LeishMANIAdb
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Putative ornithine decarboxylase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ornithine decarboxylase
Gene product:
ornithine decarboxylase - putative
Species:
Leishmania infantum
UniProt:
E9AGB5_LEIIN
TriTrypDb:
LINF_120007900
Length:
707

Annotations

Annotations by Jardim et al.

Polyamine metabolism, ornithine decarboxylase LINJ.12.0100

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AGB5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGB5

Function

Biological processes
Term Name Level Count
GO:0006576 biogenic amine metabolic process 5 7
GO:0006595 polyamine metabolic process 6 7
GO:0006596 polyamine biosynthetic process 7 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0009058 biosynthetic process 2 7
GO:0009308 amine metabolic process 4 7
GO:0009309 amine biosynthetic process 5 7
GO:0009987 cellular process 1 7
GO:0034641 cellular nitrogen compound metabolic process 3 7
GO:0042401 biogenic amine biosynthetic process 6 7
GO:0044237 cellular metabolic process 2 7
GO:0044249 cellular biosynthetic process 3 7
GO:0044271 cellular nitrogen compound biosynthetic process 4 7
GO:0071704 organic substance metabolic process 2 7
GO:1901564 organonitrogen compound metabolic process 3 7
GO:1901566 organonitrogen compound biosynthetic process 4 7
GO:1901576 organic substance biosynthetic process 3 7
GO:0006082 organic acid metabolic process 3 1
GO:0006520 amino acid metabolic process 3 1
GO:0006591 ornithine metabolic process 5 1
GO:0009445 putrescine metabolic process 7 1
GO:0009446 putrescine biosynthetic process 8 1
GO:0019752 carboxylic acid metabolic process 5 1
GO:0033387 putrescine biosynthetic process from ornithine 6 1
GO:0043436 oxoacid metabolic process 4 1
GO:0044238 primary metabolic process 2 1
GO:0044281 small molecule metabolic process 2 1
GO:1901605 alpha-amino acid metabolic process 4 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0004586 ornithine decarboxylase activity 5 6
GO:0016829 lyase activity 2 7
GO:0016830 carbon-carbon lyase activity 3 7
GO:0016831 carboxy-lyase activity 4 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 233 237 PF00656 0.448
CLV_C14_Caspase3-7 575 579 PF00656 0.619
CLV_C14_Caspase3-7 88 92 PF00656 0.781
CLV_NRD_NRD_1 162 164 PF00675 0.488
CLV_NRD_NRD_1 191 193 PF00675 0.584
CLV_NRD_NRD_1 217 219 PF00675 0.471
CLV_NRD_NRD_1 616 618 PF00675 0.343
CLV_NRD_NRD_1 621 623 PF00675 0.350
CLV_NRD_NRD_1 677 679 PF00675 0.461
CLV_NRD_NRD_1 69 71 PF00675 0.605
CLV_PCSK_KEX2_1 162 164 PF00082 0.488
CLV_PCSK_KEX2_1 191 193 PF00082 0.584
CLV_PCSK_KEX2_1 217 219 PF00082 0.471
CLV_PCSK_KEX2_1 615 617 PF00082 0.342
CLV_PCSK_KEX2_1 621 623 PF00082 0.352
CLV_PCSK_KEX2_1 677 679 PF00082 0.458
CLV_PCSK_KEX2_1 69 71 PF00082 0.690
CLV_PCSK_PC7_1 617 623 PF00082 0.330
CLV_PCSK_SKI1_1 226 230 PF00082 0.496
CLV_PCSK_SKI1_1 481 485 PF00082 0.346
CLV_PCSK_SKI1_1 501 505 PF00082 0.183
CLV_PCSK_SKI1_1 529 533 PF00082 0.363
CLV_PCSK_SKI1_1 69 73 PF00082 0.598
DEG_APCC_DBOX_1 274 282 PF00400 0.546
DEG_APCC_DBOX_1 480 488 PF00400 0.546
DEG_SPOP_SBC_1 115 119 PF00917 0.591
DOC_CYCLIN_RxL_1 515 526 PF00134 0.536
DOC_CYCLIN_RxL_1 63 73 PF00134 0.699
DOC_MAPK_gen_1 518 527 PF00069 0.509
DOC_PP1_RVXF_1 675 682 PF00149 0.348
DOC_PP2B_LxvP_1 655 658 PF13499 0.530
DOC_PP4_FxxP_1 331 334 PF00568 0.546
DOC_PP4_FxxP_1 391 394 PF00568 0.619
DOC_PP4_MxPP_1 48 51 PF00568 0.811
DOC_USP7_MATH_1 26 30 PF00917 0.637
DOC_USP7_MATH_1 286 290 PF00917 0.619
DOC_USP7_MATH_1 383 387 PF00917 0.523
DOC_USP7_MATH_1 428 432 PF00917 0.500
DOC_USP7_MATH_1 52 56 PF00917 0.690
DOC_USP7_MATH_1 531 535 PF00917 0.609
DOC_USP7_MATH_1 588 592 PF00917 0.523
DOC_WW_Pin1_4 146 151 PF00397 0.635
DOC_WW_Pin1_4 179 184 PF00397 0.529
DOC_WW_Pin1_4 322 327 PF00397 0.620
DOC_WW_Pin1_4 99 104 PF00397 0.816
LIG_14-3-3_CanoR_1 195 204 PF00244 0.567
LIG_14-3-3_CanoR_1 501 510 PF00244 0.562
LIG_14-3-3_CanoR_1 521 527 PF00244 0.306
LIG_14-3-3_CanoR_1 615 620 PF00244 0.575
LIG_14-3-3_CanoR_1 625 632 PF00244 0.517
LIG_14-3-3_CterR_2 703 707 PF00244 0.597
LIG_Actin_WH2_2 507 523 PF00022 0.464
LIG_AP2alpha_2 257 259 PF02296 0.461
LIG_BRCT_BRCA1_1 387 391 PF00533 0.546
LIG_Clathr_ClatBox_1 134 138 PF01394 0.501
LIG_FHA_1 170 176 PF00498 0.417
LIG_FHA_1 460 466 PF00498 0.584
LIG_FHA_1 517 523 PF00498 0.555
LIG_FHA_1 565 571 PF00498 0.546
LIG_FHA_1 674 680 PF00498 0.359
LIG_FHA_2 156 162 PF00498 0.619
LIG_FHA_2 25 31 PF00498 0.691
LIG_FHA_2 449 455 PF00498 0.546
LIG_FHA_2 469 475 PF00498 0.576
LIG_LIR_Apic_2 328 334 PF02991 0.546
LIG_LIR_Apic_2 388 394 PF02991 0.619
LIG_LIR_Gen_1 172 181 PF02991 0.455
LIG_LIR_Gen_1 350 358 PF02991 0.546
LIG_LIR_Gen_1 435 444 PF02991 0.619
LIG_LIR_Gen_1 471 480 PF02991 0.548
LIG_LIR_Gen_1 550 561 PF02991 0.546
LIG_LIR_Gen_1 653 660 PF02991 0.546
LIG_LIR_Nem_3 149 154 PF02991 0.573
LIG_LIR_Nem_3 168 173 PF02991 0.475
LIG_LIR_Nem_3 213 219 PF02991 0.422
LIG_LIR_Nem_3 256 262 PF02991 0.459
LIG_LIR_Nem_3 350 354 PF02991 0.546
LIG_LIR_Nem_3 435 440 PF02991 0.546
LIG_LIR_Nem_3 471 476 PF02991 0.548
LIG_LIR_Nem_3 542 547 PF02991 0.572
LIG_LIR_Nem_3 550 556 PF02991 0.516
LIG_LIR_Nem_3 653 657 PF02991 0.546
LIG_PCNA_yPIPBox_3 288 299 PF02747 0.539
LIG_Pex14_2 387 391 PF04695 0.546
LIG_Pex14_2 609 613 PF04695 0.530
LIG_Pex14_2 670 674 PF04695 0.492
LIG_SH2_CRK 173 177 PF00017 0.465
LIG_SH2_GRB2like 547 550 PF00017 0.546
LIG_SH2_NCK_1 14 18 PF00017 0.646
LIG_SH2_NCK_1 173 177 PF00017 0.589
LIG_SH2_NCK_1 663 667 PF00017 0.476
LIG_SH2_PTP2 351 354 PF00017 0.546
LIG_SH2_SRC 75 78 PF00017 0.553
LIG_SH2_STAP1 663 667 PF00017 0.476
LIG_SH2_STAP1 67 71 PF00017 0.604
LIG_SH2_STAT5 223 226 PF00017 0.483
LIG_SH2_STAT5 260 263 PF00017 0.500
LIG_SH2_STAT5 284 287 PF00017 0.546
LIG_SH2_STAT5 351 354 PF00017 0.546
LIG_SH2_STAT5 429 432 PF00017 0.518
LIG_SH2_STAT5 502 505 PF00017 0.546
LIG_SH2_STAT5 547 550 PF00017 0.546
LIG_SH2_STAT5 663 666 PF00017 0.468
LIG_SH2_STAT5 695 698 PF00017 0.640
LIG_SH3_3 177 183 PF00018 0.527
LIG_SH3_3 20 26 PF00018 0.662
LIG_SH3_3 245 251 PF00018 0.567
LIG_SH3_3 252 258 PF00018 0.437
LIG_SH3_3 320 326 PF00018 0.555
LIG_SH3_3 351 357 PF00018 0.563
LIG_SUMO_SIM_anti_2 492 498 PF11976 0.546
LIG_SUMO_SIM_anti_2 567 573 PF11976 0.546
LIG_SUMO_SIM_par_1 294 300 PF11976 0.536
LIG_SUMO_SIM_par_1 567 573 PF11976 0.546
LIG_TRAF2_1 158 161 PF00917 0.617
LIG_TRAF2_1 310 313 PF00917 0.563
LIG_TRAF2_1 59 62 PF00917 0.678
LIG_TRAF2_1 591 594 PF00917 0.536
LIG_TYR_ITIM 349 354 PF00017 0.546
LIG_UBA3_1 373 377 PF00899 0.525
LIG_WRC_WIRS_1 553 558 PF05994 0.546
MOD_CK1_1 124 130 PF00069 0.538
MOD_CK1_1 29 35 PF00069 0.638
MOD_CK1_1 386 392 PF00069 0.549
MOD_CK1_1 468 474 PF00069 0.554
MOD_CK1_1 534 540 PF00069 0.563
MOD_CK1_1 662 668 PF00069 0.471
MOD_CK2_1 155 161 PF00069 0.633
MOD_CK2_1 204 210 PF00069 0.626
MOD_CK2_1 307 313 PF00069 0.546
MOD_CK2_1 38 44 PF00069 0.618
MOD_CK2_1 468 474 PF00069 0.528
MOD_CK2_1 520 526 PF00069 0.530
MOD_CK2_1 534 540 PF00069 0.546
MOD_CK2_1 579 585 PF00069 0.504
MOD_CK2_1 588 594 PF00069 0.498
MOD_GlcNHglycan 109 112 PF01048 0.624
MOD_GlcNHglycan 198 201 PF01048 0.674
MOD_GlcNHglycan 206 209 PF01048 0.544
MOD_GlcNHglycan 232 235 PF01048 0.440
MOD_GlcNHglycan 299 302 PF01048 0.408
MOD_GlcNHglycan 368 371 PF01048 0.346
MOD_GlcNHglycan 40 43 PF01048 0.608
MOD_GlcNHglycan 420 423 PF01048 0.339
MOD_GlcNHglycan 424 429 PF01048 0.345
MOD_GlcNHglycan 430 433 PF01048 0.358
MOD_GlcNHglycan 466 470 PF01048 0.337
MOD_GlcNHglycan 52 55 PF01048 0.729
MOD_GlcNHglycan 581 584 PF01048 0.336
MOD_GlcNHglycan 599 602 PF01048 0.369
MOD_GlcNHglycan 610 613 PF01048 0.292
MOD_GlcNHglycan 91 94 PF01048 0.760
MOD_GSK3_1 121 128 PF00069 0.650
MOD_GSK3_1 204 211 PF00069 0.607
MOD_GSK3_1 217 224 PF00069 0.358
MOD_GSK3_1 29 36 PF00069 0.714
MOD_GSK3_1 424 431 PF00069 0.544
MOD_GSK3_1 465 472 PF00069 0.543
MOD_GSK3_1 516 523 PF00069 0.476
MOD_GSK3_1 85 92 PF00069 0.693
MOD_N-GLC_1 204 209 PF02516 0.643
MOD_N-GLC_1 378 383 PF02516 0.352
MOD_N-GLC_1 408 413 PF02516 0.294
MOD_N-GLC_1 469 474 PF02516 0.363
MOD_NEK2_1 137 142 PF00069 0.533
MOD_NEK2_1 408 413 PF00069 0.466
MOD_NEK2_1 448 453 PF00069 0.513
MOD_NEK2_1 552 557 PF00069 0.546
MOD_NEK2_1 608 613 PF00069 0.521
MOD_NEK2_1 624 629 PF00069 0.579
MOD_NEK2_2 33 38 PF00069 0.730
MOD_NEK2_2 413 418 PF00069 0.545
MOD_NEK2_2 516 521 PF00069 0.475
MOD_PIKK_1 125 131 PF00454 0.564
MOD_PIKK_1 137 143 PF00454 0.503
MOD_PIKK_1 221 227 PF00454 0.380
MOD_PKA_1 191 197 PF00069 0.606
MOD_PKA_1 217 223 PF00069 0.475
MOD_PKA_1 615 621 PF00069 0.563
MOD_PKA_2 191 197 PF00069 0.645
MOD_PKA_2 217 223 PF00069 0.475
MOD_PKA_2 520 526 PF00069 0.530
MOD_PKA_2 615 621 PF00069 0.571
MOD_PKA_2 624 630 PF00069 0.521
MOD_Plk_1 204 210 PF00069 0.626
MOD_Plk_1 408 414 PF00069 0.591
MOD_Plk_1 424 430 PF00069 0.489
MOD_Plk_1 469 475 PF00069 0.546
MOD_Plk_1 491 497 PF00069 0.504
MOD_Plk_1 595 601 PF00069 0.550
MOD_Plk_4 347 353 PF00069 0.522
MOD_Plk_4 448 454 PF00069 0.546
MOD_Plk_4 491 497 PF00069 0.504
MOD_Plk_4 531 537 PF00069 0.619
MOD_Plk_4 564 570 PF00069 0.546
MOD_Plk_4 625 631 PF00069 0.546
MOD_ProDKin_1 146 152 PF00069 0.639
MOD_ProDKin_1 179 185 PF00069 0.535
MOD_ProDKin_1 322 328 PF00069 0.620
MOD_ProDKin_1 99 105 PF00069 0.817
TRG_DiLeu_BaLyEn_6 67 72 PF01217 0.620
TRG_ENDOCYTIC_2 173 176 PF00928 0.481
TRG_ENDOCYTIC_2 19 22 PF00928 0.662
TRG_ENDOCYTIC_2 284 287 PF00928 0.619
TRG_ENDOCYTIC_2 351 354 PF00928 0.546
TRG_ENDOCYTIC_2 437 440 PF00928 0.546
TRG_ENDOCYTIC_2 553 556 PF00928 0.546
TRG_ER_diArg_1 191 193 PF00400 0.536
TRG_ER_diArg_1 216 218 PF00400 0.470
TRG_ER_diArg_1 45 48 PF00400 0.703
TRG_ER_diArg_1 615 617 PF00400 0.543
TRG_ER_diArg_1 621 623 PF00400 0.550
TRG_ER_diArg_1 677 679 PF00400 0.458
TRG_ER_diArg_1 69 71 PF00400 0.696
TRG_ER_diArg_1 690 693 PF00400 0.581
TRG_Pf-PMV_PEXEL_1 69 73 PF00026 0.696

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I681 Leptomonas seymouri 63% 98%
A0A3S5H6K6 Leishmania donovani 99% 100%
A4H6U3 Leishmania braziliensis 70% 96%
E9ANV5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 98%
P27116 Leishmania donovani 100% 100%
Q4QGR5 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS