Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AG52_LEIIN

TriTrypDb:

LINF_030011200

Length:

328

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AG52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG52

PDB structure(s): 7ane_ak

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.803
CLV_C14_Caspase3-7	313	317	PF00656	0.679
CLV_NRD_NRD_1	141	143	PF00675	0.571
CLV_NRD_NRD_1	194	196	PF00675	0.645
CLV_NRD_NRD_1	216	218	PF00675	0.678
CLV_NRD_NRD_1	272	274	PF00675	0.489
CLV_NRD_NRD_1	277	279	PF00675	0.483
CLV_NRD_NRD_1	291	293	PF00675	0.351
CLV_PCSK_FUR_1	192	196	PF00082	0.640
CLV_PCSK_KEX2_1	141	143	PF00082	0.600
CLV_PCSK_KEX2_1	194	196	PF00082	0.659
CLV_PCSK_KEX2_1	277	279	PF00082	0.535
CLV_PCSK_KEX2_1	291	293	PF00082	0.399
CLV_PCSK_KEX2_1	304	306	PF00082	0.423
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.501
CLV_PCSK_PC7_1	273	279	PF00082	0.575
CLV_PCSK_SKI1_1	129	133	PF00082	0.464
CLV_PCSK_SKI1_1	16	20	PF00082	0.407
CLV_PCSK_SKI1_1	218	222	PF00082	0.468
CLV_PCSK_SKI1_1	254	258	PF00082	0.494
DEG_APCC_DBOX_1	291	299	PF00400	0.577
DEG_SPOP_SBC_1	92	96	PF00917	0.739
DOC_MAPK_gen_1	215	222	PF00069	0.619
DOC_PP2B_LxvP_1	241	244	PF13499	0.479
DOC_PP4_FxxP_1	185	188	PF00568	0.561
DOC_SPAK_OSR1_1	184	188	PF12202	0.588
DOC_USP7_MATH_1	234	238	PF00917	0.415
DOC_USP7_MATH_1	44	48	PF00917	0.485
DOC_USP7_MATH_1	92	96	PF00917	0.729
DOC_USP7_UBL2_3	300	304	PF12436	0.555
DOC_WW_Pin1_4	77	82	PF00397	0.728
DOC_WW_Pin1_4	85	90	PF00397	0.690
LIG_14-3-3_CanoR_1	217	223	PF00244	0.466
LIG_14-3-3_CanoR_1	28	32	PF00244	0.503
LIG_14-3-3_CanoR_1	291	299	PF00244	0.541
LIG_14-3-3_CterR_2	325	328	PF00244	0.590
LIG_Actin_WH2_2	311	327	PF00022	0.708
LIG_APCC_ABBAyCdc20_2	14	20	PF00400	0.505
LIG_BIR_II_1	1	5	PF00653	0.476
LIG_Clathr_ClatBox_1	246	250	PF01394	0.442
LIG_CtBP_PxDLS_1	107	112	PF00389	0.570
LIG_deltaCOP1_diTrp_1	178	185	PF00928	0.578
LIG_FHA_1	217	223	PF00498	0.609
LIG_FHA_1	4	10	PF00498	0.431
LIG_FHA_2	104	110	PF00498	0.610
LIG_FHA_2	311	317	PF00498	0.650
LIG_GBD_Chelix_1	9	17	PF00786	0.448
LIG_LIR_Gen_1	121	130	PF02991	0.541
LIG_LIR_Gen_1	281	290	PF02991	0.517
LIG_LIR_Nem_3	121	125	PF02991	0.532
LIG_LIR_Nem_3	281	287	PF02991	0.474
LIG_LIR_Nem_3	30	34	PF02991	0.495
LIG_LIR_Nem_3	43	48	PF02991	0.385
LIG_Pex14_1	59	63	PF04695	0.445
LIG_PTAP_UEV_1	80	85	PF05743	0.671
LIG_SH2_CRK	45	49	PF00017	0.413
LIG_SH2_GRB2like	5	8	PF00017	0.435
LIG_SH2_STAP1	156	160	PF00017	0.456
LIG_SH2_STAP1	307	311	PF00017	0.545
LIG_SH2_STAP1	5	9	PF00017	0.432
LIG_SH2_STAT5	5	8	PF00017	0.435
LIG_SH3_3	184	190	PF00018	0.570
LIG_SH3_3	55	61	PF00018	0.560
LIG_SH3_3	78	84	PF00018	0.707
LIG_SH3_3	86	92	PF00018	0.709
LIG_SUMO_SIM_anti_2	106	112	PF11976	0.582
LIG_SUMO_SIM_anti_2	219	227	PF11976	0.609
LIG_SUMO_SIM_anti_2	285	291	PF11976	0.455
LIG_TRAF2_1	131	134	PF00917	0.491
LIG_TRAF2_1	317	320	PF00917	0.630
LIG_TYR_ITSM	41	48	PF00017	0.519
LIG_UBA3_1	246	254	PF00899	0.427
LIG_UBA3_1	266	274	PF00899	0.474
MOD_CDC14_SPxK_1	88	91	PF00782	0.731
MOD_CDK_SPxK_1	85	91	PF00069	0.729
MOD_CK1_1	90	96	PF00069	0.745
MOD_CK1_1	97	103	PF00069	0.686
MOD_CK2_1	314	320	PF00069	0.682
MOD_GlcNHglycan	102	105	PF01048	0.652
MOD_GlcNHglycan	113	116	PF01048	0.437
MOD_GSK3_1	254	261	PF00069	0.611
MOD_GSK3_1	290	297	PF00069	0.578
MOD_GSK3_1	310	317	PF00069	0.371
MOD_GSK3_1	40	47	PF00069	0.370
MOD_GSK3_1	87	94	PF00069	0.748
MOD_GSK3_1	96	103	PF00069	0.681
MOD_N-GLC_1	68	73	PF02516	0.685
MOD_NEK2_1	113	118	PF00069	0.408
MOD_NEK2_1	3	8	PF00069	0.437
MOD_NEK2_1	310	315	PF00069	0.684
MOD_NEK2_1	9	14	PF00069	0.398
MOD_NEK2_2	234	239	PF00069	0.436
MOD_OFUCOSY	35	42	PF10250	0.451
MOD_PIKK_1	290	296	PF00454	0.566
MOD_PKA_2	216	222	PF00069	0.634
MOD_PKA_2	27	33	PF00069	0.440
MOD_PKA_2	290	296	PF00069	0.566
MOD_PKA_2	3	9	PF00069	0.436
MOD_PKA_2	90	96	PF00069	0.747
MOD_Plk_4	44	50	PF00069	0.405
MOD_ProDKin_1	77	83	PF00069	0.728
MOD_ProDKin_1	85	91	PF00069	0.693
MOD_SUMO_for_1	131	134	PF00179	0.491
MOD_SUMO_rev_2	208	216	PF00179	0.729
MOD_SUMO_rev_2	250	256	PF00179	0.454
MOD_SUMO_rev_2	316	322	PF00179	0.625
TRG_DiLeu_BaEn_1	285	290	PF01217	0.454
TRG_DiLeu_BaEn_4	319	325	PF01217	0.614
TRG_ENDOCYTIC_2	307	310	PF00928	0.653
TRG_ENDOCYTIC_2	45	48	PF00928	0.397
TRG_ER_diArg_1	140	142	PF00400	0.607
TRG_ER_diArg_1	193	195	PF00400	0.648
TRG_ER_diArg_1	276	278	PF00400	0.560
TRG_ER_diArg_1	290	292	PF00400	0.459
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B1	Leptomonas seymouri	64%	100%
A0A0S4JDA3	Bodo saltans	31%	100%
A0A1X0P8U5	Trypanosomatidae	44%	100%
A0A3S5H551	Leishmania donovani	97%	100%
A0A422NMF2	Trypanosoma rangeli	44%	100%
D0A266	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ACK8	Leishmania major	94%	99%
E9AJU6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	98%
V5BCA0	Trypanosoma cruzi	43%	100%