Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AGA7_LEIIN

TriTrypDb:

LINF_120006900

Length:

908

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AGA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGA7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.599
CLV_C14_Caspase3-7	603	607	PF00656	0.391
CLV_C14_Caspase3-7	617	621	PF00656	0.375
CLV_MEL_PAP_1	11	17	PF00089	0.472
CLV_NRD_NRD_1	182	184	PF00675	0.642
CLV_NRD_NRD_1	220	222	PF00675	0.443
CLV_NRD_NRD_1	246	248	PF00675	0.600
CLV_NRD_NRD_1	254	256	PF00675	0.319
CLV_NRD_NRD_1	289	291	PF00675	0.600
CLV_NRD_NRD_1	292	294	PF00675	0.539
CLV_NRD_NRD_1	384	386	PF00675	0.789
CLV_NRD_NRD_1	502	504	PF00675	0.543
CLV_NRD_NRD_1	526	528	PF00675	0.415
CLV_NRD_NRD_1	654	656	PF00675	0.497
CLV_NRD_NRD_1	725	727	PF00675	0.628
CLV_NRD_NRD_1	732	734	PF00675	0.622
CLV_NRD_NRD_1	748	750	PF00675	0.613
CLV_PCSK_FUR_1	290	294	PF00082	0.622
CLV_PCSK_FUR_1	652	656	PF00082	0.402
CLV_PCSK_KEX2_1	184	186	PF00082	0.628
CLV_PCSK_KEX2_1	220	222	PF00082	0.443
CLV_PCSK_KEX2_1	246	248	PF00082	0.596
CLV_PCSK_KEX2_1	254	256	PF00082	0.322
CLV_PCSK_KEX2_1	289	291	PF00082	0.600
CLV_PCSK_KEX2_1	292	294	PF00082	0.539
CLV_PCSK_KEX2_1	502	504	PF00082	0.543
CLV_PCSK_KEX2_1	526	528	PF00082	0.415
CLV_PCSK_KEX2_1	654	656	PF00082	0.438
CLV_PCSK_KEX2_1	732	734	PF00082	0.692
CLV_PCSK_KEX2_1	748	750	PF00082	0.613
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.685
CLV_PCSK_SKI1_1	101	105	PF00082	0.430
CLV_PCSK_SKI1_1	229	233	PF00082	0.474
CLV_PCSK_SKI1_1	254	258	PF00082	0.353
CLV_PCSK_SKI1_1	267	271	PF00082	0.532
CLV_PCSK_SKI1_1	661	665	PF00082	0.572
CLV_PCSK_SKI1_1	703	707	PF00082	0.459
CLV_PCSK_SKI1_1	902	906	PF00082	0.434
DEG_APCC_DBOX_1	253	261	PF00400	0.428
DEG_APCC_DBOX_1	546	554	PF00400	0.407
DEG_ODPH_VHL_1	752	764	PF01847	0.562
DEG_SPOP_SBC_1	143	147	PF00917	0.641
DEG_SPOP_SBC_1	50	54	PF00917	0.561
DEG_SPOP_SBC_1	565	569	PF00917	0.521
DOC_ANK_TNKS_1	237	244	PF00023	0.571
DOC_CDC14_PxL_1	750	758	PF14671	0.563
DOC_CYCLIN_RxL_1	655	668	PF00134	0.520
DOC_CYCLIN_RxL_1	840	849	PF00134	0.433
DOC_CYCLIN_yCln2_LP_2	531	537	PF00134	0.432
DOC_MAPK_gen_1	254	260	PF00069	0.396
DOC_MAPK_gen_1	289	300	PF00069	0.500
DOC_MAPK_gen_1	526	532	PF00069	0.400
DOC_MAPK_gen_1	652	662	PF00069	0.460
DOC_MAPK_JIP1_4	324	330	PF00069	0.429
DOC_MAPK_MEF2A_6	293	302	PF00069	0.433
DOC_MAPK_MEF2A_6	352	359	PF00069	0.448
DOC_MAPK_MEF2A_6	547	555	PF00069	0.434
DOC_MAPK_MEF2A_6	655	664	PF00069	0.474
DOC_MAPK_MEF2A_6	78	87	PF00069	0.432
DOC_MAPK_MEF2A_6	861	870	PF00069	0.418
DOC_PP1_RVXF_1	265	271	PF00149	0.594
DOC_PP2B_LxvP_1	135	138	PF13499	0.655
DOC_PP2B_LxvP_1	328	331	PF13499	0.381
DOC_PP2B_LxvP_1	437	440	PF13499	0.529
DOC_PP2B_LxvP_1	853	856	PF13499	0.541
DOC_PP4_FxxP_1	509	512	PF00568	0.459
DOC_PP4_FxxP_1	833	836	PF00568	0.462
DOC_USP7_MATH_1	143	147	PF00917	0.653
DOC_USP7_MATH_1	190	194	PF00917	0.598
DOC_USP7_MATH_1	280	284	PF00917	0.745
DOC_USP7_MATH_1	42	46	PF00917	0.646
DOC_USP7_MATH_1	442	446	PF00917	0.641
DOC_USP7_MATH_1	462	466	PF00917	0.433
DOC_USP7_MATH_1	50	54	PF00917	0.635
DOC_USP7_MATH_1	546	550	PF00917	0.481
DOC_USP7_MATH_1	581	585	PF00917	0.712
DOC_USP7_MATH_1	674	678	PF00917	0.531
DOC_USP7_MATH_1	722	726	PF00917	0.616
DOC_USP7_MATH_1	739	743	PF00917	0.566
DOC_USP7_MATH_1	806	810	PF00917	0.817
DOC_USP7_MATH_1	820	824	PF00917	0.650
DOC_USP7_MATH_1	95	99	PF00917	0.475
DOC_WW_Pin1_4	169	174	PF00397	0.617
DOC_WW_Pin1_4	419	424	PF00397	0.585
DOC_WW_Pin1_4	460	465	PF00397	0.582
DOC_WW_Pin1_4	475	480	PF00397	0.490
DOC_WW_Pin1_4	579	584	PF00397	0.590
DOC_WW_Pin1_4	58	63	PF00397	0.539
LIG_14-3-3_CanoR_1	14	20	PF00244	0.493
LIG_14-3-3_CanoR_1	247	253	PF00244	0.485
LIG_14-3-3_CanoR_1	261	270	PF00244	0.495
LIG_14-3-3_CanoR_1	315	325	PF00244	0.357
LIG_14-3-3_CanoR_1	391	395	PF00244	0.587
LIG_14-3-3_CanoR_1	456	460	PF00244	0.618
LIG_14-3-3_CanoR_1	502	512	PF00244	0.513
LIG_14-3-3_CanoR_1	547	551	PF00244	0.444
LIG_14-3-3_CanoR_1	66	71	PF00244	0.623
LIG_14-3-3_CanoR_1	689	698	PF00244	0.508
LIG_14-3-3_CanoR_1	748	753	PF00244	0.588
LIG_Actin_WH2_2	638	656	PF00022	0.374
LIG_APCC_ABBA_1	638	643	PF00400	0.331
LIG_APCC_ABBA_1	711	716	PF00400	0.530
LIG_BIR_II_1	1	5	PF00653	0.503
LIG_BRCT_BRCA1_1	109	113	PF00533	0.447
LIG_BRCT_BRCA1_1	15	19	PF00533	0.490
LIG_BRCT_BRCA1_1	505	509	PF00533	0.474
LIG_deltaCOP1_diTrp_1	161	167	PF00928	0.553
LIG_EH1_1	699	707	PF00400	0.448
LIG_eIF4E_1	252	258	PF01652	0.318
LIG_FHA_1	116	122	PF00498	0.409
LIG_FHA_1	317	323	PF00498	0.380
LIG_FHA_1	487	493	PF00498	0.587
LIG_FHA_1	599	605	PF00498	0.448
LIG_FHA_1	634	640	PF00498	0.383
LIG_FHA_1	88	94	PF00498	0.506
LIG_FHA_2	20	26	PF00498	0.504
LIG_FHA_2	204	210	PF00498	0.569
LIG_FHA_2	308	314	PF00498	0.440
LIG_FHA_2	420	426	PF00498	0.513
LIG_FHA_2	441	447	PF00498	0.565
LIG_FHA_2	448	454	PF00498	0.583
LIG_FHA_2	691	697	PF00498	0.495
LIG_FHA_2	814	820	PF00498	0.637
LIG_FHA_2	901	907	PF00498	0.504
LIG_Integrin_RGD_1	32	34	PF01839	0.500
LIG_LIR_Apic_2	506	512	PF02991	0.482
LIG_LIR_Apic_2	831	836	PF02991	0.544
LIG_LIR_Gen_1	110	121	PF02991	0.450
LIG_LIR_Gen_1	296	307	PF02991	0.465
LIG_LIR_Gen_1	636	646	PF02991	0.427
LIG_LIR_Nem_3	110	116	PF02991	0.441
LIG_LIR_Nem_3	296	302	PF02991	0.475
LIG_LIR_Nem_3	636	641	PF02991	0.461
LIG_LIR_Nem_3	77	82	PF02991	0.495
LIG_LIR_Nem_3	831	837	PF02991	0.546
LIG_MLH1_MIPbox_1	505	509	PF16413	0.474
LIG_NRBOX	252	258	PF00104	0.434
LIG_NRBOX	604	610	PF00104	0.418
LIG_PCNA_PIPBox_1	1	10	PF02747	0.512
LIG_PCNA_PIPBox_1	24	33	PF02747	0.465
LIG_PCNA_PIPBox_1	827	836	PF02747	0.433
LIG_PDZ_Class_3	903	908	PF00595	0.480
LIG_Pex14_1	167	171	PF04695	0.506
LIG_Pex14_1	354	358	PF04695	0.462
LIG_Pex14_2	113	117	PF04695	0.437
LIG_REV1ctd_RIR_1	506	511	PF16727	0.394
LIG_SH2_CRK	834	838	PF00017	0.650
LIG_SH2_GRB2like	7	10	PF00017	0.468
LIG_SH2_NCK_1	457	461	PF00017	0.524
LIG_SH2_NCK_1	715	719	PF00017	0.518
LIG_SH2_SRC	7	10	PF00017	0.488
LIG_SH2_STAP1	204	208	PF00017	0.555
LIG_SH2_STAP1	312	316	PF00017	0.445
LIG_SH2_STAP1	642	646	PF00017	0.380
LIG_SH2_STAP1	715	719	PF00017	0.518
LIG_SH2_STAT5	252	255	PF00017	0.342
LIG_SH2_STAT5	299	302	PF00017	0.460
LIG_SH2_STAT5	7	10	PF00017	0.488
LIG_SH2_STAT5	846	849	PF00017	0.446
LIG_SH3_1	587	593	PF00018	0.516
LIG_SH3_3	319	325	PF00018	0.326
LIG_SH3_3	577	583	PF00018	0.640
LIG_SH3_3	587	593	PF00018	0.517
LIG_SH3_3	67	73	PF00018	0.649
LIG_SH3_3	704	710	PF00018	0.610
LIG_SH3_3	833	839	PF00018	0.448
LIG_SUMO_SIM_anti_2	118	125	PF11976	0.521
LIG_SUMO_SIM_anti_2	600	606	PF11976	0.352
LIG_SUMO_SIM_anti_2	759	766	PF11976	0.522
LIG_SUMO_SIM_anti_2	875	883	PF11976	0.454
LIG_SUMO_SIM_par_1	192	199	PF11976	0.549
LIG_SUMO_SIM_par_1	326	335	PF11976	0.422
LIG_SUMO_SIM_par_1	600	606	PF11976	0.319
LIG_SUMO_SIM_par_1	623	629	PF11976	0.529
LIG_SUMO_SIM_par_1	879	885	PF11976	0.447
LIG_TRFH_1	508	512	PF08558	0.476
LIG_TYR_ITIM	640	645	PF00017	0.343
LIG_TYR_ITIM	713	718	PF00017	0.516
LIG_UBA3_1	879	884	PF00899	0.443
LIG_WRC_WIRS_1	27	32	PF05994	0.448
MOD_CDK_SPxxK_3	419	426	PF00069	0.574
MOD_CK1_1	169	175	PF00069	0.608
MOD_CK1_1	199	205	PF00069	0.647
MOD_CK1_1	285	291	PF00069	0.638
MOD_CK1_1	399	405	PF00069	0.644
MOD_CK1_1	458	464	PF00069	0.626
MOD_CK1_1	475	481	PF00069	0.491
MOD_CK1_1	542	548	PF00069	0.476
MOD_CK1_1	567	573	PF00069	0.615
MOD_CK1_1	823	829	PF00069	0.594
MOD_CK1_1	900	906	PF00069	0.434
MOD_CK1_1	94	100	PF00069	0.542
MOD_CK2_1	203	209	PF00069	0.587
MOD_CK2_1	307	313	PF00069	0.432
MOD_CK2_1	419	425	PF00069	0.528
MOD_CK2_1	440	446	PF00069	0.697
MOD_CK2_1	447	453	PF00069	0.650
MOD_CK2_1	470	476	PF00069	0.733
MOD_CK2_1	690	696	PF00069	0.563
MOD_CK2_1	728	734	PF00069	0.629
MOD_CK2_1	767	773	PF00069	0.485
MOD_GlcNHglycan	146	149	PF01048	0.668
MOD_GlcNHglycan	15	18	PF01048	0.486
MOD_GlcNHglycan	173	176	PF01048	0.743
MOD_GlcNHglycan	192	195	PF01048	0.455
MOD_GlcNHglycan	284	287	PF01048	0.609
MOD_GlcNHglycan	365	368	PF01048	0.684
MOD_GlcNHglycan	398	401	PF01048	0.640
MOD_GlcNHglycan	42	45	PF01048	0.643
MOD_GlcNHglycan	460	463	PF01048	0.710
MOD_GlcNHglycan	472	475	PF01048	0.517
MOD_GlcNHglycan	492	495	PF01048	0.567
MOD_GlcNHglycan	569	572	PF01048	0.549
MOD_GlcNHglycan	671	674	PF01048	0.519
MOD_GlcNHglycan	809	812	PF01048	0.689
MOD_GlcNHglycan	822	825	PF01048	0.594
MOD_GlcNHglycan	899	902	PF01048	0.507
MOD_GlcNHglycan	93	96	PF01048	0.530
MOD_GlcNHglycan	97	100	PF01048	0.521
MOD_GSK3_1	117	124	PF00069	0.521
MOD_GSK3_1	15	22	PF00069	0.500
MOD_GSK3_1	167	174	PF00069	0.636
MOD_GSK3_1	185	192	PF00069	0.499
MOD_GSK3_1	199	206	PF00069	0.472
MOD_GSK3_1	280	287	PF00069	0.755
MOD_GSK3_1	332	339	PF00069	0.671
MOD_GSK3_1	358	365	PF00069	0.542
MOD_GSK3_1	395	402	PF00069	0.682
MOD_GSK3_1	42	49	PF00069	0.657
MOD_GSK3_1	458	465	PF00069	0.585
MOD_GSK3_1	486	493	PF00069	0.800
MOD_GSK3_1	51	58	PF00069	0.685
MOD_GSK3_1	542	549	PF00069	0.485
MOD_GSK3_1	567	574	PF00069	0.554
MOD_GSK3_1	87	94	PF00069	0.442
MOD_GSK3_1	891	898	PF00069	0.487
MOD_GSK3_1	900	907	PF00069	0.448
MOD_NEK2_1	107	112	PF00069	0.460
MOD_NEK2_1	117	122	PF00069	0.454
MOD_NEK2_1	284	289	PF00069	0.552
MOD_NEK2_1	316	321	PF00069	0.415
MOD_NEK2_1	455	460	PF00069	0.746
MOD_NEK2_1	564	569	PF00069	0.496
MOD_NEK2_1	74	79	PF00069	0.525
MOD_NEK2_1	756	761	PF00069	0.472
MOD_NEK2_1	767	772	PF00069	0.468
MOD_NEK2_1	891	896	PF00069	0.434
MOD_NEK2_2	307	312	PF00069	0.431
MOD_PIKK_1	823	829	PF00454	0.613
MOD_PKA_1	748	754	PF00069	0.605
MOD_PKA_2	13	19	PF00069	0.490
MOD_PKA_2	202	208	PF00069	0.572
MOD_PKA_2	390	396	PF00069	0.578
MOD_PKA_2	455	461	PF00069	0.618
MOD_PKA_2	490	496	PF00069	0.606
MOD_PKA_2	510	516	PF00069	0.403
MOD_PKA_2	546	552	PF00069	0.482
MOD_PKA_2	65	71	PF00069	0.591
MOD_PKA_2	748	754	PF00069	0.567
MOD_PKA_2	813	819	PF00069	0.653
MOD_PKB_1	183	191	PF00069	0.674
MOD_Plk_1	196	202	PF00069	0.533
MOD_Plk_1	332	338	PF00069	0.507
MOD_Plk_4	117	123	PF00069	0.501
MOD_Plk_4	15	21	PF00069	0.491
MOD_Plk_4	248	254	PF00069	0.412
MOD_Plk_4	26	32	PF00069	0.408
MOD_Plk_4	307	313	PF00069	0.400
MOD_Plk_4	336	342	PF00069	0.548
MOD_Plk_4	390	396	PF00069	0.710
MOD_Plk_4	407	413	PF00069	0.713
MOD_Plk_4	546	552	PF00069	0.508
MOD_Plk_4	581	587	PF00069	0.724
MOD_Plk_4	593	599	PF00069	0.447
MOD_Plk_4	633	639	PF00069	0.375
MOD_Plk_4	757	763	PF00069	0.520
MOD_Plk_4	88	94	PF00069	0.467
MOD_ProDKin_1	169	175	PF00069	0.616
MOD_ProDKin_1	419	425	PF00069	0.578
MOD_ProDKin_1	460	466	PF00069	0.583
MOD_ProDKin_1	475	481	PF00069	0.493
MOD_ProDKin_1	579	585	PF00069	0.592
MOD_ProDKin_1	58	64	PF00069	0.535
TRG_DiLeu_BaEn_1	227	232	PF01217	0.509
TRG_DiLeu_BaEn_1	877	882	PF01217	0.456
TRG_DiLeu_BaEn_4	227	233	PF01217	0.516
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.440
TRG_ENDOCYTIC_2	299	302	PF00928	0.460
TRG_ENDOCYTIC_2	642	645	PF00928	0.360
TRG_ENDOCYTIC_2	715	718	PF00928	0.518
TRG_ENDOCYTIC_2	834	837	PF00928	0.661
TRG_ER_diArg_1	182	185	PF00400	0.643
TRG_ER_diArg_1	220	222	PF00400	0.443
TRG_ER_diArg_1	253	255	PF00400	0.432
TRG_ER_diArg_1	289	292	PF00400	0.589
TRG_ER_diArg_1	412	415	PF00400	0.676
TRG_ER_diArg_1	501	503	PF00400	0.530
TRG_ER_diArg_1	525	527	PF00400	0.401
TRG_ER_diArg_1	652	655	PF00400	0.490
TRG_ER_diArg_1	747	749	PF00400	0.632
TRG_NES_CRM1_1	603	618	PF08389	0.432
TRG_NLS_MonoExtC_3	182	187	PF00514	0.687
TRG_NLS_MonoExtN_4	183	188	PF00514	0.680
TRG_NLS_MonoExtN_4	246	251	PF00514	0.476
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	902	906	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWE7	Leptomonas seymouri	51%	100%
A0A3S5H6K4	Leishmania donovani	99%	100%
A4H6T3	Leishmania braziliensis	76%	100%
C9ZQC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ANU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QGS5	Leishmania major	91%	100%