Mannosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Mannosyltransferase

Gene product:

dolichyl-P-Man:GDP-Man5GlcNAc2-PP-dolichyl alpha-1 -2-mannosyltransferase - putative

Species:

Leishmania infantum

UniProt:

E9AGA5_LEIIN

TriTrypDb:

LINF_120006700

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	10
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	10
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

E9AGA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGA5

Function

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Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	10
GO:0006487	protein N-linked glycosylation	5	1
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	5	1
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	1
GO:0006629	lipid metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	10

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Molecular functions
Term	Name	Level	Count
GO:0000026	alpha-1,2-mannosyltransferase activity	6	10
GO:0000030	mannosyltransferase activity	5	10
GO:0003824	catalytic activity	1	10
GO:0016740	transferase activity	2	10
GO:0016757	glycosyltransferase activity	3	10
GO:0016758	hexosyltransferase activity	4	10
GO:0052918	dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity	7	10
GO:0052926	dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity	7	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	363	367	PF00656	0.610
CLV_C14_Caspase3-7	496	500	PF00656	0.600
CLV_NRD_NRD_1	337	339	PF00675	0.432
CLV_NRD_NRD_1	511	513	PF00675	0.566
CLV_NRD_NRD_1	585	587	PF00675	0.610
CLV_NRD_NRD_1	768	770	PF00675	0.577
CLV_NRD_NRD_1	802	804	PF00675	0.586
CLV_PCSK_KEX2_1	337	339	PF00082	0.448
CLV_PCSK_KEX2_1	484	486	PF00082	0.558
CLV_PCSK_KEX2_1	511	513	PF00082	0.523

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3C3	Leptomonas seymouri	53%	100%
A0A0S4ITY5	Bodo saltans	28%	100%
A0A1X0NM38	Trypanosomatidae	37%	100%
A0A3Q8IBE5	Leishmania donovani	99%	100%
A0A422NUF2	Trypanosoma rangeli	40%	100%
C9ZQC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9ANU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%
Q4QGS7	Leishmania major	80%	99%

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