LeishMANIAdb
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Putative pteridine transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative pteridine transporter
Gene product:
pteridine transporter (truncated) - putative
Species:
Leishmania infantum
UniProt:
E9AG72_LEIIN
TriTrypDb:
LINF_060018800
Length:
653

Annotations

Annotations by Jardim et al.

Transporters, pteridine transporter

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 9
Silverman et al. no yes: 0
Pissara et al. no yes: 52
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 72
NetGPI no yes: 0, no: 72
Cellular components
Term Name Level Count
GO:0016020 membrane 2 73
GO:0110165 cellular anatomical entity 1 73
GO:0005737 cytoplasm 2 6
GO:0005886 plasma membrane 3 1

Expansion

Sequence features

E9AG72
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG72

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0015877 biopterin transport 5 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 1
GO:0015224 biopterin transmembrane transporter activity 3 1
GO:0022857 transmembrane transporter activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 289 293 PF00656 0.554
CLV_NRD_NRD_1 259 261 PF00675 0.357
CLV_NRD_NRD_1 365 367 PF00675 0.423
CLV_NRD_NRD_1 623 625 PF00675 0.489
CLV_PCSK_KEX2_1 132 134 PF00082 0.320
CLV_PCSK_KEX2_1 259 261 PF00082 0.303
CLV_PCSK_KEX2_1 271 273 PF00082 0.329
CLV_PCSK_KEX2_1 365 367 PF00082 0.423
CLV_PCSK_KEX2_1 485 487 PF00082 0.549
CLV_PCSK_KEX2_1 623 625 PF00082 0.495
CLV_PCSK_PC1ET2_1 132 134 PF00082 0.320
CLV_PCSK_PC1ET2_1 271 273 PF00082 0.385
CLV_PCSK_PC1ET2_1 485 487 PF00082 0.549
CLV_PCSK_SKI1_1 103 107 PF00082 0.361
CLV_PCSK_SKI1_1 261 265 PF00082 0.342
CLV_PCSK_SKI1_1 366 370 PF00082 0.555
CLV_PCSK_SKI1_1 461 465 PF00082 0.255
DOC_CDC14_PxL_1 40 48 PF14671 0.553
DOC_CDC14_PxL_1 571 579 PF14671 0.357
DOC_CKS1_1 583 588 PF01111 0.468
DOC_CYCLIN_yCln2_LP_2 385 391 PF00134 0.477
DOC_CYCLIN_yCln2_LP_2 583 589 PF00134 0.418
DOC_MAPK_gen_1 132 138 PF00069 0.535
DOC_MAPK_gen_1 259 267 PF00069 0.586
DOC_MAPK_gen_1 459 467 PF00069 0.475
DOC_MAPK_gen_1 485 493 PF00069 0.351
DOC_MAPK_gen_1 599 608 PF00069 0.618
DOC_MAPK_MEF2A_6 225 233 PF00069 0.359
DOC_MAPK_MEF2A_6 393 400 PF00069 0.507
DOC_MAPK_MEF2A_6 485 493 PF00069 0.390
DOC_MAPK_MEF2A_6 572 579 PF00069 0.277
DOC_MAPK_MEF2A_6 62 69 PF00069 0.563
DOC_MAPK_NFAT4_5 62 70 PF00069 0.633
DOC_PP2B_LxvP_1 385 388 PF13499 0.477
DOC_PP2B_LxvP_1 406 409 PF13499 0.414
DOC_PP2B_LxvP_1 588 591 PF13499 0.395
DOC_PP2B_LxvP_1 595 598 PF13499 0.358
DOC_PP4_FxxP_1 316 319 PF00568 0.492
DOC_USP7_MATH_1 155 159 PF00917 0.295
DOC_USP7_MATH_1 195 199 PF00917 0.515
DOC_USP7_MATH_1 305 309 PF00917 0.486
DOC_USP7_MATH_1 474 478 PF00917 0.362
DOC_USP7_MATH_1 544 548 PF00917 0.436
DOC_USP7_MATH_1 551 555 PF00917 0.428
DOC_USP7_UBL2_3 271 275 PF12436 0.559
DOC_WW_Pin1_4 582 587 PF00397 0.451
LIG_14-3-3_CanoR_1 103 108 PF00244 0.526
LIG_APCC_ABBA_1 247 252 PF00400 0.443
LIG_APCC_ABBA_1 49 54 PF00400 0.663
LIG_BIR_II_1 1 5 PF00653 0.792
LIG_BIR_III_3 1 5 PF00653 0.628
LIG_BIR_III_4 443 447 PF00653 0.222
LIG_BRCT_BRCA1_1 429 433 PF00533 0.352
LIG_EH1_1 284 292 PF00400 0.407
LIG_EVH1_2 567 571 PF00568 0.372
LIG_FHA_1 348 354 PF00498 0.386
LIG_FHA_1 446 452 PF00498 0.425
LIG_FHA_1 467 473 PF00498 0.357
LIG_FHA_1 528 534 PF00498 0.508
LIG_FHA_1 583 589 PF00498 0.455
LIG_FHA_2 25 31 PF00498 0.725
LIG_FHA_2 617 623 PF00498 0.687
LIG_GBD_Chelix_1 467 475 PF00786 0.506
LIG_GBD_Chelix_1 505 513 PF00786 0.532
LIG_LIR_Apic_2 30 34 PF02991 0.645
LIG_LIR_Apic_2 313 319 PF02991 0.564
LIG_LIR_Gen_1 402 412 PF02991 0.369
LIG_LIR_Gen_1 432 441 PF02991 0.353
LIG_LIR_Gen_1 477 484 PF02991 0.374
LIG_LIR_Gen_1 532 541 PF02991 0.541
LIG_LIR_Nem_3 227 231 PF02991 0.340
LIG_LIR_Nem_3 241 247 PF02991 0.376
LIG_LIR_Nem_3 402 408 PF02991 0.378
LIG_LIR_Nem_3 430 434 PF02991 0.327
LIG_LIR_Nem_3 477 482 PF02991 0.369
LIG_LIR_Nem_3 532 538 PF02991 0.501
LIG_LIR_Nem_3 558 563 PF02991 0.324
LIG_NRBOX 399 405 PF00104 0.447
LIG_Pex14_1 204 208 PF04695 0.420
LIG_Pex14_2 168 172 PF04695 0.405
LIG_Pex14_2 243 247 PF04695 0.330
LIG_Pex14_2 429 433 PF04695 0.341
LIG_Pex14_2 453 457 PF04695 0.397
LIG_Pex14_2 59 63 PF04695 0.508
LIG_PTB_Apo_2 570 577 PF02174 0.355
LIG_PTB_Phospho_1 570 576 PF10480 0.355
LIG_REV1ctd_RIR_1 454 463 PF16727 0.366
LIG_SH2_CRK 101 105 PF00017 0.542
LIG_SH2_CRK 135 139 PF00017 0.407
LIG_SH2_CRK 150 154 PF00017 0.361
LIG_SH2_CRK 345 349 PF00017 0.385
LIG_SH2_CRK 370 374 PF00017 0.395
LIG_SH2_CRK 434 438 PF00017 0.333
LIG_SH2_CRK 462 466 PF00017 0.530
LIG_SH2_GRB2like 399 402 PF00017 0.421
LIG_SH2_NCK_1 31 35 PF00017 0.699
LIG_SH2_NCK_1 370 374 PF00017 0.453
LIG_SH2_PTP2 228 231 PF00017 0.232
LIG_SH2_PTP2 48 51 PF00017 0.645
LIG_SH2_SRC 31 34 PF00017 0.661
LIG_SH2_SRC 399 402 PF00017 0.536
LIG_SH2_SRC 576 579 PF00017 0.232
LIG_SH2_STAP1 130 134 PF00017 0.536
LIG_SH2_STAP1 345 349 PF00017 0.432
LIG_SH2_STAP1 462 466 PF00017 0.537
LIG_SH2_STAP1 507 511 PF00017 0.443
LIG_SH2_STAT5 130 133 PF00017 0.534
LIG_SH2_STAT5 228 231 PF00017 0.385
LIG_SH2_STAT5 399 402 PF00017 0.388
LIG_SH2_STAT5 405 408 PF00017 0.379
LIG_SH2_STAT5 416 419 PF00017 0.308
LIG_SH2_STAT5 431 434 PF00017 0.295
LIG_SH2_STAT5 48 51 PF00017 0.604
LIG_SH2_STAT5 499 502 PF00017 0.326
LIG_SH2_STAT5 576 579 PF00017 0.372
LIG_SH2_STAT5 71 74 PF00017 0.545
LIG_SH3_1 421 427 PF00018 0.288
LIG_SH3_3 421 427 PF00018 0.310
LIG_SH3_3 624 630 PF00018 0.749
LIG_Sin3_3 593 600 PF02671 0.232
LIG_SUMO_SIM_anti_2 175 181 PF11976 0.401
LIG_SUMO_SIM_anti_2 480 485 PF11976 0.349
LIG_SUMO_SIM_anti_2 585 591 PF11976 0.461
LIG_TRAF2_1 6 9 PF00917 0.797
LIG_TRAF2_1 619 622 PF00917 0.810
LIG_TRFH_1 150 154 PF08558 0.401
LIG_TRFH_1 594 598 PF08558 0.329
LIG_TYR_ITIM 148 153 PF00017 0.416
LIG_TYR_ITIM 226 231 PF00017 0.496
LIG_TYR_ITIM 343 348 PF00017 0.281
LIG_TYR_ITIM 368 373 PF00017 0.414
LIG_TYR_ITIM 403 408 PF00017 0.363
LIG_TYR_ITIM 46 51 PF00017 0.505
LIG_TYR_ITIM 574 579 PF00017 0.425
LIG_TYR_ITSM 430 437 PF00017 0.442
LIG_UBA3_1 217 225 PF00899 0.232
MOD_CK1_1 198 204 PF00069 0.373
MOD_CK2_1 185 191 PF00069 0.226
MOD_CK2_1 24 30 PF00069 0.585
MOD_CK2_1 616 622 PF00069 0.631
MOD_GlcNHglycan 138 141 PF01048 0.385
MOD_GlcNHglycan 157 161 PF01048 0.391
MOD_GlcNHglycan 2 5 PF01048 0.715
MOD_GlcNHglycan 233 236 PF01048 0.411
MOD_GlcNHglycan 292 295 PF01048 0.460
MOD_GlcNHglycan 542 545 PF01048 0.436
MOD_GlcNHglycan 563 566 PF01048 0.417
MOD_GSK3_1 106 113 PF00069 0.434
MOD_GSK3_1 204 211 PF00069 0.344
MOD_GSK3_1 286 293 PF00069 0.428
MOD_GSK3_1 347 354 PF00069 0.360
MOD_GSK3_1 429 436 PF00069 0.409
MOD_GSK3_1 451 458 PF00069 0.393
MOD_GSK3_1 540 547 PF00069 0.415
MOD_N-GLC_1 254 259 PF02516 0.359
MOD_N-GLC_1 82 87 PF02516 0.416
MOD_NEK2_1 110 115 PF00069 0.398
MOD_NEK2_1 117 122 PF00069 0.385
MOD_NEK2_1 128 133 PF00069 0.373
MOD_NEK2_1 136 141 PF00069 0.378
MOD_NEK2_1 172 177 PF00069 0.379
MOD_NEK2_1 185 190 PF00069 0.385
MOD_NEK2_1 208 213 PF00069 0.364
MOD_NEK2_1 347 352 PF00069 0.393
MOD_NEK2_1 429 434 PF00069 0.395
MOD_NEK2_1 466 471 PF00069 0.397
MOD_NEK2_1 511 516 PF00069 0.404
MOD_NEK2_1 63 68 PF00069 0.444
MOD_NEK2_1 69 74 PF00069 0.467
MOD_NEK2_2 374 379 PF00069 0.390
MOD_NEK2_2 474 479 PF00069 0.408
MOD_PIKK_1 178 184 PF00454 0.366
MOD_PIKK_1 352 358 PF00454 0.228
MOD_PKA_2 527 533 PF00069 0.374
MOD_Plk_2-3 616 622 PF00069 0.461
MOD_Plk_4 103 109 PF00069 0.304
MOD_Plk_4 195 201 PF00069 0.373
MOD_Plk_4 204 210 PF00069 0.371
MOD_Plk_4 224 230 PF00069 0.357
MOD_Plk_4 238 244 PF00069 0.225
MOD_Plk_4 286 292 PF00069 0.412
MOD_Plk_4 374 380 PF00069 0.444
MOD_Plk_4 399 405 PF00069 0.409
MOD_Plk_4 429 435 PF00069 0.473
MOD_Plk_4 467 473 PF00069 0.345
MOD_Plk_4 474 480 PF00069 0.351
MOD_Plk_4 511 517 PF00069 0.346
MOD_Plk_4 551 557 PF00069 0.379
MOD_ProDKin_1 582 588 PF00069 0.451
MOD_SUMO_rev_2 222 227 PF00179 0.447
MOD_SUMO_rev_2 289 299 PF00179 0.232
MOD_SUMO_rev_2 615 620 PF00179 0.706
MOD_SUMO_rev_2 647 653 PF00179 0.747
TRG_DiLeu_BaLyEn_6 338 343 PF01217 0.417
TRG_DiLeu_BaLyEn_6 385 390 PF01217 0.398
TRG_DiLeu_BaLyEn_6 583 588 PF01217 0.360
TRG_ENDOCYTIC_2 101 104 PF00928 0.353
TRG_ENDOCYTIC_2 135 138 PF00928 0.386
TRG_ENDOCYTIC_2 150 153 PF00928 0.376
TRG_ENDOCYTIC_2 228 231 PF00928 0.496
TRG_ENDOCYTIC_2 345 348 PF00928 0.387
TRG_ENDOCYTIC_2 370 373 PF00928 0.391
TRG_ENDOCYTIC_2 405 408 PF00928 0.383
TRG_ENDOCYTIC_2 434 437 PF00928 0.385
TRG_ENDOCYTIC_2 462 465 PF00928 0.382
TRG_ENDOCYTIC_2 48 51 PF00928 0.508
TRG_ENDOCYTIC_2 576 579 PF00928 0.423
TRG_NES_CRM1_1 238 252 PF08389 0.411
TRG_NES_CRM1_1 320 334 PF08389 0.251
TRG_NES_CRM1_1 503 519 PF08389 0.232

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2U2 Leptomonas seymouri 46% 93%
A0A0N1HY49 Leptomonas seymouri 42% 97%
A0A0N1HZ06 Leptomonas seymouri 46% 100%
A0A0N1IHL1 Leptomonas seymouri 40% 91%
A0A0N1PAY4 Leptomonas seymouri 40% 74%
A0A0N1PB77 Leptomonas seymouri 42% 100%
A0A0N1PBZ2 Leptomonas seymouri 43% 97%
A0A0N1PCC1 Leptomonas seymouri 43% 98%
A0A0S4IKN0 Bodo saltans 32% 100%
A0A0S4INN8 Bodo saltans 31% 100%
A0A381MBI0 Leishmania infantum 46% 100%
A0A3Q8I8X7 Leishmania donovani 46% 99%
A0A3Q8IAZ0 Leishmania donovani 43% 93%
A0A3Q8IH50 Leishmania donovani 45% 90%
A0A3Q8IVN0 Leishmania donovani 45% 100%
A0A3R7M4J1 Trypanosoma rangeli 46% 100%
A0A3S5H5P4 Leishmania donovani 44% 96%
A0A3S5H5V2 Leishmania donovani 100% 100%
A0A3S5H6F6 Leishmania donovani 43% 94%
A0A3S5H763 Leishmania donovani 45% 97%
A0A3S7WR10 Leishmania donovani 45% 88%
A0A3S7WR14 Leishmania donovani 43% 95%
A0A3S7WR15 Leishmania donovani 42% 77%
A0A3S7WR24 Leishmania donovani 42% 93%
A4H4T8 Leishmania braziliensis 84% 100%
A4H5Y4 Leishmania braziliensis 44% 100%
A4H617 Leishmania braziliensis 45% 100%
A4H618 Leishmania braziliensis 45% 100%
A4H619 Leishmania braziliensis 44% 100%
A4H620 Leishmania braziliensis 47% 100%
A4H6C3 Leishmania braziliensis 44% 100%
A4HNH7 Leishmania braziliensis 44% 100%
A4HSS2 Leishmania infantum 45% 100%
A4HUE4 Leishmania infantum 45% 100%
A4HUE5 Leishmania infantum 43% 100%
A4HUE6 Leishmania infantum 43% 100%
A4HUE7 Leishmania infantum 43% 100%
A4HUE8 Leishmania infantum 42% 100%
A4HUF4 Leishmania infantum 41% 100%
A4HUF5 Leishmania infantum 45% 100%
A4HYA9 Leishmania infantum 46% 100%
A4IC33 Leishmania infantum 45% 100%
C9ZIK0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
C9ZIK3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
C9ZVE8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
C9ZVE9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
C9ZVF1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
D0A423 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E8NHQ5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9AI40 Leishmania braziliensis 44% 100%
E9AJY4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E9AKQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9AL06 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
E9AN44 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 100%
E9AN45 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9AN46 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9AN47 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9ANE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E9AS42 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 100%
E9B741 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 97%
Q4QDC4 Leishmania major 46% 100%
Q4QH81 Leishmania major 45% 100%
Q4QHH7 Leishmania major 46% 100%
Q4QHH8 Leishmania major 44% 100%
Q4QHH9 Leishmania major 43% 100%
Q4QHI0 Leishmania major 44% 100%
Q4QHI1 Leishmania major 46% 100%
Q4QHI2 Leishmania major 42% 100%
Q4QIU9 Leishmania major 93% 100%
Q4QJ48 Leishmania major 46% 100%
Q7KIP2 Leishmania major 43% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS