LeishMANIAdb
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TLDc domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TLDc domain-containing protein
Gene product:
TLD, putative
Species:
Leishmania major
UniProt:
E9AG16_LEIMA
TriTrypDb:
LmjF.36.1955 * , LMJLV39_360026400 * , LMJSD75_360026500 *
Length:
383

Annotations

LeishMANIAdb annotations

Distantly related to a domain found in MEAK7, a regulatory subunit of animal mTOR complex. The hydrophobic segment is likely a perimembrane anchor, not a TM region (used instead of a mirystoylation site found in mammals)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 10
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

E9AG16
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG16

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004386 helicase activity 2 3
GO:0140640 catalytic activity, acting on a nucleic acid 2 3
GO:0140657 ATP-dependent activity 1 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 356 360 PF00656 0.702
CLV_PCSK_SKI1_1 111 115 PF00082 0.501
CLV_PCSK_SKI1_1 198 202 PF00082 0.322
DOC_ANK_TNKS_1 239 246 PF00023 0.320
DOC_CKS1_1 68 73 PF01111 0.591
DOC_MAPK_HePTP_8 163 175 PF00069 0.412
DOC_MAPK_MEF2A_6 166 175 PF00069 0.412
DOC_MAPK_MEF2A_6 361 369 PF00069 0.607
DOC_PP2B_PxIxI_1 167 173 PF00149 0.416
DOC_PP4_FxxP_1 311 314 PF00568 0.287
DOC_PP4_FxxP_1 68 71 PF00568 0.586
DOC_USP7_MATH_1 258 262 PF00917 0.302
DOC_USP7_UBL2_3 86 90 PF12436 0.550
DOC_WW_Pin1_4 114 119 PF00397 0.355
DOC_WW_Pin1_4 175 180 PF00397 0.426
DOC_WW_Pin1_4 67 72 PF00397 0.760
DOC_WW_Pin1_4 97 102 PF00397 0.503
LIG_14-3-3_CanoR_1 307 312 PF00244 0.307
LIG_14-3-3_CanoR_1 315 324 PF00244 0.306
LIG_Actin_WH2_2 329 344 PF00022 0.476
LIG_APCC_ABBA_1 32 37 PF00400 0.364
LIG_BIR_II_1 1 5 PF00653 0.379
LIG_BIR_III_2 126 130 PF00653 0.411
LIG_BRCT_BRCA1_1 226 230 PF00533 0.293
LIG_FHA_1 115 121 PF00498 0.454
LIG_FHA_1 167 173 PF00498 0.306
LIG_FHA_1 244 250 PF00498 0.357
LIG_FHA_1 270 276 PF00498 0.397
LIG_FHA_1 346 352 PF00498 0.692
LIG_FHA_2 249 255 PF00498 0.449
LIG_GBD_Chelix_1 120 128 PF00786 0.390
LIG_LIR_Apic_2 309 314 PF02991 0.290
LIG_LIR_Apic_2 67 71 PF02991 0.581
LIG_LIR_Gen_1 10 21 PF02991 0.424
LIG_LIR_Gen_1 155 164 PF02991 0.265
LIG_LIR_Gen_1 187 194 PF02991 0.322
LIG_LIR_Gen_1 264 274 PF02991 0.366
LIG_LIR_Gen_1 37 47 PF02991 0.377
LIG_LIR_Nem_3 10 16 PF02991 0.610
LIG_LIR_Nem_3 141 147 PF02991 0.352
LIG_LIR_Nem_3 155 159 PF02991 0.198
LIG_LIR_Nem_3 187 193 PF02991 0.328
LIG_LIR_Nem_3 20 24 PF02991 0.502
LIG_LIR_Nem_3 229 234 PF02991 0.270
LIG_LIR_Nem_3 264 269 PF02991 0.366
LIG_LIR_Nem_3 37 42 PF02991 0.481
LIG_LIR_Nem_3 4 9 PF02991 0.687
LIG_PDZ_Class_1 378 383 PF00595 0.615
LIG_Pex14_1 143 147 PF04695 0.313
LIG_Pex14_2 266 270 PF04695 0.287
LIG_Pex14_2 293 297 PF04695 0.287
LIG_SH2_CRK 19 23 PF00017 0.384
LIG_SH2_CRK 39 43 PF00017 0.400
LIG_SH2_CRK 92 96 PF00017 0.570
LIG_SH2_PTP2 11 14 PF00017 0.412
LIG_SH2_PTP2 21 24 PF00017 0.369
LIG_SH2_PTP2 25 28 PF00017 0.366
LIG_SH2_PTP2 35 38 PF00017 0.372
LIG_SH2_SRC 11 14 PF00017 0.412
LIG_SH2_SRC 21 24 PF00017 0.369
LIG_SH2_SRC 242 245 PF00017 0.270
LIG_SH2_SRC 25 28 PF00017 0.366
LIG_SH2_SRC 35 38 PF00017 0.359
LIG_SH2_STAP1 147 151 PF00017 0.366
LIG_SH2_STAT5 11 14 PF00017 0.412
LIG_SH2_STAT5 144 147 PF00017 0.332
LIG_SH2_STAT5 17 20 PF00017 0.388
LIG_SH2_STAT5 21 24 PF00017 0.369
LIG_SH2_STAT5 25 28 PF00017 0.366
LIG_SH2_STAT5 268 271 PF00017 0.313
LIG_SH2_STAT5 29 32 PF00017 0.360
LIG_SH2_STAT5 35 38 PF00017 0.374
LIG_SH3_3 93 99 PF00018 0.677
LIG_SUMO_SIM_anti_2 169 174 PF11976 0.287
LIG_SUMO_SIM_par_1 112 117 PF11976 0.514
LIG_TRAF2_1 274 277 PF00917 0.416
LIG_UBA3_1 170 176 PF00899 0.416
LIG_WRC_WIRS_1 147 152 PF05994 0.355
MOD_CDK_SPK_2 114 119 PF00069 0.469
MOD_CDK_SPK_2 175 180 PF00069 0.345
MOD_CK1_1 138 144 PF00069 0.509
MOD_CK1_1 261 267 PF00069 0.333
MOD_CK1_1 318 324 PF00069 0.458
MOD_CK1_1 345 351 PF00069 0.674
MOD_CK1_1 67 73 PF00069 0.772
MOD_CK2_1 248 254 PF00069 0.372
MOD_CK2_1 314 320 PF00069 0.312
MOD_CK2_1 43 49 PF00069 0.372
MOD_CK2_1 81 87 PF00069 0.711
MOD_GlcNHglycan 137 140 PF01048 0.456
MOD_GlcNHglycan 201 204 PF01048 0.291
MOD_GlcNHglycan 348 351 PF01048 0.697
MOD_GlcNHglycan 81 86 PF01048 0.719
MOD_GSK3_1 162 169 PF00069 0.428
MOD_GSK3_1 185 192 PF00069 0.414
MOD_GSK3_1 243 250 PF00069 0.390
MOD_GSK3_1 257 264 PF00069 0.381
MOD_GSK3_1 314 321 PF00069 0.346
MOD_GSK3_1 342 349 PF00069 0.526
MOD_GSK3_1 60 67 PF00069 0.686
MOD_N-GLC_1 224 229 PF02516 0.355
MOD_N-GLC_1 345 350 PF02516 0.436
MOD_N-GLC_1 369 374 PF02516 0.612
MOD_N-GLC_2 78 80 PF02516 0.632
MOD_NEK2_1 1 6 PF00069 0.406
MOD_NEK2_1 145 150 PF00069 0.274
MOD_NEK2_1 269 274 PF00069 0.399
MOD_NEK2_1 340 345 PF00069 0.508
MOD_NEK2_1 42 47 PF00069 0.583
MOD_NEK2_1 64 69 PF00069 0.651
MOD_PKA_2 208 214 PF00069 0.381
MOD_PKA_2 217 223 PF00069 0.351
MOD_PKA_2 306 312 PF00069 0.339
MOD_PKA_2 314 320 PF00069 0.238
MOD_PKA_2 346 352 PF00069 0.682
MOD_Plk_2-3 248 254 PF00069 0.270
MOD_Plk_4 146 152 PF00069 0.387
MOD_Plk_4 166 172 PF00069 0.230
MOD_Plk_4 17 23 PF00069 0.434
MOD_Plk_4 226 232 PF00069 0.383
MOD_Plk_4 318 324 PF00069 0.463
MOD_ProDKin_1 114 120 PF00069 0.350
MOD_ProDKin_1 175 181 PF00069 0.426
MOD_ProDKin_1 67 73 PF00069 0.761
MOD_ProDKin_1 97 103 PF00069 0.494
MOD_SUMO_rev_2 271 279 PF00179 0.366
MOD_SUMO_rev_2 356 362 PF00179 0.495
MOD_SUMO_rev_2 82 91 PF00179 0.690
TRG_ENDOCYTIC_2 11 14 PF00928 0.407
TRG_ENDOCYTIC_2 147 150 PF00928 0.306
TRG_ENDOCYTIC_2 19 22 PF00928 0.374
TRG_ENDOCYTIC_2 25 28 PF00928 0.366
TRG_ENDOCYTIC_2 29 32 PF00928 0.360
TRG_ENDOCYTIC_2 290 293 PF00928 0.396
TRG_ENDOCYTIC_2 35 38 PF00928 0.365
TRG_ENDOCYTIC_2 39 42 PF00928 0.372

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZW5 Leptomonas seymouri 61% 100%
A0A0S4JCM6 Bodo saltans 25% 100%
A0A0S4JIE3 Bodo saltans 42% 100%
A0A1X0P7Q9 Trypanosomatidae 49% 100%
A0A3R7M9V1 Trypanosoma rangeli 46% 100%
A0A3S7XAT0 Leishmania donovani 85% 100%
A4HP62 Leishmania braziliensis 78% 100%
E9AHX4 Leishmania infantum 89% 100%
E9ASX0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
V5BGD9 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS