LeishMANIAdb
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Leucine-rich repeat protein (LRRP)

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Leucine-rich repeat protein (LRRP)
Gene product:
Leucine Rich Repeat - putative
Species:
Leishmania infantum
UniProt:
E9AG31_LEIIN
TriTrypDb:
LINF_030006000
Length:
925

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005929 cilium 4 5
GO:0042995 cell projection 2 5
GO:0043226 organelle 2 5
GO:0043227 membrane-bounded organelle 3 5
GO:0110165 cellular anatomical entity 1 6
GO:0120025 plasma membrane bounded cell projection 3 5
GO:0005737 cytoplasm 2 1
GO:0005930 axoneme 2 1

Expansion

Sequence features

E9AG31
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG31

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0019899 enzyme binding 3 1
GO:0019900 kinase binding 4 1
GO:0019901 protein kinase binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 806 810 PF00656 0.560
CLV_C14_Caspase3-7 921 925 PF00656 0.561
CLV_NRD_NRD_1 194 196 PF00675 0.537
CLV_NRD_NRD_1 339 341 PF00675 0.701
CLV_NRD_NRD_1 503 505 PF00675 0.541
CLV_NRD_NRD_1 517 519 PF00675 0.538
CLV_NRD_NRD_1 588 590 PF00675 0.551
CLV_NRD_NRD_1 610 612 PF00675 0.639
CLV_NRD_NRD_1 723 725 PF00675 0.748
CLV_NRD_NRD_1 764 766 PF00675 0.631
CLV_NRD_NRD_1 788 790 PF00675 0.585
CLV_PCSK_FUR_1 192 196 PF00082 0.531
CLV_PCSK_KEX2_1 194 196 PF00082 0.537
CLV_PCSK_KEX2_1 339 341 PF00082 0.750
CLV_PCSK_KEX2_1 503 505 PF00082 0.631
CLV_PCSK_KEX2_1 507 509 PF00082 0.612
CLV_PCSK_KEX2_1 517 519 PF00082 0.538
CLV_PCSK_KEX2_1 552 554 PF00082 0.574
CLV_PCSK_KEX2_1 588 590 PF00082 0.551
CLV_PCSK_KEX2_1 610 612 PF00082 0.639
CLV_PCSK_KEX2_1 723 725 PF00082 0.748
CLV_PCSK_KEX2_1 764 766 PF00082 0.631
CLV_PCSK_KEX2_1 788 790 PF00082 0.585
CLV_PCSK_KEX2_1 907 909 PF00082 0.629
CLV_PCSK_PC1ET2_1 507 509 PF00082 0.653
CLV_PCSK_PC1ET2_1 552 554 PF00082 0.574
CLV_PCSK_PC1ET2_1 907 909 PF00082 0.629
CLV_PCSK_PC7_1 503 509 PF00082 0.538
CLV_PCSK_PC7_1 606 612 PF00082 0.571
CLV_PCSK_SKI1_1 250 254 PF00082 0.710
CLV_PCSK_SKI1_1 258 262 PF00082 0.661
CLV_PCSK_SKI1_1 339 343 PF00082 0.712
CLV_PCSK_SKI1_1 359 363 PF00082 0.504
CLV_PCSK_SKI1_1 534 538 PF00082 0.588
CLV_PCSK_SKI1_1 67 71 PF00082 0.554
CLV_PCSK_SKI1_1 724 728 PF00082 0.633
CLV_PCSK_SKI1_1 764 768 PF00082 0.625
CLV_PCSK_SKI1_1 913 917 PF00082 0.714
CLV_Separin_Metazoa 134 138 PF03568 0.472
DEG_APCC_DBOX_1 129 137 PF00400 0.499
DEG_APCC_DBOX_1 196 204 PF00400 0.533
DEG_APCC_DBOX_1 268 276 PF00400 0.677
DEG_APCC_DBOX_1 53 61 PF00400 0.488
DEG_APCC_DBOX_1 594 602 PF00400 0.518
DEG_APCC_DBOX_1 723 731 PF00400 0.509
DOC_CKS1_1 246 251 PF01111 0.697
DOC_CKS1_1 35 40 PF01111 0.523
DOC_CKS1_1 425 430 PF01111 0.708
DOC_CYCLIN_RxL_1 594 604 PF00134 0.526
DOC_CYCLIN_RxL_1 721 731 PF00134 0.637
DOC_CYCLIN_yCln2_LP_2 387 393 PF00134 0.603
DOC_MAPK_gen_1 22 31 PF00069 0.486
DOC_PP2B_LxvP_1 894 897 PF13499 0.660
DOC_PP4_FxxP_1 35 38 PF00568 0.522
DOC_PP4_FxxP_1 462 465 PF00568 0.647
DOC_USP7_MATH_1 264 268 PF00917 0.690
DOC_USP7_MATH_1 284 288 PF00917 0.580
DOC_USP7_MATH_1 305 309 PF00917 0.720
DOC_USP7_MATH_1 311 315 PF00917 0.646
DOC_USP7_MATH_1 421 425 PF00917 0.727
DOC_USP7_MATH_1 5 9 PF00917 0.635
DOC_USP7_MATH_1 649 653 PF00917 0.747
DOC_USP7_MATH_1 65 69 PF00917 0.509
DOC_USP7_MATH_1 655 659 PF00917 0.622
DOC_USP7_MATH_1 662 666 PF00917 0.554
DOC_USP7_MATH_1 681 685 PF00917 0.592
DOC_USP7_MATH_1 717 721 PF00917 0.619
DOC_USP7_MATH_1 745 749 PF00917 0.630
DOC_USP7_MATH_1 752 756 PF00917 0.579
DOC_USP7_MATH_1 810 814 PF00917 0.715
DOC_USP7_MATH_1 844 848 PF00917 0.713
DOC_USP7_UBL2_3 913 917 PF12436 0.618
DOC_WW_Pin1_4 174 179 PF00397 0.500
DOC_WW_Pin1_4 239 244 PF00397 0.701
DOC_WW_Pin1_4 245 250 PF00397 0.660
DOC_WW_Pin1_4 292 297 PF00397 0.637
DOC_WW_Pin1_4 322 327 PF00397 0.762
DOC_WW_Pin1_4 34 39 PF00397 0.530
DOC_WW_Pin1_4 379 384 PF00397 0.667
DOC_WW_Pin1_4 386 391 PF00397 0.697
DOC_WW_Pin1_4 424 429 PF00397 0.707
DOC_WW_Pin1_4 440 445 PF00397 0.712
DOC_WW_Pin1_4 461 466 PF00397 0.796
DOC_WW_Pin1_4 624 629 PF00397 0.670
DOC_WW_Pin1_4 657 662 PF00397 0.838
DOC_WW_Pin1_4 666 671 PF00397 0.702
DOC_WW_Pin1_4 840 845 PF00397 0.672
DOC_WW_Pin1_4 872 877 PF00397 0.728
LIG_14-3-3_CanoR_1 120 125 PF00244 0.476
LIG_14-3-3_CanoR_1 156 161 PF00244 0.462
LIG_14-3-3_CanoR_1 195 201 PF00244 0.486
LIG_14-3-3_CanoR_1 229 237 PF00244 0.674
LIG_14-3-3_CanoR_1 470 478 PF00244 0.593
LIG_14-3-3_CanoR_1 517 527 PF00244 0.536
LIG_14-3-3_CanoR_1 556 566 PF00244 0.580
LIG_14-3-3_CanoR_1 575 580 PF00244 0.349
LIG_14-3-3_CanoR_1 611 620 PF00244 0.623
LIG_14-3-3_CanoR_1 664 670 PF00244 0.704
LIG_14-3-3_CanoR_1 71 77 PF00244 0.535
LIG_14-3-3_CanoR_1 723 727 PF00244 0.736
LIG_14-3-3_CanoR_1 759 763 PF00244 0.555
LIG_14-3-3_CanoR_1 78 82 PF00244 0.441
LIG_14-3-3_CanoR_1 845 854 PF00244 0.708
LIG_14-3-3_CanoR_1 908 916 PF00244 0.553
LIG_Actin_WH2_2 523 540 PF00022 0.544
LIG_BIR_II_1 1 5 PF00653 0.611
LIG_BIR_III_4 809 813 PF00653 0.636
LIG_Clathr_ClatBox_1 207 211 PF01394 0.495
LIG_CtBP_PxDLS_1 86 90 PF00389 0.400
LIG_DLG_GKlike_1 120 127 PF00625 0.475
LIG_eIF4E_1 76 82 PF01652 0.480
LIG_EVH1_1 894 898 PF00568 0.661
LIG_FHA_1 144 150 PF00498 0.603
LIG_FHA_1 175 181 PF00498 0.529
LIG_FHA_1 225 231 PF00498 0.548
LIG_FHA_1 480 486 PF00498 0.692
LIG_FHA_1 642 648 PF00498 0.673
LIG_FHA_1 691 697 PF00498 0.617
LIG_FHA_1 714 720 PF00498 0.631
LIG_FHA_1 869 875 PF00498 0.714
LIG_FHA_2 197 203 PF00498 0.561
LIG_FHA_2 35 41 PF00498 0.521
LIG_FHA_2 401 407 PF00498 0.736
LIG_FHA_2 46 52 PF00498 0.482
LIG_FHA_2 569 575 PF00498 0.528
LIG_FHA_2 576 582 PF00498 0.496
LIG_FHA_2 585 591 PF00498 0.403
LIG_FHA_2 804 810 PF00498 0.642
LIG_FHA_2 862 868 PF00498 0.707
LIG_GBD_Chelix_1 688 696 PF00786 0.647
LIG_GBD_Chelix_1 718 726 PF00786 0.625
LIG_LIR_Gen_1 115 125 PF02991 0.462
LIG_LIR_Gen_1 571 580 PF02991 0.474
LIG_LIR_Gen_1 694 703 PF02991 0.656
LIG_LIR_Gen_1 75 82 PF02991 0.566
LIG_LIR_Nem_3 115 121 PF02991 0.572
LIG_LIR_Nem_3 694 700 PF02991 0.671
LIG_LIR_Nem_3 75 79 PF02991 0.556
LIG_PCNA_TLS_4 764 771 PF02747 0.621
LIG_RPA_C_Fungi 513 525 PF08784 0.487
LIG_RPA_C_Fungi 584 596 PF08784 0.544
LIG_SH2_CRK 437 441 PF00017 0.694
LIG_SH2_CRK 697 701 PF00017 0.601
LIG_SH2_CRK 76 80 PF00017 0.600
LIG_SH2_GRB2like 221 224 PF00017 0.604
LIG_SH2_NCK_1 76 80 PF00017 0.479
LIG_SH2_SRC 221 224 PF00017 0.604
LIG_SH2_STAP1 221 225 PF00017 0.599
LIG_SH2_STAP1 580 584 PF00017 0.544
LIG_SH2_STAT3 580 583 PF00017 0.544
LIG_SH2_STAT5 164 167 PF00017 0.625
LIG_SH3_1 331 337 PF00018 0.695
LIG_SH3_2 334 339 PF14604 0.761
LIG_SH3_2 465 470 PF14604 0.639
LIG_SH3_3 183 189 PF00018 0.610
LIG_SH3_3 272 278 PF00018 0.703
LIG_SH3_3 331 337 PF00018 0.816
LIG_SH3_3 347 353 PF00018 0.572
LIG_SH3_3 380 386 PF00018 0.835
LIG_SH3_3 422 428 PF00018 0.731
LIG_SH3_3 462 468 PF00018 0.696
LIG_SH3_3 838 844 PF00018 0.668
LIG_SH3_3 873 879 PF00018 0.707
LIG_SH3_3 892 898 PF00018 0.595
LIG_SUMO_SIM_anti_2 42 48 PF11976 0.485
LIG_SUMO_SIM_par_1 206 211 PF11976 0.502
LIG_SUMO_SIM_par_1 42 48 PF11976 0.485
LIG_SUMO_SIM_par_1 85 90 PF11976 0.397
LIG_SUMO_SIM_par_1 865 875 PF11976 0.705
LIG_TRAF2_1 37 40 PF00917 0.524
LIG_TRAF2_2 782 787 PF00917 0.723
LIG_TYR_ITIM 435 440 PF00017 0.716
LIG_UBA3_1 544 552 PF00899 0.582
LIG_WRC_WIRS_1 576 581 PF05994 0.541
LIG_WRC_WIRS_1 767 772 PF05994 0.568
MOD_CDC14_SPxK_1 389 392 PF00782 0.714
MOD_CDC14_SPxK_1 467 470 PF00782 0.682
MOD_CDC14_SPxK_1 669 672 PF00782 0.714
MOD_CDK_SPK_2 245 250 PF00069 0.699
MOD_CDK_SPK_2 379 384 PF00069 0.601
MOD_CDK_SPK_2 840 845 PF00069 0.626
MOD_CDK_SPxK_1 386 392 PF00069 0.711
MOD_CDK_SPxK_1 464 470 PF00069 0.687
MOD_CDK_SPxK_1 666 672 PF00069 0.720
MOD_CDK_SPxxK_3 322 329 PF00069 0.765
MOD_CDK_SPxxK_3 657 664 PF00069 0.723
MOD_CK1_1 206 212 PF00069 0.513
MOD_CK1_1 228 234 PF00069 0.661
MOD_CK1_1 245 251 PF00069 0.596
MOD_CK1_1 287 293 PF00069 0.706
MOD_CK1_1 318 324 PF00069 0.682
MOD_CK1_1 424 430 PF00069 0.715
MOD_CK1_1 45 51 PF00069 0.385
MOD_CK1_1 464 470 PF00069 0.723
MOD_CK1_1 554 560 PF00069 0.581
MOD_CK1_1 660 666 PF00069 0.779
MOD_CK1_1 731 737 PF00069 0.655
MOD_CK1_1 755 761 PF00069 0.591
MOD_CK1_1 8 14 PF00069 0.639
MOD_CK1_1 813 819 PF00069 0.700
MOD_CK2_1 196 202 PF00069 0.548
MOD_CK2_1 264 270 PF00069 0.694
MOD_CK2_1 322 328 PF00069 0.684
MOD_CK2_1 34 40 PF00069 0.536
MOD_CK2_1 50 56 PF00069 0.470
MOD_CK2_1 568 574 PF00069 0.529
MOD_CK2_1 575 581 PF00069 0.497
MOD_CK2_1 584 590 PF00069 0.403
MOD_CK2_1 863 869 PF00069 0.732
MOD_GlcNHglycan 10 13 PF01048 0.638
MOD_GlcNHglycan 146 149 PF01048 0.441
MOD_GlcNHglycan 266 269 PF01048 0.721
MOD_GlcNHglycan 281 284 PF01048 0.646
MOD_GlcNHglycan 362 365 PF01048 0.689
MOD_GlcNHglycan 366 369 PF01048 0.692
MOD_GlcNHglycan 454 457 PF01048 0.794
MOD_GlcNHglycan 553 556 PF01048 0.576
MOD_GlcNHglycan 603 606 PF01048 0.611
MOD_GlcNHglycan 664 667 PF01048 0.728
MOD_GlcNHglycan 729 733 PF01048 0.624
MOD_GlcNHglycan 747 750 PF01048 0.567
MOD_GlcNHglycan 847 850 PF01048 0.665
MOD_GlcNHglycan 854 857 PF01048 0.661
MOD_GlcNHglycan 902 905 PF01048 0.676
MOD_GlcNHglycan 909 912 PF01048 0.632
MOD_GSK3_1 1 8 PF00069 0.614
MOD_GSK3_1 172 179 PF00069 0.523
MOD_GSK3_1 224 231 PF00069 0.624
MOD_GSK3_1 241 248 PF00069 0.590
MOD_GSK3_1 284 291 PF00069 0.752
MOD_GSK3_1 311 318 PF00069 0.711
MOD_GSK3_1 339 346 PF00069 0.823
MOD_GSK3_1 360 367 PF00069 0.726
MOD_GSK3_1 436 443 PF00069 0.715
MOD_GSK3_1 575 582 PF00069 0.544
MOD_GSK3_1 660 667 PF00069 0.785
MOD_GSK3_1 709 716 PF00069 0.631
MOD_GSK3_1 835 842 PF00069 0.676
MOD_GSK3_1 861 868 PF00069 0.676
MOD_GSK3_1 885 892 PF00069 0.664
MOD_GSK3_1 918 925 PF00069 0.625
MOD_LATS_1 905 911 PF00433 0.516
MOD_N-GLC_1 292 297 PF02516 0.619
MOD_N-GLC_1 311 316 PF02516 0.593
MOD_N-GLC_1 374 379 PF02516 0.682
MOD_N-GLC_1 72 77 PF02516 0.459
MOD_NEK2_1 1 6 PF00069 0.610
MOD_NEK2_1 114 119 PF00069 0.442
MOD_NEK2_1 172 177 PF00069 0.504
MOD_NEK2_1 355 360 PF00069 0.726
MOD_NEK2_1 411 416 PF00069 0.574
MOD_NEK2_1 478 483 PF00069 0.573
MOD_NEK2_1 485 490 PF00069 0.471
MOD_NEK2_1 50 55 PF00069 0.467
MOD_NEK2_1 579 584 PF00069 0.544
MOD_NEK2_1 599 604 PF00069 0.654
MOD_NEK2_1 696 701 PF00069 0.648
MOD_NEK2_1 72 77 PF00069 0.459
MOD_NEK2_1 722 727 PF00069 0.700
MOD_NEK2_1 730 735 PF00069 0.649
MOD_NEK2_1 87 92 PF00069 0.318
MOD_NEK2_2 421 426 PF00069 0.644
MOD_NEK2_2 436 441 PF00069 0.670
MOD_PIKK_1 103 109 PF00454 0.431
MOD_PIKK_1 253 259 PF00454 0.729
MOD_PIKK_1 471 477 PF00454 0.592
MOD_PIKK_1 518 524 PF00454 0.534
MOD_PIKK_1 525 531 PF00454 0.470
MOD_PIKK_1 568 574 PF00454 0.515
MOD_PIKK_1 579 585 PF00454 0.468
MOD_PIKK_1 740 746 PF00454 0.657
MOD_PIKK_1 803 809 PF00454 0.672
MOD_PIKK_1 813 819 PF00454 0.655
MOD_PIKK_1 87 93 PF00454 0.482
MOD_PK_1 709 715 PF00069 0.535
MOD_PKA_1 339 345 PF00069 0.716
MOD_PKA_1 907 913 PF00069 0.506
MOD_PKA_2 119 125 PF00069 0.471
MOD_PKA_2 144 150 PF00069 0.463
MOD_PKA_2 196 202 PF00069 0.488
MOD_PKA_2 228 234 PF00069 0.751
MOD_PKA_2 339 345 PF00069 0.821
MOD_PKA_2 537 543 PF00069 0.553
MOD_PKA_2 557 563 PF00069 0.584
MOD_PKA_2 599 605 PF00069 0.596
MOD_PKA_2 722 728 PF00069 0.634
MOD_PKA_2 758 764 PF00069 0.555
MOD_PKA_2 77 83 PF00069 0.482
MOD_PKA_2 8 14 PF00069 0.639
MOD_PKA_2 844 850 PF00069 0.698
MOD_PKA_2 907 913 PF00069 0.639
MOD_Plk_1 114 120 PF00069 0.449
MOD_Plk_1 311 317 PF00069 0.665
MOD_Plk_1 421 427 PF00069 0.705
MOD_Plk_1 525 531 PF00069 0.542
MOD_Plk_1 58 64 PF00069 0.528
MOD_Plk_1 709 715 PF00069 0.598
MOD_Plk_1 72 78 PF00069 0.463
MOD_Plk_1 885 891 PF00069 0.587
MOD_Plk_2-3 861 867 PF00069 0.707
MOD_Plk_4 203 209 PF00069 0.524
MOD_Plk_4 42 48 PF00069 0.432
MOD_Plk_4 485 491 PF00069 0.561
MOD_Plk_4 575 581 PF00069 0.544
MOD_Plk_4 691 697 PF00069 0.597
MOD_Plk_4 709 715 PF00069 0.535
MOD_Plk_4 758 764 PF00069 0.557
MOD_Plk_4 766 772 PF00069 0.540
MOD_Plk_4 868 874 PF00069 0.727
MOD_Plk_4 918 924 PF00069 0.718
MOD_ProDKin_1 174 180 PF00069 0.494
MOD_ProDKin_1 239 245 PF00069 0.702
MOD_ProDKin_1 292 298 PF00069 0.636
MOD_ProDKin_1 322 328 PF00069 0.763
MOD_ProDKin_1 34 40 PF00069 0.527
MOD_ProDKin_1 379 385 PF00069 0.665
MOD_ProDKin_1 386 392 PF00069 0.699
MOD_ProDKin_1 424 430 PF00069 0.708
MOD_ProDKin_1 440 446 PF00069 0.712
MOD_ProDKin_1 461 467 PF00069 0.792
MOD_ProDKin_1 624 630 PF00069 0.668
MOD_ProDKin_1 657 663 PF00069 0.840
MOD_ProDKin_1 666 672 PF00069 0.705
MOD_ProDKin_1 840 846 PF00069 0.674
MOD_ProDKin_1 872 878 PF00069 0.726
TRG_DiLeu_BaEn_1 594 599 PF01217 0.558
TRG_DiLeu_LyEn_5 594 599 PF01217 0.558
TRG_ENDOCYTIC_2 437 440 PF00928 0.718
TRG_ENDOCYTIC_2 573 576 PF00928 0.549
TRG_ENDOCYTIC_2 697 700 PF00928 0.674
TRG_ENDOCYTIC_2 76 79 PF00928 0.592
TRG_ER_diArg_1 192 195 PF00400 0.546
TRG_ER_diArg_1 338 340 PF00400 0.704
TRG_ER_diArg_1 458 461 PF00400 0.741
TRG_ER_diArg_1 502 504 PF00400 0.545
TRG_ER_diArg_1 517 519 PF00400 0.538
TRG_ER_diArg_1 595 598 PF00400 0.557
TRG_ER_diArg_1 722 724 PF00400 0.750
TRG_ER_diArg_1 763 765 PF00400 0.735
TRG_NES_CRM1_1 100 115 PF08389 0.433
TRG_NES_CRM1_1 42 56 PF08389 0.469
TRG_NES_CRM1_1 522 535 PF08389 0.540
TRG_Pf-PMV_PEXEL_1 258 262 PF00026 0.685
TRG_Pf-PMV_PEXEL_1 518 522 PF00026 0.534
TRG_Pf-PMV_PEXEL_1 589 594 PF00026 0.546
TRG_Pf-PMV_PEXEL_1 724 729 PF00026 0.637
TRG_Pf-PMV_PEXEL_1 764 768 PF00026 0.576

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H524 Leishmania donovani 100% 100%
A4H3I4 Leishmania braziliensis 71% 98%
E9ACF9 Leishmania major 91% 100%
E9AJP7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS