LeishMANIAdb
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Putative vacuolar-type Ca2+-ATPase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative vacuolar-type Ca2+-ATPase
Gene product:
vacuolar-type Ca2+-ATPase - putative
Species:
Leishmania infantum
UniProt:
E9AG74_LEIIN
TriTrypDb:
LINF_070012100
Length:
294

Annotations

Annotations by Jardim et al.

Acidocalcisome, vacuolar-type Ca2+-ATPase (Fragment)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 1
NetGPI no yes: 0, no: 1
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

E9AG74
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG74

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 2
GO:0003824 catalytic activity 1 2
GO:0005488 binding 1 2
GO:0005524 ATP binding 5 2
GO:0016462 pyrophosphatase activity 5 2
GO:0016787 hydrolase activity 2 2
GO:0016817 hydrolase activity, acting on acid anhydrides 3 2
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 2
GO:0016887 ATP hydrolysis activity 7 2
GO:0017076 purine nucleotide binding 4 2
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 2
GO:0030554 adenyl nucleotide binding 5 2
GO:0032553 ribonucleotide binding 3 2
GO:0032555 purine ribonucleotide binding 4 2
GO:0032559 adenyl ribonucleotide binding 5 2
GO:0035639 purine ribonucleoside triphosphate binding 4 2
GO:0036094 small molecule binding 2 2
GO:0043167 ion binding 2 2
GO:0043168 anion binding 3 2
GO:0097159 organic cyclic compound binding 2 2
GO:0097367 carbohydrate derivative binding 2 2
GO:1901265 nucleoside phosphate binding 3 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 116 118 PF00675 0.199
CLV_NRD_NRD_1 220 222 PF00675 0.199
CLV_NRD_NRD_1 38 40 PF00675 0.334
CLV_PCSK_FUR_1 218 222 PF00082 0.199
CLV_PCSK_KEX2_1 116 118 PF00082 0.199
CLV_PCSK_KEX2_1 203 205 PF00082 0.307
CLV_PCSK_KEX2_1 220 222 PF00082 0.199
CLV_PCSK_KEX2_1 53 55 PF00082 0.372
CLV_PCSK_PC1ET2_1 203 205 PF00082 0.307
CLV_PCSK_PC1ET2_1 53 55 PF00082 0.372
CLV_PCSK_SKI1_1 116 120 PF00082 0.199
CLV_PCSK_SKI1_1 122 126 PF00082 0.199
CLV_PCSK_SKI1_1 147 151 PF00082 0.199
CLV_PCSK_SKI1_1 224 228 PF00082 0.199
DEG_Nend_UBRbox_1 1 4 PF02207 0.622
DOC_MAPK_gen_1 218 228 PF00069 0.400
DOC_MAPK_MEF2A_6 221 230 PF00069 0.400
DOC_PP2B_LxvP_1 161 164 PF13499 0.199
DOC_PP2B_LxvP_1 245 248 PF13499 0.400
DOC_USP7_MATH_1 153 157 PF00917 0.199
DOC_USP7_UBL2_3 203 207 PF12436 0.503
DOC_WW_Pin1_4 239 244 PF00397 0.400
DOC_WW_Pin1_4 81 86 PF00397 0.480
LIG_14-3-3_CanoR_1 147 152 PF00244 0.199
LIG_14-3-3_CanoR_1 54 59 PF00244 0.570
LIG_Actin_WH2_2 89 107 PF00022 0.400
LIG_EVH1_2 129 133 PF00568 0.400
LIG_FHA_1 173 179 PF00498 0.277
LIG_FHA_1 225 231 PF00498 0.400
LIG_FHA_1 27 33 PF00498 0.560
LIG_FHA_1 282 288 PF00498 0.400
LIG_FHA_2 130 136 PF00498 0.400
LIG_FHA_2 160 166 PF00498 0.199
LIG_GBD_Chelix_1 96 104 PF00786 0.199
LIG_LIR_Gen_1 179 189 PF02991 0.199
LIG_LIR_Gen_1 202 211 PF02991 0.505
LIG_LIR_Gen_1 34 43 PF02991 0.534
LIG_LIR_Gen_1 84 93 PF02991 0.477
LIG_LIR_LC3C_4 242 247 PF02991 0.400
LIG_LIR_Nem_3 132 137 PF02991 0.400
LIG_LIR_Nem_3 179 184 PF02991 0.199
LIG_LIR_Nem_3 19 25 PF02991 0.580
LIG_LIR_Nem_3 202 208 PF02991 0.498
LIG_LIR_Nem_3 84 90 PF02991 0.479
LIG_PDZ_Class_3 289 294 PF00595 0.484
LIG_Pex14_1 177 181 PF04695 0.199
LIG_REV1ctd_RIR_1 117 125 PF16727 0.400
LIG_SH2_STAP1 28 32 PF00017 0.554
LIG_SH2_STAT5 253 256 PF00017 0.400
LIG_SH2_STAT5 28 31 PF00017 0.555
LIG_SH3_3 123 129 PF00018 0.400
LIG_SH3_3 160 166 PF00018 0.199
LIG_SUMO_SIM_anti_2 186 192 PF11976 0.199
LIG_SUMO_SIM_par_1 186 192 PF11976 0.199
LIG_SUMO_SIM_par_1 225 232 PF11976 0.400
LIG_SUMO_SIM_par_1 279 284 PF11976 0.400
MOD_CK1_1 16 22 PF00069 0.592
MOD_CK1_1 24 30 PF00069 0.564
MOD_CK1_1 264 270 PF00069 0.400
MOD_CK2_1 1 7 PF00069 0.618
MOD_CK2_1 129 135 PF00069 0.400
MOD_GlcNHglycan 15 18 PF01048 0.399
MOD_GlcNHglycan 210 215 PF01048 0.322
MOD_GSK3_1 137 144 PF00069 0.400
MOD_GSK3_1 188 195 PF00069 0.199
MOD_GSK3_1 206 213 PF00069 0.517
MOD_GSK3_1 224 231 PF00069 0.400
MOD_GSK3_1 96 103 PF00069 0.400
MOD_N-GLC_1 239 244 PF02516 0.199
MOD_NEK2_1 100 105 PF00069 0.400
MOD_NEK2_1 159 164 PF00069 0.199
MOD_NEK2_1 252 257 PF00069 0.400
MOD_NEK2_1 283 288 PF00069 0.400
MOD_NEK2_1 43 48 PF00069 0.536
MOD_NEK2_2 18 23 PF00069 0.585
MOD_PKA_2 1 7 PF00069 0.618
MOD_PKA_2 49 55 PF00069 0.563
MOD_Plk_1 141 147 PF00069 0.400
MOD_Plk_1 224 230 PF00069 0.400
MOD_Plk_1 261 267 PF00069 0.400
MOD_Plk_2-3 109 115 PF00069 0.400
MOD_Plk_4 129 135 PF00069 0.400
MOD_Plk_4 141 147 PF00069 0.400
MOD_Plk_4 153 159 PF00069 0.199
MOD_Plk_4 183 189 PF00069 0.199
MOD_Plk_4 255 261 PF00069 0.400
MOD_Plk_4 283 289 PF00069 0.400
MOD_Plk_4 54 60 PF00069 0.572
MOD_ProDKin_1 239 245 PF00069 0.400
MOD_ProDKin_1 81 87 PF00069 0.475
TRG_DiLeu_BaLyEn_6 144 149 PF01217 0.199
TRG_ENDOCYTIC_2 87 90 PF00928 0.479
TRG_ER_diArg_1 217 220 PF00400 0.400
TRG_ER_diArg_1 47 50 PF00400 0.551
TRG_NLS_MonoExtN_4 272 277 PF00514 0.400

Homologs

Protein Taxonomy Sequence identity Coverage
A5IVY3 STAA9 40% 37%
A6QK47 STAAE 40% 37%
A6U4T8 STAA2 40% 37%
A7L9Z8 MOUSE 27% 31%
A7X6S1 STAA1 40% 37%
A8Z3F8 STAAT 40% 37%
O29777 ARCFU 41% 37%
O32220 BACSU 41% 37%
O34431 BACSU 25% 33%
O43108 YARLI 35% 32%
O59868 SCHPO 30% 33%
P09627 SCHPO 26% 32%
P13586 YEAST 28% 31%
P37278 SYNE7 28% 32%
P37279 SYNE7 44% 39%
P37367 SYNY3 24% 32%
P47317 MYCGE 25% 34%
P57709 BOVIN 30% 31%
P58342 RHIME 41% 36%
P73241 SYNY3 27% 39%
P78036 MYCPN 29% 34%
P98194 HUMAN 31% 32%
Q2FDV0 STAA3 40% 37%
Q2FV64 STAA8 40% 37%
Q2YWA3 STAAB 39% 37%
Q58623 METJA 28% 37%
Q5HCZ3 STAAC 40% 37%
Q5R5K5 PONAB 31% 32%
Q5ZWR1 LEGPH 26% 40%
Q64566 RAT 31% 32%
Q6G6B7 STAAS 40% 37%
Q6GDP1 STAAR 40% 37%
Q73E41 BACC1 24% 33%
Q7A3E6 STAAN 40% 37%
Q80XR2 MOUSE 30% 32%
Q8NUQ9 STAAW 40% 37%
Q8R4C1 RAT 27% 31%
Q8Y8Q5 LISMO 30% 33%
Q99R80 STAAM 40% 37%
Q9CFU9 LACLA 29% 33%
Q9LY32 ARATH 26% 31%
Q9SJB3 ARATH 24% 31%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS