LeishMANIAdb
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Cysteine--tRNA ligase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cysteine--tRNA ligase
Gene product:
cysteinyl-tRNA synthetase - putative
Species:
Leishmania infantum
UniProt:
E9AGB4_LEIIN
TriTrypDb:
LINF_120007600
Length:
784

Annotations

Annotations by Jardim et al.

tRNA synthetase, cysteinyl-tRNA synthetase LINJ.12.0230

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 2
Pissara et al. yes yes: 8
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 4
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 4
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AGB4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGB4

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 11
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006399 tRNA metabolic process 7 11
GO:0006418 tRNA aminoacylation for protein translation 6 11
GO:0006423 cysteinyl-tRNA aminoacylation 7 11
GO:0006520 amino acid metabolic process 3 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016070 RNA metabolic process 5 11
GO:0019752 carboxylic acid metabolic process 5 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0034660 ncRNA metabolic process 6 11
GO:0043038 amino acid activation 4 11
GO:0043039 tRNA aminoacylation 5 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043436 oxoacid metabolic process 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044281 small molecule metabolic process 2 11
GO:0046483 heterocycle metabolic process 3 11
GO:0071704 organic substance metabolic process 2 11
GO:0090304 nucleic acid metabolic process 4 11
GO:1901360 organic cyclic compound metabolic process 3 11
GO:1901564 organonitrogen compound metabolic process 3 11
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004812 aminoacyl-tRNA ligase activity 4 11
GO:0004817 cysteine-tRNA ligase activity 5 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016874 ligase activity 2 11
GO:0016875 ligase activity, forming carbon-oxygen bonds 3 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140098 catalytic activity, acting on RNA 3 11
GO:0140101 catalytic activity, acting on a tRNA 4 11
GO:0140640 catalytic activity, acting on a nucleic acid 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 609 613 PF00656 0.551
CLV_NRD_NRD_1 154 156 PF00675 0.358
CLV_NRD_NRD_1 236 238 PF00675 0.327
CLV_NRD_NRD_1 559 561 PF00675 0.459
CLV_NRD_NRD_1 667 669 PF00675 0.480
CLV_NRD_NRD_1 677 679 PF00675 0.514
CLV_NRD_NRD_1 686 688 PF00675 0.559
CLV_NRD_NRD_1 87 89 PF00675 0.284
CLV_PCSK_FUR_1 675 679 PF00082 0.487
CLV_PCSK_KEX2_1 113 115 PF00082 0.284
CLV_PCSK_KEX2_1 154 156 PF00082 0.358
CLV_PCSK_KEX2_1 20 22 PF00082 0.478
CLV_PCSK_KEX2_1 333 335 PF00082 0.297
CLV_PCSK_KEX2_1 667 669 PF00082 0.605
CLV_PCSK_KEX2_1 677 679 PF00082 0.488
CLV_PCSK_KEX2_1 686 688 PF00082 0.394
CLV_PCSK_KEX2_1 87 89 PF00082 0.284
CLV_PCSK_PC1ET2_1 113 115 PF00082 0.284
CLV_PCSK_PC1ET2_1 154 156 PF00082 0.376
CLV_PCSK_PC1ET2_1 20 22 PF00082 0.503
CLV_PCSK_PC1ET2_1 333 335 PF00082 0.297
CLV_PCSK_PC1ET2_1 686 688 PF00082 0.453
CLV_PCSK_SKI1_1 110 114 PF00082 0.286
CLV_PCSK_SKI1_1 156 160 PF00082 0.408
CLV_PCSK_SKI1_1 241 245 PF00082 0.280
CLV_PCSK_SKI1_1 422 426 PF00082 0.284
CLV_PCSK_SKI1_1 428 432 PF00082 0.284
CLV_PCSK_SKI1_1 437 441 PF00082 0.284
CLV_PCSK_SKI1_1 451 455 PF00082 0.284
CLV_PCSK_SKI1_1 481 485 PF00082 0.367
CLV_PCSK_SKI1_1 507 511 PF00082 0.497
CLV_PCSK_SKI1_1 694 698 PF00082 0.560
CLV_PCSK_SKI1_1 738 742 PF00082 0.516
CLV_PCSK_SKI1_1 749 753 PF00082 0.434
DEG_APCC_DBOX_1 436 444 PF00400 0.497
DOC_MAPK_FxFP_2 696 699 PF00069 0.411
DOC_MAPK_gen_1 172 182 PF00069 0.499
DOC_MAPK_gen_1 428 436 PF00069 0.484
DOC_MAPK_MEF2A_6 175 184 PF00069 0.499
DOC_PP1_RVXF_1 449 455 PF00149 0.484
DOC_PP1_RVXF_1 55 62 PF00149 0.480
DOC_PP4_FxxP_1 344 347 PF00568 0.484
DOC_PP4_FxxP_1 696 699 PF00568 0.465
DOC_USP7_MATH_1 147 151 PF00917 0.543
DOC_USP7_MATH_1 208 212 PF00917 0.563
DOC_USP7_UBL2_3 688 692 PF12436 0.413
DOC_USP7_UBL2_3 738 742 PF12436 0.481
DOC_USP7_UBL2_3 745 749 PF12436 0.446
DOC_WW_Pin1_4 332 337 PF00397 0.520
DOC_WW_Pin1_4 351 356 PF00397 0.441
LIG_14-3-3_CanoR_1 221 227 PF00244 0.510
LIG_14-3-3_CanoR_1 260 268 PF00244 0.484
LIG_14-3-3_CanoR_1 311 318 PF00244 0.540
LIG_14-3-3_CanoR_1 553 559 PF00244 0.408
LIG_14-3-3_CanoR_1 60 69 PF00244 0.533
LIG_14-3-3_CanoR_1 694 699 PF00244 0.487
LIG_14-3-3_CanoR_1 78 84 PF00244 0.427
LIG_ActinCP_TwfCPI_2 344 351 PF01115 0.515
LIG_BIR_II_1 1 5 PF00653 0.583
LIG_BRCT_BRCA1_1 286 290 PF00533 0.491
LIG_BRCT_BRCA1_1 700 704 PF00533 0.501
LIG_deltaCOP1_diTrp_1 349 356 PF00928 0.484
LIG_deltaCOP1_diTrp_1 691 696 PF00928 0.548
LIG_FHA_1 260 266 PF00498 0.497
LIG_FHA_1 43 49 PF00498 0.416
LIG_FHA_1 447 453 PF00498 0.519
LIG_FHA_1 80 86 PF00498 0.485
LIG_FHA_2 103 109 PF00498 0.484
LIG_FHA_2 144 150 PF00498 0.443
LIG_FHA_2 311 317 PF00498 0.486
LIG_FHA_2 45 51 PF00498 0.463
LIG_FHA_2 65 71 PF00498 0.403
LIG_LIR_Apic_2 349 355 PF02991 0.484
LIG_LIR_Gen_1 201 210 PF02991 0.500
LIG_LIR_Gen_1 277 288 PF02991 0.590
LIG_LIR_Gen_1 526 534 PF02991 0.487
LIG_LIR_Gen_1 593 604 PF02991 0.586
LIG_LIR_Gen_1 753 758 PF02991 0.499
LIG_LIR_Gen_1 82 90 PF02991 0.486
LIG_LIR_Nem_3 201 206 PF02991 0.486
LIG_LIR_Nem_3 277 283 PF02991 0.596
LIG_LIR_Nem_3 301 305 PF02991 0.521
LIG_LIR_Nem_3 407 412 PF02991 0.537
LIG_LIR_Nem_3 526 531 PF02991 0.478
LIG_LIR_Nem_3 567 573 PF02991 0.441
LIG_LIR_Nem_3 593 599 PF02991 0.599
LIG_LIR_Nem_3 691 696 PF02991 0.445
LIG_LIR_Nem_3 701 706 PF02991 0.419
LIG_LIR_Nem_3 713 719 PF02991 0.481
LIG_LIR_Nem_3 753 757 PF02991 0.495
LIG_LIR_Nem_3 82 86 PF02991 0.486
LIG_LIR_Nem_3 91 96 PF02991 0.487
LIG_LYPXL_yS_3 28 31 PF13949 0.481
LIG_LYPXL_yS_3 302 305 PF13949 0.508
LIG_MLH1_MIPbox_1 286 290 PF16413 0.484
LIG_MLH1_MIPbox_1 700 704 PF16413 0.501
LIG_MYND_1 303 307 PF01753 0.497
LIG_PCNA_TLS_4 87 94 PF02747 0.484
LIG_Pex14_1 386 390 PF04695 0.497
LIG_Pex14_1 409 413 PF04695 0.484
LIG_Pex14_2 203 207 PF04695 0.484
LIG_SH2_CRK 96 100 PF00017 0.497
LIG_SH2_NCK_1 239 243 PF00017 0.576
LIG_SH2_NCK_1 719 723 PF00017 0.553
LIG_SH2_NCK_1 96 100 PF00017 0.564
LIG_SH2_SRC 719 722 PF00017 0.556
LIG_SH2_STAP1 239 243 PF00017 0.497
LIG_SH2_STAP1 750 754 PF00017 0.494
LIG_SH2_STAP1 96 100 PF00017 0.540
LIG_SH2_STAT3 264 267 PF00017 0.515
LIG_SH2_STAT5 264 267 PF00017 0.490
LIG_SH2_STAT5 282 285 PF00017 0.572
LIG_SH2_STAT5 295 298 PF00017 0.553
LIG_SH2_STAT5 412 415 PF00017 0.496
LIG_SH2_STAT5 547 550 PF00017 0.411
LIG_SH2_STAT5 565 568 PF00017 0.351
LIG_SH2_STAT5 62 65 PF00017 0.514
LIG_SH2_STAT5 703 706 PF00017 0.425
LIG_SH2_STAT5 80 83 PF00017 0.432
LIG_SH2_STAT5 93 96 PF00017 0.484
LIG_SH3_3 344 350 PF00018 0.484
LIG_SH3_3 643 649 PF00018 0.542
LIG_SUMO_SIM_anti_2 486 491 PF11976 0.417
LIG_TRAF2_1 669 672 PF00917 0.571
LIG_TRAF2_1 731 734 PF00917 0.596
LIG_WRC_WIRS_1 80 85 PF05994 0.323
MOD_CK1_1 222 228 PF00069 0.421
MOD_CK1_1 466 472 PF00069 0.346
MOD_CK2_1 143 149 PF00069 0.301
MOD_CK2_1 311 317 PF00069 0.330
MOD_CK2_1 40 46 PF00069 0.385
MOD_CK2_1 466 472 PF00069 0.323
MOD_CK2_1 733 739 PF00069 0.605
MOD_CK2_1 750 756 PF00069 0.433
MOD_GlcNHglycan 1 4 PF01048 0.624
MOD_GlcNHglycan 149 152 PF01048 0.435
MOD_GlcNHglycan 210 213 PF01048 0.417
MOD_GlcNHglycan 219 224 PF01048 0.342
MOD_GlcNHglycan 382 385 PF01048 0.342
MOD_GlcNHglycan 549 552 PF01048 0.483
MOD_GlcNHglycan 554 557 PF01048 0.383
MOD_GlcNHglycan 588 591 PF01048 0.655
MOD_GSK3_1 143 150 PF00069 0.422
MOD_GSK3_1 161 168 PF00069 0.274
MOD_GSK3_1 365 372 PF00069 0.323
MOD_GSK3_1 40 47 PF00069 0.432
MOD_GSK3_1 60 67 PF00069 0.342
MOD_GSK3_1 647 654 PF00069 0.611
MOD_GSK3_1 694 701 PF00069 0.464
MOD_GSK3_1 720 727 PF00069 0.480
MOD_N-GLC_1 102 107 PF02516 0.323
MOD_N-GLC_1 311 316 PF02516 0.323
MOD_N-GLC_1 463 468 PF02516 0.342
MOD_N-GLC_2 395 397 PF02516 0.323
MOD_NEK2_1 184 189 PF00069 0.371
MOD_NEK2_1 424 429 PF00069 0.326
MOD_NEK2_1 443 448 PF00069 0.185
MOD_NEK2_1 94 99 PF00069 0.453
MOD_NEK2_2 284 289 PF00069 0.323
MOD_PIKK_1 184 190 PF00454 0.367
MOD_PIKK_1 404 410 PF00454 0.435
MOD_PIKK_1 496 502 PF00454 0.514
MOD_PKA_1 741 747 PF00069 0.494
MOD_PKA_2 259 265 PF00069 0.328
MOD_PKA_2 310 316 PF00069 0.453
MOD_PKA_2 552 558 PF00069 0.401
MOD_Plk_1 284 290 PF00069 0.367
MOD_Plk_1 365 371 PF00069 0.323
MOD_Plk_1 466 472 PF00069 0.323
MOD_Plk_1 69 75 PF00069 0.342
MOD_Plk_2-3 733 739 PF00069 0.578
MOD_Plk_4 284 290 PF00069 0.339
MOD_Plk_4 365 371 PF00069 0.323
MOD_Plk_4 5 11 PF00069 0.653
MOD_Plk_4 527 533 PF00069 0.456
MOD_Plk_4 536 542 PF00069 0.394
MOD_Plk_4 554 560 PF00069 0.343
MOD_Plk_4 599 605 PF00069 0.448
MOD_Plk_4 64 70 PF00069 0.325
MOD_Plk_4 761 767 PF00069 0.589
MOD_Plk_4 772 778 PF00069 0.509
MOD_Plk_4 94 100 PF00069 0.414
MOD_ProDKin_1 332 338 PF00069 0.374
MOD_ProDKin_1 351 357 PF00069 0.263
MOD_SUMO_for_1 19 22 PF00179 0.483
MOD_SUMO_rev_2 106 112 PF00179 0.323
MOD_SUMO_rev_2 174 180 PF00179 0.324
MOD_SUMO_rev_2 186 194 PF00179 0.325
MOD_SUMO_rev_2 383 391 PF00179 0.342
MOD_SUMO_rev_2 612 620 PF00179 0.531
MOD_SUMO_rev_2 708 717 PF00179 0.535
MOD_SUMO_rev_2 733 743 PF00179 0.500
MOD_SUMO_rev_2 775 783 PF00179 0.378
TRG_DiLeu_BaLyEn_6 448 453 PF01217 0.323
TRG_ENDOCYTIC_2 28 31 PF00928 0.481
TRG_ENDOCYTIC_2 302 305 PF00928 0.338
TRG_ENDOCYTIC_2 703 706 PF00928 0.418
TRG_ENDOCYTIC_2 719 722 PF00928 0.463
TRG_ENDOCYTIC_2 754 757 PF00928 0.463
TRG_ENDOCYTIC_2 80 83 PF00928 0.341
TRG_ENDOCYTIC_2 96 99 PF00928 0.323
TRG_ER_diArg_1 114 117 PF00400 0.323
TRG_ER_diArg_1 675 678 PF00400 0.599
TRG_ER_diArg_1 86 88 PF00400 0.323
TRG_NLS_MonoExtC_3 685 691 PF00514 0.452
TRG_NLS_MonoExtN_4 110 117 PF00514 0.323
TRG_Pf-PMV_PEXEL_1 662 666 PF00026 0.539
TRG_Pf-PMV_PEXEL_1 677 682 PF00026 0.492
TRG_Pf-PMV_PEXEL_1 687 691 PF00026 0.454

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2U0 Leptomonas seymouri 83% 99%
A0A0S4JIJ5 Bodo saltans 65% 100%
A0A1X0NM71 Trypanosomatidae 69% 98%
A0A3S7WRW6 Leishmania donovani 100% 100%
A0A422N5J6 Trypanosoma rangeli 68% 100%
A4H6U0 Leishmania braziliensis 89% 100%
C9ZQB2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 65% 100%
E9ANV2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
P49589 Homo sapiens 41% 100%
P53852 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 40% 100%
Q09860 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 39% 100%
Q291L4 Drosophila pseudoobscura pseudoobscura 40% 100%
Q4QGR8 Leishmania major 97% 100%
Q4R550 Macaca fascicularis 41% 100%
Q54KR1 Dictyostelium discoideum 44% 100%
Q5F408 Gallus gallus 40% 100%
Q5M7N8 Xenopus tropicalis 41% 100%
Q7KN90 Drosophila melanogaster 40% 100%
Q7ZWR2 Xenopus laevis 41% 100%
Q9ER72 Mus musculus 40% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS