LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AG61_LEIIN
TriTrypDb:
LINF_040009650
Length:
1008

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AG61
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG61

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 1000 1004 PF00656 0.530
CLV_C14_Caspase3-7 259 263 PF00656 0.745
CLV_C14_Caspase3-7 406 410 PF00656 0.530
CLV_C14_Caspase3-7 809 813 PF00656 0.509
CLV_C14_Caspase3-7 946 950 PF00656 0.529
CLV_NRD_NRD_1 353 355 PF00675 0.547
CLV_NRD_NRD_1 705 707 PF00675 0.531
CLV_NRD_NRD_1 766 768 PF00675 0.633
CLV_NRD_NRD_1 824 826 PF00675 0.574
CLV_NRD_NRD_1 87 89 PF00675 0.652
CLV_NRD_NRD_1 875 877 PF00675 0.501
CLV_NRD_NRD_1 909 911 PF00675 0.646
CLV_PCSK_FUR_1 873 877 PF00082 0.498
CLV_PCSK_KEX2_1 207 209 PF00082 0.742
CLV_PCSK_KEX2_1 353 355 PF00082 0.547
CLV_PCSK_KEX2_1 705 707 PF00082 0.536
CLV_PCSK_KEX2_1 766 768 PF00082 0.676
CLV_PCSK_KEX2_1 87 89 PF00082 0.652
CLV_PCSK_KEX2_1 875 877 PF00082 0.501
CLV_PCSK_KEX2_1 900 902 PF00082 0.628
CLV_PCSK_KEX2_1 908 910 PF00082 0.626
CLV_PCSK_PC1ET2_1 207 209 PF00082 0.742
CLV_PCSK_PC1ET2_1 900 902 PF00082 0.603
CLV_PCSK_SKI1_1 186 190 PF00082 0.533
CLV_PCSK_SKI1_1 470 474 PF00082 0.302
CLV_PCSK_SKI1_1 633 637 PF00082 0.393
CLV_PCSK_SKI1_1 839 843 PF00082 0.645
CLV_PCSK_SKI1_1 861 865 PF00082 0.535
CLV_PCSK_SKI1_1 900 904 PF00082 0.633
CLV_PCSK_SKI1_1 954 958 PF00082 0.440
DEG_APCC_DBOX_1 185 193 PF00400 0.541
DEG_SCF_FBW7_1 754 759 PF00400 0.549
DEG_SPOP_SBC_1 153 157 PF00917 0.560
DEG_SPOP_SBC_1 379 383 PF00917 0.635
DEG_SPOP_SBC_1 400 404 PF00917 0.477
DEG_SPOP_SBC_1 785 789 PF00917 0.568
DOC_CDC14_PxL_1 450 458 PF14671 0.495
DOC_CKS1_1 102 107 PF01111 0.506
DOC_CKS1_1 233 238 PF01111 0.562
DOC_CKS1_1 641 646 PF01111 0.680
DOC_CKS1_1 753 758 PF01111 0.552
DOC_CKS1_1 814 819 PF01111 0.514
DOC_CYCLIN_RxL_1 858 868 PF00134 0.538
DOC_CYCLIN_RxL_1 951 958 PF00134 0.482
DOC_CYCLIN_yCln2_LP_2 63 69 PF00134 0.466
DOC_MAPK_gen_1 207 215 PF00069 0.589
DOC_MAPK_gen_1 353 360 PF00069 0.551
DOC_MAPK_gen_1 680 688 PF00069 0.474
DOC_MAPK_gen_1 87 95 PF00069 0.489
DOC_MAPK_gen_1 900 907 PF00069 0.609
DOC_MAPK_MEF2A_6 207 215 PF00069 0.555
DOC_MAPK_MEF2A_6 224 233 PF00069 0.565
DOC_MAPK_MEF2A_6 353 360 PF00069 0.589
DOC_MAPK_MEF2A_6 900 907 PF00069 0.609
DOC_MAPK_NFAT4_5 900 908 PF00069 0.614
DOC_PP4_FxxP_1 913 916 PF00568 0.562
DOC_USP7_MATH_1 111 115 PF00917 0.590
DOC_USP7_MATH_1 151 155 PF00917 0.552
DOC_USP7_MATH_1 199 203 PF00917 0.657
DOC_USP7_MATH_1 227 231 PF00917 0.622
DOC_USP7_MATH_1 270 274 PF00917 0.590
DOC_USP7_MATH_1 295 299 PF00917 0.623
DOC_USP7_MATH_1 310 314 PF00917 0.665
DOC_USP7_MATH_1 325 329 PF00917 0.593
DOC_USP7_MATH_1 380 384 PF00917 0.635
DOC_USP7_MATH_1 503 507 PF00917 0.429
DOC_USP7_MATH_1 669 673 PF00917 0.406
DOC_USP7_MATH_1 756 760 PF00917 0.548
DOC_USP7_MATH_1 815 819 PF00917 0.545
DOC_USP7_MATH_1 893 897 PF00917 0.769
DOC_USP7_MATH_1 960 964 PF00917 0.457
DOC_WW_Pin1_4 232 237 PF00397 0.576
DOC_WW_Pin1_4 250 255 PF00397 0.590
DOC_WW_Pin1_4 279 284 PF00397 0.625
DOC_WW_Pin1_4 358 363 PF00397 0.584
DOC_WW_Pin1_4 41 46 PF00397 0.490
DOC_WW_Pin1_4 455 460 PF00397 0.407
DOC_WW_Pin1_4 492 497 PF00397 0.589
DOC_WW_Pin1_4 599 604 PF00397 0.646
DOC_WW_Pin1_4 636 641 PF00397 0.567
DOC_WW_Pin1_4 752 757 PF00397 0.554
DOC_WW_Pin1_4 79 84 PF00397 0.488
DOC_WW_Pin1_4 813 818 PF00397 0.537
DOC_WW_Pin1_4 832 837 PF00397 0.567
DOC_WW_Pin1_4 844 849 PF00397 0.500
DOC_WW_Pin1_4 914 919 PF00397 0.632
DOC_WW_Pin1_4 967 972 PF00397 0.518
DOC_WW_Pin1_4 97 102 PF00397 0.591
LIG_14-3-3_CanoR_1 338 347 PF00244 0.613
LIG_14-3-3_CanoR_1 514 523 PF00244 0.307
LIG_14-3-3_CanoR_1 619 628 PF00244 0.619
LIG_14-3-3_CanoR_1 743 748 PF00244 0.720
LIG_14-3-3_CanoR_1 793 803 PF00244 0.609
LIG_14-3-3_CanoR_1 806 814 PF00244 0.472
LIG_14-3-3_CanoR_1 908 914 PF00244 0.622
LIG_14-3-3_CanoR_1 989 993 PF00244 0.526
LIG_Actin_WH2_2 17 32 PF00022 0.492
LIG_ActinCP_TwfCPI_2 913 921 PF01115 0.561
LIG_BRCT_BRCA1_1 56 60 PF00533 0.463
LIG_Clathr_ClatBox_1 607 611 PF01394 0.338
LIG_Clathr_ClatBox_1 71 75 PF01394 0.478
LIG_eIF4E_1 226 232 PF01652 0.545
LIG_FHA_1 1000 1006 PF00498 0.553
LIG_FHA_1 102 108 PF00498 0.509
LIG_FHA_1 168 174 PF00498 0.507
LIG_FHA_1 286 292 PF00498 0.799
LIG_FHA_1 338 344 PF00498 0.718
LIG_FHA_1 400 406 PF00498 0.561
LIG_FHA_1 445 451 PF00498 0.718
LIG_FHA_1 487 493 PF00498 0.459
LIG_FHA_1 497 503 PF00498 0.451
LIG_FHA_1 574 580 PF00498 0.364
LIG_FHA_1 641 647 PF00498 0.493
LIG_FHA_1 672 678 PF00498 0.347
LIG_FHA_1 711 717 PF00498 0.441
LIG_FHA_1 836 842 PF00498 0.651
LIG_FHA_1 849 855 PF00498 0.502
LIG_FHA_2 158 164 PF00498 0.585
LIG_FHA_2 302 308 PF00498 0.584
LIG_KLC1_Yacidic_2 1003 1008 PF13176 0.543
LIG_LIR_Apic_2 223 229 PF02991 0.536
LIG_LIR_Apic_2 33 38 PF02991 0.472
LIG_LIR_Apic_2 912 916 PF02991 0.557
LIG_LIR_Gen_1 475 485 PF02991 0.435
LIG_LIR_Gen_1 57 68 PF02991 0.467
LIG_LIR_Gen_1 748 757 PF02991 0.693
LIG_LIR_Gen_1 868 879 PF02991 0.490
LIG_LIR_Gen_1 9 20 PF02991 0.452
LIG_LIR_Nem_3 475 480 PF02991 0.411
LIG_LIR_Nem_3 57 63 PF02991 0.617
LIG_LIR_Nem_3 611 615 PF02991 0.349
LIG_LIR_Nem_3 713 717 PF02991 0.426
LIG_LIR_Nem_3 748 754 PF02991 0.758
LIG_LIR_Nem_3 75 81 PF02991 0.493
LIG_LIR_Nem_3 868 874 PF02991 0.539
LIG_LIR_Nem_3 9 15 PF02991 0.462
LIG_NRBOX 57 63 PF00104 0.467
LIG_PCNA_PIPBox_1 65 74 PF02747 0.468
LIG_PCNA_yPIPBox_3 14 25 PF02747 0.448
LIG_PCNA_yPIPBox_3 65 79 PF02747 0.475
LIG_Pex14_2 228 232 PF04695 0.565
LIG_Pex14_2 632 636 PF04695 0.399
LIG_Pex14_2 691 695 PF04695 0.462
LIG_SH2_CRK 326 330 PF00017 0.602
LIG_SH2_CRK 708 712 PF00017 0.459
LIG_SH2_CRK 90 94 PF00017 0.488
LIG_SH2_GRB2like 90 93 PF00017 0.486
LIG_SH2_NCK_1 90 94 PF00017 0.488
LIG_SH2_PTP2 239 242 PF00017 0.514
LIG_SH2_SRC 35 38 PF00017 0.478
LIG_SH2_SRC 708 711 PF00017 0.464
LIG_SH2_STAP1 326 330 PF00017 0.602
LIG_SH2_STAP1 553 557 PF00017 0.367
LIG_SH2_STAP1 90 94 PF00017 0.488
LIG_SH2_STAT5 11 14 PF00017 0.499
LIG_SH2_STAT5 239 242 PF00017 0.514
LIG_SH2_STAT5 35 38 PF00017 0.478
LIG_SH2_STAT5 613 616 PF00017 0.367
LIG_SH2_STAT5 859 862 PF00017 0.500
LIG_SH3_3 219 225 PF00018 0.602
LIG_SH3_3 280 286 PF00018 0.582
LIG_SH3_3 31 37 PF00018 0.469
LIG_SH3_3 439 445 PF00018 0.647
LIG_SH3_3 590 596 PF00018 0.529
LIG_SH3_3 600 606 PF00018 0.485
LIG_SH3_3 638 644 PF00018 0.523
LIG_SH3_3 71 77 PF00018 0.478
LIG_SH3_3 842 848 PF00018 0.536
LIG_SH3_3 886 892 PF00018 0.601
LIG_SH3_3 95 101 PF00018 0.492
LIG_SUMO_SIM_anti_2 59 65 PF11976 0.469
LIG_SUMO_SIM_anti_2 91 97 PF11976 0.494
LIG_SUMO_SIM_par_1 489 495 PF11976 0.449
LIG_SUMO_SIM_par_1 65 70 PF11976 0.464
LIG_SUMO_SIM_par_1 716 722 PF11976 0.376
LIG_SUMO_SIM_par_1 840 847 PF11976 0.636
LIG_SUMO_SIM_par_1 851 858 PF11976 0.499
LIG_SUMO_SIM_par_1 94 100 PF11976 0.492
LIG_TRAF2_1 129 132 PF00917 0.484
LIG_TRAF2_1 384 387 PF00917 0.583
LIG_TRAF2_1 829 832 PF00917 0.607
LIG_TRAF2_1 865 868 PF00917 0.468
LIG_TYR_ITIM 324 329 PF00017 0.602
LIG_WRC_WIRS_1 688 693 PF05994 0.463
LIG_WW_3 100 104 PF00397 0.495
MOD_CDC14_SPxK_1 100 103 PF00782 0.492
MOD_CDK_SPK_2 232 237 PF00069 0.560
MOD_CDK_SPxK_1 97 103 PF00069 0.491
MOD_CDK_SPxxK_3 101 108 PF00069 0.507
MOD_CDK_SPxxK_3 832 839 PF00069 0.556
MOD_CDK_SPxxK_3 914 921 PF00069 0.627
MOD_CK1_1 126 132 PF00069 0.685
MOD_CK1_1 146 152 PF00069 0.623
MOD_CK1_1 154 160 PF00069 0.547
MOD_CK1_1 162 168 PF00069 0.473
MOD_CK1_1 255 261 PF00069 0.698
MOD_CK1_1 296 302 PF00069 0.657
MOD_CK1_1 374 380 PF00069 0.645
MOD_CK1_1 381 387 PF00069 0.706
MOD_CK1_1 44 50 PF00069 0.618
MOD_CK1_1 569 575 PF00069 0.608
MOD_CK1_1 665 671 PF00069 0.549
MOD_CK1_1 690 696 PF00069 0.475
MOD_CK1_1 719 725 PF00069 0.386
MOD_CK1_1 797 803 PF00069 0.692
MOD_CK2_1 10 16 PF00069 0.460
MOD_CK2_1 126 132 PF00069 0.501
MOD_CK2_1 157 163 PF00069 0.586
MOD_CK2_1 301 307 PF00069 0.587
MOD_CK2_1 381 387 PF00069 0.665
MOD_CK2_1 422 428 PF00069 0.560
MOD_CK2_1 816 822 PF00069 0.694
MOD_CK2_1 826 832 PF00069 0.679
MOD_CK2_1 862 868 PF00069 0.465
MOD_Cter_Amidation 205 208 PF01082 0.591
MOD_Cter_Amidation 703 706 PF01082 0.528
MOD_GlcNHglycan 128 131 PF01048 0.618
MOD_GlcNHglycan 151 154 PF01048 0.615
MOD_GlcNHglycan 163 167 PF01048 0.693
MOD_GlcNHglycan 215 218 PF01048 0.654
MOD_GlcNHglycan 312 315 PF01048 0.672
MOD_GlcNHglycan 340 343 PF01048 0.572
MOD_GlcNHglycan 375 379 PF01048 0.555
MOD_GlcNHglycan 483 486 PF01048 0.494
MOD_GlcNHglycan 509 512 PF01048 0.425
MOD_GlcNHglycan 516 519 PF01048 0.377
MOD_GlcNHglycan 539 542 PF01048 0.358
MOD_GlcNHglycan 622 625 PF01048 0.509
MOD_GlcNHglycan 665 668 PF01048 0.513
MOD_GlcNHglycan 796 799 PF01048 0.601
MOD_GlcNHglycan 808 811 PF01048 0.475
MOD_GlcNHglycan 818 821 PF01048 0.541
MOD_GlcNHglycan 896 899 PF01048 0.707
MOD_GlcNHglycan 945 948 PF01048 0.538
MOD_GSK3_1 143 150 PF00069 0.632
MOD_GSK3_1 153 160 PF00069 0.776
MOD_GSK3_1 195 202 PF00069 0.535
MOD_GSK3_1 270 277 PF00069 0.606
MOD_GSK3_1 298 305 PF00069 0.682
MOD_GSK3_1 374 381 PF00069 0.681
MOD_GSK3_1 399 406 PF00069 0.565
MOD_GSK3_1 412 419 PF00069 0.624
MOD_GSK3_1 422 429 PF00069 0.522
MOD_GSK3_1 444 451 PF00069 0.680
MOD_GSK3_1 455 462 PF00069 0.389
MOD_GSK3_1 492 499 PF00069 0.526
MOD_GSK3_1 503 510 PF00069 0.350
MOD_GSK3_1 558 565 PF00069 0.575
MOD_GSK3_1 569 576 PF00069 0.675
MOD_GSK3_1 636 643 PF00069 0.555
MOD_GSK3_1 661 668 PF00069 0.606
MOD_GSK3_1 687 694 PF00069 0.464
MOD_GSK3_1 722 729 PF00069 0.473
MOD_GSK3_1 752 759 PF00069 0.514
MOD_GSK3_1 762 769 PF00069 0.573
MOD_GSK3_1 794 801 PF00069 0.538
MOD_GSK3_1 826 833 PF00069 0.652
MOD_GSK3_1 835 842 PF00069 0.563
MOD_GSK3_1 844 851 PF00069 0.474
MOD_GSK3_1 855 862 PF00069 0.443
MOD_GSK3_1 948 955 PF00069 0.524
MOD_GSK3_1 97 104 PF00069 0.558
MOD_N-GLC_1 126 131 PF02516 0.494
MOD_N-GLC_1 293 298 PF02516 0.576
MOD_N-GLC_1 30 35 PF02516 0.468
MOD_N-GLC_1 338 343 PF02516 0.788
MOD_N-GLC_1 356 361 PF02516 0.546
MOD_N-GLC_1 656 661 PF02516 0.431
MOD_N-GLC_1 691 696 PF02516 0.481
MOD_N-GLC_1 794 799 PF02516 0.594
MOD_N-GLC_2 431 433 PF02516 0.532
MOD_NEK2_1 274 279 PF00069 0.700
MOD_NEK2_1 426 431 PF00069 0.593
MOD_NEK2_1 582 587 PF00069 0.289
MOD_NEK2_1 620 625 PF00069 0.478
MOD_NEK2_1 656 661 PF00069 0.491
MOD_NEK2_1 691 696 PF00069 0.492
MOD_NEK2_1 716 721 PF00069 0.373
MOD_NEK2_1 762 767 PF00069 0.618
MOD_NEK2_1 965 970 PF00069 0.498
MOD_NEK2_2 111 116 PF00069 0.490
MOD_NEK2_2 988 993 PF00069 0.527
MOD_PIKK_1 44 50 PF00454 0.493
MOD_PK_1 293 299 PF00069 0.644
MOD_PK_1 30 36 PF00069 0.468
MOD_PK_1 743 749 PF00069 0.504
MOD_PKA_1 766 772 PF00069 0.612
MOD_PKA_1 909 915 PF00069 0.556
MOD_PKA_2 200 206 PF00069 0.660
MOD_PKA_2 337 343 PF00069 0.624
MOD_PKA_2 562 568 PF00069 0.648
MOD_PKA_2 766 772 PF00069 0.627
MOD_PKA_2 909 915 PF00069 0.556
MOD_PKA_2 960 966 PF00069 0.524
MOD_PKA_2 988 994 PF00069 0.523
MOD_Plk_1 270 276 PF00069 0.531
MOD_Plk_1 293 299 PF00069 0.582
MOD_Plk_1 338 344 PF00069 0.789
MOD_Plk_1 356 362 PF00069 0.547
MOD_Plk_1 436 442 PF00069 0.544
MOD_Plk_1 691 697 PF00069 0.487
MOD_Plk_1 948 954 PF00069 0.457
MOD_Plk_4 111 117 PF00069 0.489
MOD_Plk_4 167 173 PF00069 0.528
MOD_Plk_4 227 233 PF00069 0.565
MOD_Plk_4 286 292 PF00069 0.532
MOD_Plk_4 30 36 PF00069 0.468
MOD_Plk_4 412 418 PF00069 0.554
MOD_Plk_4 476 482 PF00069 0.350
MOD_Plk_4 56 62 PF00069 0.491
MOD_Plk_4 67 73 PF00069 0.513
MOD_Plk_4 855 861 PF00069 0.516
MOD_Plk_4 866 872 PF00069 0.490
MOD_Plk_4 948 954 PF00069 0.567
MOD_Plk_4 960 966 PF00069 0.488
MOD_ProDKin_1 232 238 PF00069 0.576
MOD_ProDKin_1 250 256 PF00069 0.589
MOD_ProDKin_1 279 285 PF00069 0.625
MOD_ProDKin_1 358 364 PF00069 0.584
MOD_ProDKin_1 41 47 PF00069 0.491
MOD_ProDKin_1 455 461 PF00069 0.403
MOD_ProDKin_1 492 498 PF00069 0.580
MOD_ProDKin_1 599 605 PF00069 0.632
MOD_ProDKin_1 636 642 PF00069 0.570
MOD_ProDKin_1 752 758 PF00069 0.553
MOD_ProDKin_1 79 85 PF00069 0.488
MOD_ProDKin_1 813 819 PF00069 0.541
MOD_ProDKin_1 832 838 PF00069 0.567
MOD_ProDKin_1 844 850 PF00069 0.498
MOD_ProDKin_1 914 920 PF00069 0.634
MOD_ProDKin_1 967 973 PF00069 0.510
MOD_ProDKin_1 97 103 PF00069 0.595
MOD_SUMO_rev_2 818 828 PF00179 0.552
TRG_DiLeu_BaEn_1 16 21 PF01217 0.441
TRG_DiLeu_BaEn_4 131 137 PF01217 0.539
TRG_DiLeu_BaLyEn_6 451 456 PF01217 0.505
TRG_DiLeu_BaLyEn_6 603 608 PF01217 0.496
TRG_DiLeu_BaLyEn_6 901 906 PF01217 0.568
TRG_ENDOCYTIC_2 239 242 PF00928 0.514
TRG_ENDOCYTIC_2 326 329 PF00928 0.599
TRG_ENDOCYTIC_2 751 754 PF00928 0.610
TRG_ENDOCYTIC_2 90 93 PF00928 0.486
TRG_ER_diArg_1 353 355 PF00400 0.547
TRG_ER_diArg_1 705 707 PF00400 0.536
TRG_ER_diArg_1 873 876 PF00400 0.493
TRG_ER_diArg_1 907 910 PF00400 0.567
TRG_Pf-PMV_PEXEL_1 134 138 PF00026 0.547
TRG_Pf-PMV_PEXEL_1 743 748 PF00026 0.570

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZH0 Leptomonas seymouri 39% 100%
A0A3S5H5A7 Leishmania donovani 99% 100%
A4H3W6 Leishmania braziliensis 70% 98%
E9AK28 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS