Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AG15_LEIMA

TriTrypDb:

LmjF.36.1905 , LMJLV39_360025600 , LMJSD75_360025700

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AG15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.598
CLV_NRD_NRD_1	160	162	PF00675	0.738
CLV_NRD_NRD_1	313	315	PF00675	0.720
CLV_NRD_NRD_1	330	332	PF00675	0.503
CLV_NRD_NRD_1	380	382	PF00675	0.682
CLV_NRD_NRD_1	396	398	PF00675	0.571
CLV_NRD_NRD_1	409	411	PF00675	0.630
CLV_NRD_NRD_1	91	93	PF00675	0.585
CLV_PCSK_FUR_1	158	162	PF00082	0.712
CLV_PCSK_FUR_1	410	414	PF00082	0.643
CLV_PCSK_KEX2_1	160	162	PF00082	0.760
CLV_PCSK_KEX2_1	313	315	PF00082	0.720
CLV_PCSK_KEX2_1	330	332	PF00082	0.511
CLV_PCSK_KEX2_1	396	398	PF00082	0.652
CLV_PCSK_KEX2_1	409	411	PF00082	0.630
CLV_PCSK_KEX2_1	412	414	PF00082	0.655
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.655
CLV_PCSK_SKI1_1	136	140	PF00082	0.658
CLV_PCSK_SKI1_1	243	247	PF00082	0.682
CLV_PCSK_SKI1_1	265	269	PF00082	0.750
CLV_PCSK_SKI1_1	381	385	PF00082	0.575
CLV_PCSK_SKI1_1	41	45	PF00082	0.704
CLV_Separin_Metazoa	42	46	PF03568	0.704
DEG_Nend_UBRbox_1	1	4	PF02207	0.807
DEG_SPOP_SBC_1	20	24	PF00917	0.700
DOC_CKS1_1	209	214	PF01111	0.759
DOC_CKS1_1	6	11	PF01111	0.574
DOC_CYCLIN_RxL_1	394	404	PF00134	0.613
DOC_PP1_RVXF_1	395	402	PF00149	0.609
DOC_PP4_FxxP_1	97	100	PF00568	0.773
DOC_USP7_MATH_1	10	14	PF00917	0.784
DOC_USP7_MATH_1	109	113	PF00917	0.634
DOC_USP7_MATH_1	171	175	PF00917	0.689
DOC_USP7_MATH_1	231	235	PF00917	0.698
DOC_USP7_MATH_1	271	275	PF00917	0.759
DOC_USP7_MATH_1	296	300	PF00917	0.640
DOC_USP7_MATH_1	347	351	PF00917	0.678
DOC_USP7_MATH_1	373	377	PF00917	0.697
DOC_USP7_MATH_1	48	52	PF00917	0.745
DOC_USP7_MATH_1	60	64	PF00917	0.601
DOC_WW_Pin1_4	115	120	PF00397	0.513
DOC_WW_Pin1_4	148	153	PF00397	0.820
DOC_WW_Pin1_4	165	170	PF00397	0.735
DOC_WW_Pin1_4	194	199	PF00397	0.740
DOC_WW_Pin1_4	205	210	PF00397	0.664
DOC_WW_Pin1_4	235	240	PF00397	0.560
DOC_WW_Pin1_4	26	31	PF00397	0.731
DOC_WW_Pin1_4	299	304	PF00397	0.698
DOC_WW_Pin1_4	343	348	PF00397	0.709
DOC_WW_Pin1_4	383	388	PF00397	0.735
DOC_WW_Pin1_4	5	10	PF00397	0.602
DOC_WW_Pin1_4	85	90	PF00397	0.741
DOC_WW_Pin1_4	96	101	PF00397	0.771
LIG_14-3-3_CanoR_1	135	139	PF00244	0.706
LIG_14-3-3_CanoR_1	148	152	PF00244	0.712
LIG_14-3-3_CanoR_1	243	249	PF00244	0.464
LIG_14-3-3_CanoR_1	375	379	PF00244	0.777
LIG_14-3-3_CanoR_1	65	73	PF00244	0.692
LIG_Actin_WH2_2	121	137	PF00022	0.541
LIG_Actin_WH2_2	29	47	PF00022	0.728
LIG_BRCT_BRCA1_1	233	237	PF00533	0.678
LIG_CSL_BTD_1	97	100	PF09270	0.738
LIG_FHA_1	262	268	PF00498	0.570
LIG_FHA_1	33	39	PF00498	0.736
LIG_FHA_1	375	381	PF00498	0.782
LIG_LIR_Apic_2	94	100	PF02991	0.772
LIG_LIR_Gen_1	140	146	PF02991	0.647
LIG_LIR_Gen_1	338	347	PF02991	0.731
LIG_LIR_Nem_3	140	145	PF02991	0.644
LIG_LIR_Nem_3	338	343	PF02991	0.724
LIG_MYND_1	115	119	PF01753	0.634
LIG_NRP_CendR_1	412	414	PF00754	0.721
LIG_PCNA_TLS_4	214	221	PF02747	0.678
LIG_Pex14_1	282	286	PF04695	0.660
LIG_Pex14_1	98	102	PF04695	0.776
LIG_SH2_CRK	366	370	PF00017	0.772
LIG_SH2_CRK	68	72	PF00017	0.701
LIG_SH2_NCK_1	68	72	PF00017	0.701
LIG_SH2_SRC	220	223	PF00017	0.642
LIG_SH2_STAP1	68	72	PF00017	0.701
LIG_SH2_STAT5	220	223	PF00017	0.677
LIG_SH2_STAT5	68	71	PF00017	0.737
LIG_SH3_2	100	105	PF14604	0.562
LIG_SH3_2	209	214	PF14604	0.689
LIG_SH3_2	77	82	PF14604	0.794
LIG_SH3_3	113	119	PF00018	0.523
LIG_SH3_3	206	212	PF00018	0.758
LIG_SH3_3	354	360	PF00018	0.747
LIG_SH3_3	74	80	PF00018	0.786
LIG_SH3_3	97	103	PF00018	0.734
LIG_WRC_WIRS_1	139	144	PF05994	0.558
LIG_WW_3	102	106	PF00397	0.566
LIG_WW_3	386	390	PF00397	0.584
LIG_WW_3	79	83	PF00397	0.739
MOD_CDC14_SPxK_1	346	349	PF00782	0.714
MOD_CDC14_SPxK_1	386	389	PF00782	0.725
MOD_CDK_SPxK_1	208	214	PF00069	0.692
MOD_CDK_SPxK_1	343	349	PF00069	0.711
MOD_CDK_SPxK_1	383	389	PF00069	0.734
MOD_CDK_SPxxK_3	148	155	PF00069	0.738
MOD_CDK_SPxxK_3	85	92	PF00069	0.591
MOD_CK1_1	151	157	PF00069	0.780
MOD_CK1_1	163	169	PF00069	0.741
MOD_CK1_1	174	180	PF00069	0.611
MOD_CK1_1	200	206	PF00069	0.715
MOD_CK1_1	208	214	PF00069	0.621
MOD_CK1_1	21	27	PF00069	0.730
MOD_CK1_1	254	260	PF00069	0.587
MOD_CK1_1	299	305	PF00069	0.643
MOD_CK1_1	307	313	PF00069	0.706
MOD_CK1_1	338	344	PF00069	0.756
MOD_CK1_1	350	356	PF00069	0.601
MOD_GlcNHglycan	111	114	PF01048	0.649
MOD_GlcNHglycan	180	183	PF01048	0.715
MOD_GlcNHglycan	199	202	PF01048	0.593
MOD_GlcNHglycan	227	230	PF01048	0.754
MOD_GlcNHglycan	256	259	PF01048	0.685
MOD_GlcNHglycan	26	29	PF01048	0.744
MOD_GlcNHglycan	293	296	PF01048	0.626
MOD_GlcNHglycan	298	301	PF01048	0.619
MOD_GlcNHglycan	306	309	PF01048	0.616
MOD_GlcNHglycan	46	49	PF01048	0.470
MOD_GlcNHglycan	62	65	PF01048	0.676
MOD_GSK3_1	10	17	PF00069	0.779
MOD_GSK3_1	120	127	PF00069	0.676
MOD_GSK3_1	130	137	PF00069	0.560
MOD_GSK3_1	147	154	PF00069	0.709
MOD_GSK3_1	156	163	PF00069	0.707
MOD_GSK3_1	173	180	PF00069	0.640
MOD_GSK3_1	19	26	PF00069	0.674
MOD_GSK3_1	200	207	PF00069	0.702
MOD_GSK3_1	231	238	PF00069	0.728
MOD_GSK3_1	261	268	PF00069	0.687
MOD_GSK3_1	338	345	PF00069	0.726
MOD_GSK3_1	383	390	PF00069	0.764
MOD_GSK3_1	44	51	PF00069	0.710
MOD_GSK3_1	71	78	PF00069	0.783
MOD_GSK3_1	92	99	PF00069	0.618
MOD_LATS_1	263	269	PF00433	0.674
MOD_NEK2_1	134	139	PF00069	0.621
MOD_NEK2_1	164	169	PF00069	0.599
MOD_NEK2_1	291	296	PF00069	0.778
MOD_NEK2_1	335	340	PF00069	0.737
MOD_NEK2_1	4	9	PF00069	0.574
MOD_NEK2_1	44	49	PF00069	0.648
MOD_NEK2_2	241	246	PF00069	0.681
MOD_PIKK_1	75	81	PF00454	0.782
MOD_PKA_1	160	166	PF00069	0.750
MOD_PKA_1	92	98	PF00069	0.569
MOD_PKA_2	134	140	PF00069	0.670
MOD_PKA_2	147	153	PF00069	0.698
MOD_PKA_2	160	166	PF00069	0.665
MOD_PKA_2	321	327	PF00069	0.687
MOD_PKA_2	374	380	PF00069	0.753
MOD_PKA_2	44	50	PF00069	0.653
MOD_PKB_1	158	166	PF00069	0.711
MOD_Plk_1	120	126	PF00069	0.684
MOD_Plk_1	373	379	PF00069	0.740
MOD_Plk_1	93	99	PF00069	0.603
MOD_Plk_4	120	126	PF00069	0.618
MOD_Plk_4	134	140	PF00069	0.648
MOD_Plk_4	244	250	PF00069	0.505
MOD_Plk_4	93	99	PF00069	0.639
MOD_ProDKin_1	115	121	PF00069	0.512
MOD_ProDKin_1	148	154	PF00069	0.821
MOD_ProDKin_1	165	171	PF00069	0.728
MOD_ProDKin_1	194	200	PF00069	0.741
MOD_ProDKin_1	205	211	PF00069	0.658
MOD_ProDKin_1	235	241	PF00069	0.552
MOD_ProDKin_1	26	32	PF00069	0.730
MOD_ProDKin_1	299	305	PF00069	0.697
MOD_ProDKin_1	343	349	PF00069	0.711
MOD_ProDKin_1	383	389	PF00069	0.734
MOD_ProDKin_1	5	11	PF00069	0.605
MOD_ProDKin_1	85	91	PF00069	0.740
MOD_ProDKin_1	96	102	PF00069	0.772
TRG_ENDOCYTIC_2	68	71	PF00928	0.737
TRG_ER_diArg_1	157	160	PF00400	0.754
TRG_ER_diArg_1	329	331	PF00400	0.575
TRG_ER_diArg_1	395	397	PF00400	0.646
TRG_ER_diArg_1	409	411	PF00400	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL64	Leptomonas seymouri	28%	100%
A0A3Q8IG15	Leishmania donovani	87%	100%
A4HP55	Leishmania braziliensis	57%	94%
E9AHX3	Leishmania infantum	87%	100%
E9ASW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%