A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)
Proteasome, 26S protease regulatory subunit
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | yes | yes: 4 |
| Forrest at al. (procyclic) | yes | yes: 4 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | yes | yes: 15 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 5 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | yes | yes: 10 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0000502 | proteasome complex | 3 | 12 |
| GO:0005737 | cytoplasm | 2 | 11 |
| GO:0032991 | protein-containing complex | 1 | 12 |
| GO:0110165 | cellular anatomical entity | 1 | 11 |
| GO:0140535 | intracellular protein-containing complex | 2 | 12 |
| GO:1902494 | catalytic complex | 2 | 12 |
| GO:1905368 | peptidase complex | 3 | 12 |
| GO:1905369 | endopeptidase complex | 4 | 12 |
| GO:0008540 | proteasome regulatory particle, base subcomplex | 2 | 1 |
| GO:0031597 | cytosolic proteasome complex | 4 | 1 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pescher et al. (upgregulation) | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
|
Lahav et al. - mRNA
- Protein
|
Related structures:
AlphaFold database: E9AG43
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006508 | proteolysis | 4 | 12 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 12 |
| GO:0008152 | metabolic process | 1 | 12 |
| GO:0009056 | catabolic process | 2 | 12 |
| GO:0009057 | macromolecule catabolic process | 4 | 12 |
| GO:0019538 | protein metabolic process | 3 | 12 |
| GO:0030163 | protein catabolic process | 4 | 12 |
| GO:0043170 | macromolecule metabolic process | 3 | 12 |
| GO:0044238 | primary metabolic process | 2 | 12 |
| GO:0071704 | organic substance metabolic process | 2 | 12 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 12 |
| GO:1901565 | organonitrogen compound catabolic process | 4 | 12 |
| GO:1901575 | organic substance catabolic process | 3 | 12 |
| GO:0006355 | regulation of DNA-templated transcription | 6 | 1 |
| GO:0006357 | regulation of transcription by RNA polymerase II | 7 | 1 |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 7 | 1 |
| GO:0006950 | response to stress | 2 | 1 |
| GO:0009889 | regulation of biosynthetic process | 4 | 1 |
| GO:0009891 | positive regulation of biosynthetic process | 5 | 1 |
| GO:0009893 | positive regulation of metabolic process | 4 | 1 |
| GO:0009987 | cellular process | 1 | 1 |
| GO:0010033 | response to organic substance | 3 | 1 |
| GO:0010243 | response to organonitrogen compound | 4 | 1 |
| GO:0010468 | regulation of gene expression | 5 | 1 |
| GO:0010498 | proteasomal protein catabolic process | 5 | 1 |
| GO:0010556 | regulation of macromolecule biosynthetic process | 5 | 1 |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 6 | 1 |
| GO:0010604 | positive regulation of macromolecule metabolic process | 5 | 1 |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 5 | 1 |
| GO:0019222 | regulation of metabolic process | 3 | 1 |
| GO:0019941 | modification-dependent protein catabolic process | 6 | 1 |
| GO:0030433 | ubiquitin-dependent ERAD pathway | 6 | 1 |
| GO:0031323 | regulation of cellular metabolic process | 4 | 1 |
| GO:0031325 | positive regulation of cellular metabolic process | 5 | 1 |
| GO:0031326 | regulation of cellular biosynthetic process | 5 | 1 |
| GO:0031328 | positive regulation of cellular biosynthetic process | 6 | 1 |
| GO:0031334 | positive regulation of protein-containing complex assembly | 6 | 1 |
| GO:0033554 | cellular response to stress | 3 | 1 |
| GO:0034976 | response to endoplasmic reticulum stress | 4 | 1 |
| GO:0036503 | ERAD pathway | 5 | 1 |
| GO:0042221 | response to chemical | 2 | 1 |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 6 | 1 |
| GO:0043254 | regulation of protein-containing complex assembly | 5 | 1 |
| GO:0043632 | modification-dependent macromolecule catabolic process | 5 | 1 |
| GO:0044087 | regulation of cellular component biogenesis | 4 | 1 |
| GO:0044089 | positive regulation of cellular component biogenesis | 5 | 1 |
| GO:0044237 | cellular metabolic process | 2 | 1 |
| GO:0044248 | cellular catabolic process | 3 | 1 |
| GO:0044260 | obsolete cellular macromolecule metabolic process | 3 | 1 |
| GO:0044265 | obsolete cellular macromolecule catabolic process | 4 | 1 |
| GO:0045893 | positive regulation of DNA-templated transcription | 7 | 1 |
| GO:0045898 | regulation of RNA polymerase II transcription preinitiation complex assembly | 6 | 1 |
| GO:0045899 | positive regulation of RNA polymerase II transcription preinitiation complex assembly | 7 | 1 |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 6 | 1 |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 8 | 1 |
| GO:0048518 | positive regulation of biological process | 3 | 1 |
| GO:0048522 | positive regulation of cellular process | 4 | 1 |
| GO:0050789 | regulation of biological process | 2 | 1 |
| GO:0050794 | regulation of cellular process | 3 | 1 |
| GO:0050896 | response to stimulus | 1 | 1 |
| GO:0051128 | regulation of cellular component organization | 4 | 1 |
| GO:0051130 | positive regulation of cellular component organization | 5 | 1 |
| GO:0051171 | regulation of nitrogen compound metabolic process | 4 | 1 |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 5 | 1 |
| GO:0051252 | regulation of RNA metabolic process | 5 | 1 |
| GO:0051254 | positive regulation of RNA metabolic process | 6 | 1 |
| GO:0051603 | proteolysis involved in protein catabolic process | 5 | 1 |
| GO:0051716 | cellular response to stimulus | 2 | 1 |
| GO:0060255 | regulation of macromolecule metabolic process | 4 | 1 |
| GO:0060260 | regulation of transcription initiation by RNA polymerase II | 8 | 1 |
| GO:0060261 | positive regulation of transcription initiation by RNA polymerase II | 9 | 1 |
| GO:0065007 | biological regulation | 1 | 1 |
| GO:0080090 | regulation of primary metabolic process | 4 | 1 |
| GO:1901698 | response to nitrogen compound | 3 | 1 |
| GO:1902680 | positive regulation of RNA biosynthetic process | 7 | 1 |
| GO:1903506 | regulation of nucleic acid-templated transcription | 7 | 1 |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 8 | 1 |
| GO:2000142 | regulation of DNA-templated transcription initiation | 7 | 1 |
| GO:2000144 | positive regulation of DNA-templated transcription initiation | 8 | 1 |
| GO:2001141 | regulation of RNA biosynthetic process | 6 | 1 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0000166 | nucleotide binding | 3 | 12 |
| GO:0003824 | catalytic activity | 1 | 12 |
| GO:0005488 | binding | 1 | 12 |
| GO:0005524 | ATP binding | 5 | 12 |
| GO:0008233 | peptidase activity | 3 | 12 |
| GO:0016462 | pyrophosphatase activity | 5 | 12 |
| GO:0016787 | hydrolase activity | 2 | 12 |
| GO:0016817 | hydrolase activity, acting on acid anhydrides | 3 | 12 |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 4 | 12 |
| GO:0016887 | ATP hydrolysis activity | 7 | 12 |
| GO:0017076 | purine nucleotide binding | 4 | 12 |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 6 | 12 |
| GO:0030554 | adenyl nucleotide binding | 5 | 12 |
| GO:0032553 | ribonucleotide binding | 3 | 12 |
| GO:0032555 | purine ribonucleotide binding | 4 | 12 |
| GO:0032559 | adenyl ribonucleotide binding | 5 | 12 |
| GO:0035639 | purine ribonucleoside triphosphate binding | 4 | 12 |
| GO:0036094 | small molecule binding | 2 | 12 |
| GO:0036402 | proteasome-activating activity | 2 | 12 |
| GO:0043167 | ion binding | 2 | 12 |
| GO:0043168 | anion binding | 3 | 12 |
| GO:0097159 | organic cyclic compound binding | 2 | 12 |
| GO:0097367 | carbohydrate derivative binding | 2 | 12 |
| GO:0140096 | catalytic activity, acting on a protein | 2 | 12 |
| GO:0140657 | ATP-dependent activity | 1 | 12 |
| GO:1901265 | nucleoside phosphate binding | 3 | 12 |
| GO:1901363 | heterocyclic compound binding | 2 | 12 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 240 | 244 | PF00656 | 0.220 |
| CLV_C14_Caspase3-7 | 289 | 293 | PF00656 | 0.312 |
| CLV_MEL_PAP_1 | 165 | 171 | PF00089 | 0.325 |
| CLV_NRD_NRD_1 | 302 | 304 | PF00675 | 0.248 |
| CLV_NRD_NRD_1 | 377 | 379 | PF00675 | 0.321 |
| CLV_NRD_NRD_1 | 89 | 91 | PF00675 | 0.295 |
| CLV_PCSK_KEX2_1 | 248 | 250 | PF00082 | 0.284 |
| CLV_PCSK_KEX2_1 | 384 | 386 | PF00082 | 0.529 |
| CLV_PCSK_KEX2_1 | 68 | 70 | PF00082 | 0.295 |
| CLV_PCSK_PC1ET2_1 | 248 | 250 | PF00082 | 0.284 |
| CLV_PCSK_PC1ET2_1 | 384 | 386 | PF00082 | 0.529 |
| CLV_PCSK_PC1ET2_1 | 68 | 70 | PF00082 | 0.295 |
| CLV_PCSK_SKI1_1 | 103 | 107 | PF00082 | 0.257 |
| CLV_PCSK_SKI1_1 | 11 | 15 | PF00082 | 0.497 |
| CLV_PCSK_SKI1_1 | 175 | 179 | PF00082 | 0.220 |
| CLV_PCSK_SKI1_1 | 187 | 191 | PF00082 | 0.220 |
| CLV_PCSK_SKI1_1 | 223 | 227 | PF00082 | 0.220 |
| CLV_PCSK_SKI1_1 | 25 | 29 | PF00082 | 0.340 |
| CLV_PCSK_SKI1_1 | 91 | 95 | PF00082 | 0.204 |
| DEG_Nend_UBRbox_3 | 1 | 3 | PF02207 | 0.540 |
| DOC_CYCLIN_yClb1_LxF_4 | 95 | 100 | PF00134 | 0.431 |
| DOC_MAPK_gen_1 | 150 | 160 | PF00069 | 0.310 |
| DOC_MAPK_gen_1 | 297 | 307 | PF00069 | 0.220 |
| DOC_MAPK_gen_1 | 31 | 41 | PF00069 | 0.360 |
| DOC_MAPK_gen_1 | 325 | 334 | PF00069 | 0.492 |
| DOC_MAPK_gen_1 | 90 | 100 | PF00069 | 0.393 |
| DOC_MAPK_JIP1_4 | 94 | 100 | PF00069 | 0.413 |
| DOC_MAPK_MEF2A_6 | 153 | 160 | PF00069 | 0.307 |
| DOC_MAPK_MEF2A_6 | 230 | 238 | PF00069 | 0.266 |
| DOC_MAPK_MEF2A_6 | 275 | 283 | PF00069 | 0.202 |
| DOC_MAPK_MEF2A_6 | 300 | 309 | PF00069 | 0.233 |
| DOC_MAPK_MEF2A_6 | 99 | 108 | PF00069 | 0.393 |
| DOC_MAPK_NFAT4_5 | 153 | 161 | PF00069 | 0.456 |
| DOC_MAPK_RevD_3 | 234 | 249 | PF00069 | 0.220 |
| DOC_MAPK_RevD_3 | 75 | 91 | PF00069 | 0.456 |
| DOC_PP1_RVXF_1 | 133 | 140 | PF00149 | 0.369 |
| DOC_PP1_RVXF_1 | 95 | 101 | PF00149 | 0.414 |
| DOC_SPAK_OSR1_1 | 74 | 78 | PF12202 | 0.431 |
| DOC_USP7_MATH_1 | 244 | 248 | PF00917 | 0.367 |
| DOC_USP7_UBL2_3 | 325 | 329 | PF12436 | 0.456 |
| DOC_USP7_UBL2_3 | 375 | 379 | PF12436 | 0.315 |
| LIG_14-3-3_CanoR_1 | 25 | 32 | PF00244 | 0.447 |
| LIG_14-3-3_CanoR_1 | 350 | 359 | PF00244 | 0.220 |
| LIG_Actin_WH2_2 | 191 | 206 | PF00022 | 0.220 |
| LIG_Actin_WH2_2 | 20 | 35 | PF00022 | 0.504 |
| LIG_Actin_WH2_2 | 52 | 70 | PF00022 | 0.366 |
| LIG_BIR_III_4 | 243 | 247 | PF00653 | 0.220 |
| LIG_BRCT_BRCA1_1 | 340 | 344 | PF00533 | 0.236 |
| LIG_FHA_1 | 108 | 114 | PF00498 | 0.432 |
| LIG_FHA_2 | 159 | 165 | PF00498 | 0.314 |
| LIG_FHA_2 | 260 | 266 | PF00498 | 0.220 |
| LIG_LIR_Gen_1 | 109 | 118 | PF02991 | 0.495 |
| LIG_LIR_Gen_1 | 136 | 147 | PF02991 | 0.351 |
| LIG_LIR_Gen_1 | 164 | 174 | PF02991 | 0.361 |
| LIG_LIR_Gen_1 | 199 | 210 | PF02991 | 0.220 |
| LIG_LIR_Gen_1 | 271 | 281 | PF02991 | 0.220 |
| LIG_LIR_Gen_1 | 331 | 340 | PF02991 | 0.234 |
| LIG_LIR_Nem_3 | 109 | 114 | PF02991 | 0.495 |
| LIG_LIR_Nem_3 | 136 | 142 | PF02991 | 0.363 |
| LIG_LIR_Nem_3 | 164 | 169 | PF02991 | 0.362 |
| LIG_LIR_Nem_3 | 199 | 205 | PF02991 | 0.247 |
| LIG_LIR_Nem_3 | 271 | 276 | PF02991 | 0.254 |
| LIG_LIR_Nem_3 | 331 | 337 | PF02991 | 0.220 |
| LIG_MAD2 | 115 | 123 | PF02301 | 0.465 |
| LIG_NRBOX | 262 | 268 | PF00104 | 0.220 |
| LIG_PCNA_yPIPBox_3 | 257 | 267 | PF02747 | 0.220 |
| LIG_PTB_Apo_2 | 367 | 374 | PF02174 | 0.234 |
| LIG_SH2_CRK | 180 | 184 | PF00017 | 0.220 |
| LIG_SH2_STAP1 | 126 | 130 | PF00017 | 0.405 |
| LIG_SH2_STAT3 | 126 | 129 | PF00017 | 0.352 |
| LIG_SH2_STAT3 | 393 | 396 | PF00017 | 0.490 |
| LIG_SH2_STAT5 | 214 | 217 | PF00017 | 0.220 |
| LIG_SH2_STAT5 | 367 | 370 | PF00017 | 0.220 |
| LIG_SH2_STAT5 | 62 | 65 | PF00017 | 0.305 |
| LIG_SH3_2 | 6 | 11 | PF14604 | 0.444 |
| LIG_SH3_3 | 3 | 9 | PF00018 | 0.607 |
| LIG_UBA3_1 | 266 | 275 | PF00899 | 0.202 |
| LIG_UBA3_1 | 318 | 325 | PF00899 | 0.433 |
| LIG_WRC_WIRS_1 | 108 | 113 | PF05994 | 0.495 |
| MOD_CK2_1 | 158 | 164 | PF00069 | 0.316 |
| MOD_CK2_1 | 252 | 258 | PF00069 | 0.220 |
| MOD_CK2_1 | 259 | 265 | PF00069 | 0.116 |
| MOD_GlcNHglycan | 217 | 220 | PF01048 | 0.269 |
| MOD_GlcNHglycan | 322 | 325 | PF01048 | 0.481 |
| MOD_GlcNHglycan | 80 | 83 | PF01048 | 0.190 |
| MOD_GSK3_1 | 320 | 327 | PF00069 | 0.449 |
| MOD_N-GLC_1 | 25 | 30 | PF02516 | 0.382 |
| MOD_N-GLC_2 | 351 | 353 | PF02516 | 0.220 |
| MOD_NEK2_1 | 106 | 111 | PF00069 | 0.436 |
| MOD_NEK2_1 | 386 | 391 | PF00069 | 0.613 |
| MOD_NEK2_2 | 89 | 94 | PF00069 | 0.400 |
| MOD_PIKK_1 | 25 | 31 | PF00454 | 0.447 |
| MOD_PKA_2 | 89 | 95 | PF00069 | 0.495 |
| MOD_Plk_1 | 106 | 112 | PF00069 | 0.400 |
| MOD_Plk_1 | 135 | 141 | PF00069 | 0.370 |
| MOD_Plk_4 | 185 | 191 | PF00069 | 0.224 |
| MOD_Plk_4 | 206 | 212 | PF00069 | 0.266 |
| MOD_Plk_4 | 333 | 339 | PF00069 | 0.234 |
| MOD_SUMO_for_1 | 93 | 96 | PF00179 | 0.413 |
| MOD_SUMO_rev_2 | 37 | 41 | PF00179 | 0.352 |
| TRG_NES_CRM1_1 | 107 | 120 | PF08389 | 0.413 |
| TRG_NES_CRM1_1 | 151 | 164 | PF08389 | 0.314 |
| TRG_Pf-PMV_PEXEL_1 | 220 | 224 | PF00026 | 0.277 |
| TRG_Pf-PMV_PEXEL_1 | 261 | 265 | PF00026 | 0.220 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P4E9 | Leptomonas seymouri | 93% | 100% |
| A0A0N0P5B8 | Leptomonas seymouri | 46% | 89% |
| A0A0N0P7K1 | Leptomonas seymouri | 44% | 97% |
| A0A0N1IGY9 | Leptomonas seymouri | 43% | 95% |
| A0A0N1IM81 | Leptomonas seymouri | 43% | 90% |
| A0A0N1PAS8 | Leptomonas seymouri | 46% | 91% |
| A0A0S4IJE6 | Bodo saltans | 51% | 91% |
| A0A0S4ITX1 | Bodo saltans | 46% | 89% |
| A0A0S4IUM1 | Bodo saltans | 33% | 67% |
| A0A0S4IY28 | Bodo saltans | 84% | 100% |
| A0A0S4JAH0 | Bodo saltans | 33% | 68% |
| A0A0S4JCD0 | Bodo saltans | 45% | 99% |
| A0A0S4JDU3 | Bodo saltans | 47% | 100% |
| A0A0S4JSD8 | Bodo saltans | 44% | 100% |
| A0A1X0NMZ3 | Trypanosomatidae | 45% | 91% |
| A0A1X0NNS1 | Trypanosomatidae | 46% | 96% |
| A0A1X0NQI9 | Trypanosomatidae | 24% | 68% |
| A0A1X0NT86 | Trypanosomatidae | 48% | 90% |
| A0A1X0NUX3 | Trypanosomatidae | 50% | 91% |
| A0A1X0P1T5 | Trypanosomatidae | 47% | 97% |
| A0A1X0P8T7 | Trypanosomatidae | 80% | 99% |
| A0A3Q8IIF1 | Leishmania donovani | 33% | 73% |
| A0A3Q8IJP7 | Leishmania donovani | 33% | 66% |
| A0A3Q8IJS0 | Leishmania donovani | 46% | 97% |
| A0A3R7LUG9 | Trypanosoma rangeli | 49% | 90% |
| A0A3R7N4Y5 | Trypanosoma rangeli | 44% | 98% |
| A0A3S5H547 | Leishmania donovani | 100% | 100% |
| A0A3S7WRY0 | Leishmania donovani | 44% | 96% |
| A0A3S7WSK7 | Leishmania donovani | 43% | 90% |
| A0A3S7WX14 | Leishmania donovani | 46% | 89% |
| A0A3S7WX46 | Leishmania donovani | 50% | 91% |
| A0A422NDS9 | Trypanosoma rangeli | 51% | 91% |
| A0A422NLD8 | Trypanosoma rangeli | 45% | 91% |
| A0A422NMN6 | Trypanosoma rangeli | 80% | 99% |
| A0A422NUD9 | Trypanosoma rangeli | 44% | 99% |
| A0JWY3 | Arthrobacter sp. (strain FB24) | 40% | 67% |
| A3CV35 | Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1) | 53% | 96% |
| A4G0S4 | Methanococcus maripaludis (strain C5 / ATCC BAA-1333) | 51% | 97% |
| A4H3L6 | Leishmania braziliensis | 97% | 100% |
| A4H6T6 | Leishmania braziliensis | 44% | 100% |
| A4H795 | Leishmania braziliensis | 43% | 100% |
| A4H9H1 | Leishmania braziliensis | 33% | 66% |
| A4HAA8 | Leishmania braziliensis | 33% | 66% |
| A4HCA3 | Leishmania braziliensis | 51% | 100% |
| A4HCA7 | Leishmania braziliensis | 46% | 89% |
| A4HPV3 | Leishmania braziliensis | 45% | 100% |
| A4HVN7 | Leishmania infantum | 43% | 100% |
| A4HXT7 | Leishmania infantum | 33% | 66% |
| A4HZT4 | Leishmania infantum | 50% | 91% |
| A4HZT9 | Leishmania infantum | 46% | 89% |
| A4IAA1 | Leishmania infantum | 33% | 73% |
| A4IE38 | Leishmania infantum | 46% | 100% |
| A6UQT3 | Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB) | 50% | 97% |
| A6VHR1 | Methanococcus maripaludis (strain C7 / ATCC BAA-1331) | 51% | 97% |
| A7I8B8 | Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8) | 51% | 91% |
| A9A916 | Methanococcus maripaludis (strain C6 / ATCC BAA-1332) | 52% | 97% |
| A9WSI4 | Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235) | 37% | 67% |
| B0K657 | Thermoanaerobacter sp. (strain X514) | 36% | 78% |
| B3DRN4 | Bifidobacterium longum (strain DJO10A) | 35% | 76% |
| B6YXR2 | Thermococcus onnurineus (strain NA1) | 50% | 99% |
| B7GUP3 | Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12) | 34% | 76% |
| B8GGN4 | Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c) | 48% | 96% |
| B8H8L3 | Pseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) | 39% | 68% |
| C3MRF1 | Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) | 43% | 100% |
| C3MY47 | Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) | 43% | 100% |
| C3MZI6 | Sulfolobus islandicus (strain M.16.27) | 43% | 100% |
| C3N7K8 | Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) | 43% | 100% |
| C3NFW6 | Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) | 43% | 100% |
| C4KIR6 | Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) | 43% | 100% |
| C5A6P8 | Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3) | 49% | 100% |
| C5BVA6 | Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432) | 37% | 71% |
| C7PVU9 | Catenulispora acidiphila (strain DSM 44928 / JCM 14897 / NBRC 102108 / NRRL B-24433 / ID139908) | 37% | 67% |
| C9ZQC1 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 44% | 98% |
| C9ZRM0 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 50% | 91% |
| C9ZRM8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 50% | 89% |
| D0A259 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 80% | 99% |
| D0A4A2 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 45% | 97% |
| D0A6K9 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 44% | 91% |
| D1BHU2 | Sanguibacter keddieii (strain ATCC 51767 / DSM 10542 / NCFB 3025 / ST-74) | 34% | 68% |
| D1BS23 | Xylanimonas cellulosilytica (strain DSM 15894 / CECT 5975 / LMG 20990 / XIL07) | 37% | 73% |
| D2S6D9 | Geodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 / KCC A-0152 / KCTC 9177 / NBRC 13315 / NRRL B-3577 / G-20) | 35% | 67% |
| D4GUJ7 | Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) | 43% | 98% |
| E9ACJ9 | Leishmania major | 99% | 100% |
| E9AGB0 | Leishmania infantum | 44% | 96% |
| E9AJT7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 99% | 100% |
| E9ANU8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 44% | 100% |
| E9APD3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 43% | 100% |
| E9ATM0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 46% | 100% |
| E9AVN9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 50% | 100% |
| E9AVP4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 46% | 89% |
| O04019 | Arabidopsis thaliana | 49% | 94% |
| O14126 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 47% | 90% |
| O16368 | Caenorhabditis elegans | 44% | 89% |
| O17071 | Caenorhabditis elegans | 64% | 98% |
| O18413 | Drosophila melanogaster | 48% | 98% |
| O23894 | Brassica campestris | 48% | 93% |
| O26824 | Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) | 50% | 97% |
| O28303 | Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) | 52% | 99% |
| O42586 | Xenopus laevis | 46% | 98% |
| O42587 | Xenopus laevis | 47% | 94% |
| O42931 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 44% | 90% |
| O57940 | Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) | 51% | 99% |
| O64982 | Prunus persica | 49% | 93% |
| O74445 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 65% | 100% |
| O74894 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 42% | 100% |
| O76371 | Caenorhabditis elegans | 44% | 92% |
| O88685 | Mus musculus | 45% | 90% |
| P0DKJ9 | Oryza sativa subsp. japonica | 44% | 93% |
| P0DKK0 | Oryza sativa subsp. japonica | 44% | 93% |
| P17980 | Homo sapiens | 45% | 90% |
| P33297 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 48% | 91% |
| P33298 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 42% | 93% |
| P33299 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 46% | 85% |
| P34123 | Dictyostelium discoideum | 47% | 98% |
| P34124 | Dictyostelium discoideum | 44% | 98% |
| P35998 | Homo sapiens | 44% | 91% |
| P36612 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 41% | 88% |
| P40327 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 46% | 91% |
| P41836 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 44% | 98% |
| P43686 | Homo sapiens | 46% | 95% |
| P46465 | Oryza sativa subsp. japonica | 49% | 92% |
| P46466 | Oryza sativa subsp. japonica | 45% | 88% |
| P46470 | Xenopus laevis | 50% | 86% |
| P46471 | Mus musculus | 44% | 91% |
| P46472 | Xenopus laevis | 44% | 91% |
| P46502 | Caenorhabditis elegans | 46% | 96% |
| P46507 | Manduca sexta | 46% | 95% |
| P48601 | Drosophila melanogaster | 44% | 90% |
| P53549 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 62% | 91% |
| P54775 | Mus musculus | 46% | 95% |
| P54776 | Solanum lycopersicum | 48% | 94% |
| P54778 | Solanum tuberosum | 46% | 96% |
| P54814 | Manduca sexta | 48% | 99% |
| P62191 | Homo sapiens | 45% | 90% |
| P62192 | Mus musculus | 45% | 90% |
| P62193 | Rattus norvegicus | 45% | 90% |
| P62194 | Bos taurus | 51% | 98% |
| P62195 | Homo sapiens | 51% | 98% |
| P62196 | Mus musculus | 51% | 98% |
| P62197 | Sus scrofa | 51% | 98% |
| P62198 | Rattus norvegicus | 51% | 98% |
| P62333 | Homo sapiens | 65% | 100% |
| P62334 | Mus musculus | 65% | 100% |
| P62335 | Ictidomys tridecemlineatus | 65% | 100% |
| P78578 | Aspergillus niger | 42% | 94% |
| P85200 | Helianthus annuus | 45% | 96% |
| Q01939 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 47% | 98% |
| Q0W257 | Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50) | 45% | 95% |
| Q18787 | Caenorhabditis elegans | 49% | 91% |
| Q25544 | Naegleria fowleri | 44% | 96% |
| Q2FQ56 | Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1) | 50% | 96% |
| Q2KIW6 | Bos taurus | 65% | 100% |
| Q3T030 | Bos taurus | 46% | 95% |
| Q41365 | Spinacia oleracea | 44% | 93% |
| Q47NX7 | Thermobifida fusca (strain YX) | 38% | 68% |
| Q4Q0X8 | Leishmania major | 46% | 100% |
| Q4Q2K9 | Leishmania major | 34% | 74% |
| Q4QBT5 | Leishmania major | 46% | 89% |
| Q4QBU0 | Leishmania major | 50% | 100% |
| Q4QDY0 | Leishmania major | 34% | 66% |
| Q4QG45 | Leishmania major | 43% | 100% |
| Q4QGS2 | Leishmania major | 44% | 100% |
| Q4R4R0 | Macaca fascicularis | 44% | 91% |
| Q4R7L3 | Macaca fascicularis | 46% | 95% |
| Q54PJ1 | Dictyostelium discoideum | 63% | 100% |
| Q54PN7 | Dictyostelium discoideum | 42% | 94% |
| Q55BV5 | Dictyostelium discoideum | 49% | 90% |
| Q58576 | Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) | 52% | 92% |
| Q58889 | Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) | 33% | 100% |
| Q5E9F9 | Bos taurus | 44% | 91% |
| Q5JHS5 | Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) | 51% | 100% |
| Q5R8D7 | Pongo abelii | 44% | 91% |
| Q5UT56 | Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) | 41% | 96% |
| Q63347 | Rattus norvegicus | 44% | 91% |
| Q63569 | Rattus norvegicus | 45% | 90% |
| Q63570 | Rattus norvegicus | 46% | 95% |
| Q6LWR0 | Methanococcus maripaludis (strain S2 / LL) | 51% | 97% |
| Q86JA1 | Dictyostelium discoideum | 49% | 93% |
| Q8G3G6 | Bifidobacterium longum (strain NCC 2705) | 34% | 76% |
| Q8PY58 | Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) | 47% | 94% |
| Q8SQI9 | Encephalitozoon cuniculi (strain GB-M1) | 44% | 100% |
| Q8SQK0 | Encephalitozoon cuniculi (strain GB-M1) | 46% | 100% |
| Q8SR13 | Encephalitozoon cuniculi (strain GB-M1) | 42% | 99% |
| Q8SRH0 | Encephalitozoon cuniculi (strain GB-M1) | 44% | 93% |
| Q8TI88 | Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) | 47% | 94% |
| Q8TX03 | Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) | 49% | 91% |
| Q8U4H3 | Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) | 51% | 100% |
| Q90732 | Gallus gallus | 45% | 90% |
| Q94BQ2 | Arabidopsis thaliana | 48% | 95% |
| Q975U2 | Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) | 50% | 100% |
| Q980M1 | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) | 46% | 100% |
| Q9C5U3 | Arabidopsis thaliana | 47% | 95% |
| Q9HNP9 | Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) | 40% | 96% |
| Q9HRW6 | Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) | 41% | 98% |
| Q9MAK9 | Arabidopsis thaliana | 63% | 99% |
| Q9SEI2 | Arabidopsis thaliana | 48% | 93% |
| Q9SEI3 | Arabidopsis thaliana | 62% | 99% |
| Q9SEI4 | Arabidopsis thaliana | 45% | 97% |
| Q9SEX2 | Arabidopsis thaliana | 38% | 76% |
| Q9SL67 | Arabidopsis thaliana | 45% | 89% |
| Q9SSB4 | Arabidopsis thaliana | 47% | 85% |
| Q9SSB5 | Arabidopsis thaliana | 48% | 93% |
| Q9SZD4 | Arabidopsis thaliana | 45% | 89% |
| Q9V287 | Pyrococcus abyssi (strain GE5 / Orsay) | 51% | 100% |
| Q9VQN8 | Drosophila melanogaster | 36% | 76% |
| Q9XTT9 | Caenorhabditis elegans | 49% | 95% |
| Q9YAC7 | Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) | 48% | 97% |
| V5AV12 | Trypanosoma cruzi | 45% | 91% |
| V5B5X1 | Trypanosoma cruzi | 51% | 91% |
| V5B5X6 | Trypanosoma cruzi | 49% | 90% |
| V5BKL6 | Trypanosoma cruzi | 48% | 98% |
| V5BSS5 | Trypanosoma cruzi | 80% | 99% |