Leucine Rich repeat-containing domain protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine rich repeat/Leucine Rich Repeat - putative

Species:

Leishmania infantum

UniProt:

E9AG69_LEIIN

TriTrypDb:

LINF_060015500

Length:

1029

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AG69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG69

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	622	626	PF00656	0.623
CLV_C14_Caspase3-7	657	661	PF00656	0.716
CLV_MEL_PAP_1	333	339	PF00089	0.626
CLV_NRD_NRD_1	1015	1017	PF00675	0.663
CLV_NRD_NRD_1	473	475	PF00675	0.612
CLV_NRD_NRD_1	628	630	PF00675	0.591
CLV_NRD_NRD_1	853	855	PF00675	0.771
CLV_PCSK_FUR_1	187	191	PF00082	0.619
CLV_PCSK_KEX2_1	1015	1017	PF00082	0.676
CLV_PCSK_KEX2_1	189	191	PF00082	0.623
CLV_PCSK_KEX2_1	211	213	PF00082	0.586
CLV_PCSK_KEX2_1	286	288	PF00082	0.768
CLV_PCSK_KEX2_1	358	360	PF00082	0.545
CLV_PCSK_KEX2_1	473	475	PF00082	0.621
CLV_PCSK_KEX2_1	628	630	PF00082	0.611
CLV_PCSK_KEX2_1	652	654	PF00082	0.578
CLV_PCSK_KEX2_1	853	855	PF00082	0.792
CLV_PCSK_KEX2_1	867	869	PF00082	0.721
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.623
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.596
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.768
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.545
CLV_PCSK_PC1ET2_1	652	654	PF00082	0.617
CLV_PCSK_PC1ET2_1	867	869	PF00082	0.831
CLV_PCSK_SKI1_1	1015	1019	PF00082	0.663
CLV_PCSK_SKI1_1	145	149	PF00082	0.557
CLV_PCSK_SKI1_1	189	193	PF00082	0.419
CLV_PCSK_SKI1_1	283	287	PF00082	0.724
CLV_PCSK_SKI1_1	474	478	PF00082	0.558
CLV_PCSK_SKI1_1	513	517	PF00082	0.564
CLV_PCSK_SKI1_1	520	524	PF00082	0.508
CLV_PCSK_SKI1_1	525	529	PF00082	0.578
CLV_PCSK_SKI1_1	548	552	PF00082	0.445
CLV_PCSK_SKI1_1	553	557	PF00082	0.432
CLV_PCSK_SKI1_1	607	611	PF00082	0.551
CLV_PCSK_SKI1_1	71	75	PF00082	0.637
CLV_PCSK_SKI1_1	737	741	PF00082	0.591
CLV_PCSK_SKI1_1	755	759	PF00082	0.475
CLV_PCSK_SKI1_1	867	871	PF00082	0.849
CLV_PCSK_SKI1_1	943	947	PF00082	0.563
DEG_APCC_DBOX_1	211	219	PF00400	0.588
DEG_APCC_DBOX_1	852	860	PF00400	0.774
DEG_SPOP_SBC_1	27	31	PF00917	0.783
DOC_AGCK_PIF_3	1026	1029	PF00069	0.762
DOC_CDC14_PxL_1	113	121	PF14671	0.522
DOC_CDC14_PxL_1	135	143	PF14671	0.578
DOC_CDC14_PxL_1	428	436	PF14671	0.341
DOC_CDC14_PxL_1	527	535	PF14671	0.615
DOC_CYCLIN_RxL_1	137	148	PF00134	0.602
DOC_CYCLIN_RxL_1	259	268	PF00134	0.557
DOC_CYCLIN_RxL_1	471	480	PF00134	0.571
DOC_CYCLIN_RxL_1	82	94	PF00134	0.536
DOC_MAPK_FxFP_2	521	524	PF00069	0.572
DOC_MAPK_gen_1	105	114	PF00069	0.483
DOC_MAPK_gen_1	187	196	PF00069	0.583
DOC_MAPK_gen_1	211	220	PF00069	0.584
DOC_MAPK_gen_1	262	269	PF00069	0.513
DOC_MAPK_gen_1	452	459	PF00069	0.617
DOC_MAPK_gen_1	463	472	PF00069	0.504
DOC_MAPK_gen_1	628	635	PF00069	0.557
DOC_MAPK_MEF2A_6	105	114	PF00069	0.522
DOC_MAPK_MEF2A_6	452	459	PF00069	0.617
DOC_PP1_RVXF_1	1013	1020	PF00149	0.670
DOC_PP1_RVXF_1	260	267	PF00149	0.571
DOC_PP1_RVXF_1	433	440	PF00149	0.559
DOC_PP1_RVXF_1	551	558	PF00149	0.435
DOC_PP1_RVXF_1	638	645	PF00149	0.499
DOC_PP1_RVXF_1	753	760	PF00149	0.633
DOC_PP1_SILK_1	920	925	PF00149	0.655
DOC_PP2B_LxvP_1	251	254	PF13499	0.580
DOC_PP2B_LxvP_1	788	791	PF13499	0.790
DOC_PP2B_PxIxI_1	175	181	PF00149	0.560
DOC_PP2B_PxIxI_1	880	886	PF00149	0.627
DOC_PP4_FxxP_1	227	230	PF00568	0.515
DOC_PP4_FxxP_1	521	524	PF00568	0.572
DOC_USP7_MATH_1	128	132	PF00917	0.597
DOC_USP7_MATH_1	27	31	PF00917	0.783
DOC_USP7_MATH_1	332	336	PF00917	0.804
DOC_USP7_MATH_1	418	422	PF00917	0.687
DOC_USP7_MATH_1	712	716	PF00917	0.614
DOC_USP7_MATH_1	837	841	PF00917	0.872
DOC_USP7_MATH_1	852	856	PF00917	0.731
DOC_USP7_MATH_1	862	866	PF00917	0.678
DOC_USP7_MATH_1	937	941	PF00917	0.721
DOC_USP7_MATH_1	977	981	PF00917	0.817
DOC_USP7_MATH_1	991	995	PF00917	0.727
DOC_USP7_MATH_1	998	1002	PF00917	0.751
DOC_USP7_UBL2_3	189	193	PF12436	0.516
DOC_USP7_UBL2_3	372	376	PF12436	0.557
DOC_USP7_UBL2_3	815	819	PF12436	0.862
DOC_WW_Pin1_4	28	33	PF00397	0.782
DOC_WW_Pin1_4	446	451	PF00397	0.668
LIG_14-3-3_CanoR_1	1015	1020	PF00244	0.708
LIG_14-3-3_CanoR_1	121	127	PF00244	0.515
LIG_14-3-3_CanoR_1	140	145	PF00244	0.286
LIG_14-3-3_CanoR_1	212	220	PF00244	0.496
LIG_14-3-3_CanoR_1	336	340	PF00244	0.772
LIG_14-3-3_CanoR_1	359	363	PF00244	0.510
LIG_14-3-3_CanoR_1	463	468	PF00244	0.593
LIG_14-3-3_CanoR_1	71	77	PF00244	0.483
LIG_14-3-3_CanoR_1	793	798	PF00244	0.715
LIG_14-3-3_CanoR_1	853	857	PF00244	0.774
LIG_14-3-3_CanoR_1	868	872	PF00244	0.794
LIG_14-3-3_CanoR_1	893	900	PF00244	0.608
LIG_APCC_ABBA_1	931	936	PF00400	0.670
LIG_BRCT_BRCA1_1	30	34	PF00533	0.802
LIG_Clathr_ClatBox_1	905	909	PF01394	0.629
LIG_deltaCOP1_diTrp_1	641	650	PF00928	0.485
LIG_deltaCOP1_diTrp_1	743	753	PF00928	0.643
LIG_DLG_GKlike_1	140	147	PF00625	0.573
LIG_eIF4E_1	900	906	PF01652	0.652
LIG_FHA_1	274	280	PF00498	0.509
LIG_FHA_1	332	338	PF00498	0.759
LIG_FHA_1	350	356	PF00498	0.607
LIG_FHA_1	404	410	PF00498	0.592
LIG_FHA_1	476	482	PF00498	0.621
LIG_FHA_1	675	681	PF00498	0.625
LIG_FHA_1	684	690	PF00498	0.582
LIG_FHA_1	772	778	PF00498	0.684
LIG_FHA_1	793	799	PF00498	0.805
LIG_FHA_1	880	886	PF00498	0.631
LIG_FHA_1	892	898	PF00498	0.574
LIG_FHA_2	146	152	PF00498	0.590
LIG_FHA_2	214	220	PF00498	0.545
LIG_FHA_2	224	230	PF00498	0.536
LIG_FHA_2	464	470	PF00498	0.600
LIG_FHA_2	514	520	PF00498	0.624
LIG_FHA_2	524	530	PF00498	0.542
LIG_FHA_2	590	596	PF00498	0.565
LIG_FHA_2	683	689	PF00498	0.681
LIG_IRF3_LxIS_1	215	221	PF10401	0.491
LIG_LIR_Apic_2	226	230	PF02991	0.518
LIG_LIR_Apic_2	519	524	PF02991	0.586
LIG_LIR_Gen_1	552	562	PF02991	0.491
LIG_LIR_Gen_1	690	699	PF02991	0.636
LIG_LIR_Gen_1	944	955	PF02991	0.741
LIG_LIR_Nem_3	1023	1029	PF02991	0.744
LIG_LIR_Nem_3	125	129	PF02991	0.501
LIG_LIR_Nem_3	424	428	PF02991	0.543
LIG_LIR_Nem_3	490	496	PF02991	0.578
LIG_LIR_Nem_3	552	557	PF02991	0.455
LIG_LIR_Nem_3	603	609	PF02991	0.631
LIG_LIR_Nem_3	641	647	PF02991	0.486
LIG_LIR_Nem_3	750	756	PF02991	0.577
LIG_LIR_Nem_3	944	950	PF02991	0.690
LIG_Pex14_1	930	934	PF04695	0.614
LIG_PTB_Apo_2	804	811	PF02174	0.809
LIG_REV1ctd_RIR_1	230	237	PF16727	0.601
LIG_SH2_CRK	565	569	PF00017	0.581
LIG_SH2_CRK	580	584	PF00017	0.490
LIG_SH2_CRK	920	924	PF00017	0.696
LIG_SH2_CRK	990	994	PF00017	0.617
LIG_SH2_NCK_1	934	938	PF00017	0.716
LIG_SH2_SRC	934	937	PF00017	0.729
LIG_SH2_SRC	990	993	PF00017	0.629
LIG_SH2_STAP1	565	569	PF00017	0.619
LIG_SH2_STAP1	934	938	PF00017	0.684
LIG_SH2_STAT3	949	952	PF00017	0.688
LIG_SH2_STAT5	373	376	PF00017	0.525
LIG_SH2_STAT5	493	496	PF00017	0.602
LIG_SH2_STAT5	554	557	PF00017	0.421
LIG_SH2_STAT5	756	759	PF00017	0.553
LIG_SH2_STAT5	776	779	PF00017	0.453
LIG_SH2_STAT5	816	819	PF00017	0.744
LIG_SH2_STAT5	938	941	PF00017	0.621
LIG_SH2_STAT5	949	952	PF00017	0.640
LIG_SH2_STAT5	992	995	PF00017	0.675
LIG_SH3_3	111	117	PF00018	0.495
LIG_SH3_3	348	354	PF00018	0.633
LIG_SH3_3	407	413	PF00018	0.534
LIG_SH3_3	52	58	PF00018	0.635
LIG_SH3_3	565	571	PF00018	0.516
LIG_SH3_3	774	780	PF00018	0.696
LIG_SH3_3	952	958	PF00018	0.744
LIG_SUMO_SIM_anti_2	275	281	PF11976	0.504
LIG_SUMO_SIM_anti_2	52	57	PF11976	0.628
LIG_SUMO_SIM_anti_2	574	579	PF11976	0.544
LIG_SUMO_SIM_anti_2	909	915	PF11976	0.686
LIG_SUMO_SIM_par_1	140	146	PF11976	0.529
LIG_TRAF2_1	309	312	PF00917	0.845
LIG_TRAF2_1	782	785	PF00917	0.818
LIG_TYR_ITIM	578	583	PF00017	0.562
LIG_WRC_WIRS_1	606	611	PF05994	0.594
MOD_CDC14_SPxK_1	449	452	PF00782	0.686
MOD_CDK_SPxK_1	446	452	PF00069	0.692
MOD_CK1_1	1021	1027	PF00069	0.737
MOD_CK1_1	143	149	PF00069	0.536
MOD_CK1_1	293	299	PF00069	0.773
MOD_CK1_1	331	337	PF00069	0.727
MOD_CK1_1	340	346	PF00069	0.717
MOD_CK1_1	349	355	PF00069	0.524
MOD_CK1_1	400	406	PF00069	0.561
MOD_CK1_1	6	12	PF00069	0.735
MOD_CK1_1	695	701	PF00069	0.628
MOD_CK1_1	715	721	PF00069	0.578
MOD_CK1_1	855	861	PF00069	0.763
MOD_CK1_1	980	986	PF00069	0.642
MOD_CK2_1	150	156	PF00069	0.603
MOD_CK2_1	237	243	PF00069	0.486
MOD_CK2_1	383	389	PF00069	0.533
MOD_CK2_1	418	424	PF00069	0.713
MOD_CK2_1	463	469	PF00069	0.603
MOD_CK2_1	496	502	PF00069	0.627
MOD_CK2_1	513	519	PF00069	0.402
MOD_CK2_1	523	529	PF00069	0.609
MOD_CK2_1	589	595	PF00069	0.599
MOD_CK2_1	682	688	PF00069	0.688
MOD_CMANNOS	439	442	PF00535	0.548
MOD_Cter_Amidation	1013	1016	PF01082	0.727
MOD_GlcNHglycan	10	13	PF01048	0.765
MOD_GlcNHglycan	1020	1023	PF01048	0.672
MOD_GlcNHglycan	219	223	PF01048	0.563
MOD_GlcNHglycan	325	328	PF01048	0.791
MOD_GlcNHglycan	330	333	PF01048	0.755
MOD_GlcNHglycan	35	38	PF01048	0.758
MOD_GlcNHglycan	42	45	PF01048	0.663
MOD_GlcNHglycan	47	51	PF01048	0.559
MOD_GlcNHglycan	636	639	PF01048	0.611
MOD_GlcNHglycan	656	659	PF01048	0.686
MOD_GlcNHglycan	667	670	PF01048	0.694
MOD_GlcNHglycan	700	703	PF01048	0.609
MOD_GlcNHglycan	838	842	PF01048	0.858
MOD_GlcNHglycan	848	851	PF01048	0.823
MOD_GlcNHglycan	972	976	PF01048	0.809
MOD_GlcNHglycan	979	982	PF01048	0.819
MOD_GSK3_1	12	19	PF00069	0.774
MOD_GSK3_1	214	221	PF00069	0.465
MOD_GSK3_1	233	240	PF00069	0.520
MOD_GSK3_1	299	306	PF00069	0.836
MOD_GSK3_1	319	326	PF00069	0.756
MOD_GSK3_1	328	335	PF00069	0.698
MOD_GSK3_1	4	11	PF00069	0.791
MOD_GSK3_1	446	453	PF00069	0.647
MOD_GSK3_1	665	672	PF00069	0.718
MOD_GSK3_1	683	690	PF00069	0.550
MOD_GSK3_1	711	718	PF00069	0.583
MOD_GSK3_1	72	79	PF00069	0.513
MOD_GSK3_1	842	849	PF00069	0.780
MOD_GSK3_1	973	980	PF00069	0.829
MOD_N-GLC_1	122	127	PF02516	0.430
MOD_N-GLC_1	249	254	PF02516	0.583
MOD_N-GLC_1	293	298	PF02516	0.760
MOD_N-GLC_1	394	399	PF02516	0.564
MOD_N-GLC_1	4	9	PF02516	0.820
MOD_N-GLC_1	446	451	PF02516	0.653
MOD_N-GLC_1	806	811	PF02516	0.695
MOD_N-GLC_2	736	738	PF02516	0.643
MOD_NEK2_1	10	15	PF00069	0.805
MOD_NEK2_1	213	218	PF00069	0.555
MOD_NEK2_1	233	238	PF00069	0.398
MOD_NEK2_1	249	254	PF00069	0.528
MOD_NEK2_1	634	639	PF00069	0.548
MOD_NEK2_1	654	659	PF00069	0.640
MOD_NEK2_1	69	74	PF00069	0.683
MOD_NEK2_1	725	730	PF00069	0.539
MOD_NEK2_1	76	81	PF00069	0.522
MOD_NEK2_1	945	950	PF00069	0.742
MOD_NEK2_2	128	133	PF00069	0.559
MOD_NEK2_2	394	399	PF00069	0.588
MOD_NEK2_2	581	586	PF00069	0.542
MOD_NMyristoyl	1	7	PF02799	0.751
MOD_PIKK_1	349	355	PF00454	0.646
MOD_PIKK_1	416	422	PF00454	0.720
MOD_PIKK_1	687	693	PF00454	0.634
MOD_PKA_1	1015	1021	PF00069	0.630
MOD_PKA_1	358	364	PF00069	0.531
MOD_PKA_1	867	873	PF00069	0.757
MOD_PKA_2	1015	1021	PF00069	0.615
MOD_PKA_2	213	219	PF00069	0.532
MOD_PKA_2	335	341	PF00069	0.772
MOD_PKA_2	358	364	PF00069	0.535
MOD_PKA_2	654	660	PF00069	0.697
MOD_PKA_2	76	82	PF00069	0.526
MOD_PKA_2	792	798	PF00069	0.732
MOD_PKA_2	852	858	PF00069	0.770
MOD_PKA_2	867	873	PF00069	0.775
MOD_PKA_2	892	898	PF00069	0.605
MOD_PKB_1	212	220	PF00069	0.569
MOD_Plk_1	122	128	PF00069	0.453
MOD_Plk_1	150	156	PF00069	0.508
MOD_Plk_1	394	400	PF00069	0.558
MOD_Plk_1	496	502	PF00069	0.640
MOD_Plk_1	669	675	PF00069	0.645
MOD_Plk_1	742	748	PF00069	0.599
MOD_Plk_1	806	812	PF00069	0.696
MOD_Plk_2-3	619	625	PF00069	0.633
MOD_Plk_4	237	243	PF00069	0.500
MOD_Plk_4	394	400	PF00069	0.569
MOD_Plk_4	481	487	PF00069	0.585
MOD_Plk_4	619	625	PF00069	0.605
MOD_Plk_4	692	698	PF00069	0.591
MOD_Plk_4	742	748	PF00069	0.646
MOD_Plk_4	758	764	PF00069	0.500
MOD_Plk_4	793	799	PF00069	0.724
MOD_Plk_4	867	873	PF00069	0.827
MOD_Plk_4	901	907	PF00069	0.698
MOD_ProDKin_1	28	34	PF00069	0.783
MOD_ProDKin_1	446	452	PF00069	0.662
MOD_SPalmitoyl_4	1	7	PF01529	0.783
MOD_SUMO_rev_2	171	181	PF00179	0.589
MOD_SUMO_rev_2	935	945	PF00179	0.722
TRG_DiLeu_BaEn_1	784	789	PF01217	0.829
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.611
TRG_DiLeu_BaLyEn_6	676	681	PF01217	0.648
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.555
TRG_ENDOCYTIC_2	493	496	PF00928	0.594
TRG_ENDOCYTIC_2	554	557	PF00928	0.434
TRG_ENDOCYTIC_2	565	568	PF00928	0.561
TRG_ENDOCYTIC_2	580	583	PF00928	0.394
TRG_ENDOCYTIC_2	606	609	PF00928	0.527
TRG_ENDOCYTIC_2	756	759	PF00928	0.542
TRG_ENDOCYTIC_2	802	805	PF00928	0.713
TRG_ENDOCYTIC_2	900	903	PF00928	0.594
TRG_ENDOCYTIC_2	920	923	PF00928	0.686
TRG_ENDOCYTIC_2	990	993	PF00928	0.629
TRG_ER_diArg_1	1015	1017	PF00400	0.704
TRG_ER_diArg_1	212	215	PF00400	0.595
TRG_ER_diArg_1	462	465	PF00400	0.623
TRG_ER_diArg_1	472	474	PF00400	0.514
TRG_ER_diArg_1	628	630	PF00400	0.623
TRG_NLS_MonoExtC_3	188	193	PF00514	0.449
TRG_NLS_MonoExtN_4	187	193	PF00514	0.455
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	97	102	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY3	Leptomonas seymouri	69%	97%
A0A0S4JW61	Bodo saltans	26%	100%
A0A3S7WPK9	Leishmania donovani	99%	100%
A0A422NZ80	Trypanosoma rangeli	41%	100%
A4H4R1	Leishmania braziliensis	80%	100%
C9ZTM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AKX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QIX9	Leishmania major	94%	100%
V5BNJ3	Trypanosoma cruzi	40%	100%