Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AG11_LEIMA

TriTrypDb:

LmjF.35.5380 , LMJLV39_350062100 , LMJSD75_350061400

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AG11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.492
CLV_NRD_NRD_1	165	167	PF00675	0.352
CLV_PCSK_KEX2_1	27	29	PF00082	0.462
CLV_PCSK_KEX2_1	87	89	PF00082	0.468
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.410
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.468
CLV_PCSK_SKI1_1	105	109	PF00082	0.481
CLV_PCSK_SKI1_1	144	148	PF00082	0.516
CLV_PCSK_SKI1_1	15	19	PF00082	0.444
CLV_PCSK_SKI1_1	167	171	PF00082	0.584
CLV_PCSK_SKI1_1	196	200	PF00082	0.606
CLV_PCSK_SKI1_1	209	213	PF00082	0.536
CLV_PCSK_SKI1_1	224	228	PF00082	0.465
CLV_PCSK_SKI1_1	28	32	PF00082	0.387
DEG_APCC_KENBOX_2	43	47	PF00400	0.379
DEG_Nend_UBRbox_1	1	4	PF02207	0.670
DEG_SCF_TRCP1_1	123	128	PF00400	0.477
DOC_CYCLIN_RxL_1	12	19	PF00134	0.490
DOC_CYCLIN_RxL_1	24	34	PF00134	0.461
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.479
DOC_CYCLIN_yCln2_LP_2	75	78	PF00134	0.474
DOC_MAPK_DCC_7	144	154	PF00069	0.347
DOC_PP2B_LxvP_1	54	57	PF13499	0.531
DOC_PP2B_LxvP_1	75	78	PF13499	0.429
DOC_PP4_FxxP_1	165	168	PF00568	0.455
DOC_USP7_MATH_1	13	17	PF00917	0.603
DOC_USP7_MATH_1	192	196	PF00917	0.531
DOC_USP7_MATH_1	198	202	PF00917	0.472
DOC_WW_Pin1_4	16	21	PF00397	0.477
DOC_WW_Pin1_4	48	53	PF00397	0.402
LIG_FHA_1	37	43	PF00498	0.449
LIG_FHA_1	49	55	PF00498	0.319
LIG_FHA_1	88	94	PF00498	0.448
LIG_FHA_2	106	112	PF00498	0.500
LIG_FHA_2	168	174	PF00498	0.511
LIG_HCF-1_HBM_1	94	97	PF13415	0.363
LIG_LIR_Apic_2	162	168	PF02991	0.449
LIG_LIR_Gen_1	135	146	PF02991	0.504
LIG_LIR_Nem_3	135	141	PF02991	0.488
LIG_LIR_Nem_3	94	100	PF02991	0.349
LIG_PDZ_Class_1	254	259	PF00595	0.492
LIG_Pex14_1	161	165	PF04695	0.399
LIG_SH2_STAT5	101	104	PF00017	0.330
LIG_SH2_STAT5	145	148	PF00017	0.428
LIG_SH2_STAT5	159	162	PF00017	0.340
LIG_SH2_STAT5	234	237	PF00017	0.361
LIG_SH2_STAT5	97	100	PF00017	0.328
LIG_SH3_3	143	149	PF00018	0.522
LIG_SH3_3	4	10	PF00018	0.440
LIG_SH3_3	73	79	PF00018	0.583
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.504
LIG_SUMO_SIM_par_1	187	193	PF11976	0.265
LIG_TRAF2_1	127	130	PF00917	0.530
LIG_UBA3_1	82	87	PF00899	0.532
MOD_CK1_1	16	22	PF00069	0.513
MOD_CK1_1	201	207	PF00069	0.533
MOD_CK1_1	218	224	PF00069	0.457
MOD_CK1_1	252	258	PF00069	0.543
MOD_CK1_1	34	40	PF00069	0.408
MOD_CK2_1	105	111	PF00069	0.388
MOD_GlcNHglycan	123	126	PF01048	0.541
MOD_GlcNHglycan	173	176	PF01048	0.515
MOD_GlcNHglycan	2	5	PF01048	0.642
MOD_GlcNHglycan	200	203	PF01048	0.554
MOD_GlcNHglycan	33	36	PF01048	0.613
MOD_GSK3_1	121	128	PF00069	0.434
MOD_GSK3_1	167	174	PF00069	0.498
MOD_GSK3_1	192	199	PF00069	0.514
MOD_GSK3_1	211	218	PF00069	0.325
MOD_N-GLC_1	196	201	PF02516	0.391
MOD_NEK2_1	121	126	PF00069	0.466
MOD_NEK2_1	203	208	PF00069	0.416
MOD_NEK2_1	211	216	PF00069	0.425
MOD_NEK2_1	31	36	PF00069	0.487
MOD_NEK2_2	100	105	PF00069	0.420
MOD_PIKK_1	113	119	PF00454	0.391
MOD_PIKK_1	125	131	PF00454	0.559
MOD_PIKK_1	190	196	PF00454	0.494
MOD_PKA_1	87	93	PF00069	0.442
MOD_PKA_2	87	93	PF00069	0.442
MOD_Plk_1	249	255	PF00069	0.551
MOD_ProDKin_1	16	22	PF00069	0.474
MOD_ProDKin_1	48	54	PF00069	0.397
TRG_DiLeu_BaEn_1	81	86	PF01217	0.398
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.462
TRG_ENDOCYTIC_2	101	104	PF00928	0.338
TRG_ENDOCYTIC_2	236	239	PF00928	0.400
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXE1	Leptomonas seymouri	48%	96%
A0A1X0NWL1	Trypanosomatidae	28%	92%
A0A3S7XA73	Leishmania donovani	92%	100%
A0A422N815	Trypanosoma rangeli	22%	97%
A4HNJ9	Leishmania braziliensis	80%	100%
A4IC68	Leishmania infantum	92%	100%
E9B764	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DS95	Trypanosoma cruzi	23%	97%