Membrane-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AG75_LEIIN

TriTrypDb:

LINF_070014400

Length:

800

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 1
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AG75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG75

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.389
CLV_C14_Caspase3-7	486	490	PF00656	0.464
CLV_PCSK_SKI1_1	187	191	PF00082	0.347
CLV_PCSK_SKI1_1	196	200	PF00082	0.292
CLV_PCSK_SKI1_1	357	361	PF00082	0.323
CLV_PCSK_SKI1_1	424	428	PF00082	0.512
CLV_PCSK_SKI1_1	767	771	PF00082	0.432
DEG_APCC_DBOX_1	423	431	PF00400	0.386
DEG_SPOP_SBC_1	546	550	PF00917	0.457
DEG_SPOP_SBC_1	654	658	PF00917	0.323
DEG_SPOP_SBC_1	673	677	PF00917	0.336
DEG_SPOP_SBC_1	761	765	PF00917	0.396
DOC_CKS1_1	155	160	PF01111	0.295
DOC_CKS1_1	38	43	PF01111	0.312
DOC_CKS1_1	595	600	PF01111	0.281
DOC_CYCLIN_yCln2_LP_2	759	762	PF00134	0.368
DOC_MAPK_HePTP_8	290	302	PF00069	0.284
DOC_MAPK_MEF2A_6	293	302	PF00069	0.289
DOC_MAPK_MEF2A_6	517	526	PF00069	0.338
DOC_MAPK_MEF2A_6	728	735	PF00069	0.369
DOC_PP2B_LxvP_1	758	761	PF13499	0.355
DOC_PP4_FxxP_1	463	466	PF00568	0.293
DOC_USP7_MATH_1	108	112	PF00917	0.358
DOC_USP7_MATH_1	216	220	PF00917	0.276
DOC_USP7_MATH_1	244	248	PF00917	0.328
DOC_USP7_MATH_1	29	33	PF00917	0.469
DOC_USP7_MATH_1	336	340	PF00917	0.313
DOC_USP7_MATH_1	358	362	PF00917	0.417
DOC_USP7_MATH_1	403	407	PF00917	0.300
DOC_USP7_MATH_1	450	454	PF00917	0.305
DOC_USP7_MATH_1	52	56	PF00917	0.281
DOC_USP7_MATH_1	546	550	PF00917	0.512
DOC_USP7_MATH_1	578	582	PF00917	0.324
DOC_USP7_MATH_1	734	738	PF00917	0.380
DOC_USP7_MATH_1	762	766	PF00917	0.404
DOC_WW_Pin1_4	123	128	PF00397	0.367
DOC_WW_Pin1_4	136	141	PF00397	0.293
DOC_WW_Pin1_4	154	159	PF00397	0.346
DOC_WW_Pin1_4	222	227	PF00397	0.287
DOC_WW_Pin1_4	323	328	PF00397	0.328
DOC_WW_Pin1_4	37	42	PF00397	0.347
DOC_WW_Pin1_4	466	471	PF00397	0.336
DOC_WW_Pin1_4	538	543	PF00397	0.260
DOC_WW_Pin1_4	594	599	PF00397	0.331
DOC_WW_Pin1_4	633	638	PF00397	0.341
DOC_WW_Pin1_4	72	77	PF00397	0.298
LIG_14-3-3_CanoR_1	196	201	PF00244	0.342
LIG_14-3-3_CanoR_1	236	241	PF00244	0.299
LIG_14-3-3_CanoR_1	316	321	PF00244	0.257
LIG_14-3-3_CanoR_1	517	523	PF00244	0.476
LIG_14-3-3_CanoR_1	623	628	PF00244	0.302
LIG_14-3-3_CanoR_1	647	655	PF00244	0.317
LIG_14-3-3_CanoR_1	747	753	PF00244	0.310
LIG_14-3-3_CanoR_1	767	773	PF00244	0.404
LIG_APCC_ABBA_1	163	168	PF00400	0.279
LIG_APCC_ABBAyCdc20_2	162	168	PF00400	0.285
LIG_BIR_II_1	1	5	PF00653	0.468
LIG_BIR_III_4	484	488	PF00653	0.448
LIG_BRCT_BRCA1_1	244	248	PF00533	0.299
LIG_BRCT_BRCA1_1	470	474	PF00533	0.375
LIG_BRCT_BRCA1_1	563	567	PF00533	0.465
LIG_CtBP_PxDLS_1	503	507	PF00389	0.308
LIG_FHA_1	188	194	PF00498	0.490
LIG_FHA_1	230	236	PF00498	0.552
LIG_FHA_1	275	281	PF00498	0.292
LIG_FHA_1	305	311	PF00498	0.306
LIG_FHA_1	365	371	PF00498	0.292
LIG_FHA_1	40	46	PF00498	0.378
LIG_FHA_1	434	440	PF00498	0.308
LIG_FHA_1	492	498	PF00498	0.331
LIG_FHA_1	506	512	PF00498	0.274
LIG_FHA_1	519	525	PF00498	0.444
LIG_FHA_1	539	545	PF00498	0.320
LIG_FHA_1	551	557	PF00498	0.515
LIG_FHA_1	558	564	PF00498	0.484
LIG_FHA_1	584	590	PF00498	0.329
LIG_FHA_1	59	65	PF00498	0.289
LIG_FHA_1	591	597	PF00498	0.342
LIG_FHA_1	624	630	PF00498	0.362
LIG_FHA_1	656	662	PF00498	0.295
LIG_FHA_1	682	688	PF00498	0.312
LIG_FHA_1	754	760	PF00498	0.402
LIG_FHA_1	775	781	PF00498	0.399
LIG_FHA_1	791	797	PF00498	0.411
LIG_FHA_2	52	58	PF00498	0.297
LIG_FHA_2	710	716	PF00498	0.365
LIG_IRF3_LxIS_1	58	65	PF10401	0.295
LIG_IRF3_LxIS_1	780	786	PF10401	0.344
LIG_LIR_Apic_2	460	466	PF02991	0.308
LIG_LIR_Gen_1	125	136	PF02991	0.332
LIG_LIR_Gen_1	245	253	PF02991	0.313
LIG_LIR_Gen_1	619	629	PF02991	0.276
LIG_LIR_Gen_1	753	762	PF02991	0.434
LIG_LIR_Nem_3	125	131	PF02991	0.346
LIG_LIR_Nem_3	139	145	PF02991	0.259
LIG_LIR_Nem_3	225	230	PF02991	0.286
LIG_LIR_Nem_3	247	253	PF02991	0.312
LIG_LIR_Nem_3	284	290	PF02991	0.250
LIG_LIR_Nem_3	306	311	PF02991	0.366
LIG_LIR_Nem_3	375	380	PF02991	0.319
LIG_LIR_Nem_3	40	46	PF02991	0.285
LIG_LIR_Nem_3	471	477	PF02991	0.305
LIG_LIR_Nem_3	512	516	PF02991	0.390
LIG_LIR_Nem_3	619	624	PF02991	0.293
LIG_LIR_Nem_3	753	758	PF02991	0.432
LIG_LYPXL_yS_3	43	46	PF13949	0.262
LIG_LYPXL_yS_3	513	516	PF13949	0.285
LIG_MAD2	309	317	PF02301	0.257
LIG_MYND_1	542	546	PF01753	0.344
LIG_MYND_1	598	602	PF01753	0.270
LIG_NRBOX	693	699	PF00104	0.279
LIG_PDZ_Class_2	795	800	PF00595	0.371
LIG_SH2_CRK	250	254	PF00017	0.244
LIG_SH2_CRK	377	381	PF00017	0.309
LIG_SH2_CRK	755	759	PF00017	0.341
LIG_SH2_GRB2like	393	396	PF00017	0.284
LIG_SH2_PTP2	621	624	PF00017	0.261
LIG_SH2_STAP1	321	325	PF00017	0.291
LIG_SH2_STAP1	755	759	PF00017	0.341
LIG_SH2_STAT3	230	233	PF00017	0.310
LIG_SH2_STAT3	393	396	PF00017	0.284
LIG_SH2_STAT5	200	203	PF00017	0.385
LIG_SH2_STAT5	230	233	PF00017	0.453
LIG_SH2_STAT5	286	289	PF00017	0.296
LIG_SH2_STAT5	393	396	PF00017	0.284
LIG_SH2_STAT5	464	467	PF00017	0.352
LIG_SH2_STAT5	475	478	PF00017	0.322
LIG_SH2_STAT5	621	624	PF00017	0.318
LIG_SH2_STAT5	63	66	PF00017	0.309
LIG_SH2_STAT5	755	758	PF00017	0.336
LIG_SH3_2	642	647	PF14604	0.341
LIG_SH3_3	297	303	PF00018	0.320
LIG_SH3_3	38	44	PF00018	0.357
LIG_SH3_3	494	500	PF00018	0.313
LIG_SH3_3	596	602	PF00018	0.271
LIG_SH3_3	608	614	PF00018	0.250
LIG_SH3_3	639	645	PF00018	0.445
LIG_SH3_3	726	732	PF00018	0.356
LIG_SUMO_SIM_par_1	14	19	PF11976	0.478
LIG_SUMO_SIM_par_1	213	219	PF11976	0.276
LIG_SUMO_SIM_par_1	502	508	PF11976	0.308
LIG_SUMO_SIM_par_1	656	664	PF11976	0.281
LIG_SUMO_SIM_par_1	731	737	PF11976	0.381
LIG_SxIP_EBH_1	395	409	PF03271	0.288
LIG_SxIP_EBH_1	647	659	PF03271	0.295
LIG_TRFH_1	499	503	PF08558	0.310
LIG_TYR_ITIM	511	516	PF00017	0.419
LIG_TYR_ITSM	373	380	PF00017	0.269
LIG_WRC_WIRS_1	305	310	PF05994	0.271
MOD_CK1_1	120	126	PF00069	0.349
MOD_CK1_1	146	152	PF00069	0.337
MOD_CK1_1	170	176	PF00069	0.315
MOD_CK1_1	204	210	PF00069	0.302
MOD_CK1_1	243	249	PF00069	0.511
MOD_CK1_1	252	258	PF00069	0.274
MOD_CK1_1	383	389	PF00069	0.354
MOD_CK1_1	440	446	PF00069	0.321
MOD_CK1_1	459	465	PF00069	0.481
MOD_CK1_1	469	475	PF00069	0.355
MOD_CK1_1	491	497	PF00069	0.352
MOD_CK1_1	534	540	PF00069	0.323
MOD_CK1_1	547	553	PF00069	0.471
MOD_CK1_1	554	560	PF00069	0.477
MOD_CK1_1	561	567	PF00069	0.459
MOD_CK1_1	590	596	PF00069	0.366
MOD_CK1_1	65	71	PF00069	0.343
MOD_CK1_1	660	666	PF00069	0.316
MOD_CK1_1	679	685	PF00069	0.314
MOD_CK1_1	709	715	PF00069	0.383
MOD_CK1_1	72	78	PF00069	0.331
MOD_CK1_1	737	743	PF00069	0.351
MOD_CK1_1	750	756	PF00069	0.338
MOD_CK1_1	790	796	PF00069	0.439
MOD_CK2_1	182	188	PF00069	0.323
MOD_CK2_1	450	456	PF00069	0.312
MOD_CK2_1	709	715	PF00069	0.383
MOD_GlcNHglycan	120	123	PF01048	0.363
MOD_GlcNHglycan	145	148	PF01048	0.336
MOD_GlcNHglycan	242	245	PF01048	0.304
MOD_GlcNHglycan	353	356	PF01048	0.429
MOD_GlcNHglycan	362	365	PF01048	0.368
MOD_GlcNHglycan	382	385	PF01048	0.311
MOD_GlcNHglycan	413	416	PF01048	0.371
MOD_GlcNHglycan	424	427	PF01048	0.380
MOD_GlcNHglycan	484	488	PF01048	0.448
MOD_GlcNHglycan	533	536	PF01048	0.348
MOD_GlcNHglycan	618	621	PF01048	0.317
MOD_GlcNHglycan	65	68	PF01048	0.348
MOD_GlcNHglycan	744	747	PF01048	0.327
MOD_GlcNHglycan	752	755	PF01048	0.327
MOD_GlcNHglycan	764	767	PF01048	0.406
MOD_GlcNHglycan	774	777	PF01048	0.394
MOD_GlcNHglycan	789	792	PF01048	0.446
MOD_GlcNHglycan	99	102	PF01048	0.303
MOD_GSK3_1	118	125	PF00069	0.320
MOD_GSK3_1	143	150	PF00069	0.341
MOD_GSK3_1	166	173	PF00069	0.357
MOD_GSK3_1	178	185	PF00069	0.346
MOD_GSK3_1	236	243	PF00069	0.381
MOD_GSK3_1	353	360	PF00069	0.392
MOD_GSK3_1	362	369	PF00069	0.347
MOD_GSK3_1	379	386	PF00069	0.311
MOD_GSK3_1	418	425	PF00069	0.422
MOD_GSK3_1	433	440	PF00069	0.269
MOD_GSK3_1	450	457	PF00069	0.430
MOD_GSK3_1	466	473	PF00069	0.380
MOD_GSK3_1	475	482	PF00069	0.303
MOD_GSK3_1	483	490	PF00069	0.442
MOD_GSK3_1	505	512	PF00069	0.307
MOD_GSK3_1	534	541	PF00069	0.374
MOD_GSK3_1	544	551	PF00069	0.574
MOD_GSK3_1	552	559	PF00069	0.722
MOD_GSK3_1	58	65	PF00069	0.338
MOD_GSK3_1	583	590	PF00069	0.325
MOD_GSK3_1	653	660	PF00069	0.375
MOD_GSK3_1	672	679	PF00069	0.507
MOD_GSK3_1	68	75	PF00069	0.344
MOD_GSK3_1	718	725	PF00069	0.338
MOD_GSK3_1	76	83	PF00069	0.321
MOD_GSK3_1	767	774	PF00069	0.423
MOD_GSK3_1	783	790	PF00069	0.384
MOD_N-GLC_1	210	215	PF02516	0.342
MOD_N-GLC_1	631	636	PF02516	0.540
MOD_N-GLC_1	68	73	PF02516	0.307
MOD_N-GLC_1	89	94	PF02516	0.351
MOD_N-GLC_1	96	101	PF02516	0.329
MOD_NEK2_1	16	21	PF00069	0.481
MOD_NEK2_1	189	194	PF00069	0.314
MOD_NEK2_1	345	350	PF00069	0.303
MOD_NEK2_1	366	371	PF00069	0.326
MOD_NEK2_1	439	444	PF00069	0.362
MOD_NEK2_1	50	55	PF00069	0.376
MOD_NEK2_1	587	592	PF00069	0.366
MOD_NEK2_1	62	67	PF00069	0.309
MOD_NEK2_1	648	653	PF00069	0.395
MOD_NEK2_1	681	686	PF00069	0.306
MOD_NEK2_1	687	692	PF00069	0.278
MOD_NEK2_1	742	747	PF00069	0.323
MOD_NEK2_1	80	85	PF00069	0.340
MOD_NEK2_1	96	101	PF00069	0.261
MOD_NEK2_2	244	249	PF00069	0.299
MOD_NEK2_2	274	279	PF00069	0.299
MOD_NEK2_2	304	309	PF00069	0.272
MOD_NEK2_2	470	475	PF00069	0.328
MOD_NEK2_2	58	63	PF00069	0.307
MOD_PIKK_1	229	235	PF00454	0.398
MOD_PIKK_1	515	521	PF00454	0.352
MOD_PIKK_1	674	680	PF00454	0.298
MOD_PIKK_1	706	712	PF00454	0.321
MOD_PIKK_1	737	743	PF00454	0.351
MOD_PIKK_1	80	86	PF00454	0.333
MOD_PK_1	236	242	PF00069	0.288
MOD_PKA_2	166	172	PF00069	0.304
MOD_PKA_2	281	287	PF00069	0.276
MOD_PKA_2	380	386	PF00069	0.295
MOD_PKA_2	479	485	PF00069	0.502
MOD_Plk_1	147	153	PF00069	0.355
MOD_Plk_1	210	216	PF00069	0.305
MOD_Plk_1	58	64	PF00069	0.300
MOD_Plk_1	631	637	PF00069	0.464
MOD_Plk_4	170	176	PF00069	0.356
MOD_Plk_4	196	202	PF00069	0.410
MOD_Plk_4	204	210	PF00069	0.308
MOD_Plk_4	281	287	PF00069	0.338
MOD_Plk_4	316	322	PF00069	0.287
MOD_Plk_4	372	378	PF00069	0.285
MOD_Plk_4	444	450	PF00069	0.348
MOD_Plk_4	459	465	PF00069	0.434
MOD_Plk_4	470	476	PF00069	0.398
MOD_Plk_4	563	569	PF00069	0.465
MOD_Plk_4	591	597	PF00069	0.324
MOD_Plk_4	603	609	PF00069	0.265
MOD_ProDKin_1	123	129	PF00069	0.365
MOD_ProDKin_1	136	142	PF00069	0.292
MOD_ProDKin_1	154	160	PF00069	0.349
MOD_ProDKin_1	222	228	PF00069	0.289
MOD_ProDKin_1	323	329	PF00069	0.327
MOD_ProDKin_1	37	43	PF00069	0.346
MOD_ProDKin_1	466	472	PF00069	0.338
MOD_ProDKin_1	538	544	PF00069	0.271
MOD_ProDKin_1	594	600	PF00069	0.331
MOD_ProDKin_1	633	639	PF00069	0.335
MOD_ProDKin_1	72	78	PF00069	0.292
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.331
TRG_ENDOCYTIC_2	250	253	PF00928	0.280
TRG_ENDOCYTIC_2	377	380	PF00928	0.305
TRG_ENDOCYTIC_2	43	46	PF00928	0.269
TRG_ENDOCYTIC_2	498	501	PF00928	0.367
TRG_ENDOCYTIC_2	513	516	PF00928	0.405
TRG_ENDOCYTIC_2	621	624	PF00928	0.278
TRG_ENDOCYTIC_2	755	758	PF00928	0.336
TRG_ER_diArg_1	235	238	PF00400	0.322
TRG_ER_diArg_1	622	625	PF00400	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HAG1	Leishmania braziliensis	33%	100%
E9AI27	Leishmania braziliensis	36%	100%
V5DPX9	Trypanosoma cruzi	29%	82%