LeishMANIAdb
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Membrane-associated protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Membrane-associated protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AGB3_LEIIN
TriTrypDb:
LINF_120007500
Length:
698

Annotations

LeishMANIAdb annotations

This membrane protein has considerable similarity to beta-lactamases found in Streptomyces species. A protein family found in a single copy in parazitic species, while multiple paralogs exist in B.saltans.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 4, no: 6
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

E9AGB3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGB3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 152 156 PF00656 0.316
CLV_C14_Caspase3-7 335 339 PF00656 0.351
CLV_C14_Caspase3-7 671 675 PF00656 0.784
CLV_NRD_NRD_1 640 642 PF00675 0.600
CLV_NRD_NRD_1 648 650 PF00675 0.513
CLV_NRD_NRD_1 684 686 PF00675 0.491
CLV_PCSK_FUR_1 644 648 PF00082 0.499
CLV_PCSK_KEX2_1 125 127 PF00082 0.737
CLV_PCSK_KEX2_1 639 641 PF00082 0.598
CLV_PCSK_KEX2_1 644 646 PF00082 0.623
CLV_PCSK_KEX2_1 647 649 PF00082 0.640
CLV_PCSK_KEX2_1 684 686 PF00082 0.491
CLV_PCSK_PC1ET2_1 125 127 PF00082 0.737
CLV_PCSK_PC7_1 640 646 PF00082 0.612
CLV_PCSK_SKI1_1 326 330 PF00082 0.651
CLV_PCSK_SKI1_1 689 693 PF00082 0.565
CLV_PCSK_SKI1_1 75 79 PF00082 0.597
DEG_APCC_DBOX_1 24 32 PF00400 0.562
DEG_SPOP_SBC_1 86 90 PF00917 0.373
DOC_CYCLIN_RxL_1 72 81 PF00134 0.346
DOC_PP4_FxxP_1 180 183 PF00568 0.291
DOC_USP7_MATH_1 164 168 PF00917 0.394
DOC_USP7_MATH_1 224 228 PF00917 0.397
DOC_USP7_MATH_1 311 315 PF00917 0.501
DOC_USP7_MATH_1 433 437 PF00917 0.461
DOC_USP7_MATH_1 459 463 PF00917 0.352
DOC_USP7_MATH_1 496 500 PF00917 0.300
DOC_USP7_MATH_1 584 588 PF00917 0.727
DOC_USP7_MATH_1 632 636 PF00917 0.735
DOC_WW_Pin1_4 481 486 PF00397 0.495
DOC_WW_Pin1_4 54 59 PF00397 0.560
DOC_WW_Pin1_4 593 598 PF00397 0.768
DOC_WW_Pin1_4 619 624 PF00397 0.758
DOC_WW_Pin1_4 684 689 PF00397 0.674
LIG_14-3-3_CanoR_1 126 134 PF00244 0.446
LIG_14-3-3_CanoR_1 25 33 PF00244 0.497
LIG_14-3-3_CanoR_1 313 321 PF00244 0.444
LIG_14-3-3_CanoR_1 376 382 PF00244 0.385
LIG_14-3-3_CanoR_1 633 639 PF00244 0.792
LIG_14-3-3_CanoR_1 678 686 PF00244 0.779
LIG_BIR_II_1 1 5 PF00653 0.608
LIG_BIR_III_2 10 14 PF00653 0.606
LIG_BIR_III_2 155 159 PF00653 0.317
LIG_BRCT_BRCA1_1 226 230 PF00533 0.338
LIG_BRCT_BRCA1_1 293 297 PF00533 0.356
LIG_Clathr_ClatBox_1 148 152 PF01394 0.344
LIG_eIF4E_1 544 550 PF01652 0.489
LIG_FHA_1 152 158 PF00498 0.372
LIG_FHA_1 160 166 PF00498 0.351
LIG_FHA_1 185 191 PF00498 0.346
LIG_FHA_1 232 238 PF00498 0.418
LIG_FHA_1 294 300 PF00498 0.329
LIG_FHA_1 332 338 PF00498 0.442
LIG_FHA_1 383 389 PF00498 0.295
LIG_FHA_1 398 404 PF00498 0.324
LIG_FHA_1 448 454 PF00498 0.439
LIG_FHA_1 533 539 PF00498 0.338
LIG_FHA_1 544 550 PF00498 0.517
LIG_FHA_1 55 61 PF00498 0.506
LIG_FHA_1 620 626 PF00498 0.758
LIG_FHA_1 87 93 PF00498 0.400
LIG_FHA_2 203 209 PF00498 0.476
LIG_FHA_2 353 359 PF00498 0.311
LIG_FHA_2 432 438 PF00498 0.404
LIG_FHA_2 61 67 PF00498 0.528
LIG_GBD_Chelix_1 541 549 PF00786 0.523
LIG_Integrin_isoDGR_2 603 605 PF01839 0.506
LIG_LIR_Apic_2 179 183 PF02991 0.382
LIG_LIR_Gen_1 270 279 PF02991 0.395
LIG_LIR_Gen_1 281 291 PF02991 0.376
LIG_LIR_Gen_1 348 357 PF02991 0.350
LIG_LIR_Gen_1 35 43 PF02991 0.237
LIG_LIR_Gen_1 413 421 PF02991 0.375
LIG_LIR_Gen_1 464 475 PF02991 0.356
LIG_LIR_LC3C_4 535 538 PF02991 0.397
LIG_LIR_Nem_3 184 188 PF02991 0.391
LIG_LIR_Nem_3 270 276 PF02991 0.398
LIG_LIR_Nem_3 281 287 PF02991 0.350
LIG_LIR_Nem_3 345 350 PF02991 0.320
LIG_LIR_Nem_3 35 41 PF02991 0.237
LIG_LIR_Nem_3 413 419 PF02991 0.387
LIG_LIR_Nem_3 464 470 PF02991 0.357
LIG_LIR_Nem_3 71 77 PF02991 0.367
LIG_LYPXL_yS_3 99 102 PF13949 0.425
LIG_NRBOX 191 197 PF00104 0.291
LIG_PALB2_WD40_1 522 530 PF16756 0.285
LIG_Pex14_2 523 527 PF04695 0.285
LIG_PTB_Apo_2 179 186 PF02174 0.305
LIG_SH2_CRK 24 28 PF00017 0.577
LIG_SH2_CRK 273 277 PF00017 0.403
LIG_SH2_CRK 416 420 PF00017 0.398
LIG_SH2_CRK 74 78 PF00017 0.365
LIG_SH2_NCK_1 251 255 PF00017 0.367
LIG_SH2_NCK_1 416 420 PF00017 0.380
LIG_SH2_NCK_1 430 434 PF00017 0.277
LIG_SH2_SRC 150 153 PF00017 0.373
LIG_SH2_SRC 169 172 PF00017 0.384
LIG_SH2_STAT3 421 424 PF00017 0.320
LIG_SH2_STAT3 548 551 PF00017 0.614
LIG_SH2_STAT5 150 153 PF00017 0.306
LIG_SH2_STAT5 169 172 PF00017 0.345
LIG_SH2_STAT5 174 177 PF00017 0.367
LIG_SH2_STAT5 249 252 PF00017 0.323
LIG_SH2_STAT5 261 264 PF00017 0.247
LIG_SH2_STAT5 346 349 PF00017 0.341
LIG_SH2_STAT5 395 398 PF00017 0.374
LIG_SH2_STAT5 427 430 PF00017 0.392
LIG_SH2_STAT5 544 547 PF00017 0.533
LIG_SH2_STAT5 548 551 PF00017 0.592
LIG_SH2_STAT5 624 627 PF00017 0.773
LIG_SH3_1 109 115 PF00018 0.542
LIG_SH3_2 552 557 PF14604 0.716
LIG_SH3_3 109 115 PF00018 0.506
LIG_SH3_3 180 186 PF00018 0.306
LIG_SH3_3 283 289 PF00018 0.369
LIG_SH3_3 363 369 PF00018 0.364
LIG_SH3_3 453 459 PF00018 0.408
LIG_SH3_3 506 512 PF00018 0.474
LIG_SH3_3 549 555 PF00018 0.653
LIG_SH3_3 94 100 PF00018 0.387
LIG_SUMO_SIM_anti_2 450 457 PF11976 0.376
LIG_SUMO_SIM_anti_2 535 541 PF11976 0.350
LIG_SUMO_SIM_par_1 385 392 PF11976 0.394
LIG_SUMO_SIM_par_1 537 543 PF11976 0.350
LIG_TYR_ITIM 97 102 PF00017 0.429
LIG_TYR_ITSM 412 419 PF00017 0.384
LIG_UBA3_1 59 67 PF00899 0.480
MOD_CDK_SPK_2 684 689 PF00069 0.640
MOD_CK1_1 184 190 PF00069 0.347
MOD_CK1_1 200 206 PF00069 0.299
MOD_CK1_1 220 226 PF00069 0.337
MOD_CK1_1 228 234 PF00069 0.357
MOD_CK1_1 274 280 PF00069 0.334
MOD_CK1_1 314 320 PF00069 0.469
MOD_CK1_1 331 337 PF00069 0.355
MOD_CK1_1 345 351 PF00069 0.346
MOD_CK1_1 481 487 PF00069 0.456
MOD_CK1_1 543 549 PF00069 0.536
MOD_CK1_1 658 664 PF00069 0.796
MOD_CK1_1 680 686 PF00069 0.723
MOD_CK2_1 198 204 PF00069 0.282
MOD_CK2_1 431 437 PF00069 0.360
MOD_CK2_1 466 472 PF00069 0.343
MOD_GlcNHglycan 121 124 PF01048 0.778
MOD_GlcNHglycan 215 218 PF01048 0.653
MOD_GlcNHglycan 222 225 PF01048 0.605
MOD_GlcNHglycan 238 241 PF01048 0.597
MOD_GlcNHglycan 273 276 PF01048 0.580
MOD_GlcNHglycan 28 31 PF01048 0.285
MOD_GlcNHglycan 313 316 PF01048 0.699
MOD_GlcNHglycan 338 341 PF01048 0.676
MOD_GlcNHglycan 355 358 PF01048 0.541
MOD_GlcNHglycan 406 409 PF01048 0.615
MOD_GlcNHglycan 421 424 PF01048 0.655
MOD_GlcNHglycan 431 434 PF01048 0.630
MOD_GlcNHglycan 437 440 PF01048 0.636
MOD_GlcNHglycan 475 478 PF01048 0.597
MOD_GlcNHglycan 570 573 PF01048 0.566
MOD_GlcNHglycan 613 616 PF01048 0.618
MOD_GlcNHglycan 627 630 PF01048 0.517
MOD_GlcNHglycan 663 666 PF01048 0.559
MOD_GSK3_1 172 179 PF00069 0.459
MOD_GSK3_1 184 191 PF00069 0.337
MOD_GSK3_1 198 205 PF00069 0.270
MOD_GSK3_1 213 220 PF00069 0.414
MOD_GSK3_1 224 231 PF00069 0.309
MOD_GSK3_1 232 239 PF00069 0.412
MOD_GSK3_1 243 250 PF00069 0.332
MOD_GSK3_1 267 274 PF00069 0.371
MOD_GSK3_1 313 320 PF00069 0.491
MOD_GSK3_1 328 335 PF00069 0.359
MOD_GSK3_1 389 396 PF00069 0.402
MOD_GSK3_1 429 436 PF00069 0.441
MOD_GSK3_1 459 466 PF00069 0.342
MOD_GSK3_1 471 478 PF00069 0.302
MOD_GSK3_1 515 522 PF00069 0.507
MOD_GSK3_1 680 687 PF00069 0.664
MOD_GSK3_1 76 83 PF00069 0.374
MOD_GSK3_1 86 93 PF00069 0.368
MOD_N-GLC_1 271 276 PF02516 0.629
MOD_N-GLC_1 332 337 PF02516 0.583
MOD_N-GLC_1 60 65 PF02516 0.687
MOD_NEK2_1 119 124 PF00069 0.497
MOD_NEK2_1 159 164 PF00069 0.332
MOD_NEK2_1 202 207 PF00069 0.335
MOD_NEK2_1 225 230 PF00069 0.299
MOD_NEK2_1 238 243 PF00069 0.335
MOD_NEK2_1 245 250 PF00069 0.308
MOD_NEK2_1 267 272 PF00069 0.385
MOD_NEK2_1 282 287 PF00069 0.243
MOD_NEK2_1 291 296 PF00069 0.298
MOD_NEK2_1 32 37 PF00069 0.389
MOD_NEK2_1 351 356 PF00069 0.310
MOD_NEK2_1 377 382 PF00069 0.321
MOD_NEK2_1 404 409 PF00069 0.404
MOD_NEK2_1 411 416 PF00069 0.373
MOD_NEK2_1 42 47 PF00069 0.407
MOD_NEK2_1 444 449 PF00069 0.375
MOD_NEK2_1 473 478 PF00069 0.386
MOD_NEK2_1 60 65 PF00069 0.361
MOD_NEK2_1 85 90 PF00069 0.349
MOD_NEK2_2 634 639 PF00069 0.715
MOD_PIKK_1 238 244 PF00454 0.414
MOD_PIKK_1 76 82 PF00454 0.352
MOD_PK_1 332 338 PF00069 0.326
MOD_PKA_2 331 337 PF00069 0.420
MOD_PKA_2 393 399 PF00069 0.341
MOD_PKA_2 632 638 PF00069 0.715
MOD_PKA_2 672 678 PF00069 0.786
MOD_PKB_1 631 639 PF00069 0.636
MOD_Plk_1 271 277 PF00069 0.424
MOD_Plk_1 332 338 PF00069 0.330
MOD_Plk_1 342 348 PF00069 0.302
MOD_Plk_1 471 477 PF00069 0.299
MOD_Plk_1 52 58 PF00069 0.493
MOD_Plk_1 80 86 PF00069 0.381
MOD_Plk_2-3 672 678 PF00069 0.819
MOD_Plk_4 165 171 PF00069 0.394
MOD_Plk_4 176 182 PF00069 0.412
MOD_Plk_4 225 231 PF00069 0.321
MOD_Plk_4 233 239 PF00069 0.258
MOD_Plk_4 293 299 PF00069 0.368
MOD_Plk_4 32 38 PF00069 0.362
MOD_Plk_4 332 338 PF00069 0.411
MOD_Plk_4 342 348 PF00069 0.340
MOD_Plk_4 377 383 PF00069 0.300
MOD_Plk_4 411 417 PF00069 0.382
MOD_Plk_4 532 538 PF00069 0.343
MOD_Plk_4 540 546 PF00069 0.372
MOD_Plk_4 80 86 PF00069 0.371
MOD_Plk_4 87 93 PF00069 0.338
MOD_ProDKin_1 481 487 PF00069 0.488
MOD_ProDKin_1 54 60 PF00069 0.559
MOD_ProDKin_1 593 599 PF00069 0.767
MOD_ProDKin_1 619 625 PF00069 0.761
MOD_ProDKin_1 684 690 PF00069 0.672
TRG_DiLeu_BaLyEn_6 55 60 PF01217 0.510
TRG_ENDOCYTIC_2 273 276 PF00928 0.395
TRG_ENDOCYTIC_2 350 353 PF00928 0.395
TRG_ENDOCYTIC_2 416 419 PF00928 0.390
TRG_ENDOCYTIC_2 73 76 PF00928 0.363
TRG_ENDOCYTIC_2 99 102 PF00928 0.454
TRG_ER_diArg_1 638 641 PF00400 0.782
TRG_ER_diArg_1 643 646 PF00400 0.779
TRG_ER_diArg_1 647 649 PF00400 0.791
TRG_ER_diArg_1 684 686 PF00400 0.701
TRG_NES_CRM1_1 137 152 PF08389 0.344

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZA5 Leptomonas seymouri 43% 99%
A0A0S4JQ75 Bodo saltans 29% 100%
A0A1X0NMU7 Trypanosomatidae 31% 100%
A0A3S7WRU5 Leishmania donovani 99% 100%
A0A422NUF1 Trypanosoma rangeli 29% 100%
A4H6T9 Leishmania braziliensis 64% 100%
E9ANV1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4QGR9 Leishmania major 88% 100%
V5BD98 Trypanosoma cruzi 29% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS