LeishMANIAdb
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tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase
Gene product:
Met-10+ like-protein/Methyltransferase small domain/Methyltransferase domain containing protein - putative
Species:
Leishmania infantum
UniProt:
E9AG25_LEIIN
TriTrypDb:
LINF_030005400
Length:
390

Annotations

Annotations by Jardim et al.

Transporters, MFS/sugar transport

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

E9AG25
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG25

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006396 RNA processing 6 12
GO:0006399 tRNA metabolic process 7 12
GO:0006400 tRNA modification 6 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008033 tRNA processing 8 12
GO:0008152 metabolic process 1 12
GO:0009451 RNA modification 5 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0034470 ncRNA processing 7 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034660 ncRNA metabolic process 6 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:0001510 RNA methylation 4 1
GO:0030488 tRNA methylation 5 1
GO:0032259 methylation 2 3
GO:0043414 macromolecule methylation 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0016740 transferase activity 2 12
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 3 12
GO:0102522 tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity 4 12
GO:0140098 catalytic activity, acting on RNA 3 12
GO:0140101 catalytic activity, acting on a tRNA 4 12
GO:0140640 catalytic activity, acting on a nucleic acid 2 12
GO:0008168 methyltransferase activity 4 3
GO:0008173 RNA methyltransferase activity 4 1
GO:0008175 tRNA methyltransferase activity 5 1
GO:0016741 transferase activity, transferring one-carbon groups 3 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 134 136 PF00675 0.381
CLV_NRD_NRD_1 156 158 PF00675 0.425
CLV_NRD_NRD_1 161 163 PF00675 0.389
CLV_NRD_NRD_1 166 168 PF00675 0.318
CLV_NRD_NRD_1 38 40 PF00675 0.503
CLV_NRD_NRD_1 44 46 PF00675 0.485
CLV_NRD_NRD_1 76 78 PF00675 0.347
CLV_NRD_NRD_1 80 82 PF00675 0.342
CLV_PCSK_KEX2_1 134 136 PF00082 0.405
CLV_PCSK_KEX2_1 156 158 PF00082 0.415
CLV_PCSK_KEX2_1 161 163 PF00082 0.344
CLV_PCSK_KEX2_1 168 170 PF00082 0.243
CLV_PCSK_KEX2_1 323 325 PF00082 0.317
CLV_PCSK_KEX2_1 37 39 PF00082 0.555
CLV_PCSK_KEX2_1 379 381 PF00082 0.364
CLV_PCSK_KEX2_1 76 78 PF00082 0.329
CLV_PCSK_PC1ET2_1 168 170 PF00082 0.438
CLV_PCSK_PC1ET2_1 323 325 PF00082 0.362
CLV_PCSK_PC1ET2_1 37 39 PF00082 0.557
CLV_PCSK_PC1ET2_1 379 381 PF00082 0.364
CLV_PCSK_PC7_1 157 163 PF00082 0.427
CLV_PCSK_SKI1_1 150 154 PF00082 0.331
CLV_PCSK_SKI1_1 209 213 PF00082 0.287
CLV_PCSK_SKI1_1 312 316 PF00082 0.362
CLV_PCSK_SKI1_1 34 38 PF00082 0.585
CLV_PCSK_SKI1_1 371 375 PF00082 0.313
CLV_PCSK_SKI1_1 46 50 PF00082 0.546
CLV_PCSK_SKI1_1 7 11 PF00082 0.547
CLV_PCSK_SKI1_1 76 80 PF00082 0.422
DEG_APCC_DBOX_1 134 142 PF00400 0.605
DOC_CYCLIN_RxL_1 4 13 PF00134 0.298
DOC_MAPK_gen_1 134 142 PF00069 0.624
DOC_MAPK_MEF2A_6 134 142 PF00069 0.624
DOC_MAPK_MEF2A_6 7 14 PF00069 0.268
DOC_PIKK_1 95 103 PF02985 0.549
DOC_PP1_RVXF_1 207 213 PF00149 0.470
DOC_PP1_RVXF_1 315 322 PF00149 0.424
DOC_PP4_FxxP_1 243 246 PF00568 0.476
DOC_PP4_FxxP_1 26 29 PF00568 0.646
DOC_USP7_MATH_1 179 183 PF00917 0.637
DOC_USP7_MATH_1 327 331 PF00917 0.525
DOC_USP7_MATH_1 68 72 PF00917 0.613
DOC_USP7_UBL2_3 30 34 PF12436 0.772
DOC_WW_Pin1_4 187 192 PF00397 0.563
LIG_14-3-3_CanoR_1 156 160 PF00244 0.600
LIG_14-3-3_CanoR_1 169 177 PF00244 0.592
LIG_14-3-3_CanoR_1 186 193 PF00244 0.604
LIG_14-3-3_CanoR_1 317 322 PF00244 0.476
LIG_14-3-3_CanoR_1 366 373 PF00244 0.534
LIG_14-3-3_CanoR_1 7 13 PF00244 0.342
LIG_Actin_WH2_2 262 278 PF00022 0.525
LIG_Actin_WH2_2 336 353 PF00022 0.635
LIG_Actin_WH2_2 358 373 PF00022 0.589
LIG_BRCT_BRCA1_1 189 193 PF00533 0.549
LIG_BRCT_BRCA1_1 264 268 PF00533 0.501
LIG_BRCT_BRCA1_2 264 270 PF00533 0.501
LIG_Clathr_ClatBox_1 123 127 PF01394 0.596
LIG_DLG_GKlike_1 134 141 PF00625 0.625
LIG_EH1_1 381 389 PF00400 0.535
LIG_FHA_1 14 20 PF00498 0.326
LIG_FHA_1 192 198 PF00498 0.484
LIG_FHA_1 242 248 PF00498 0.470
LIG_FHA_1 3 9 PF00498 0.451
LIG_FHA_1 58 64 PF00498 0.566
LIG_FHA_2 225 231 PF00498 0.581
LIG_FHA_2 96 102 PF00498 0.597
LIG_LIR_Gen_1 265 275 PF02991 0.517
LIG_LIR_Nem_3 112 117 PF02991 0.555
LIG_LIR_Nem_3 235 240 PF02991 0.468
LIG_LIR_Nem_3 265 271 PF02991 0.476
LIG_NRBOX 5 11 PF00104 0.369
LIG_Pex14_2 110 114 PF04695 0.516
LIG_Pex14_2 79 83 PF04695 0.532
LIG_SH2_CRK 336 340 PF00017 0.504
LIG_SH2_STAP1 203 207 PF00017 0.505
LIG_SH2_STAT5 21 24 PF00017 0.376
LIG_SH2_STAT5 242 245 PF00017 0.476
LIG_SH2_STAT5 307 310 PF00017 0.471
LIG_SUMO_SIM_par_1 120 125 PF11976 0.490
LIG_SUMO_SIM_par_1 8 13 PF11976 0.446
LIG_TRAF2_1 345 348 PF00917 0.583
LIG_TRAF2_1 99 102 PF00917 0.582
LIG_TYR_ITIM 18 23 PF00017 0.339
LIG_TYR_ITIM 240 245 PF00017 0.328
LIG_TYR_ITIM 334 339 PF00017 0.369
LIG_UBA3_1 304 312 PF00899 0.444
LIG_WRC_WIRS_1 202 207 PF05994 0.449
MOD_CK1_1 13 19 PF00069 0.475
MOD_CK1_1 173 179 PF00069 0.492
MOD_CK1_1 214 220 PF00069 0.397
MOD_CK2_1 95 101 PF00069 0.529
MOD_GlcNHglycan 213 216 PF01048 0.328
MOD_GlcNHglycan 26 29 PF01048 0.613
MOD_GlcNHglycan 330 333 PF01048 0.461
MOD_GlcNHglycan 343 346 PF01048 0.476
MOD_GSK3_1 146 153 PF00069 0.490
MOD_GSK3_1 169 176 PF00069 0.475
MOD_GSK3_1 185 192 PF00069 0.373
MOD_GSK3_1 201 208 PF00069 0.309
MOD_GSK3_1 210 217 PF00069 0.145
MOD_N-GLC_1 215 220 PF02516 0.328
MOD_N-GLC_2 62 64 PF02516 0.398
MOD_NEK2_1 110 115 PF00069 0.378
MOD_NEK2_1 155 160 PF00069 0.483
MOD_NEK2_1 180 185 PF00069 0.472
MOD_NEK2_1 205 210 PF00069 0.396
MOD_NEK2_1 211 216 PF00069 0.205
MOD_NEK2_1 8 13 PF00069 0.449
MOD_NEK2_2 151 156 PF00069 0.445
MOD_PKA_1 134 140 PF00069 0.514
MOD_PKA_2 134 140 PF00069 0.510
MOD_PKA_2 155 161 PF00069 0.492
MOD_PKA_2 185 191 PF00069 0.543
MOD_PKA_2 328 334 PF00069 0.463
MOD_PKA_2 365 371 PF00069 0.521
MOD_PKB_1 167 175 PF00069 0.515
MOD_Plk_1 180 186 PF00069 0.552
MOD_Plk_1 205 211 PF00069 0.432
MOD_Plk_1 68 74 PF00069 0.521
MOD_Plk_2-3 96 102 PF00069 0.530
MOD_Plk_4 13 19 PF00069 0.372
MOD_Plk_4 310 316 PF00069 0.371
MOD_Plk_4 317 323 PF00069 0.308
MOD_ProDKin_1 187 193 PF00069 0.445
MOD_SUMO_rev_2 41 48 PF00179 0.661
TRG_DiLeu_BaEn_3 359 365 PF01217 0.474
TRG_DiLeu_BaEn_4 101 107 PF01217 0.418
TRG_DiLeu_BaLyEn_6 4 9 PF01217 0.502
TRG_ENDOCYTIC_2 20 23 PF00928 0.339
TRG_ENDOCYTIC_2 242 245 PF00928 0.328
TRG_ENDOCYTIC_2 336 339 PF00928 0.365
TRG_ER_diArg_1 133 135 PF00400 0.517
TRG_ER_diArg_1 155 157 PF00400 0.531
TRG_ER_diArg_1 161 163 PF00400 0.543
TRG_ER_diArg_1 76 78 PF00400 0.401
TRG_NES_CRM1_1 355 369 PF08389 0.481
TRG_NLS_Bipartite_1 156 171 PF00514 0.494
TRG_NLS_MonoExtC_3 33 38 PF00514 0.735

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4L5 Leptomonas seymouri 64% 97%
A0A0S4JHI6 Bodo saltans 49% 95%
A0A1X0P9M7 Trypanosomatidae 57% 95%
A0A422N7F4 Trypanosoma rangeli 53% 100%
A0A451EJL2 Leishmania donovani 100% 100%
A4H3H8 Leishmania braziliensis 83% 100%
D0A212 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 99%
E9ACF3 Leishmania major 94% 100%
E9AJP1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
V5B8P6 Trypanosoma cruzi 51% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS