476	481	PF00069	0.530
MOD_NEK2_1	58	63	PF00069	0.564
MOD_NEK2_2	478	483	PF00069	0.535
MOD_PIKK_1	175	181	PF00454	0.594
MOD_PIKK_1	189	195	PF00454	0.481
MOD_PIKK_1	28	34	PF00454	0.711
MOD_PIKK_1	336	342	PF00454	0.589
MOD_PIKK_1	355	361	PF00454	0.369
MOD_PIKK_1	490	496	PF00454	0.535
MOD_PIKK_1	519	525	PF00454	0.602
MOD_PKA_2	100	106	PF00069	0.691
MOD_Plk_1	156	162	PF00069	0.555
MOD_Plk_1	257	263	PF00069	0.726
MOD_Plk_1	346	352	PF00069	0.538
MOD_Plk_1	355	361	PF00069	0.464
MOD_Plk_1	413	419	PF00069	0.535
MOD_Plk_1	505	511	PF00069	0.535
MOD_Plk_2-3	458	464	PF00069	0.535
MOD_Plk_4	20	26	PF00069	0.800
MOD_Plk_4	220	226	PF00069	0.542
MOD_Plk_4	413	419	PF00069	0.535
MOD_Plk_4	458	464	PF00069	0.535
MOD_Plk_4	478	484	PF00069	0.400
MOD_ProDKin_1	240	246	PF00069	0.737
MOD_ProDKin_1	317	323	PF00069	0.740
MOD_ProDKin_1	553	559	PF00069	0.752
MOD_SUMO_for_1	412	415	PF00179	0.535
MOD_SUMO_rev_2	383	393	PF00179	0.545
TRG_DiLeu_BaEn_1	506	511	PF01217	0.542
TRG_ENDOCYTIC_2	384	387	PF00928	0.697
TRG_ENDOCYTIC_2	480	483	PF00928	0.535
TRG_ER_diArg_1	126	129	PF00400	0.600
TRG_NLS_MonoCore_2	396	401	PF00514	0.535
TRG_NLS_MonoExtC_3	396	401	PF00514	0.535
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	435	439	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WRX6	Leishmania donovani	99%	99%
E9ANW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QGQ8	Leishmania major	95%	100%