Myotubularin phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AG91_LEIIN

TriTrypDb:

LINF_080017400

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AG91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG91

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	346	350	PF00656	0.737
CLV_NRD_NRD_1	270	272	PF00675	0.567
CLV_NRD_NRD_1	337	339	PF00675	0.711
CLV_NRD_NRD_1	87	89	PF00675	0.650
CLV_PCSK_KEX2_1	270	272	PF00082	0.567
CLV_PCSK_KEX2_1	337	339	PF00082	0.711
CLV_PCSK_KEX2_1	87	89	PF00082	0.650
CLV_PCSK_SKI1_1	234	238	PF00082	0.756
CLV_PCSK_SKI1_1	408	412	PF00082	0.476
CLV_PCSK_SKI1_1	87	91	PF00082	0.647
DEG_SPOP_SBC_1	19	23	PF00917	0.739
DOC_MAPK_gen_1	270	276	PF00069	0.484
DOC_MAPK_gen_1	87	95	PF00069	0.663
DOC_MAPK_MEF2A_6	257	265	PF00069	0.581
DOC_PP4_FxxP_1	295	298	PF00568	0.547
DOC_USP7_MATH_1	241	245	PF00917	0.719
DOC_USP7_MATH_1	298	302	PF00917	0.607
DOC_USP7_MATH_1	30	34	PF00917	0.763
DOC_USP7_MATH_1	305	309	PF00917	0.672
DOC_USP7_MATH_1	4	8	PF00917	0.672
DOC_USP7_MATH_1	426	430	PF00917	0.548
DOC_USP7_MATH_1	57	61	PF00917	0.728
DOC_WW_Pin1_4	11	16	PF00397	0.679
DOC_WW_Pin1_4	140	145	PF00397	0.618
DOC_WW_Pin1_4	256	261	PF00397	0.686
DOC_WW_Pin1_4	276	281	PF00397	0.385
DOC_WW_Pin1_4	308	313	PF00397	0.755
DOC_WW_Pin1_4	336	341	PF00397	0.599
DOC_WW_Pin1_4	417	422	PF00397	0.691
DOC_WW_Pin1_4	95	100	PF00397	0.728
LIG_14-3-3_CanoR_1	304	313	PF00244	0.677
LIG_14-3-3_CanoR_1	329	335	PF00244	0.604
LIG_14-3-3_CanoR_1	408	415	PF00244	0.446
LIG_APCC_ABBA_1	387	392	PF00400	0.554
LIG_BIR_III_2	349	353	PF00653	0.647
LIG_CSL_BTD_1	421	424	PF09270	0.566
LIG_FHA_1	122	128	PF00498	0.711
LIG_FHA_1	129	135	PF00498	0.572
LIG_FHA_1	154	160	PF00498	0.644
LIG_FHA_1	181	187	PF00498	0.624
LIG_FHA_1	192	198	PF00498	0.607
LIG_FHA_1	337	343	PF00498	0.618
LIG_FHA_1	410	416	PF00498	0.590
LIG_FHA_1	53	59	PF00498	0.692
LIG_FHA_2	409	415	PF00498	0.540
LIG_GBD_Chelix_1	261	269	PF00786	0.621
LIG_LIR_Apic_2	373	379	PF02991	0.573
LIG_LIR_Gen_1	36	44	PF02991	0.621
LIG_LIR_Gen_1	381	389	PF02991	0.630
LIG_LIR_Nem_3	143	149	PF02991	0.640
LIG_LIR_Nem_3	36	42	PF02991	0.626
LIG_LIR_Nem_3	381	387	PF02991	0.635
LIG_PCNA_yPIPBox_3	243	257	PF02747	0.642
LIG_PDZ_Class_2	427	432	PF00595	0.611
LIG_PDZ_Wminus1_1	430	432	PF00595	0.618
LIG_Pex14_2	295	299	PF04695	0.421
LIG_SH2_CRK	384	388	PF00017	0.624
LIG_SH2_PTP2	148	151	PF00017	0.594
LIG_SH2_PTP2	376	379	PF00017	0.580
LIG_SH2_PTP2	39	42	PF00017	0.618
LIG_SH2_SRC	376	379	PF00017	0.580
LIG_SH2_SRC	39	42	PF00017	0.618
LIG_SH2_STAP1	318	322	PF00017	0.721
LIG_SH2_STAP1	52	56	PF00017	0.672
LIG_SH2_STAT5	148	151	PF00017	0.594
LIG_SH2_STAT5	294	297	PF00017	0.626
LIG_SH2_STAT5	376	379	PF00017	0.580
LIG_SH2_STAT5	39	42	PF00017	0.618
LIG_SH2_STAT5	406	409	PF00017	0.644
LIG_SH3_3	148	154	PF00018	0.605
LIG_SH3_3	309	315	PF00018	0.752
LIG_SH3_3	418	424	PF00018	0.589
LIG_SUMO_SIM_par_1	92	98	PF11976	0.697
LIG_WRC_WIRS_1	331	336	PF05994	0.551
LIG_WW_1	144	147	PF00397	0.652
MOD_CK1_1	180	186	PF00069	0.668
MOD_CK1_1	21	27	PF00069	0.749
MOD_CK1_1	279	285	PF00069	0.708
MOD_CK1_1	308	314	PF00069	0.754
MOD_CK1_1	33	39	PF00069	0.544
MOD_CK1_1	333	339	PF00069	0.592
MOD_CK1_1	60	66	PF00069	0.730
MOD_CK1_1	69	75	PF00069	0.674
MOD_CK2_1	408	414	PF00069	0.534
MOD_GlcNHglycan	239	242	PF01048	0.763
MOD_GlcNHglycan	307	310	PF01048	0.715
MOD_GlcNHglycan	320	323	PF01048	0.481
MOD_GlcNHglycan	33	36	PF01048	0.720
MOD_GlcNHglycan	346	349	PF01048	0.721
MOD_GlcNHglycan	362	365	PF01048	0.505
MOD_GlcNHglycan	60	63	PF01048	0.733
MOD_GlcNHglycan	68	71	PF01048	0.687
MOD_GSK3_1	112	119	PF00069	0.510
MOD_GSK3_1	19	26	PF00069	0.712
MOD_GSK3_1	191	198	PF00069	0.688
MOD_GSK3_1	237	244	PF00069	0.746
MOD_GSK3_1	276	283	PF00069	0.688
MOD_GSK3_1	304	311	PF00069	0.684
MOD_GSK3_1	57	64	PF00069	0.713
MOD_GSK3_1	95	102	PF00069	0.671
MOD_N-GLC_1	31	36	PF02516	0.535
MOD_NEK2_1	128	133	PF00069	0.693
MOD_NEK2_1	168	173	PF00069	0.628
MOD_NEK2_1	237	242	PF00069	0.764
MOD_NEK2_1	287	292	PF00069	0.621
MOD_NEK2_1	303	308	PF00069	0.487
MOD_NEK2_1	330	335	PF00069	0.554
MOD_NEK2_1	342	347	PF00069	0.551
MOD_NEK2_1	358	363	PF00069	0.521
MOD_OFUCOSY	111	116	PF10250	0.647
MOD_PIKK_1	205	211	PF00454	0.730
MOD_PKA_2	121	127	PF00069	0.605
MOD_PKA_2	303	309	PF00069	0.668
MOD_PKA_2	392	398	PF00069	0.646
MOD_Plk_4	168	174	PF00069	0.631
MOD_Plk_4	264	270	PF00069	0.618
MOD_Plk_4	313	319	PF00069	0.652
MOD_ProDKin_1	11	17	PF00069	0.688
MOD_ProDKin_1	140	146	PF00069	0.616
MOD_ProDKin_1	256	262	PF00069	0.677
MOD_ProDKin_1	276	282	PF00069	0.379
MOD_ProDKin_1	308	314	PF00069	0.754
MOD_ProDKin_1	336	342	PF00069	0.598
MOD_ProDKin_1	417	423	PF00069	0.686
MOD_ProDKin_1	95	101	PF00069	0.734
TRG_DiLeu_BaEn_1	326	331	PF01217	0.642
TRG_DiLeu_LyEn_5	326	331	PF01217	0.642
TRG_ENDOCYTIC_2	146	149	PF00928	0.611
TRG_ENDOCYTIC_2	294	297	PF00928	0.626
TRG_ENDOCYTIC_2	384	387	PF00928	0.628
TRG_ENDOCYTIC_2	39	42	PF00928	0.618
TRG_ER_diArg_1	269	271	PF00400	0.555
TRG_ER_diArg_1	86	88	PF00400	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H698	Leishmania donovani	100%	100%
A4HC45	Leishmania braziliensis	72%	98%
E9ACQ6	Leishmania major	94%	100%
E9AMJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%