Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AG59_LEIIN

TriTrypDb:

LINF_040005300

Length:

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AG59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG59

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	28	30	PF00675	0.474
CLV_NRD_NRD_1	35	37	PF00675	0.451
DOC_MAPK_gen_1	36	43	PF00069	0.656
DOC_SPAK_OSR1_1	51	55	PF12202	0.636
DOC_USP7_MATH_1	16	20	PF00917	0.419
DOC_USP7_MATH_1	68	72	PF00917	0.791
LIG_14-3-3_CanoR_1	36	43	PF00244	0.721
LIG_14-3-3_CterR_2	69	73	PF00244	0.771
LIG_BIR_II_1	1	5	PF00653	0.356
LIG_FHA_1	36	42	PF00498	0.652
LIG_FHA_2	59	65	PF00498	0.746
LIG_SH2_CRK	25	29	PF00017	0.665
LIG_TYR_ITIM	23	28	PF00017	0.732
MOD_CK2_1	58	64	PF00069	0.671
MOD_GlcNHglycan	18	21	PF01048	0.411
MOD_GSK3_1	12	19	PF00069	0.386
MOD_GSK3_1	31	38	PF00069	0.668
MOD_PKA_2	35	41	PF00069	0.721
TRG_ENDOCYTIC_2	25	28	PF00928	0.621
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C0	Leptomonas seymouri	63%	88%
A0A3S5H572	Leishmania donovani	100%	100%
E9ACP4	Leishmania major	92%	100%
E9AI21	Leishmania braziliensis	88%	100%
E9AJY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%