Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AG45_LEIIN

TriTrypDb:

LINF_030010400

Length:

716

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AG45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.545
CLV_NRD_NRD_1	214	216	PF00675	0.535
CLV_NRD_NRD_1	248	250	PF00675	0.634
CLV_NRD_NRD_1	306	308	PF00675	0.672
CLV_NRD_NRD_1	337	339	PF00675	0.564
CLV_NRD_NRD_1	347	349	PF00675	0.580
CLV_NRD_NRD_1	389	391	PF00675	0.528
CLV_NRD_NRD_1	438	440	PF00675	0.665
CLV_NRD_NRD_1	48	50	PF00675	0.458
CLV_NRD_NRD_1	527	529	PF00675	0.751
CLV_NRD_NRD_1	568	570	PF00675	0.614
CLV_NRD_NRD_1	62	64	PF00675	0.498
CLV_NRD_NRD_1	707	709	PF00675	0.529
CLV_NRD_NRD_1	76	78	PF00675	0.442
CLV_PCSK_FUR_1	18	22	PF00082	0.513
CLV_PCSK_FUR_1	566	570	PF00082	0.607
CLV_PCSK_KEX2_1	18	20	PF00082	0.523
CLV_PCSK_KEX2_1	214	216	PF00082	0.535
CLV_PCSK_KEX2_1	247	249	PF00082	0.636
CLV_PCSK_KEX2_1	306	308	PF00082	0.668
CLV_PCSK_KEX2_1	337	339	PF00082	0.564
CLV_PCSK_KEX2_1	347	349	PF00082	0.580
CLV_PCSK_KEX2_1	365	367	PF00082	0.522
CLV_PCSK_KEX2_1	389	391	PF00082	0.528
CLV_PCSK_KEX2_1	437	439	PF00082	0.671
CLV_PCSK_KEX2_1	48	50	PF00082	0.458
CLV_PCSK_KEX2_1	527	529	PF00082	0.751
CLV_PCSK_KEX2_1	568	570	PF00082	0.614
CLV_PCSK_KEX2_1	62	64	PF00082	0.498
CLV_PCSK_KEX2_1	707	709	PF00082	0.529
CLV_PCSK_KEX2_1	76	78	PF00082	0.462
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.545
CLV_PCSK_SKI1_1	113	117	PF00082	0.456
CLV_PCSK_SKI1_1	187	191	PF00082	0.596
CLV_PCSK_SKI1_1	62	66	PF00082	0.535
DEG_ODPH_VHL_1	553	564	PF01847	0.370
DEG_ODPH_VHL_1	637	648	PF01847	0.654
DEG_SPOP_SBC_1	193	197	PF00917	0.813
DEG_SPOP_SBC_1	209	213	PF00917	0.666
DEG_SPOP_SBC_1	531	535	PF00917	0.572
DEG_SPOP_SBC_1	599	603	PF00917	0.705
DEG_SPOP_SBC_1	610	614	PF00917	0.712
DOC_ANK_TNKS_1	52	59	PF00023	0.687
DOC_CKS1_1	147	152	PF01111	0.753
DOC_CYCLIN_yCln2_LP_2	419	425	PF00134	0.420
DOC_MAPK_MEF2A_6	635	643	PF00069	0.627
DOC_MAPK_MEF2A_6	649	657	PF00069	0.627
DOC_PP2B_LxvP_1	419	422	PF13499	0.420
DOC_PP2B_LxvP_1	552	555	PF13499	0.420
DOC_PP2B_LxvP_1	657	660	PF13499	0.641
DOC_USP7_MATH_1	171	175	PF00917	0.807
DOC_USP7_MATH_1	193	197	PF00917	0.722
DOC_USP7_MATH_1	258	262	PF00917	0.797
DOC_USP7_MATH_1	299	303	PF00917	0.814
DOC_USP7_MATH_1	311	315	PF00917	0.696
DOC_USP7_MATH_1	318	322	PF00917	0.650
DOC_USP7_MATH_1	449	453	PF00917	0.555
DOC_USP7_MATH_1	470	474	PF00917	0.544
DOC_USP7_MATH_1	531	535	PF00917	0.553
DOC_USP7_MATH_1	544	548	PF00917	0.289
DOC_USP7_MATH_1	598	602	PF00917	0.783
DOC_USP7_MATH_1	609	613	PF00917	0.712
DOC_USP7_MATH_1	689	693	PF00917	0.692
DOC_USP7_MATH_1	696	700	PF00917	0.674
DOC_WW_Pin1_4	117	122	PF00397	0.694
DOC_WW_Pin1_4	146	151	PF00397	0.859
DOC_WW_Pin1_4	180	185	PF00397	0.691
DOC_WW_Pin1_4	260	265	PF00397	0.782
DOC_WW_Pin1_4	352	357	PF00397	0.769
DOC_WW_Pin1_4	366	371	PF00397	0.746
DOC_WW_Pin1_4	587	592	PF00397	0.768
DOC_WW_Pin1_4	601	606	PF00397	0.649
DOC_WW_Pin1_4	675	680	PF00397	0.667
DOC_WW_Pin1_4	94	99	PF00397	0.728
LIG_14-3-3_CanoR_1	187	192	PF00244	0.795
LIG_14-3-3_CanoR_1	20	28	PF00244	0.697
LIG_14-3-3_CanoR_1	399	405	PF00244	0.593
LIG_14-3-3_CanoR_1	455	459	PF00244	0.512
LIG_14-3-3_CanoR_1	53	57	PF00244	0.705
LIG_14-3-3_CanoR_1	608	617	PF00244	0.670
LIG_14-3-3_CanoR_1	695	701	PF00244	0.737
LIG_BIR_II_1	1	5	PF00653	0.679
LIG_BRCT_BRCA1_1	1	5	PF00533	0.679
LIG_Clathr_ClatBox_1	425	429	PF01394	0.420
LIG_deltaCOP1_diTrp_1	669	674	PF00928	0.715
LIG_eIF4E_1	283	289	PF01652	0.772
LIG_FHA_1	110	116	PF00498	0.688
LIG_FHA_1	142	148	PF00498	0.733
LIG_FHA_1	193	199	PF00498	0.809
LIG_FHA_1	283	289	PF00498	0.714
LIG_FHA_1	416	422	PF00498	0.420
LIG_FHA_1	488	494	PF00498	0.558
LIG_FHA_1	699	705	PF00498	0.729
LIG_FHA_1	88	94	PF00498	0.715
LIG_FHA_2	298	304	PF00498	0.721
LIG_FHA_2	32	38	PF00498	0.745
LIG_LIR_Gen_1	2	12	PF02991	0.698
LIG_LIR_Gen_1	30	40	PF02991	0.664
LIG_LIR_Gen_1	409	420	PF02991	0.340
LIG_LIR_Gen_1	629	639	PF02991	0.593
LIG_LIR_Nem_3	2	8	PF02991	0.691
LIG_LIR_Nem_3	278	282	PF02991	0.732
LIG_LIR_Nem_3	30	35	PF02991	0.667
LIG_LIR_Nem_3	409	415	PF02991	0.340
LIG_LIR_Nem_3	614	620	PF02991	0.697
LIG_LIR_Nem_3	629	634	PF02991	0.604
LIG_LIR_Nem_3	645	650	PF02991	0.680
LIG_PCNA_PIPBox_1	640	649	PF02747	0.628
LIG_PCNA_yPIPBox_3	556	569	PF02747	0.512
LIG_PCNA_yPIPBox_3	633	647	PF02747	0.632
LIG_SH2_STAP1	650	654	PF00017	0.663
LIG_SH3_3	144	150	PF00018	0.815
LIG_SH3_3	178	184	PF00018	0.711
LIG_SH3_3	186	192	PF00018	0.868
LIG_SH3_3	364	370	PF00018	0.789
LIG_SH3_3	399	405	PF00018	0.739
LIG_SUMO_SIM_par_1	382	388	PF11976	0.650
LIG_SUMO_SIM_par_1	584	590	PF11976	0.673
LIG_TRAF2_1	680	683	PF00917	0.818
LIG_TYR_ITIM	648	653	PF00017	0.490
MOD_CDK_SPK_2	146	151	PF00069	0.697
MOD_CDK_SPxxK_3	180	187	PF00069	0.609
MOD_CDK_SPxxK_3	601	608	PF00069	0.647
MOD_CDK_SPxxK_3	94	101	PF00069	0.633
MOD_CK1_1	132	138	PF00069	0.653
MOD_CK1_1	158	164	PF00069	0.682
MOD_CK1_1	196	202	PF00069	0.784
MOD_CK1_1	203	209	PF00069	0.702
MOD_CK1_1	210	216	PF00069	0.626
MOD_CK1_1	24	30	PF00069	0.637
MOD_CK1_1	302	308	PF00069	0.724
MOD_CK1_1	369	375	PF00069	0.690
MOD_CK1_1	376	382	PF00069	0.687
MOD_CK1_1	385	391	PF00069	0.514
MOD_CK1_1	453	459	PF00069	0.650
MOD_CK1_1	487	493	PF00069	0.806
MOD_CK1_1	511	517	PF00069	0.769
MOD_CK1_1	534	540	PF00069	0.640
MOD_CK1_1	601	607	PF00069	0.749
MOD_CK1_1	668	674	PF00069	0.585
MOD_CK1_1	71	77	PF00069	0.562
MOD_CK2_1	180	186	PF00069	0.656
MOD_CK2_1	297	303	PF00069	0.599
MOD_CK2_1	385	391	PF00069	0.716
MOD_CK2_1	610	616	PF00069	0.647
MOD_Cter_Amidation	335	338	PF01082	0.597
MOD_Cter_Amidation	74	77	PF01082	0.652
MOD_DYRK1A_RPxSP_1	366	370	PF00069	0.724
MOD_GlcNHglycan	173	176	PF01048	0.727
MOD_GlcNHglycan	202	205	PF01048	0.723
MOD_GlcNHglycan	218	221	PF01048	0.754
MOD_GlcNHglycan	313	316	PF01048	0.799
MOD_GlcNHglycan	320	323	PF01048	0.648
MOD_GlcNHglycan	447	450	PF01048	0.714
MOD_GlcNHglycan	452	455	PF01048	0.817
MOD_GlcNHglycan	486	489	PF01048	0.690
MOD_GlcNHglycan	501	504	PF01048	0.659
MOD_GlcNHglycan	510	513	PF01048	0.703
MOD_GlcNHglycan	516	519	PF01048	0.740
MOD_GlcNHglycan	537	540	PF01048	0.601
MOD_GlcNHglycan	54	57	PF01048	0.671
MOD_GlcNHglycan	65	68	PF01048	0.629
MOD_GlcNHglycan	70	73	PF01048	0.539
MOD_GlcNHglycan	78	81	PF01048	0.566
MOD_GSK3_1	109	116	PF00069	0.580
MOD_GSK3_1	117	124	PF00069	0.654
MOD_GSK3_1	125	132	PF00069	0.597
MOD_GSK3_1	192	199	PF00069	0.681
MOD_GSK3_1	203	210	PF00069	0.681
MOD_GSK3_1	23	30	PF00069	0.608
MOD_GSK3_1	260	267	PF00069	0.820
MOD_GSK3_1	342	349	PF00069	0.761
MOD_GSK3_1	357	364	PF00069	0.626
MOD_GSK3_1	369	376	PF00069	0.675
MOD_GSK3_1	411	418	PF00069	0.420
MOD_GSK3_1	445	452	PF00069	0.693
MOD_GSK3_1	453	460	PF00069	0.599
MOD_GSK3_1	493	500	PF00069	0.633
MOD_GSK3_1	508	515	PF00069	0.739
MOD_GSK3_1	530	537	PF00069	0.767
MOD_GSK3_1	589	596	PF00069	0.712
MOD_GSK3_1	696	703	PF00069	0.635
MOD_N-GLC_1	324	329	PF02516	0.653
MOD_N-GLC_1	484	489	PF02516	0.645
MOD_N-GLC_1	689	694	PF02516	0.703
MOD_NEK2_1	143	148	PF00069	0.653
MOD_NEK2_1	207	212	PF00069	0.779
MOD_NEK2_1	282	287	PF00069	0.639
MOD_NEK2_1	324	329	PF00069	0.653
MOD_NEK2_1	346	351	PF00069	0.638
MOD_NEK2_1	400	405	PF00069	0.482
MOD_NEK2_1	415	420	PF00069	0.375
MOD_NEK2_1	498	503	PF00069	0.622
MOD_NEK2_1	593	598	PF00069	0.639
MOD_PIKK_1	346	352	PF00454	0.630
MOD_PK_1	382	388	PF00069	0.622
MOD_PKA_1	337	343	PF00069	0.601
MOD_PKA_1	568	574	PF00069	0.807
MOD_PKA_1	76	82	PF00069	0.674
MOD_PKA_2	213	219	PF00069	0.625
MOD_PKA_2	22	28	PF00069	0.606
MOD_PKA_2	337	343	PF00069	0.641
MOD_PKA_2	346	352	PF00069	0.742
MOD_PKA_2	454	460	PF00069	0.670
MOD_PKA_2	52	58	PF00069	0.660
MOD_PKA_2	568	574	PF00069	0.807
MOD_PKA_2	76	82	PF00069	0.721
MOD_PKB_1	19	27	PF00069	0.584
MOD_PKB_1	566	574	PF00069	0.795
MOD_Plk_1	193	199	PF00069	0.770
MOD_Plk_1	252	258	PF00069	0.630
MOD_Plk_1	324	330	PF00069	0.656
MOD_Plk_1	440	446	PF00069	0.669
MOD_Plk_2-3	297	303	PF00069	0.680
MOD_Plk_2-3	31	37	PF00069	0.682
MOD_Plk_2-3	582	588	PF00069	0.613
MOD_Plk_4	143	149	PF00069	0.725
MOD_Plk_4	324	330	PF00069	0.706
MOD_Plk_4	411	417	PF00069	0.358
MOD_Plk_4	544	550	PF00069	0.373
MOD_Plk_4	582	588	PF00069	0.707
MOD_Plk_4	700	706	PF00069	0.652
MOD_ProDKin_1	117	123	PF00069	0.610
MOD_ProDKin_1	146	152	PF00069	0.836
MOD_ProDKin_1	180	186	PF00069	0.606
MOD_ProDKin_1	260	266	PF00069	0.732
MOD_ProDKin_1	352	358	PF00069	0.711
MOD_ProDKin_1	366	372	PF00069	0.678
MOD_ProDKin_1	587	593	PF00069	0.713
MOD_ProDKin_1	601	607	PF00069	0.547
MOD_ProDKin_1	675	681	PF00069	0.573
MOD_ProDKin_1	94	100	PF00069	0.656
MOD_SUMO_rev_2	524	534	PF00179	0.595
MOD_SUMO_rev_2	678	687	PF00179	0.629
TRG_ENDOCYTIC_2	617	620	PF00928	0.689
TRG_ENDOCYTIC_2	631	634	PF00928	0.431
TRG_ENDOCYTIC_2	650	653	PF00928	0.643
TRG_ER_diArg_1	17	20	PF00400	0.640
TRG_ER_diArg_1	176	179	PF00400	0.641
TRG_ER_diArg_1	247	249	PF00400	0.761
TRG_ER_diArg_1	306	308	PF00400	0.800
TRG_ER_diArg_1	346	348	PF00400	0.701
TRG_ER_diArg_1	436	439	PF00400	0.572
TRG_ER_diArg_1	47	49	PF00400	0.563
TRG_ER_diArg_1	526	528	PF00400	0.689
TRG_ER_diArg_1	566	569	PF00400	0.763
TRG_ER_diArg_1	706	708	PF00400	0.591
TRG_Pf-PMV_PEXEL_1	248	253	PF00026	0.680
TRG_Pf-PMV_PEXEL_1	618	623	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.662
TRG_Pf-PMV_PEXEL_1	635	640	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4E7	Leptomonas seymouri	30%	100%
A0A3S5H548	Leishmania donovani	100%	100%
A4H3L8	Leishmania braziliensis	59%	97%
E9ACK1	Leishmania major	86%	100%
E9AJT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%