Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AG53_LEIIN

TriTrypDb:

LINF_030011300

Length:

608

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AG53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	412	416	PF00656	0.623
CLV_C14_Caspase3-7	456	460	PF00656	0.559
CLV_C14_Caspase3-7	47	51	PF00656	0.440
CLV_NRD_NRD_1	3	5	PF00675	0.620
CLV_NRD_NRD_1	349	351	PF00675	0.470
CLV_NRD_NRD_1	501	503	PF00675	0.433
CLV_PCSK_KEX2_1	164	166	PF00082	0.560
CLV_PCSK_KEX2_1	3	5	PF00082	0.619
CLV_PCSK_KEX2_1	349	351	PF00082	0.516
CLV_PCSK_KEX2_1	500	502	PF00082	0.464
CLV_PCSK_KEX2_1	601	603	PF00082	0.514
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.560
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.638
CLV_PCSK_PC1ET2_1	601	603	PF00082	0.534
CLV_PCSK_SKI1_1	113	117	PF00082	0.477
CLV_PCSK_SKI1_1	170	174	PF00082	0.459
CLV_PCSK_SKI1_1	257	261	PF00082	0.711
CLV_PCSK_SKI1_1	292	296	PF00082	0.581
CLV_PCSK_SKI1_1	319	323	PF00082	0.384
CLV_PCSK_SKI1_1	351	355	PF00082	0.657
CLV_PCSK_SKI1_1	466	470	PF00082	0.421
CLV_PCSK_SKI1_1	509	513	PF00082	0.411
CLV_PCSK_SKI1_1	556	560	PF00082	0.538
CLV_Separin_Metazoa	289	293	PF03568	0.513
DEG_APCC_DBOX_1	304	312	PF00400	0.560
DEG_Nend_Nbox_1	1	3	PF02207	0.605
DEG_SPOP_SBC_1	239	243	PF00917	0.780
DEG_SPOP_SBC_1	246	250	PF00917	0.718
DEG_SPOP_SBC_1	477	481	PF00917	0.391
DEG_SPOP_SBC_1	68	72	PF00917	0.581
DOC_CYCLIN_RxL_1	314	323	PF00134	0.440
DOC_CYCLIN_RxL_1	348	356	PF00134	0.595
DOC_CYCLIN_RxL_1	463	470	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	139	145	PF00134	0.503
DOC_MAPK_FxFP_2	29	32	PF00069	0.462
DOC_MAPK_gen_1	309	318	PF00069	0.428
DOC_MAPK_gen_1	349	355	PF00069	0.589
DOC_MAPK_JIP1_4	312	318	PF00069	0.453
DOC_MAPK_MEF2A_6	309	317	PF00069	0.379
DOC_MAPK_MEF2A_6	319	326	PF00069	0.373
DOC_MAPK_MEF2A_6	361	369	PF00069	0.422
DOC_MAPK_MEF2A_6	489	498	PF00069	0.479
DOC_PP2B_LxvP_1	322	325	PF13499	0.404
DOC_PP2B_LxvP_1	447	450	PF13499	0.373
DOC_PP4_FxxP_1	29	32	PF00568	0.462
DOC_SPAK_OSR1_1	429	433	PF12202	0.451
DOC_USP7_MATH_1	221	225	PF00917	0.714
DOC_USP7_MATH_1	227	231	PF00917	0.729
DOC_USP7_MATH_1	239	243	PF00917	0.753
DOC_USP7_MATH_1	246	250	PF00917	0.625
DOC_USP7_MATH_1	418	422	PF00917	0.638
DOC_USP7_MATH_1	478	482	PF00917	0.521
DOC_USP7_MATH_1	526	530	PF00917	0.351
DOC_USP7_MATH_1	68	72	PF00917	0.745
DOC_USP7_MATH_1	74	78	PF00917	0.735
DOC_USP7_UBL2_3	109	113	PF12436	0.496
DOC_WW_Pin1_4	251	256	PF00397	0.766
DOC_WW_Pin1_4	457	462	PF00397	0.493
LIG_14-3-3_CanoR_1	13	18	PF00244	0.630
LIG_14-3-3_CanoR_1	3	7	PF00244	0.608
LIG_14-3-3_CanoR_1	451	461	PF00244	0.456
LIG_14-3-3_CanoR_1	489	498	PF00244	0.535
LIG_14-3-3_CanoR_1	87	93	PF00244	0.560
LIG_Actin_RPEL_3	354	373	PF02755	0.566
LIG_Actin_WH2_2	276	294	PF00022	0.487
LIG_APCC_ABBA_1	396	401	PF00400	0.557
LIG_BIR_III_2	604	608	PF00653	0.573
LIG_BIR_III_4	401	405	PF00653	0.528
LIG_BIR_III_4	50	54	PF00653	0.584
LIG_BRCT_BRCA1_1	459	463	PF00533	0.551
LIG_BRCT_BRCA1_1	481	485	PF00533	0.629
LIG_BRCT_BRCA1_1	65	69	PF00533	0.551
LIG_Clathr_ClatBox_1	115	119	PF01394	0.518
LIG_CtBP_PxDLS_1	24	28	PF00389	0.518
LIG_EH1_1	593	601	PF00400	0.489
LIG_FHA_1	193	199	PF00498	0.389
LIG_FHA_1	277	283	PF00498	0.478
LIG_FHA_1	321	327	PF00498	0.383
LIG_FHA_1	434	440	PF00498	0.385
LIG_FHA_1	87	93	PF00498	0.607
LIG_FHA_2	302	308	PF00498	0.557
LIG_FHA_2	410	416	PF00498	0.574
LIG_FHA_2	454	460	PF00498	0.573
LIG_FHA_2	563	569	PF00498	0.496
LIG_LIR_Apic_2	26	32	PF02991	0.453
LIG_LIR_Apic_2	307	313	PF02991	0.441
LIG_LIR_Gen_1	274	283	PF02991	0.527
LIG_LIR_Gen_1	441	450	PF02991	0.464
LIG_LIR_Gen_1	482	491	PF02991	0.531
LIG_LIR_Nem_3	274	280	PF02991	0.530
LIG_LIR_Nem_3	441	445	PF02991	0.378
LIG_LIR_Nem_3	482	488	PF02991	0.541
LIG_LYPXL_S_1	517	521	PF13949	0.543
LIG_NRBOX	317	323	PF00104	0.485
LIG_NRBOX	368	374	PF00104	0.481
LIG_PCNA_yPIPBox_3	132	140	PF02747	0.453
LIG_PCNA_yPIPBox_3	284	292	PF02747	0.539
LIG_PDZ_Class_2	603	608	PF00595	0.564
LIG_Pex14_2	203	207	PF04695	0.383
LIG_SH2_CRK	370	374	PF00017	0.516
LIG_SH2_NCK_1	406	410	PF00017	0.568
LIG_SH2_SRC	343	346	PF00017	0.556
LIG_SH2_SRC	406	409	PF00017	0.606
LIG_SH2_SRC	544	547	PF00017	0.404
LIG_SH2_STAP1	144	148	PF00017	0.435
LIG_SH2_STAP1	162	166	PF00017	0.501
LIG_SH2_STAP1	435	439	PF00017	0.363
LIG_SH2_STAP1	442	446	PF00017	0.355
LIG_SH2_STAP1	577	581	PF00017	0.407
LIG_SH2_STAT5	277	280	PF00017	0.518
LIG_SH2_STAT5	30	33	PF00017	0.446
LIG_SH2_STAT5	343	346	PF00017	0.501
LIG_SH2_STAT5	435	438	PF00017	0.382
LIG_SH2_STAT5	544	547	PF00017	0.404
LIG_SH3_3	128	134	PF00018	0.584
LIG_SH3_3	211	217	PF00018	0.637
LIG_SUMO_SIM_anti_2	114	119	PF11976	0.517
LIG_SUMO_SIM_anti_2	279	285	PF11976	0.492
LIG_SUMO_SIM_par_1	114	119	PF11976	0.517
LIG_SUMO_SIM_par_1	473	482	PF11976	0.493
LIG_TRAF2_1	585	588	PF00917	0.484
LIG_TRFH_1	469	473	PF08558	0.525
LIG_TYR_ITIM	575	580	PF00017	0.392
LIG_UBA3_1	315	319	PF00899	0.378
LIG_UBA3_1	354	359	PF00899	0.573
LIG_WRC_WIRS_1	17	22	PF05994	0.586
MOD_CDC14_SPxK_1	254	257	PF00782	0.669
MOD_CDK_SPxK_1	251	257	PF00069	0.676
MOD_CK1_1	16	22	PF00069	0.585
MOD_CK1_1	229	235	PF00069	0.756
MOD_CK1_1	240	246	PF00069	0.770
MOD_CK1_1	248	254	PF00069	0.627
MOD_CK1_1	59	65	PF00069	0.729
MOD_CK1_1	77	83	PF00069	0.694
MOD_CK2_1	301	307	PF00069	0.532
MOD_CK2_1	562	568	PF00069	0.475
MOD_CK2_1	582	588	PF00069	0.273
MOD_CK2_1	59	65	PF00069	0.682
MOD_CK2_1	70	76	PF00069	0.717
MOD_GlcNHglycan	223	226	PF01048	0.708
MOD_GlcNHglycan	250	253	PF01048	0.725
MOD_GlcNHglycan	552	555	PF01048	0.399
MOD_GlcNHglycan	72	75	PF01048	0.738
MOD_GlcNHglycan	76	79	PF01048	0.694
MOD_GlcNHglycan	92	95	PF01048	0.491
MOD_GSK3_1	12	19	PF00069	0.549
MOD_GSK3_1	226	233	PF00069	0.746
MOD_GSK3_1	234	241	PF00069	0.715
MOD_GSK3_1	244	251	PF00069	0.632
MOD_GSK3_1	320	327	PF00069	0.372
MOD_GSK3_1	453	460	PF00069	0.569
MOD_GSK3_1	473	480	PF00069	0.311
MOD_GSK3_1	526	533	PF00069	0.434
MOD_GSK3_1	59	66	PF00069	0.723
MOD_GSK3_1	70	77	PF00069	0.494
MOD_GSK3_1	83	90	PF00069	0.551
MOD_GSK3_1	92	99	PF00069	0.663
MOD_N-GLC_1	151	156	PF02516	0.581
MOD_N-GLC_1	244	249	PF02516	0.770
MOD_N-GLC_1	410	415	PF02516	0.644
MOD_N-GLC_1	489	494	PF02516	0.510
MOD_NEK2_1	193	198	PF00069	0.421
MOD_NEK2_1	2	7	PF00069	0.635
MOD_NEK2_1	278	283	PF00069	0.449
MOD_NEK2_1	420	425	PF00069	0.546
MOD_NEK2_1	545	550	PF00069	0.397
MOD_NEK2_1	562	567	PF00069	0.388
MOD_NEK2_1	69	74	PF00069	0.728
MOD_PIKK_1	227	233	PF00454	0.707
MOD_PK_1	13	19	PF00069	0.671
MOD_PKA_1	500	506	PF00069	0.431
MOD_PKA_2	12	18	PF00069	0.524
MOD_PKA_2	2	8	PF00069	0.601
MOD_PKA_2	500	506	PF00069	0.501
MOD_PKA_2	56	62	PF00069	0.651
MOD_PKA_2	86	92	PF00069	0.555
MOD_Plk_1	193	199	PF00069	0.442
MOD_Plk_1	410	416	PF00069	0.677
MOD_Plk_1	563	569	PF00069	0.393
MOD_Plk_1	64	70	PF00069	0.708
MOD_Plk_4	111	117	PF00069	0.525
MOD_Plk_4	16	22	PF00069	0.529
MOD_Plk_4	278	284	PF00069	0.437
MOD_Plk_4	479	485	PF00069	0.589
MOD_Plk_4	527	533	PF00069	0.406
MOD_ProDKin_1	251	257	PF00069	0.768
MOD_ProDKin_1	457	463	PF00069	0.481
MOD_SUMO_rev_2	417	426	PF00179	0.619
TRG_DiLeu_BaEn_1	595	600	PF01217	0.458
TRG_DiLeu_BaEn_4	288	294	PF01217	0.515
TRG_DiLeu_BaLyEn_6	175	180	PF01217	0.476
TRG_DiLeu_BaLyEn_6	470	475	PF01217	0.499
TRG_ENDOCYTIC_2	277	280	PF00928	0.518
TRG_ENDOCYTIC_2	370	373	PF00928	0.514
TRG_ENDOCYTIC_2	442	445	PF00928	0.378
TRG_ENDOCYTIC_2	518	521	PF00928	0.545
TRG_ENDOCYTIC_2	577	580	PF00928	0.404
TRG_ER_diArg_1	2	4	PF00400	0.615
TRG_ER_diArg_1	500	502	PF00400	0.497
TRG_Pf-PMV_PEXEL_1	335	339	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	515	520	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9Q3	Leptomonas seymouri	64%	99%
A0A0S4JDH1	Bodo saltans	29%	100%
A0A1X0P9P0	Trypanosomatidae	48%	100%
A0A422NMG4	Trypanosoma rangeli	48%	100%
A0A451EJR4	Leishmania donovani	100%	100%
A4H3M5	Leishmania braziliensis	87%	100%
D0A267	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	97%
E9ACK9	Leishmania major	95%	100%
E9AJU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
V5BSR7	Trypanosoma cruzi	47%	100%