LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AG19_LEIIN
TriTrypDb:
LINF_020012200
Length:
454

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AG19
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG19

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 55 59 PF00656 0.525
CLV_NRD_NRD_1 171 173 PF00675 0.611
CLV_NRD_NRD_1 211 213 PF00675 0.669
CLV_NRD_NRD_1 37 39 PF00675 0.617
CLV_NRD_NRD_1 391 393 PF00675 0.514
CLV_NRD_NRD_1 91 93 PF00675 0.687
CLV_PCSK_KEX2_1 170 172 PF00082 0.614
CLV_PCSK_KEX2_1 211 213 PF00082 0.739
CLV_PCSK_KEX2_1 36 38 PF00082 0.644
CLV_PCSK_KEX2_1 391 393 PF00082 0.514
CLV_PCSK_KEX2_1 91 93 PF00082 0.687
CLV_PCSK_PC1ET2_1 170 172 PF00082 0.591
CLV_PCSK_PC1ET2_1 36 38 PF00082 0.620
CLV_PCSK_SKI1_1 305 309 PF00082 0.425
CLV_PCSK_SKI1_1 392 396 PF00082 0.590
DEG_Kelch_Keap1_1 110 115 PF01344 0.569
DEG_SPOP_SBC_1 108 112 PF00917 0.486
DEG_SPOP_SBC_1 289 293 PF00917 0.599
DEG_SPOP_SBC_1 94 98 PF00917 0.676
DOC_MAPK_gen_1 28 34 PF00069 0.581
DOC_MAPK_gen_1 436 443 PF00069 0.534
DOC_MAPK_MEF2A_6 418 425 PF00069 0.501
DOC_MAPK_NFAT4_5 418 426 PF00069 0.514
DOC_USP7_MATH_1 124 128 PF00917 0.717
DOC_USP7_MATH_1 143 147 PF00917 0.448
DOC_USP7_MATH_1 189 193 PF00917 0.747
DOC_USP7_MATH_1 254 258 PF00917 0.551
DOC_USP7_MATH_1 290 294 PF00917 0.620
DOC_USP7_MATH_1 41 45 PF00917 0.557
DOC_USP7_MATH_1 61 65 PF00917 0.531
DOC_USP7_UBL2_3 276 280 PF12436 0.471
DOC_WW_Pin1_4 196 201 PF00397 0.697
DOC_WW_Pin1_4 429 434 PF00397 0.500
LIG_14-3-3_CanoR_1 190 198 PF00244 0.725
LIG_14-3-3_CanoR_1 92 101 PF00244 0.636
LIG_AP2alpha_1 71 75 PF02296 0.581
LIG_FHA_1 111 117 PF00498 0.703
LIG_FHA_1 346 352 PF00498 0.530
LIG_LIR_Apic_2 427 433 PF02991 0.487
LIG_LIR_Gen_1 48 59 PF02991 0.492
LIG_LIR_Nem_3 48 54 PF02991 0.484
LIG_NRBOX 420 426 PF00104 0.427
LIG_PCNA_yPIPBox_3 327 338 PF02747 0.525
LIG_Pex14_2 71 75 PF04695 0.581
LIG_Rb_pABgroove_1 45 53 PF01858 0.523
LIG_SH2_STAP1 283 287 PF00017 0.552
LIG_SUMO_SIM_anti_2 420 427 PF11976 0.432
LIG_TRAF2_1 394 397 PF00917 0.589
MOD_CDK_SPxK_1 196 202 PF00069 0.664
MOD_CDK_SPxxK_3 429 436 PF00069 0.423
MOD_CK1_1 109 115 PF00069 0.663
MOD_CK1_1 127 133 PF00069 0.701
MOD_CK1_1 192 198 PF00069 0.733
MOD_CK1_1 291 297 PF00069 0.584
MOD_CK1_1 325 331 PF00069 0.575
MOD_CK1_1 343 349 PF00069 0.413
MOD_CK1_1 448 454 PF00069 0.655
MOD_CK2_1 109 115 PF00069 0.570
MOD_CK2_1 190 196 PF00069 0.660
MOD_CK2_1 448 454 PF00069 0.565
MOD_GlcNHglycan 119 122 PF01048 0.662
MOD_GlcNHglycan 184 187 PF01048 0.735
MOD_GlcNHglycan 277 280 PF01048 0.470
MOD_GlcNHglycan 299 302 PF01048 0.528
MOD_GlcNHglycan 309 312 PF01048 0.467
MOD_GlcNHglycan 43 46 PF01048 0.577
MOD_GlcNHglycan 54 57 PF01048 0.620
MOD_GlcNHglycan 84 87 PF01048 0.616
MOD_GlcNHglycan 97 100 PF01048 0.707
MOD_GSK3_1 106 113 PF00069 0.631
MOD_GSK3_1 149 156 PF00069 0.510
MOD_GSK3_1 19 26 PF00069 0.698
MOD_GSK3_1 190 197 PF00069 0.757
MOD_GSK3_1 235 242 PF00069 0.589
MOD_GSK3_1 285 292 PF00069 0.588
MOD_GSK3_1 41 48 PF00069 0.530
MOD_GSK3_1 445 452 PF00069 0.550
MOD_N-GLC_1 322 327 PF02516 0.471
MOD_N-GLC_1 340 345 PF02516 0.620
MOD_NEK2_1 1 6 PF00069 0.699
MOD_NEK2_1 154 159 PF00069 0.520
MOD_NEK2_1 275 280 PF00069 0.473
MOD_NEK2_1 307 312 PF00069 0.512
MOD_NEK2_1 322 327 PF00069 0.562
MOD_NEK2_1 50 55 PF00069 0.496
MOD_NEK2_1 62 67 PF00069 0.428
MOD_NEK2_1 84 89 PF00069 0.649
MOD_NEK2_1 95 100 PF00069 0.774
MOD_PIKK_1 345 351 PF00454 0.492
MOD_PIKK_1 369 375 PF00454 0.474
MOD_PIKK_1 62 68 PF00454 0.661
MOD_PK_1 437 443 PF00069 0.512
MOD_PKA_2 189 195 PF00069 0.746
MOD_PKA_2 2 8 PF00069 0.660
MOD_PKB_1 188 196 PF00069 0.748
MOD_Plk_1 19 25 PF00069 0.620
MOD_Plk_1 239 245 PF00069 0.562
MOD_Plk_1 340 346 PF00069 0.630
MOD_Plk_1 437 443 PF00069 0.537
MOD_Plk_2-3 235 241 PF00069 0.562
MOD_Plk_4 437 443 PF00069 0.510
MOD_Plk_4 84 90 PF00069 0.666
MOD_ProDKin_1 196 202 PF00069 0.697
MOD_ProDKin_1 429 435 PF00069 0.498
MOD_SUMO_for_1 417 420 PF00179 0.520
MOD_SUMO_rev_2 300 310 PF00179 0.434
MOD_SUMO_rev_2 52 62 PF00179 0.449
TRG_DiLeu_BaEn_1 420 425 PF01217 0.424
TRG_ER_diArg_1 171 173 PF00400 0.561
TRG_ER_diArg_1 187 190 PF00400 0.726
TRG_ER_diArg_1 211 213 PF00400 0.645
TRG_ER_diArg_1 91 93 PF00400 0.694
TRG_Pf-PMV_PEXEL_1 406 410 PF00026 0.530

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAB8 Leptomonas seymouri 49% 77%
A0A3S5H515 Leishmania donovani 99% 100%
A0A3S7X120 Leishmania donovani 100% 100%
A4HG32 Leishmania braziliensis 74% 100%
C9ZJ54 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9ACE3 Leishmania major 92% 100%
E9ACX2 Leishmania major 94% 100%
E9AG20 Leishmania infantum 100% 100%
E9AJN1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
V5BA51 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS