Basic immunoglobulin-like variable motif-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AG67_LEIIN

TriTrypDb:

LINF_060011000

Length:

976

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AG67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG67

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.651
CLV_C14_Caspase3-7	283	287	PF00656	0.723
CLV_C14_Caspase3-7	727	731	PF00656	0.617
CLV_C14_Caspase3-7	736	740	PF00656	0.606
CLV_C14_Caspase3-7	866	870	PF00656	0.604
CLV_NRD_NRD_1	105	107	PF00675	0.531
CLV_NRD_NRD_1	24	26	PF00675	0.507
CLV_NRD_NRD_1	332	334	PF00675	0.766
CLV_NRD_NRD_1	51	53	PF00675	0.520
CLV_NRD_NRD_1	609	611	PF00675	0.571
CLV_NRD_NRD_1	638	640	PF00675	0.630
CLV_NRD_NRD_1	91	93	PF00675	0.514
CLV_PCSK_FUR_1	20	24	PF00082	0.526
CLV_PCSK_FUR_1	48	52	PF00082	0.505
CLV_PCSK_KEX2_1	105	107	PF00082	0.531
CLV_PCSK_KEX2_1	22	24	PF00082	0.517
CLV_PCSK_KEX2_1	48	50	PF00082	0.497
CLV_PCSK_KEX2_1	51	53	PF00082	0.517
CLV_PCSK_KEX2_1	638	640	PF00082	0.630
CLV_PCSK_KEX2_1	78	80	PF00082	0.511
CLV_PCSK_KEX2_1	91	93	PF00082	0.503
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.517
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.511
CLV_PCSK_PC7_1	18	24	PF00082	0.534
CLV_PCSK_PC7_1	87	93	PF00082	0.508
CLV_PCSK_SKI1_1	275	279	PF00082	0.676
CLV_PCSK_SKI1_1	33	37	PF00082	0.470
CLV_PCSK_SKI1_1	333	337	PF00082	0.671
CLV_PCSK_SKI1_1	408	412	PF00082	0.563
CLV_PCSK_SKI1_1	426	430	PF00082	0.388
CLV_PCSK_SKI1_1	52	56	PF00082	0.514
CLV_PCSK_SKI1_1	546	550	PF00082	0.552
CLV_PCSK_SKI1_1	788	792	PF00082	0.678
DEG_SCF_FBW7_1	212	219	PF00400	0.678
DEG_SPOP_SBC_1	742	746	PF00917	0.634
DEG_SPOP_SBC_1	878	882	PF00917	0.785
DOC_CYCLIN_RxL_1	338	352	PF00134	0.477
DOC_CYCLIN_RxL_1	955	966	PF00134	0.678
DOC_CYCLIN_yCln2_LP_2	41	47	PF00134	0.482
DOC_CYCLIN_yCln2_LP_2	772	778	PF00134	0.778
DOC_MAPK_HePTP_8	806	818	PF00069	0.596
DOC_MAPK_MEF2A_6	809	818	PF00069	0.591
DOC_MAPK_MEF2A_6	95	104	PF00069	0.517
DOC_PP2B_LxvP_1	193	196	PF13499	0.646
DOC_PP2B_LxvP_1	41	44	PF13499	0.479
DOC_PP2B_LxvP_1	429	432	PF13499	0.541
DOC_PP2B_LxvP_1	59	62	PF13499	0.480
DOC_PP2B_LxvP_1	960	963	PF13499	0.602
DOC_PP4_FxxP_1	484	487	PF00568	0.650
DOC_PP4_FxxP_1	580	583	PF00568	0.603
DOC_PP4_FxxP_1	795	798	PF00568	0.701
DOC_USP7_MATH_1	130	134	PF00917	0.601
DOC_USP7_MATH_1	216	220	PF00917	0.708
DOC_USP7_MATH_1	227	231	PF00917	0.626
DOC_USP7_MATH_1	264	268	PF00917	0.681
DOC_USP7_MATH_1	282	286	PF00917	0.593
DOC_USP7_MATH_1	390	394	PF00917	0.655
DOC_USP7_MATH_1	525	529	PF00917	0.485
DOC_USP7_MATH_1	705	709	PF00917	0.629
DOC_USP7_MATH_1	741	745	PF00917	0.715
DOC_USP7_MATH_1	759	763	PF00917	0.592
DOC_USP7_MATH_1	783	787	PF00917	0.714
DOC_USP7_MATH_1	796	800	PF00917	0.589
DOC_USP7_MATH_1	840	844	PF00917	0.720
DOC_USP7_MATH_1	860	864	PF00917	0.532
DOC_USP7_MATH_1	867	871	PF00917	0.690
DOC_USP7_MATH_1	878	882	PF00917	0.571
DOC_USP7_MATH_1	904	908	PF00917	0.766
DOC_USP7_MATH_1	913	917	PF00917	0.649
DOC_USP7_MATH_1	956	960	PF00917	0.677
DOC_USP7_UBL2_3	334	338	PF12436	0.665
DOC_USP7_UBL2_3	643	647	PF12436	0.736
DOC_WW_Pin1_4	12	17	PF00397	0.528
DOC_WW_Pin1_4	158	163	PF00397	0.656
DOC_WW_Pin1_4	199	204	PF00397	0.657
DOC_WW_Pin1_4	212	217	PF00397	0.577
DOC_WW_Pin1_4	300	305	PF00397	0.683
DOC_WW_Pin1_4	388	393	PF00397	0.701
DOC_WW_Pin1_4	620	625	PF00397	0.564
DOC_WW_Pin1_4	695	700	PF00397	0.608
DOC_WW_Pin1_4	70	75	PF00397	0.530
DOC_WW_Pin1_4	757	762	PF00397	0.766
DOC_WW_Pin1_4	765	770	PF00397	0.677
DOC_WW_Pin1_4	777	782	PF00397	0.599
DOC_WW_Pin1_4	835	840	PF00397	0.718
DOC_WW_Pin1_4	872	877	PF00397	0.740
DOC_WW_Pin1_4	879	884	PF00397	0.723
DOC_WW_Pin1_4	900	905	PF00397	0.711
DOC_WW_Pin1_4	909	914	PF00397	0.733
LIG_14-3-3_CanoR_1	217	226	PF00244	0.597
LIG_14-3-3_CanoR_1	268	276	PF00244	0.671
LIG_14-3-3_CanoR_1	470	479	PF00244	0.506
LIG_14-3-3_CanoR_1	52	62	PF00244	0.514
LIG_14-3-3_CanoR_1	610	619	PF00244	0.571
LIG_14-3-3_CanoR_1	743	753	PF00244	0.726
LIG_14-3-3_CanoR_1	79	85	PF00244	0.508
LIG_14-3-3_CanoR_1	842	847	PF00244	0.706
LIG_14-3-3_CanoR_1	958	963	PF00244	0.775
LIG_APCC_ABBA_1	934	939	PF00400	0.517
LIG_BIR_III_2	261	265	PF00653	0.697
LIG_BIR_III_4	850	854	PF00653	0.662
LIG_BRCT_BRCA1_1	174	178	PF00533	0.566
LIG_BRCT_BRCA1_1	218	222	PF00533	0.606
LIG_BRCT_BRCA1_1	622	626	PF00533	0.569
LIG_deltaCOP1_diTrp_1	490	496	PF00928	0.566
LIG_FHA_1	145	151	PF00498	0.633
LIG_FHA_1	207	213	PF00498	0.733
LIG_FHA_1	218	224	PF00498	0.647
LIG_FHA_1	245	251	PF00498	0.575
LIG_FHA_1	380	386	PF00498	0.687
LIG_FHA_1	401	407	PF00498	0.598
LIG_FHA_1	529	535	PF00498	0.556
LIG_FHA_1	537	543	PF00498	0.442
LIG_FHA_1	576	582	PF00498	0.582
LIG_FHA_1	591	597	PF00498	0.449
LIG_FHA_1	758	764	PF00498	0.734
LIG_FHA_1	785	791	PF00498	0.690
LIG_FHA_1	863	869	PF00498	0.630
LIG_FHA_2	111	117	PF00498	0.585
LIG_FHA_2	334	340	PF00498	0.658
LIG_FHA_2	417	423	PF00498	0.577
LIG_FHA_2	743	749	PF00498	0.777
LIG_LIR_Apic_2	578	583	PF02991	0.594
LIG_LIR_Apic_2	794	798	PF02991	0.699
LIG_LIR_Gen_1	452	461	PF02991	0.562
LIG_LIR_Nem_3	452	457	PF02991	0.549
LIG_LIR_Nem_3	485	491	PF02991	0.603
LIG_LIR_Nem_3	623	629	PF02991	0.548
LIG_MLH1_MIPbox_1	622	626	PF16413	0.569
LIG_PALB2_WD40_1	501	509	PF16756	0.489
LIG_PCNA_yPIPBox_3	499	511	PF02747	0.497
LIG_PDZ_Class_3	971	976	PF00595	0.692
LIG_Pex14_1	320	324	PF04695	0.717
LIG_Pex14_2	484	488	PF04695	0.544
LIG_Pex14_2	89	93	PF04695	0.510
LIG_PTB_Apo_2	452	459	PF02174	0.471
LIG_PTB_Phospho_1	452	458	PF10480	0.471
LIG_Rb_LxCxE_1	826	845	PF01857	0.576
LIG_REV1ctd_RIR_1	624	631	PF16727	0.545
LIG_SH2_CRK	454	458	PF00017	0.471
LIG_SH2_CRK	564	568	PF00017	0.477
LIG_SH2_GRB2like	535	538	PF00017	0.495
LIG_SH2_NCK_1	941	945	PF00017	0.648
LIG_SH2_SRC	242	245	PF00017	0.683
LIG_SH2_SRC	456	459	PF00017	0.471
LIG_SH2_SRC	570	573	PF00017	0.509
LIG_SH2_SRC	941	944	PF00017	0.634
LIG_SH2_STAP1	608	612	PF00017	0.544
LIG_SH2_STAP1	703	707	PF00017	0.692
LIG_SH2_STAP1	85	89	PF00017	0.508
LIG_SH2_STAT5	236	239	PF00017	0.701
LIG_SH2_STAT5	456	459	PF00017	0.476
LIG_SH2_STAT5	520	523	PF00017	0.596
LIG_SH2_STAT5	85	88	PF00017	0.507
LIG_SH3_1	95	101	PF00018	0.510
LIG_SH3_2	100	105	PF14604	0.525
LIG_SH3_2	44	49	PF14604	0.486
LIG_SH3_3	184	190	PF00018	0.590
LIG_SH3_3	197	203	PF00018	0.614
LIG_SH3_3	221	227	PF00018	0.689
LIG_SH3_3	234	240	PF00018	0.605
LIG_SH3_3	323	329	PF00018	0.610
LIG_SH3_3	389	395	PF00018	0.657
LIG_SH3_3	41	47	PF00018	0.482
LIG_SH3_3	580	586	PF00018	0.490
LIG_SH3_3	676	682	PF00018	0.689
LIG_SH3_3	758	764	PF00018	0.763
LIG_SH3_3	787	793	PF00018	0.676
LIG_SH3_3	849	855	PF00018	0.627
LIG_SH3_3	868	874	PF00018	0.644
LIG_SH3_3	95	101	PF00018	0.510
LIG_Sin3_3	844	851	PF02671	0.587
LIG_SUMO_SIM_anti_2	145	152	PF11976	0.646
LIG_SUMO_SIM_par_1	402	407	PF11976	0.545
LIG_TRAF2_1	162	165	PF00917	0.703
LIG_TRAF2_1	474	477	PF00917	0.542
LIG_TRAF2_1	672	675	PF00917	0.588
LIG_TYR_ITIM	568	573	PF00017	0.498
LIG_WRC_WIRS_1	861	866	PF05994	0.629
LIG_WW_2	100	103	PF00397	0.515
MOD_CDC14_SPxK_1	912	915	PF00782	0.715
MOD_CDK_SPK_2	212	217	PF00069	0.601
MOD_CDK_SPK_2	300	305	PF00069	0.683
MOD_CDK_SPK_2	879	884	PF00069	0.727
MOD_CDK_SPxK_1	12	18	PF00069	0.532
MOD_CDK_SPxK_1	909	915	PF00069	0.718
MOD_CDK_SPxxK_3	835	842	PF00069	0.655
MOD_CDK_SPxxK_3	879	886	PF00069	0.727
MOD_CK1_1	110	116	PF00069	0.630
MOD_CK1_1	206	212	PF00069	0.720
MOD_CK1_1	267	273	PF00069	0.697
MOD_CK1_1	388	394	PF00069	0.708
MOD_CK1_1	449	455	PF00069	0.471
MOD_CK1_1	528	534	PF00069	0.566
MOD_CK1_1	720	726	PF00069	0.743
MOD_CK1_1	744	750	PF00069	0.744
MOD_CK1_1	762	768	PF00069	0.586
MOD_CK1_1	777	783	PF00069	0.572
MOD_CK1_1	799	805	PF00069	0.658
MOD_CK1_1	807	813	PF00069	0.667
MOD_CK1_1	903	909	PF00069	0.679
MOD_CK1_1	961	967	PF00069	0.758
MOD_CK1_1	968	974	PF00069	0.673
MOD_CK2_1	110	116	PF00069	0.588
MOD_CK2_1	130	136	PF00069	0.629
MOD_CK2_1	267	273	PF00069	0.735
MOD_CK2_1	333	339	PF00069	0.713
MOD_CK2_1	471	477	PF00069	0.513
MOD_CK2_1	642	648	PF00069	0.637
MOD_CK2_1	860	866	PF00069	0.757
MOD_CK2_1	867	873	PF00069	0.674
MOD_Cter_Amidation	20	23	PF01082	0.530
MOD_Cter_Amidation	89	92	PF01082	0.509
MOD_GlcNHglycan	205	208	PF01048	0.694
MOD_GlcNHglycan	229	232	PF01048	0.683
MOD_GlcNHglycan	253	256	PF01048	0.748
MOD_GlcNHglycan	270	273	PF01048	0.590
MOD_GlcNHglycan	354	357	PF01048	0.603
MOD_GlcNHglycan	387	390	PF01048	0.813
MOD_GlcNHglycan	463	466	PF01048	0.544
MOD_GlcNHglycan	527	530	PF01048	0.578
MOD_GlcNHglycan	6	9	PF01048	0.517
MOD_GlcNHglycan	699	702	PF01048	0.735
MOD_GlcNHglycan	703	706	PF01048	0.724
MOD_GlcNHglycan	719	722	PF01048	0.572
MOD_GlcNHglycan	754	757	PF01048	0.660
MOD_GlcNHglycan	764	767	PF01048	0.680
MOD_GlcNHglycan	797	801	PF01048	0.685
MOD_GlcNHglycan	832	836	PF01048	0.715
MOD_GlcNHglycan	842	845	PF01048	0.679
MOD_GSK3_1	130	137	PF00069	0.672
MOD_GSK3_1	199	206	PF00069	0.631
MOD_GSK3_1	212	219	PF00069	0.625
MOD_GSK3_1	264	271	PF00069	0.828
MOD_GSK3_1	329	336	PF00069	0.755
MOD_GSK3_1	352	359	PF00069	0.685
MOD_GSK3_1	372	379	PF00069	0.515
MOD_GSK3_1	384	391	PF00069	0.657
MOD_GSK3_1	411	418	PF00069	0.514
MOD_GSK3_1	494	501	PF00069	0.543
MOD_GSK3_1	585	592	PF00069	0.544
MOD_GSK3_1	61	68	PF00069	0.503
MOD_GSK3_1	659	666	PF00069	0.762
MOD_GSK3_1	697	704	PF00069	0.765
MOD_GSK3_1	742	749	PF00069	0.738
MOD_GSK3_1	831	838	PF00069	0.701
MOD_GSK3_1	842	849	PF00069	0.648
MOD_GSK3_1	900	907	PF00069	0.671
MOD_GSK3_1	909	916	PF00069	0.672
MOD_GSK3_1	958	965	PF00069	0.734
MOD_N-GLC_1	217	222	PF02516	0.750
MOD_N-GLC_1	498	503	PF02516	0.500
MOD_N-GLC_1	536	541	PF02516	0.552
MOD_N-GLC_1	66	71	PF02516	0.523
MOD_N-GLC_1	695	700	PF02516	0.658
MOD_N-GLC_1	966	971	PF02516	0.713
MOD_N-GLC_2	892	894	PF02516	0.663
MOD_NEK2_1	108	113	PF00069	0.633
MOD_NEK2_1	205	210	PF00069	0.653
MOD_NEK2_1	4	9	PF00069	0.516
MOD_NEK2_1	435	440	PF00069	0.465
MOD_NEK2_1	461	466	PF00069	0.629
MOD_NEK2_1	54	59	PF00069	0.521
MOD_NEK2_1	710	715	PF00069	0.657
MOD_NEK2_1	776	781	PF00069	0.677
MOD_NEK2_2	590	595	PF00069	0.532
MOD_NEK2_2	804	809	PF00069	0.680
MOD_PIKK_1	284	290	PF00454	0.780
MOD_PIKK_1	314	320	PF00454	0.721
MOD_PIKK_1	347	353	PF00454	0.604
MOD_PIKK_1	471	477	PF00454	0.551
MOD_PIKK_1	610	616	PF00454	0.532
MOD_PIKK_1	885	891	PF00454	0.711
MOD_PIKK_1	904	910	PF00454	0.549
MOD_PKA_1	24	30	PF00069	0.496
MOD_PKA_1	333	339	PF00069	0.732
MOD_PKA_1	610	616	PF00069	0.532
MOD_PKA_1	642	648	PF00069	0.654
MOD_PKA_1	91	97	PF00069	0.510
MOD_PKA_2	216	222	PF00069	0.603
MOD_PKA_2	24	30	PF00069	0.485
MOD_PKA_2	267	273	PF00069	0.672
MOD_PKA_2	339	345	PF00069	0.567
MOD_PKA_2	742	748	PF00069	0.712
MOD_PKA_2	80	86	PF00069	0.506
MOD_PKA_2	9	15	PF00069	0.522
MOD_PKA_2	91	97	PF00069	0.501
MOD_PKB_1	347	355	PF00069	0.677
MOD_Plk_1	144	150	PF00069	0.579
MOD_Plk_1	217	223	PF00069	0.668
MOD_Plk_1	498	504	PF00069	0.503
MOD_Plk_1	590	596	PF00069	0.530
MOD_Plk_1	66	72	PF00069	0.524
MOD_Plk_4	376	382	PF00069	0.647
MOD_Plk_4	449	455	PF00069	0.552
MOD_Plk_4	456	462	PF00069	0.487
MOD_Plk_4	477	483	PF00069	0.534
MOD_Plk_4	498	504	PF00069	0.503
MOD_Plk_4	590	596	PF00069	0.553
MOD_Plk_4	705	711	PF00069	0.751
MOD_Plk_4	80	86	PF00069	0.506
MOD_Plk_4	842	848	PF00069	0.593
MOD_ProDKin_1	12	18	PF00069	0.532
MOD_ProDKin_1	158	164	PF00069	0.657
MOD_ProDKin_1	199	205	PF00069	0.659
MOD_ProDKin_1	212	218	PF00069	0.577
MOD_ProDKin_1	300	306	PF00069	0.682
MOD_ProDKin_1	388	394	PF00069	0.699
MOD_ProDKin_1	620	626	PF00069	0.557
MOD_ProDKin_1	695	701	PF00069	0.605
MOD_ProDKin_1	70	76	PF00069	0.528
MOD_ProDKin_1	757	763	PF00069	0.766
MOD_ProDKin_1	765	771	PF00069	0.676
MOD_ProDKin_1	777	783	PF00069	0.599
MOD_ProDKin_1	835	841	PF00069	0.719
MOD_ProDKin_1	872	878	PF00069	0.741
MOD_ProDKin_1	879	885	PF00069	0.722
MOD_ProDKin_1	900	906	PF00069	0.711
MOD_ProDKin_1	909	915	PF00069	0.732
MOD_SUMO_for_1	808	811	PF00179	0.601
MOD_SUMO_rev_2	618	624	PF00179	0.541
MOD_SUMO_rev_2	674	679	PF00179	0.598
TRG_DiLeu_BaEn_3	476	482	PF01217	0.532
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.531
TRG_ENDOCYTIC_2	454	457	PF00928	0.471
TRG_ENDOCYTIC_2	458	461	PF00928	0.454
TRG_ENDOCYTIC_2	570	573	PF00928	0.509
TRG_ER_diArg_1	104	106	PF00400	0.538
TRG_ER_diArg_1	23	25	PF00400	0.518
TRG_ER_diArg_1	346	349	PF00400	0.670
TRG_ER_diArg_1	47	50	PF00400	0.495
TRG_ER_diArg_1	515	518	PF00400	0.517
TRG_ER_diArg_1	91	93	PF00400	0.514
TRG_NLS_MonoCore_2	21	26	PF00514	0.516
TRG_NLS_MonoExtN_4	20	26	PF00514	0.520
TRG_NLS_MonoExtN_4	639	646	PF00514	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPG2	Leishmania donovani	99%	100%
A4H4M0	Leishmania braziliensis	61%	100%
E9AKT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QJ24	Leishmania major	89%	100%