Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AG22_LEIIN

TriTrypDb:

LINF_030005100

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AG22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	208	210	PF00675	0.508
CLV_NRD_NRD_1	236	238	PF00675	0.534
CLV_NRD_NRD_1	34	36	PF00675	0.503
CLV_NRD_NRD_1	92	94	PF00675	0.601
CLV_PCSK_KEX2_1	208	210	PF00082	0.492
CLV_PCSK_KEX2_1	236	238	PF00082	0.555
CLV_PCSK_KEX2_1	34	36	PF00082	0.591
CLV_PCSK_KEX2_1	94	96	PF00082	0.582
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.582
CLV_PCSK_SKI1_1	208	212	PF00082	0.483
DEG_APCC_DBOX_1	198	206	PF00400	0.529
DEG_SPOP_SBC_1	67	71	PF00917	0.631
DOC_CYCLIN_yCln2_LP_2	256	262	PF00134	0.561
DOC_MAPK_DCC_7	8	17	PF00069	0.489
DOC_MAPK_gen_1	240	249	PF00069	0.590
DOC_MAPK_gen_1	8	14	PF00069	0.494
DOC_MAPK_MEF2A_6	8	17	PF00069	0.478
DOC_PP4_FxxP_1	211	214	PF00568	0.474
DOC_USP7_MATH_1	170	174	PF00917	0.514
DOC_USP7_MATH_1	46	50	PF00917	0.640
DOC_USP7_MATH_1	67	71	PF00917	0.665
DOC_USP7_MATH_1	76	80	PF00917	0.742
DOC_USP7_UBL2_3	154	158	PF12436	0.538
DOC_WW_Pin1_4	190	195	PF00397	0.484
DOC_WW_Pin1_4	238	243	PF00397	0.552
DOC_WW_Pin1_4	255	260	PF00397	0.550
DOC_WW_Pin1_4	72	77	PF00397	0.654
LIG_14-3-3_CanoR_1	24	33	PF00244	0.578
LIG_14-3-3_CanoR_1	95	102	PF00244	0.627
LIG_BRCT_BRCA1_1	128	132	PF00533	0.594
LIG_deltaCOP1_diTrp_1	203	211	PF00928	0.485
LIG_EH1_1	225	233	PF00400	0.457
LIG_eIF4E_1	131	137	PF01652	0.530
LIG_FHA_1	151	157	PF00498	0.473
LIG_FHA_1	170	176	PF00498	0.375
LIG_FHA_1	187	193	PF00498	0.378
LIG_FHA_2	250	256	PF00498	0.495
LIG_LIR_Gen_1	133	142	PF02991	0.426
LIG_LIR_Gen_1	16	21	PF02991	0.448
LIG_LIR_Gen_1	203	211	PF02991	0.408
LIG_LIR_Nem_3	128	134	PF02991	0.476
LIG_LIR_Nem_3	16	20	PF02991	0.447
LIG_LIR_Nem_3	203	207	PF02991	0.384
LIG_LIR_Nem_3	241	247	PF02991	0.594
LIG_MLH1_MIPbox_1	128	132	PF16413	0.594
LIG_MYND_3	12	16	PF01753	0.560
LIG_PDZ_Class_3	263	268	PF00595	0.657
LIG_SH2_PTP2	167	170	PF00017	0.499
LIG_SH2_STAP1	68	72	PF00017	0.618
LIG_SH2_STAT5	131	134	PF00017	0.452
LIG_SH2_STAT5	167	170	PF00017	0.373
LIG_SH3_3	256	262	PF00018	0.639
LIG_SH3_3	82	88	PF00018	0.575
LIG_SUMO_SIM_par_1	179	184	PF11976	0.469
LIG_SUMO_SIM_par_1	187	193	PF11976	0.470
LIG_TRAF2_1	252	255	PF00917	0.658
LIG_TRAF2_1	88	91	PF00917	0.554
MOD_CDC14_SPxK_1	193	196	PF00782	0.517
MOD_CDK_SPK_2	238	243	PF00069	0.596
MOD_CDK_SPxK_1	190	196	PF00069	0.495
MOD_CK1_1	184	190	PF00069	0.516
MOD_CK1_1	258	264	PF00069	0.652
MOD_CK1_1	71	77	PF00069	0.630
MOD_CK2_1	227	233	PF00069	0.395
MOD_CK2_1	249	255	PF00069	0.512
MOD_CK2_1	46	52	PF00069	0.733
MOD_CK2_1	95	101	PF00069	0.705
MOD_GlcNHglycan	109	112	PF01048	0.593
MOD_GlcNHglycan	76	79	PF01048	0.730
MOD_GSK3_1	170	177	PF00069	0.453
MOD_GSK3_1	186	193	PF00069	0.328
MOD_GSK3_1	238	245	PF00069	0.635
MOD_GSK3_1	254	261	PF00069	0.518
MOD_GSK3_1	67	74	PF00069	0.778
MOD_NEK2_1	119	124	PF00069	0.510
MOD_NEK2_1	132	137	PF00069	0.506
MOD_PIKK_1	24	30	PF00454	0.547
MOD_PIKK_1	261	267	PF00454	0.572
MOD_PK_1	227	233	PF00069	0.341
MOD_PKA_1	93	99	PF00069	0.646
MOD_PKB_1	93	101	PF00069	0.608
MOD_Plk_1	132	138	PF00069	0.462
MOD_Plk_1	181	187	PF00069	0.534
MOD_Plk_1	47	53	PF00069	0.648
MOD_Plk_4	170	176	PF00069	0.437
MOD_Plk_4	186	192	PF00069	0.458
MOD_Plk_4	227	233	PF00069	0.341
MOD_ProDKin_1	190	196	PF00069	0.497
MOD_ProDKin_1	238	244	PF00069	0.548
MOD_ProDKin_1	255	261	PF00069	0.553
MOD_ProDKin_1	72	78	PF00069	0.654
MOD_SUMO_for_1	42	45	PF00179	0.748
MOD_SUMO_for_1	58	61	PF00179	0.536
TRG_DiLeu_BaEn_2	15	21	PF01217	0.541
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.513
TRG_ENDOCYTIC_2	131	134	PF00928	0.452
TRG_ER_diArg_1	207	209	PF00400	0.514
TRG_ER_diArg_1	33	35	PF00400	0.521
TRG_ER_diArg_1	92	95	PF00400	0.598
TRG_NLS_MonoExtC_3	92	97	PF00514	0.695
TRG_NLS_MonoExtN_4	93	98	PF00514	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9W5	Leptomonas seymouri	46%	100%
A0A1X0P8M5	Trypanosomatidae	31%	100%
A0A3R7KU56	Trypanosoma rangeli	29%	100%
A0A3S5H519	Leishmania donovani	99%	100%
A4H3H5	Leishmania braziliensis	73%	100%
E9ACF0	Leishmania major	90%	100%
E9AJN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5ANT9	Trypanosoma cruzi	32%	100%