Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

E9AG14_LEIMA

TriTrypDb:

LmjF.36.1265

Length:

134

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AG14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.411
CLV_PCSK_KEX2_1	122	124	PF00082	0.411
CLV_PCSK_KEX2_1	128	130	PF00082	0.405
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.411
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.405
CLV_PCSK_SKI1_1	129	133	PF00082	0.408
DEG_APCC_KENBOX_2	84	88	PF00400	0.647
DEG_Nend_UBRbox_2	1	3	PF02207	0.645
DOC_CYCLIN_RxL_1	123	134	PF00134	0.609
DOC_MAPK_MEF2A_6	15	23	PF00069	0.435
DOC_PP1_RVXF_1	93	99	PF00149	0.785
DOC_USP7_MATH_1	47	51	PF00917	0.250
DOC_USP7_UBL2_3	120	124	PF12436	0.683
DOC_WW_Pin1_4	43	48	PF00397	0.266
LIG_14-3-3_CanoR_1	64	70	PF00244	0.434
LIG_FHA_1	30	36	PF00498	0.275
LIG_LIR_Gen_1	16	26	PF02991	0.292
LIG_LIR_Gen_1	46	56	PF02991	0.249
LIG_LIR_Gen_1	99	106	PF02991	0.606
LIG_LIR_Nem_3	12	17	PF02991	0.634
LIG_LIR_Nem_3	46	51	PF02991	0.417
LIG_LIR_Nem_3	60	66	PF02991	0.260
LIG_LIR_Nem_3	99	105	PF02991	0.606
LIG_Pex14_2	54	58	PF04695	0.332
LIG_SH2_CRK	14	18	PF00017	0.471
LIG_SH2_GRB2like	18	21	PF00017	0.249
LIG_SH2_PTP2	18	21	PF00017	0.299
LIG_SH2_PTP2	22	25	PF00017	0.279
LIG_SH2_PTP2	26	29	PF00017	0.344
LIG_SH2_SRC	18	21	PF00017	0.466
LIG_SH2_SRC	22	25	PF00017	0.413
LIG_SH2_STAP1	59	63	PF00017	0.249
LIG_SH2_STAT5	102	105	PF00017	0.677
LIG_SH2_STAT5	18	21	PF00017	0.501
LIG_SH2_STAT5	22	25	PF00017	0.437
LIG_SH2_STAT5	26	29	PF00017	0.494
LIG_SH2_STAT5	69	72	PF00017	0.638
MOD_CK1_1	5	11	PF00069	0.632
MOD_GSK3_1	43	50	PF00069	0.250
MOD_GSK3_1	71	78	PF00069	0.658
MOD_GSK3_1	97	104	PF00069	0.612
MOD_LATS_1	77	83	PF00433	0.636
MOD_NEK2_1	29	34	PF00069	0.329
MOD_NEK2_1	57	62	PF00069	0.299
MOD_NEK2_1	96	101	PF00069	0.614
MOD_NEK2_2	97	102	PF00069	0.612
MOD_Plk_4	13	19	PF00069	0.471
MOD_Plk_4	47	53	PF00069	0.249
MOD_Plk_4	58	64	PF00069	0.249
MOD_Plk_4	65	71	PF00069	0.418
MOD_Plk_4	97	103	PF00069	0.611
MOD_ProDKin_1	43	49	PF00069	0.266
MOD_SUMO_rev_2	104	112	PF00179	0.580
TRG_ENDOCYTIC_2	102	105	PF00928	0.605
TRG_ENDOCYTIC_2	14	17	PF00928	0.588
TRG_ENDOCYTIC_2	18	21	PF00928	0.279
TRG_ENDOCYTIC_2	22	25	PF00928	0.259
TRG_ENDOCYTIC_2	26	29	PF00928	0.299
TRG_ENDOCYTIC_2	59	62	PF00928	0.249
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IKD2	Leishmania donovani	53%	100%
E9AHX2	Leishmania infantum	40%	95%