Putative ubiquitin hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin hydrolase - putative

Species:

Leishmania infantum

UniProt:

E9AGA8_LEIIN

TriTrypDb:

LINF_120007000

Length:

1646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AGA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGA8

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	7
GO:0006511	ubiquitin-dependent protein catabolic process	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009057	macromolecule catabolic process	4	7
GO:0009987	cellular process	1	7
GO:0016579	protein deubiquitination	6	7
GO:0019538	protein metabolic process	3	7
GO:0019941	modification-dependent protein catabolic process	6	7

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004843	cysteine-type deubiquitinase activity	5	7
GO:0008233	peptidase activity	3	7
GO:0008234	cysteine-type peptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0019783	ubiquitin-like protein peptidase activity	4	7
GO:0101005	deubiquitinase activity	5	7
GO:0140096	catalytic activity, acting on a protein	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1185	1189	PF00656	0.295
CLV_C14_Caspase3-7	1560	1564	PF00656	0.634
CLV_C14_Caspase3-7	480	484	PF00656	0.556
CLV_C14_Caspase3-7	549	553	PF00656	0.599
CLV_C14_Caspase3-7	60	64	PF00656	0.440
CLV_C14_Caspase3-7	632	636	PF00656	0.566
CLV_C14_Caspase3-7	817	821	PF00656	0.345
CLV_C14_Caspase3-7	928	932	PF00656	0.320
CLV_NRD_NRD_1	1019	1021	PF00675	0.381
CLV_NRD_NRD_1	1132	1134	PF00675	0.414

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5E3	Leptomonas seymouri	38%	98%
A0A3Q8IHM3	Leishmania donovani	99%	100%
A4H6T4	Leishmania braziliensis	61%	96%
E9ANU6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QGS4	Leishmania major	86%	98%

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