Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AG80_LEIIN

TriTrypDb:

LINF_080009700

Length:

291

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 0
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AG80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG80

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	285	287	PF00675	0.534
CLV_PCSK_KEX2_1	285	287	PF00082	0.536
CLV_PCSK_SKI1_1	2	6	PF00082	0.734
CLV_PCSK_SKI1_1	229	233	PF00082	0.616
DEG_APCC_DBOX_1	228	236	PF00400	0.284
DEG_MDM2_SWIB_1	129	136	PF02201	0.311
DEG_SPOP_SBC_1	96	100	PF00917	0.416
DOC_USP7_MATH_1	189	193	PF00917	0.396
DOC_USP7_MATH_1	240	244	PF00917	0.486
DOC_USP7_MATH_1	96	100	PF00917	0.458
DOC_USP7_UBL2_3	260	264	PF12436	0.597
DOC_WW_Pin1_4	4	9	PF00397	0.658
DOC_WW_Pin1_4	77	82	PF00397	0.417
LIG_BRCT_BRCA1_1	104	108	PF00533	0.433
LIG_FHA_1	11	17	PF00498	0.608
LIG_FHA_1	119	125	PF00498	0.474
LIG_FHA_1	140	146	PF00498	0.353
LIG_FHA_1	170	176	PF00498	0.376
LIG_FHA_1	218	224	PF00498	0.436
LIG_FHA_1	82	88	PF00498	0.299
LIG_FHA_2	152	158	PF00498	0.415
LIG_FHA_2	204	210	PF00498	0.506
LIG_LIR_Apic_2	209	214	PF02991	0.507
LIG_LIR_Gen_1	127	136	PF02991	0.400
LIG_LIR_Gen_1	275	282	PF02991	0.635
LIG_LIR_Nem_3	127	132	PF02991	0.405
LIG_LIR_Nem_3	275	280	PF02991	0.640
LIG_LIR_Nem_3	70	75	PF02991	0.344
LIG_MLH1_MIPbox_1	104	108	PF16413	0.367
LIG_Pex14_2	129	133	PF04695	0.335
LIG_SH2_CRK	72	76	PF00017	0.333
LIG_SH2_GRB2like	83	86	PF00017	0.322
LIG_SH2_PTP2	211	214	PF00017	0.507
LIG_SH2_SRC	64	67	PF00017	0.367
LIG_SH2_STAP1	141	145	PF00017	0.310
LIG_SH2_STAP1	219	223	PF00017	0.405
LIG_SH2_STAP1	83	87	PF00017	0.362
LIG_SH2_STAT3	219	222	PF00017	0.394
LIG_SH2_STAT5	119	122	PF00017	0.425
LIG_SH2_STAT5	141	144	PF00017	0.400
LIG_SH2_STAT5	205	208	PF00017	0.428
LIG_SH2_STAT5	211	214	PF00017	0.431
LIG_SH2_STAT5	219	222	PF00017	0.437
LIG_SH2_STAT5	64	67	PF00017	0.367
LIG_SH2_STAT5	83	86	PF00017	0.295
LIG_SH3_3	212	218	PF00018	0.456
LIG_SH3_4	260	267	PF00018	0.599
LIG_SUMO_SIM_anti_2	154	161	PF11976	0.462
LIG_SUMO_SIM_par_1	27	33	PF11976	0.662
LIG_SUMO_SIM_par_1	7	13	PF11976	0.499
LIG_TRFH_1	50	54	PF08558	0.478
LIG_WW_2	215	218	PF00397	0.439
MOD_CK1_1	117	123	PF00069	0.391
MOD_CK1_1	275	281	PF00069	0.740
MOD_CK1_1	30	36	PF00069	0.689
MOD_CK2_1	275	281	PF00069	0.739
MOD_GlcNHglycan	104	107	PF01048	0.584
MOD_GlcNHglycan	111	114	PF01048	0.599
MOD_GlcNHglycan	116	119	PF01048	0.582
MOD_GlcNHglycan	22	25	PF01048	0.622
MOD_GlcNHglycan	32	35	PF01048	0.625
MOD_GSK3_1	114	121	PF00069	0.395
MOD_GSK3_1	16	23	PF00069	0.503
MOD_GSK3_1	169	176	PF00069	0.403
MOD_GSK3_1	77	84	PF00069	0.340
MOD_GSK3_1	91	98	PF00069	0.364
MOD_N-GLC_1	109	114	PF02516	0.589
MOD_N-GLC_1	203	208	PF02516	0.632
MOD_NEK2_1	10	15	PF00069	0.505
MOD_NEK2_1	108	113	PF00069	0.432
MOD_NEK2_1	235	240	PF00069	0.337
MOD_NEK2_1	29	34	PF00069	0.622
MOD_OFUCOSY	196	201	PF10250	0.616
MOD_PIKK_1	203	209	PF00454	0.432
MOD_PIKK_1	222	228	PF00454	0.414
MOD_PKA_2	256	262	PF00069	0.776
MOD_Plk_4	10	16	PF00069	0.493
MOD_Plk_4	272	278	PF00069	0.646
MOD_ProDKin_1	4	10	PF00069	0.654
MOD_ProDKin_1	77	83	PF00069	0.411
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.651
TRG_ENDOCYTIC_2	72	75	PF00928	0.337
TRG_ER_diArg_1	285	288	PF00400	0.759
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICA2	Leptomonas seymouri	67%	100%
A0A3S7WQ91	Leishmania donovani	99%	100%
E9AMC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QIC3	Leishmania major	87%	100%