LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
RNA recognition motif. (a.k.a. RRM - RBD - or RNP domain) - putative
Species:
Leishmania infantum
UniProt:
E9AG41_LEIIN
TriTrypDb:
LINF_030010000
Length:
857

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0000243 commitment complex 5 1
GO:0005681 spliceosomal complex 3 1
GO:0005684 U2-type spliceosomal complex 4 1
GO:0016604 nuclear body 2 1
GO:0016607 nuclear speck 3 1
GO:0032991 protein-containing complex 1 1
GO:0071004 U2-type prespliceosome 5 1
GO:0071010 prespliceosome 4 1
GO:0089701 U2AF complex 3 1
GO:0110165 cellular anatomical entity 1 1
GO:0140513 nuclear protein-containing complex 2 1
GO:1990904 ribonucleoprotein complex 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

E9AG41
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG41

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 9
GO:0003723 RNA binding 4 8
GO:0005488 binding 1 9
GO:0097159 organic cyclic compound binding 2 9
GO:1901363 heterocyclic compound binding 2 9
GO:0003727 single-stranded RNA binding 5 1
GO:0008187 poly-pyrimidine tract binding 6 1
GO:0030628 pre-mRNA 3'-splice site binding 6 1
GO:0036002 pre-mRNA binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 211 215 PF00656 0.591
CLV_C14_Caspase3-7 414 418 PF00656 0.428
CLV_C14_Caspase3-7 482 486 PF00656 0.446
CLV_C14_Caspase3-7 8 12 PF00656 0.671
CLV_MEL_PAP_1 342 348 PF00089 0.383
CLV_NRD_NRD_1 297 299 PF00675 0.407
CLV_NRD_NRD_1 303 305 PF00675 0.335
CLV_NRD_NRD_1 331 333 PF00675 0.316
CLV_NRD_NRD_1 426 428 PF00675 0.357
CLV_NRD_NRD_1 47 49 PF00675 0.572
CLV_NRD_NRD_1 60 62 PF00675 0.662
CLV_NRD_NRD_1 675 677 PF00675 0.413
CLV_NRD_NRD_1 710 712 PF00675 0.321
CLV_NRD_NRD_1 80 82 PF00675 0.770
CLV_NRD_NRD_1 83 85 PF00675 0.641
CLV_NRD_NRD_1 830 832 PF00675 0.519
CLV_NRD_NRD_1 9 11 PF00675 0.604
CLV_PCSK_FUR_1 45 49 PF00082 0.661
CLV_PCSK_FUR_1 667 671 PF00082 0.365
CLV_PCSK_FUR_1 81 85 PF00082 0.619
CLV_PCSK_KEX2_1 297 299 PF00082 0.407
CLV_PCSK_KEX2_1 303 305 PF00082 0.335
CLV_PCSK_KEX2_1 331 333 PF00082 0.316
CLV_PCSK_KEX2_1 426 428 PF00082 0.357
CLV_PCSK_KEX2_1 47 49 PF00082 0.557
CLV_PCSK_KEX2_1 60 62 PF00082 0.665
CLV_PCSK_KEX2_1 669 671 PF00082 0.388
CLV_PCSK_KEX2_1 675 677 PF00082 0.393
CLV_PCSK_KEX2_1 80 82 PF00082 0.663
CLV_PCSK_KEX2_1 83 85 PF00082 0.645
CLV_PCSK_KEX2_1 9 11 PF00082 0.604
CLV_PCSK_PC1ET2_1 669 671 PF00082 0.364
CLV_PCSK_PC7_1 43 49 PF00082 0.591
CLV_PCSK_SKI1_1 280 284 PF00082 0.448
CLV_PCSK_SKI1_1 409 413 PF00082 0.422
CLV_PCSK_SKI1_1 441 445 PF00082 0.317
CLV_PCSK_SKI1_1 457 461 PF00082 0.149
CLV_PCSK_SKI1_1 465 469 PF00082 0.216
CLV_PCSK_SKI1_1 484 488 PF00082 0.117
CLV_PCSK_SKI1_1 513 517 PF00082 0.341
CLV_PCSK_SKI1_1 594 598 PF00082 0.436
DEG_APCC_DBOX_1 279 287 PF00400 0.456
DEG_SPOP_SBC_1 265 269 PF00917 0.615
DEG_SPOP_SBC_1 824 828 PF00917 0.670
DOC_CKS1_1 105 110 PF01111 0.573
DOC_CKS1_1 629 634 PF01111 0.401
DOC_CYCLIN_RxL_1 406 415 PF00134 0.434
DOC_CYCLIN_RxL_1 462 470 PF00134 0.446
DOC_CYCLIN_RxL_1 591 600 PF00134 0.504
DOC_MAPK_FxFP_2 767 770 PF00069 0.454
DOC_MAPK_gen_1 381 390 PF00069 0.318
DOC_MAPK_gen_1 664 673 PF00069 0.330
DOC_MAPK_MEF2A_6 243 250 PF00069 0.611
DOC_MAPK_MEF2A_6 383 392 PF00069 0.325
DOC_MAPK_MEF2A_6 518 525 PF00069 0.420
DOC_MAPK_NFAT4_5 243 251 PF00069 0.615
DOC_PP1_RVXF_1 463 470 PF00149 0.446
DOC_PP2B_LxvP_1 286 289 PF13499 0.525
DOC_PP2B_LxvP_1 325 328 PF13499 0.398
DOC_PP2B_LxvP_1 671 674 PF13499 0.310
DOC_PP4_FxxP_1 143 146 PF00568 0.744
DOC_PP4_FxxP_1 59 62 PF00568 0.656
DOC_PP4_FxxP_1 601 604 PF00568 0.473
DOC_PP4_FxxP_1 767 770 PF00568 0.454
DOC_USP7_MATH_1 108 112 PF00917 0.600
DOC_USP7_MATH_1 146 150 PF00917 0.642
DOC_USP7_MATH_1 264 268 PF00917 0.671
DOC_USP7_MATH_1 305 309 PF00917 0.430
DOC_USP7_MATH_1 452 456 PF00917 0.480
DOC_USP7_MATH_1 545 549 PF00917 0.661
DOC_USP7_MATH_1 572 576 PF00917 0.624
DOC_USP7_MATH_1 834 838 PF00917 0.706
DOC_USP7_UBL2_3 534 538 PF12436 0.494
DOC_WW_Pin1_4 104 109 PF00397 0.650
DOC_WW_Pin1_4 162 167 PF00397 0.676
DOC_WW_Pin1_4 198 203 PF00397 0.639
DOC_WW_Pin1_4 628 633 PF00397 0.424
LIG_14-3-3_CanoR_1 331 339 PF00244 0.424
LIG_14-3-3_CanoR_1 381 386 PF00244 0.421
LIG_14-3-3_CanoR_1 724 728 PF00244 0.465
LIG_14-3-3_CanoR_1 761 770 PF00244 0.344
LIG_AP2alpha_2 57 59 PF02296 0.637
LIG_APCC_ABBA_1 637 642 PF00400 0.348
LIG_APCC_ABBAyCdc20_2 848 854 PF00400 0.492
LIG_BIR_III_2 430 434 PF00653 0.460
LIG_BIR_III_4 137 141 PF00653 0.500
LIG_BIR_III_4 784 788 PF00653 0.505
LIG_BIR_III_4 839 843 PF00653 0.507
LIG_BRCT_BRCA1_1 383 387 PF00533 0.320
LIG_BRCT_BRCA1_1 765 769 PF00533 0.381
LIG_Clathr_ClatBox_1 283 287 PF01394 0.593
LIG_Clathr_ClatBox_1 466 470 PF01394 0.416
LIG_eIF4E_1 629 635 PF01652 0.315
LIG_FHA_1 226 232 PF00498 0.635
LIG_FHA_1 361 367 PF00498 0.472
LIG_FHA_1 418 424 PF00498 0.506
LIG_FHA_1 545 551 PF00498 0.593
LIG_FHA_1 629 635 PF00498 0.314
LIG_FHA_1 724 730 PF00498 0.426
LIG_FHA_1 763 769 PF00498 0.375
LIG_FHA_1 851 857 PF00498 0.542
LIG_FHA_2 312 318 PF00498 0.400
LIG_FHA_2 433 439 PF00498 0.449
LIG_FHA_2 522 528 PF00498 0.425
LIG_FHA_2 600 606 PF00498 0.481
LIG_FHA_2 740 746 PF00498 0.397
LIG_FHA_2 774 780 PF00498 0.552
LIG_Integrin_RGD_1 212 214 PF01839 0.620
LIG_LIR_Apic_2 142 146 PF02991 0.556
LIG_LIR_Apic_2 57 62 PF02991 0.648
LIG_LIR_Apic_2 598 604 PF02991 0.496
LIG_LIR_Apic_2 627 632 PF02991 0.428
LIG_LIR_Apic_2 765 770 PF02991 0.445
LIG_LIR_Apic_2 91 97 PF02991 0.576
LIG_LIR_Gen_1 320 330 PF02991 0.365
LIG_LIR_Gen_1 384 395 PF02991 0.299
LIG_LIR_Gen_1 479 486 PF02991 0.416
LIG_LIR_Gen_1 648 658 PF02991 0.337
LIG_LIR_Gen_1 739 747 PF02991 0.342
LIG_LIR_Nem_3 235 240 PF02991 0.580
LIG_LIR_Nem_3 320 326 PF02991 0.336
LIG_LIR_Nem_3 384 390 PF02991 0.303
LIG_LIR_Nem_3 461 466 PF02991 0.413
LIG_LIR_Nem_3 479 483 PF02991 0.331
LIG_LIR_Nem_3 648 654 PF02991 0.345
LIG_LIR_Nem_3 663 668 PF02991 0.335
LIG_LIR_Nem_3 739 743 PF02991 0.339
LIG_LIR_Nem_3 766 772 PF02991 0.376
LIG_LYPXL_S_1 613 617 PF13949 0.469
LIG_LYPXL_yS_3 421 424 PF13949 0.411
LIG_LYPXL_yS_3 614 617 PF13949 0.492
LIG_MAD2 441 449 PF02301 0.387
LIG_MYND_1 615 619 PF01753 0.413
LIG_NRBOX 182 188 PF00104 0.501
LIG_NRBOX 511 517 PF00104 0.366
LIG_PCNA_TLS_4 316 323 PF02747 0.423
LIG_Pex14_2 143 147 PF04695 0.626
LIG_Rb_pABgroove_1 634 642 PF01858 0.334
LIG_SH2_CRK 463 467 PF00017 0.446
LIG_SH2_CRK 629 633 PF00017 0.344
LIG_SH2_CRK 651 655 PF00017 0.355
LIG_SH2_CRK 665 669 PF00017 0.296
LIG_SH2_CRK 733 737 PF00017 0.432
LIG_SH2_GRB2like 621 624 PF00017 0.516
LIG_SH2_GRB2like 721 724 PF00017 0.455
LIG_SH2_NCK_1 692 696 PF00017 0.369
LIG_SH2_NCK_1 740 744 PF00017 0.356
LIG_SH2_SRC 475 478 PF00017 0.458
LIG_SH2_SRC 621 624 PF00017 0.498
LIG_SH2_SRC 692 695 PF00017 0.375
LIG_SH2_STAP1 647 651 PF00017 0.370
LIG_SH2_STAT3 109 112 PF00017 0.602
LIG_SH2_STAT5 322 325 PF00017 0.337
LIG_SH2_STAT5 535 538 PF00017 0.526
LIG_SH3_3 199 205 PF00018 0.683
LIG_SH3_3 236 242 PF00018 0.537
LIG_SH3_3 442 448 PF00018 0.376
LIG_SH3_3 501 507 PF00018 0.374
LIG_SH3_3 677 683 PF00018 0.450
LIG_SH3_5 688 692 PF00018 0.512
LIG_SUMO_SIM_anti_2 631 637 PF11976 0.281
LIG_SUMO_SIM_par_1 282 287 PF11976 0.612
LIG_SUMO_SIM_par_1 575 584 PF11976 0.613
LIG_TRAF2_1 233 236 PF00917 0.541
LIG_TRAF2_1 315 318 PF00917 0.449
LIG_TRAF2_1 776 779 PF00917 0.524
LIG_TRAF2_1 798 801 PF00917 0.678
LIG_TYR_ITIM 738 743 PF00017 0.332
LIG_UBA3_1 768 774 PF00899 0.406
LIG_WRC_WIRS_1 764 769 PF05994 0.347
LIG_WW_3 203 207 PF00397 0.645
LIG_WW_3 61 65 PF00397 0.651
MOD_CK1_1 111 117 PF00069 0.618
MOD_CK1_1 21 27 PF00069 0.646
MOD_CK1_1 267 273 PF00069 0.695
MOD_CK1_1 376 382 PF00069 0.450
MOD_CK1_1 624 630 PF00069 0.485
MOD_CK1_1 649 655 PF00069 0.414
MOD_CK1_1 850 856 PF00069 0.591
MOD_CK2_1 230 236 PF00069 0.584
MOD_CK2_1 311 317 PF00069 0.405
MOD_CK2_1 365 371 PF00069 0.553
MOD_CK2_1 383 389 PF00069 0.281
MOD_CK2_1 447 453 PF00069 0.482
MOD_CK2_1 739 745 PF00069 0.365
MOD_CK2_1 773 779 PF00069 0.534
MOD_CK2_1 82 88 PF00069 0.499
MOD_GlcNHglycan 113 116 PF01048 0.575
MOD_GlcNHglycan 148 151 PF01048 0.704
MOD_GlcNHglycan 256 259 PF01048 0.641
MOD_GlcNHglycan 307 310 PF01048 0.466
MOD_GlcNHglycan 34 37 PF01048 0.571
MOD_GlcNHglycan 402 405 PF01048 0.403
MOD_GlcNHglycan 531 534 PF01048 0.408
MOD_GlcNHglycan 546 550 PF01048 0.630
MOD_GlcNHglycan 575 578 PF01048 0.673
MOD_GlcNHglycan 69 74 PF01048 0.700
MOD_GlcNHglycan 835 839 PF01048 0.690
MOD_GSK3_1 104 111 PF00069 0.584
MOD_GSK3_1 371 378 PF00069 0.485
MOD_GSK3_1 5 12 PF00069 0.737
MOD_GSK3_1 624 631 PF00069 0.471
MOD_GSK3_1 759 766 PF00069 0.393
MOD_N-GLC_1 412 417 PF02516 0.421
MOD_N-GLC_1 649 654 PF02516 0.418
MOD_NEK2_1 216 221 PF00069 0.601
MOD_NEK2_1 375 380 PF00069 0.410
MOD_NEK2_1 411 416 PF00069 0.420
MOD_NEK2_1 597 602 PF00069 0.472
MOD_NEK2_1 82 87 PF00069 0.628
MOD_NEK2_2 452 457 PF00069 0.468
MOD_PIKK_1 108 114 PF00454 0.594
MOD_PIKK_1 267 273 PF00454 0.608
MOD_PIKK_1 398 404 PF00454 0.390
MOD_PIKK_1 621 627 PF00454 0.523
MOD_PIKK_1 649 655 PF00454 0.414
MOD_PIKK_1 825 831 PF00454 0.643
MOD_PK_1 373 379 PF00069 0.398
MOD_PKA_1 9 15 PF00069 0.473
MOD_PKA_2 3 9 PF00069 0.680
MOD_PKA_2 723 729 PF00069 0.460
MOD_PKA_2 82 88 PF00069 0.615
MOD_Plk_1 412 418 PF00069 0.423
MOD_Plk_1 452 458 PF00069 0.446
MOD_Plk_1 521 527 PF00069 0.450
MOD_Plk_1 545 551 PF00069 0.589
MOD_Plk_1 597 603 PF00069 0.452
MOD_Plk_1 649 655 PF00069 0.382
MOD_Plk_1 759 765 PF00069 0.428
MOD_Plk_2-3 739 745 PF00069 0.337
MOD_Plk_4 241 247 PF00069 0.513
MOD_Plk_4 624 630 PF00069 0.463
MOD_Plk_4 763 769 PF00069 0.341
MOD_ProDKin_1 104 110 PF00069 0.654
MOD_ProDKin_1 162 168 PF00069 0.676
MOD_ProDKin_1 198 204 PF00069 0.640
MOD_ProDKin_1 628 634 PF00069 0.414
MOD_SUMO_for_1 467 470 PF00179 0.446
MOD_SUMO_rev_2 368 375 PF00179 0.435
MOD_SUMO_rev_2 438 443 PF00179 0.404
MOD_SUMO_rev_2 784 793 PF00179 0.646
TRG_DiLeu_BaEn_1 344 349 PF01217 0.460
TRG_ENDOCYTIC_2 122 125 PF00928 0.656
TRG_ENDOCYTIC_2 322 325 PF00928 0.372
TRG_ENDOCYTIC_2 421 424 PF00928 0.479
TRG_ENDOCYTIC_2 463 466 PF00928 0.464
TRG_ENDOCYTIC_2 477 480 PF00928 0.336
TRG_ENDOCYTIC_2 509 512 PF00928 0.279
TRG_ENDOCYTIC_2 614 617 PF00928 0.492
TRG_ENDOCYTIC_2 651 654 PF00928 0.335
TRG_ENDOCYTIC_2 665 668 PF00928 0.328
TRG_ENDOCYTIC_2 733 736 PF00928 0.370
TRG_ENDOCYTIC_2 740 743 PF00928 0.322
TRG_ER_diArg_1 297 300 PF00400 0.437
TRG_ER_diArg_1 330 332 PF00400 0.304
TRG_ER_diArg_1 425 427 PF00400 0.343
TRG_ER_diArg_1 43 46 PF00400 0.648
TRG_ER_diArg_1 59 61 PF00400 0.604
TRG_ER_diArg_1 674 676 PF00400 0.361
TRG_ER_diArg_1 80 83 PF00400 0.614
TRG_NES_CRM1_1 338 352 PF08389 0.392
TRG_NES_CRM1_1 591 605 PF08389 0.495
TRG_Pf-PMV_PEXEL_1 331 336 PF00026 0.442
TRG_Pf-PMV_PEXEL_1 337 341 PF00026 0.497
TRG_Pf-PMV_PEXEL_1 594 598 PF00026 0.436

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HWG2 Leptomonas seymouri 57% 100%
A0A0S4IUY1 Bodo saltans 32% 100%
A0A3R7MIS4 Trypanosoma rangeli 38% 97%
A0A3S5H546 Leishmania donovani 98% 100%
A4H3L4 Leishmania braziliensis 80% 97%
E9ACJ7 Leishmania major 91% 99%
E9AJT5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS