Leucine Rich repeat-containing domain protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine rich repeat/Leucine Rich Repeat - putative

Species:

Leishmania infantum

UniProt:

E9AG69_LEIIN

TriTrypDb:

LINF_060015500

Length:

1029

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

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Expansion

Sequence features

E9AG69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG69

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	622	626	PF00656	0.623
CLV_C14_Caspase3-7	657	661	PF00656	0.716
CLV_MEL_PAP_1	333	339	PF00089	0.626
CLV_NRD_NRD_1	1015	1017	PF00675	0.663
CLV_NRD_NRD_1	473	475	PF00675	0.612
CLV_NRD_NRD_1	628	630	PF00675	0.591
CLV_NRD_NRD_1	853	855	PF00675	0.771
CLV_PCSK_FUR_1	187	191	PF00082	0.619
CLV_PCSK_KEX2_1	1015	1017	PF00082	0.676
CLV_PCSK_KEX2_1	189	191	PF00082	0.623

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY3	Leptomonas seymouri	69%	97%
A0A0S4JW61	Bodo saltans	26%	100%
A0A3S7WPK9	Leishmania donovani	99%	100%
A0A422NZ80	Trypanosoma rangeli	41%	100%
A4H4R1	Leishmania braziliensis	80%	100%
C9ZTM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AKX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QIX9	Leishmania major	94%	100%
V5BNJ3	Trypanosoma cruzi	40%	100%

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