Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AGA2_LEIIN

TriTrypDb:

LINF_110011800

Length:

1071

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099080	supramolecular complex	2	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AGA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGA2

Function

Biological processes
Term	Name	Level	Count
GO:0044145	modulation of formation of structure involved in a symbiotic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0065007	biological regulation	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	348	352	PF00656	0.675
CLV_MEL_PAP_1	834	840	PF00089	0.567
CLV_MEL_PAP_1	888	894	PF00089	0.520
CLV_NRD_NRD_1	45	47	PF00675	0.726
CLV_NRD_NRD_1	722	724	PF00675	0.751
CLV_NRD_NRD_1	791	793	PF00675	0.741
CLV_NRD_NRD_1	914	916	PF00675	0.595
CLV_PCSK_KEX2_1	45	47	PF00082	0.732
CLV_PCSK_KEX2_1	791	793	PF00082	0.741
CLV_PCSK_KEX2_1	914	916	PF00082	0.595
DEG_COP1_1	21	28	PF00400	0.570
DEG_COP1_1	540	550	PF00400	0.576
DEG_Nend_UBRbox_2	1	3	PF02207	0.627
DEG_SCF_FBW7_1	47	53	PF00400	0.747
DEG_SCF_FBW7_2	200	206	PF00400	0.694
DEG_SPOP_SBC_1	19	23	PF00917	0.603
DEG_SPOP_SBC_1	397	401	PF00917	0.684
DEG_SPOP_SBC_1	464	468	PF00917	0.724
DEG_SPOP_SBC_1	715	719	PF00917	0.709
DOC_CDC14_PxL_1	817	825	PF14671	0.545
DOC_CKS1_1	200	205	PF01111	0.695
DOC_CKS1_1	374	379	PF01111	0.677
DOC_CKS1_1	47	52	PF01111	0.747
DOC_CYCLIN_RxL_1	635	647	PF00134	0.670
DOC_CYCLIN_yClb1_LxF_4	733	739	PF00134	0.527
DOC_CYCLIN_yCln2_LP_2	197	203	PF00134	0.592
DOC_PP2B_LxvP_1	387	390	PF13499	0.587
DOC_PP2B_LxvP_1	749	752	PF13499	0.551
DOC_PP4_FxxP_1	1064	1067	PF00568	0.713
DOC_PP4_FxxP_1	135	138	PF00568	0.724
DOC_PP4_FxxP_1	374	377	PF00568	0.616
DOC_PP4_FxxP_1	454	457	PF00568	0.573
DOC_USP7_MATH_1	1040	1044	PF00917	0.666
DOC_USP7_MATH_1	1046	1050	PF00917	0.612
DOC_USP7_MATH_1	131	135	PF00917	0.644
DOC_USP7_MATH_1	305	309	PF00917	0.676
DOC_USP7_MATH_1	337	341	PF00917	0.610
DOC_USP7_MATH_1	397	401	PF00917	0.684
DOC_USP7_MATH_1	421	425	PF00917	0.733
DOC_USP7_MATH_1	469	473	PF00917	0.716
DOC_USP7_MATH_1	499	503	PF00917	0.698
DOC_USP7_MATH_1	548	552	PF00917	0.691
DOC_USP7_MATH_1	561	565	PF00917	0.516
DOC_USP7_MATH_1	667	671	PF00917	0.757
DOC_USP7_MATH_1	715	719	PF00917	0.654
DOC_USP7_MATH_1	760	764	PF00917	0.751
DOC_USP7_MATH_1	803	807	PF00917	0.681
DOC_USP7_MATH_1	984	988	PF00917	0.692
DOC_USP7_MATH_1	999	1003	PF00917	0.526
DOC_WW_Pin1_4	1015	1020	PF00397	0.711
DOC_WW_Pin1_4	1029	1034	PF00397	0.541
DOC_WW_Pin1_4	196	201	PF00397	0.749
DOC_WW_Pin1_4	373	378	PF00397	0.678
DOC_WW_Pin1_4	398	403	PF00397	0.762
DOC_WW_Pin1_4	46	51	PF00397	0.752
DOC_WW_Pin1_4	465	470	PF00397	0.699
DOC_WW_Pin1_4	482	487	PF00397	0.557
DOC_WW_Pin1_4	546	551	PF00397	0.712
DOC_WW_Pin1_4	553	558	PF00397	0.637
DOC_WW_Pin1_4	592	597	PF00397	0.743
DOC_WW_Pin1_4	616	621	PF00397	0.688
DOC_WW_Pin1_4	633	638	PF00397	0.581
DOC_WW_Pin1_4	672	677	PF00397	0.673
DOC_WW_Pin1_4	694	699	PF00397	0.701
DOC_WW_Pin1_4	811	816	PF00397	0.507
LIG_14-3-3_CanoR_1	193	198	PF00244	0.682
LIG_14-3-3_CanoR_1	270	275	PF00244	0.689
LIG_14-3-3_CanoR_1	276	285	PF00244	0.624
LIG_14-3-3_CanoR_1	395	404	PF00244	0.683
LIG_14-3-3_CanoR_1	441	446	PF00244	0.593
LIG_14-3-3_CanoR_1	537	547	PF00244	0.580
LIG_14-3-3_CanoR_1	590	596	PF00244	0.609
LIG_14-3-3_CanoR_1	791	795	PF00244	0.742
LIG_14-3-3_CanoR_1	921	931	PF00244	0.597
LIG_APCC_ABBA_1	738	743	PF00400	0.539
LIG_BRCT_BRCA1_1	1017	1021	PF00533	0.625
LIG_BRCT_BRCA1_1	181	185	PF00533	0.674
LIG_BRCT_BRCA1_1	370	374	PF00533	0.623
LIG_BRCT_BRCA1_1	40	44	PF00533	0.785
LIG_BRCT_BRCA1_1	54	58	PF00533	0.574
LIG_BRCT_BRCA1_1	6	10	PF00533	0.579
LIG_BRCT_BRCA1_1	646	650	PF00533	0.699
LIG_BRCT_BRCA1_1	93	97	PF00533	0.696
LIG_BRCT_BRCA1_2	93	99	PF00533	0.567
LIG_DLG_GKlike_1	270	277	PF00625	0.701
LIG_FHA_1	211	217	PF00498	0.700
LIG_FHA_1	374	380	PF00498	0.674
LIG_FHA_1	51	57	PF00498	0.690
LIG_FHA_1	717	723	PF00498	0.659
LIG_FHA_1	748	754	PF00498	0.709
LIG_FHA_1	812	818	PF00498	0.600
LIG_FHA_1	863	869	PF00498	0.560
LIG_FHA_1	871	877	PF00498	0.420
LIG_FHA_1	9	15	PF00498	0.613
LIG_FHA_1	923	929	PF00498	0.605
LIG_FHA_2	223	229	PF00498	0.645
LIG_FHA_2	27	33	PF00498	0.730
LIG_FHA_2	328	334	PF00498	0.695
LIG_FHA_2	346	352	PF00498	0.586
LIG_FHA_2	715	721	PF00498	0.746
LIG_FHA_2	859	865	PF00498	0.584
LIG_GBD_Chelix_1	933	941	PF00786	0.485
LIG_Integrin_RGD_1	811	813	PF01839	0.718
LIG_LIR_Apic_2	1061	1067	PF02991	0.709
LIG_LIR_Apic_2	134	138	PF02991	0.645
LIG_LIR_Apic_2	371	377	PF02991	0.620
LIG_LIR_Apic_2	453	457	PF02991	0.573
LIG_LIR_Gen_1	210	220	PF02991	0.754
LIG_LIR_Gen_1	621	632	PF02991	0.754
LIG_LIR_Gen_1	901	909	PF02991	0.523
LIG_LIR_Nem_3	210	215	PF02991	0.760
LIG_LIR_Nem_3	289	293	PF02991	0.702
LIG_LIR_Nem_3	320	325	PF02991	0.777
LIG_LIR_Nem_3	332	338	PF02991	0.590
LIG_LIR_Nem_3	41	47	PF02991	0.781
LIG_LIR_Nem_3	578	583	PF02991	0.674
LIG_LIR_Nem_3	621	627	PF02991	0.756
LIG_LIR_Nem_3	98	104	PF02991	0.624
LIG_Pex14_1	877	881	PF04695	0.506
LIG_Pex14_2	826	830	PF04695	0.465
LIG_Pex14_2	97	101	PF04695	0.565
LIG_SH2_CRK	212	216	PF00017	0.764
LIG_SH2_GRB2like	158	161	PF00017	0.570
LIG_SH2_NCK_1	338	342	PF00017	0.585
LIG_SH2_SRC	230	233	PF00017	0.649
LIG_SH2_STAP1	212	216	PF00017	0.764
LIG_SH2_STAP1	230	234	PF00017	0.469
LIG_SH2_STAP1	518	522	PF00017	0.757
LIG_SH2_STAP1	896	900	PF00017	0.487
LIG_SH2_STAT3	518	521	PF00017	0.759
LIG_SH2_STAT5	107	110	PF00017	0.738
LIG_SH2_STAT5	212	215	PF00017	0.764
LIG_SH2_STAT5	465	468	PF00017	0.745
LIG_SH2_STAT5	538	541	PF00017	0.579
LIG_SH2_STAT5	573	576	PF00017	0.726
LIG_SH2_STAT5	624	627	PF00017	0.750
LIG_SH2_STAT5	903	906	PF00017	0.513
LIG_SH2_STAT5	909	912	PF00017	0.458
LIG_SH3_1	54	60	PF00018	0.661
LIG_SH3_3	1016	1022	PF00018	0.559
LIG_SH3_3	197	203	PF00018	0.741
LIG_SH3_3	212	218	PF00018	0.549
LIG_SH3_3	308	314	PF00018	0.705
LIG_SH3_3	374	380	PF00018	0.750
LIG_SH3_3	417	423	PF00018	0.681
LIG_SH3_3	54	60	PF00018	0.691
LIG_SH3_3	544	550	PF00018	0.711
LIG_SH3_3	571	577	PF00018	0.727
LIG_SH3_3	634	640	PF00018	0.731
LIG_SH3_3	709	715	PF00018	0.734
LIG_SH3_3	734	740	PF00018	0.485
LIG_SH3_3	818	824	PF00018	0.564
LIG_SH3_3	926	932	PF00018	0.585
LIG_SUMO_SIM_par_1	931	936	PF11976	0.518
LIG_TRAF2_1	204	207	PF00917	0.749
LIG_TYR_ITSM	208	215	PF00017	0.697
LIG_WRC_WIRS_1	319	324	PF05994	0.777
LIG_WRC_WIRS_1	856	861	PF05994	0.506
MOD_CDC14_SPxK_1	636	639	PF00782	0.699
MOD_CDK_SPxK_1	633	639	PF00069	0.706
MOD_CDK_SPxxK_3	694	701	PF00069	0.699
MOD_CK1_1	1051	1057	PF00069	0.665
MOD_CK1_1	121	127	PF00069	0.700
MOD_CK1_1	171	177	PF00069	0.641
MOD_CK1_1	184	190	PF00069	0.618
MOD_CK1_1	191	197	PF00069	0.533
MOD_CK1_1	199	205	PF00069	0.561
MOD_CK1_1	253	259	PF00069	0.689
MOD_CK1_1	265	271	PF00069	0.583
MOD_CK1_1	326	332	PF00069	0.695
MOD_CK1_1	339	345	PF00069	0.570
MOD_CK1_1	502	508	PF00069	0.736
MOD_CK1_1	541	547	PF00069	0.599
MOD_CK1_1	555	561	PF00069	0.622
MOD_CK1_1	564	570	PF00069	0.581
MOD_CK1_1	595	601	PF00069	0.762
MOD_CK1_1	618	624	PF00069	0.627
MOD_CK1_1	697	703	PF00069	0.746
MOD_CK1_1	761	767	PF00069	0.738
MOD_CK1_1	772	778	PF00069	0.597
MOD_CK1_1	790	796	PF00069	0.531
MOD_CK1_1	8	14	PF00069	0.577
MOD_CK1_1	806	812	PF00069	0.530
MOD_CK1_1	858	864	PF00069	0.584
MOD_CK1_1	91	97	PF00069	0.665
MOD_CK1_1	982	988	PF00069	0.708
MOD_CK1_1	994	1000	PF00069	0.552
MOD_CK2_1	26	32	PF00069	0.731
MOD_CK2_1	525	531	PF00069	0.661
MOD_CK2_1	610	616	PF00069	0.751
MOD_CK2_1	778	784	PF00069	0.747
MOD_CK2_1	858	864	PF00069	0.584
MOD_GlcNHglycan	1050	1053	PF01048	0.706
MOD_GlcNHglycan	120	123	PF01048	0.685
MOD_GlcNHglycan	129	132	PF01048	0.622
MOD_GlcNHglycan	142	145	PF01048	0.695
MOD_GlcNHglycan	181	184	PF01048	0.678
MOD_GlcNHglycan	186	189	PF01048	0.629
MOD_GlcNHglycan	255	258	PF01048	0.712
MOD_GlcNHglycan	279	282	PF01048	0.708
MOD_GlcNHglycan	293	296	PF01048	0.567
MOD_GlcNHglycan	308	311	PF01048	0.671
MOD_GlcNHglycan	339	342	PF01048	0.611
MOD_GlcNHglycan	361	364	PF01048	0.704
MOD_GlcNHglycan	370	373	PF01048	0.671
MOD_GlcNHglycan	424	427	PF01048	0.713
MOD_GlcNHglycan	448	451	PF01048	0.725
MOD_GlcNHglycan	459	462	PF01048	0.582
MOD_GlcNHglycan	482	485	PF01048	0.754
MOD_GlcNHglycan	487	490	PF01048	0.675
MOD_GlcNHglycan	543	546	PF01048	0.700
MOD_GlcNHglycan	561	564	PF01048	0.513
MOD_GlcNHglycan	566	569	PF01048	0.671
MOD_GlcNHglycan	600	603	PF01048	0.748
MOD_GlcNHglycan	612	615	PF01048	0.582
MOD_GlcNHglycan	646	649	PF01048	0.698
MOD_GlcNHglycan	655	658	PF01048	0.610
MOD_GlcNHglycan	667	670	PF01048	0.616
MOD_GlcNHglycan	70	73	PF01048	0.713
MOD_GlcNHglycan	743	746	PF01048	0.642
MOD_GlcNHglycan	758	761	PF01048	0.605
MOD_GlcNHglycan	769	772	PF01048	0.609
MOD_GlcNHglycan	80	83	PF01048	0.585
MOD_GlcNHglycan	975	978	PF01048	0.689
MOD_GlcNHglycan	986	989	PF01048	0.646
MOD_GlcNHglycan	993	996	PF01048	0.552
MOD_GSK3_1	1046	1053	PF00069	0.743
MOD_GSK3_1	127	134	PF00069	0.601
MOD_GSK3_1	150	157	PF00069	0.718
MOD_GSK3_1	184	191	PF00069	0.714
MOD_GSK3_1	192	199	PF00069	0.624
MOD_GSK3_1	207	214	PF00069	0.551
MOD_GSK3_1	216	223	PF00069	0.629
MOD_GSK3_1	262	269	PF00069	0.727
MOD_GSK3_1	323	330	PF00069	0.762
MOD_GSK3_1	4	11	PF00069	0.681
MOD_GSK3_1	404	411	PF00069	0.740
MOD_GSK3_1	433	440	PF00069	0.754
MOD_GSK3_1	441	448	PF00069	0.629
MOD_GSK3_1	459	466	PF00069	0.508
MOD_GSK3_1	46	53	PF00069	0.751
MOD_GSK3_1	469	476	PF00069	0.591
MOD_GSK3_1	478	485	PF00069	0.590
MOD_GSK3_1	498	505	PF00069	0.502
MOD_GSK3_1	523	530	PF00069	0.743
MOD_GSK3_1	537	544	PF00069	0.558
MOD_GSK3_1	548	555	PF00069	0.629
MOD_GSK3_1	591	598	PF00069	0.708
MOD_GSK3_1	601	608	PF00069	0.654
MOD_GSK3_1	615	622	PF00069	0.568
MOD_GSK3_1	649	656	PF00069	0.663
MOD_GSK3_1	674	681	PF00069	0.705
MOD_GSK3_1	690	697	PF00069	0.541
MOD_GSK3_1	752	759	PF00069	0.728
MOD_GSK3_1	761	768	PF00069	0.631
MOD_GSK3_1	769	776	PF00069	0.528
MOD_GSK3_1	858	865	PF00069	0.585
MOD_GSK3_1	91	98	PF00069	0.709
MOD_GSK3_1	999	1006	PF00069	0.714
MOD_LATS_1	284	290	PF00433	0.679
MOD_N-GLC_1	139	144	PF02516	0.762
MOD_N-GLC_1	150	155	PF02516	0.598
MOD_N-GLC_1	250	255	PF02516	0.672
MOD_N-GLC_1	473	478	PF02516	0.707
MOD_N-GLC_1	503	508	PF02516	0.754
MOD_N-GLC_1	592	597	PF02516	0.697
MOD_N-GLC_1	633	638	PF02516	0.751
MOD_N-GLC_1	741	746	PF02516	0.515
MOD_N-GLC_1	761	766	PF02516	0.548
MOD_N-GLC_1	982	987	PF02516	0.698
MOD_NEK2_1	10	15	PF00069	0.661
MOD_NEK2_1	1004	1009	PF00069	0.696
MOD_NEK2_1	139	144	PF00069	0.762
MOD_NEK2_1	186	191	PF00069	0.723
MOD_NEK2_1	277	282	PF00069	0.731
MOD_NEK2_1	359	364	PF00069	0.672
MOD_NEK2_1	367	372	PF00069	0.599
MOD_NEK2_1	404	409	PF00069	0.641
MOD_NEK2_1	473	478	PF00069	0.651
MOD_NEK2_1	552	557	PF00069	0.722
MOD_NEK2_1	572	577	PF00069	0.507
MOD_NEK2_1	68	73	PF00069	0.746
MOD_NEK2_1	765	770	PF00069	0.730
MOD_NEK2_1	787	792	PF00069	0.622
MOD_NEK2_1	971	976	PF00069	0.662
MOD_NEK2_2	181	186	PF00069	0.735
MOD_NEK2_2	667	672	PF00069	0.770
MOD_NEK2_2	909	914	PF00069	0.484
MOD_PIKK_1	378	384	PF00454	0.631
MOD_PIKK_1	38	44	PF00454	0.724
MOD_PIKK_1	433	439	PF00454	0.704
MOD_PIKK_1	508	514	PF00454	0.700
MOD_PIKK_1	607	613	PF00454	0.666
MOD_PIKK_1	649	655	PF00454	0.703
MOD_PIKK_1	91	97	PF00454	0.709
MOD_PK_1	441	447	PF00069	0.592
MOD_PK_1	706	712	PF00069	0.667
MOD_PKA_2	171	177	PF00069	0.675
MOD_PKA_2	192	198	PF00069	0.738
MOD_PKA_2	269	275	PF00069	0.683
MOD_PKA_2	790	796	PF00069	0.741
MOD_Plk_1	761	767	PF00069	0.670
MOD_Plk_1	863	869	PF00069	0.546
MOD_Plk_1	982	988	PF00069	0.696
MOD_Plk_2-3	813	819	PF00069	0.516
MOD_Plk_4	10	16	PF00069	0.710
MOD_Plk_4	108	114	PF00069	0.556
MOD_Plk_4	181	187	PF00069	0.734
MOD_Plk_4	193	199	PF00069	0.589
MOD_Plk_4	211	217	PF00069	0.610
MOD_Plk_4	450	456	PF00069	0.740
MOD_Plk_4	761	767	PF00069	0.639
MOD_Plk_4	863	869	PF00069	0.546
MOD_Plk_4	88	94	PF00069	0.587
MOD_Plk_4	999	1005	PF00069	0.740
MOD_ProDKin_1	1015	1021	PF00069	0.707
MOD_ProDKin_1	1029	1035	PF00069	0.541
MOD_ProDKin_1	196	202	PF00069	0.748
MOD_ProDKin_1	373	379	PF00069	0.678
MOD_ProDKin_1	398	404	PF00069	0.761
MOD_ProDKin_1	46	52	PF00069	0.751
MOD_ProDKin_1	465	471	PF00069	0.700
MOD_ProDKin_1	482	488	PF00069	0.555
MOD_ProDKin_1	546	552	PF00069	0.715
MOD_ProDKin_1	553	559	PF00069	0.637
MOD_ProDKin_1	592	598	PF00069	0.741
MOD_ProDKin_1	616	622	PF00069	0.687
MOD_ProDKin_1	633	639	PF00069	0.584
MOD_ProDKin_1	672	678	PF00069	0.670
MOD_ProDKin_1	694	700	PF00069	0.700
MOD_ProDKin_1	811	817	PF00069	0.486
MOD_SUMO_rev_2	111	121	PF00179	0.683
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.753
TRG_DiLeu_BaLyEn_6	399	404	PF01217	0.601
TRG_DiLeu_BaLyEn_6	567	572	PF01217	0.673
TRG_ENDOCYTIC_2	212	215	PF00928	0.764
TRG_ENDOCYTIC_2	624	627	PF00928	0.750
TRG_ENDOCYTIC_2	903	906	PF00928	0.513
TRG_ER_diArg_1	170	173	PF00400	0.646
TRG_ER_diArg_1	44	46	PF00400	0.724
TRG_ER_diArg_1	883	886	PF00400	0.485
TRG_ER_diArg_1	913	915	PF00400	0.582
TRG_ER_diArg_1	968	971	PF00400	0.704
TRG_ER_FFAT_2	182	191	PF00635	0.670
TRG_NES_CRM1_1	878	890	PF08389	0.496
TRG_Pf-PMV_PEXEL_1	639	644	PF00026	0.680
TRG_Pf-PMV_PEXEL_1	886	890	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	914	918	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	943	948	PF00026	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H6I8	Leishmania donovani	99%	100%
E9AI42	Leishmania braziliensis	64%	100%
E9ANK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QH19	Leishmania major	88%	100%