Arp2/3 complex 34 kDa subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ARP2/3 complex subunit - putative

Species:

Leishmania infantum

UniProt:

E9AGA0_LEIIN

TriTrypDb:

LINF_100017100

Length:

400

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0005885	Arp2/3 protein complex	2	6
GO:0032991	protein-containing complex	1	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AGA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AGA0

Function

Biological processes
Term	Name	Level	Count
GO:0007015	actin filament organization	5	6
GO:0008064	regulation of actin polymerization or depolymerization	6	6
GO:0008154	actin polymerization or depolymerization	6	6
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	6
GO:0022607	cellular component assembly	4	6
GO:0030041	actin filament polymerization	7	6
GO:0030832	regulation of actin filament length	5	6
GO:0030833	regulation of actin filament polymerization	7	6
GO:0032271	regulation of protein polymerization	6	6
GO:0032535	regulation of cellular component size	4	6
GO:0032956	regulation of actin cytoskeleton organization	5	6
GO:0032970	regulation of actin filament-based process	4	6
GO:0033043	regulation of organelle organization	5	6
GO:0034314	Arp2/3 complex-mediated actin nucleation	7	6
GO:0043254	regulation of protein-containing complex assembly	5	6
GO:0043933	protein-containing complex organization	4	6
GO:0044087	regulation of cellular component biogenesis	4	6
GO:0045010	actin nucleation	6	6
GO:0050789	regulation of biological process	2	6
GO:0050794	regulation of cellular process	3	6
GO:0051128	regulation of cellular component organization	4	6
GO:0051258	protein polymerization	6	6
GO:0051493	regulation of cytoskeleton organization	6	6
GO:0065003	protein-containing complex assembly	5	6
GO:0065007	biological regulation	1	6
GO:0065008	regulation of biological quality	2	6
GO:0071840	cellular component organization or biogenesis	2	6
GO:0090066	regulation of anatomical structure size	3	6
GO:0097435	supramolecular fiber organization	4	6
GO:0110053	regulation of actin filament organization	6	6
GO:1902903	regulation of supramolecular fiber organization	5	6

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	3
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0008092	cytoskeletal protein binding	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	298	300	PF00675	0.612
CLV_PCSK_KEX2_1	298	300	PF00082	0.612
CLV_PCSK_KEX2_1	308	310	PF00082	0.521
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.609
CLV_PCSK_SKI1_1	199	203	PF00082	0.511
CLV_PCSK_SKI1_1	246	250	PF00082	0.376
DEG_APCC_DBOX_1	198	206	PF00400	0.506
DOC_CYCLIN_yClb5_NLxxxL_5	128	136	PF00134	0.596
DOC_CYCLIN_yCln2_LP_2	172	178	PF00134	0.524
DOC_MAPK_gen_1	308	316	PF00069	0.564
DOC_MAPK_gen_1	367	375	PF00069	0.495
DOC_MAPK_MEF2A_6	308	316	PF00069	0.634
DOC_MAPK_MEF2A_6	367	375	PF00069	0.495
DOC_PP1_RVXF_1	359	366	PF00149	0.493
DOC_PP2B_LxvP_1	172	175	PF13499	0.539
DOC_PP2B_LxvP_1	219	222	PF13499	0.636
DOC_PP2B_PxIxI_1	110	116	PF00149	0.605
DOC_PP4_FxxP_1	117	120	PF00568	0.679
DOC_USP7_MATH_1	163	167	PF00917	0.676
DOC_USP7_MATH_1	258	262	PF00917	0.645
DOC_USP7_MATH_1	383	387	PF00917	0.403
DOC_USP7_MATH_2	156	162	PF00917	0.682
DOC_WW_Pin1_4	150	155	PF00397	0.695
DOC_WW_Pin1_4	176	181	PF00397	0.646
DOC_WW_Pin1_4	250	255	PF00397	0.576
LIG_14-3-3_CanoR_1	103	113	PF00244	0.622
LIG_14-3-3_CanoR_1	24	29	PF00244	0.655
LIG_14-3-3_CanoR_1	389	399	PF00244	0.513
LIG_Actin_WH2_2	186	201	PF00022	0.511
LIG_Actin_WH2_2	355	372	PF00022	0.492
LIG_APCC_ABBA_1	375	380	PF00400	0.490
LIG_BIR_II_1	1	5	PF00653	0.679
LIG_FHA_1	146	152	PF00498	0.624
LIG_FHA_1	277	283	PF00498	0.458
LIG_FHA_1	30	36	PF00498	0.645
LIG_FHA_1	334	340	PF00498	0.532
LIG_FHA_1	343	349	PF00498	0.438
LIG_FHA_2	177	183	PF00498	0.639
LIG_HCF-1_HBM_1	337	340	PF13415	0.613
LIG_LIR_Apic_2	148	152	PF02991	0.687
LIG_LIR_Gen_1	302	312	PF02991	0.558
LIG_LIR_Nem_3	107	113	PF02991	0.670
LIG_LIR_Nem_3	302	307	PF02991	0.537
LIG_LYPXL_yS_3	110	113	PF13949	0.641
LIG_NRBOX	201	207	PF00104	0.460
LIG_Pex14_1	342	346	PF04695	0.543
LIG_SH2_CRK	149	153	PF00017	0.629
LIG_SH2_SRC	300	303	PF00017	0.467
LIG_SH2_STAP1	395	399	PF00017	0.519
LIG_SH2_STAT5	26	29	PF00017	0.640
LIG_SH2_STAT5	300	303	PF00017	0.489
LIG_SH3_2	19	24	PF14604	0.706
LIG_SH3_3	16	22	PF00018	0.713
LIG_SH3_3	344	350	PF00018	0.535
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.553
LIG_SUMO_SIM_par_1	277	283	PF11976	0.458
LIG_SUMO_SIM_par_1	312	319	PF11976	0.618
LIG_TRAF2_1	179	182	PF00917	0.541
LIG_TRFH_1	346	350	PF08558	0.585
LIG_TYR_ITSM	106	113	PF00017	0.676
LIG_WRC_WIRS_1	25	30	PF05994	0.636
MOD_CDK_SPxxK_3	176	183	PF00069	0.641
MOD_CK1_1	106	112	PF00069	0.622
MOD_CK1_1	166	172	PF00069	0.624
MOD_CK1_1	209	215	PF00069	0.618
MOD_CK1_1	241	247	PF00069	0.542
MOD_CK1_1	261	267	PF00069	0.767
MOD_CK1_1	332	338	PF00069	0.486
MOD_CK1_1	355	361	PF00069	0.515
MOD_CK1_1	57	63	PF00069	0.807
MOD_CK2_1	176	182	PF00069	0.640
MOD_CK2_1	34	40	PF00069	0.639
MOD_CK2_1	73	79	PF00069	0.705
MOD_CK2_1	93	99	PF00069	0.619
MOD_GlcNHglycan	15	18	PF01048	0.586
MOD_GlcNHglycan	160	163	PF01048	0.651
MOD_GlcNHglycan	208	211	PF01048	0.526
MOD_GlcNHglycan	238	241	PF01048	0.616
MOD_GlcNHglycan	243	246	PF01048	0.551
MOD_GlcNHglycan	264	267	PF01048	0.716
MOD_GlcNHglycan	276	279	PF01048	0.454
MOD_GlcNHglycan	318	321	PF01048	0.596
MOD_GlcNHglycan	331	334	PF01048	0.492
MOD_GlcNHglycan	354	357	PF01048	0.483
MOD_GlcNHglycan	71	74	PF01048	0.736
MOD_GlcNHglycan	75	78	PF01048	0.712
MOD_GSK3_1	158	165	PF00069	0.577
MOD_GSK3_1	221	228	PF00069	0.671
MOD_GSK3_1	248	255	PF00069	0.507
MOD_GSK3_1	258	265	PF00069	0.618
MOD_GSK3_1	274	281	PF00069	0.553
MOD_GSK3_1	29	36	PF00069	0.544
MOD_GSK3_1	329	336	PF00069	0.396
MOD_GSK3_1	351	358	PF00069	0.422
MOD_GSK3_1	54	61	PF00069	0.746
MOD_GSK3_1	69	76	PF00069	0.622
MOD_GSK3_1	99	106	PF00069	0.683
MOD_NEK2_1	104	109	PF00069	0.552
MOD_NEK2_1	206	211	PF00069	0.493
MOD_NEK2_1	248	253	PF00069	0.447
MOD_NEK2_2	191	196	PF00069	0.535
MOD_PIKK_1	230	236	PF00454	0.714
MOD_PIKK_1	49	55	PF00454	0.656
MOD_PKA_2	104	110	PF00069	0.539
MOD_PKA_2	316	322	PF00069	0.561
MOD_PKA_2	369	375	PF00069	0.459
MOD_PKB_1	103	111	PF00069	0.539
MOD_Plk_1	191	197	PF00069	0.507
MOD_Plk_1	33	39	PF00069	0.683
MOD_Plk_2-3	34	40	PF00069	0.677
MOD_Plk_4	109	115	PF00069	0.610
MOD_Plk_4	238	244	PF00069	0.669
MOD_Plk_4	342	348	PF00069	0.407
MOD_Plk_4	369	375	PF00069	0.493
MOD_Plk_4	383	389	PF00069	0.506
MOD_ProDKin_1	150	156	PF00069	0.702
MOD_ProDKin_1	176	182	PF00069	0.640
MOD_ProDKin_1	250	256	PF00069	0.591
MOD_SUMO_rev_2	302	310	PF00179	0.561
TRG_DiLeu_BaEn_1	216	221	PF01217	0.544
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.375
TRG_ENDOCYTIC_2	110	113	PF00928	0.654
TRG_ENDOCYTIC_2	129	132	PF00928	0.380
TRG_ER_diArg_1	297	299	PF00400	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P323	Leptomonas seymouri	32%	95%
A0A3Q8I8S8	Leishmania donovani	99%	100%
A4H688	Leishmania braziliensis	63%	100%
E9ANB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QHB4	Leishmania major	88%	100%