ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dynein heavy chain and region D6 of dynein motor/Ankyrin repeats (3 copies), putative

Species:

Leishmania major

UniProt:

E9AG07_LEIMA

TriTrypDb:

LmjF.35.5340 , LMJLV39_350061600 , LMJSD75_350060900

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0005875	microtubule associated complex	2	3
GO:0030286	dynein complex	3	3
GO:0032991	protein-containing complex	1	3
GO:1902494	catalytic complex	2	3

Expansion

Sequence features

E9AG07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG07

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	3
GO:0007018	microtubule-based movement	3	3
GO:0009987	cellular process	1	3

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	3
GO:0003777	microtubule motor activity	2	3
GO:0008569	minus-end-directed microtubule motor activity	3	3
GO:0140657	ATP-dependent activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.430
CLV_NRD_NRD_1	182	184	PF00675	0.499
CLV_NRD_NRD_1	241	243	PF00675	0.475
CLV_NRD_NRD_1	252	254	PF00675	0.449
CLV_NRD_NRD_1	342	344	PF00675	0.481
CLV_PCSK_KEX2_1	116	118	PF00082	0.422
CLV_PCSK_KEX2_1	182	184	PF00082	0.529
CLV_PCSK_KEX2_1	241	243	PF00082	0.449
CLV_PCSK_KEX2_1	51	53	PF00082	0.505
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.505
CLV_PCSK_SKI1_1	117	121	PF00082	0.426
CLV_PCSK_SKI1_1	169	173	PF00082	0.630
CLV_PCSK_SKI1_1	21	25	PF00082	0.465
CLV_PCSK_SKI1_1	253	257	PF00082	0.362
CLV_PCSK_SKI1_1	268	272	PF00082	0.365
DOC_CYCLIN_RxL_1	163	173	PF00134	0.574
DOC_CYCLIN_yCln2_LP_2	108	114	PF00134	0.388
DOC_CYCLIN_yCln2_LP_2	132	138	PF00134	0.637
DOC_PP2B_LxvP_1	132	135	PF13499	0.600
DOC_PP2B_PxIxI_1	30	36	PF00149	0.518
DOC_USP7_MATH_1	287	291	PF00917	0.321
DOC_WW_Pin1_4	11	16	PF00397	0.565
DOC_WW_Pin1_4	257	262	PF00397	0.328
DOC_WW_Pin1_4	27	32	PF00397	0.279
LIG_14-3-3_CanoR_1	152	161	PF00244	0.565
LIG_14-3-3_CanoR_1	241	251	PF00244	0.451
LIG_AP2alpha_2	40	42	PF02296	0.421
LIG_BIR_II_1	1	5	PF00653	0.530
LIG_BRCT_BRCA1_1	9	13	PF00533	0.495
LIG_EVH1_1	138	142	PF00568	0.532
LIG_FHA_1	218	224	PF00498	0.614
LIG_FHA_1	28	34	PF00498	0.410
LIG_FHA_2	325	331	PF00498	0.487
LIG_FHA_2	85	91	PF00498	0.412
LIG_GBD_Chelix_1	100	108	PF00786	0.540
LIG_LIR_Gen_1	159	167	PF02991	0.617
LIG_LIR_Gen_1	40	49	PF02991	0.400
LIG_LIR_Gen_1	72	78	PF02991	0.425
LIG_LIR_Gen_1	82	91	PF02991	0.310
LIG_LIR_Nem_3	10	16	PF02991	0.519
LIG_LIR_Nem_3	103	108	PF02991	0.520
LIG_LIR_Nem_3	118	123	PF02991	0.266
LIG_LIR_Nem_3	159	164	PF02991	0.577
LIG_LIR_Nem_3	318	323	PF02991	0.455
LIG_LIR_Nem_3	40	45	PF02991	0.409
LIG_LIR_Nem_3	72	76	PF02991	0.414
LIG_LIR_Nem_3	82	86	PF02991	0.353
LIG_LIR_Nem_3	94	100	PF02991	0.411
LIG_MYND_1	111	115	PF01753	0.551
LIG_NRBOX	273	279	PF00104	0.242
LIG_Pex14_2	120	124	PF04695	0.357
LIG_Pex14_2	140	144	PF04695	0.546
LIG_Pex14_2	9	13	PF04695	0.495
LIG_SH2_CRK	105	109	PF00017	0.551
LIG_SH2_PTP2	73	76	PF00017	0.407
LIG_SH2_SRC	73	76	PF00017	0.407
LIG_SH2_STAT5	18	21	PF00017	0.442
LIG_SH2_STAT5	338	341	PF00017	0.564
LIG_SH2_STAT5	47	50	PF00017	0.485
LIG_SH2_STAT5	73	76	PF00017	0.419
LIG_SH2_STAT5	85	88	PF00017	0.366
LIG_SH2_STAT5	96	99	PF00017	0.410
LIG_SH3_3	123	129	PF00018	0.537
LIG_SH3_3	133	139	PF00018	0.509
LIG_SH3_3	147	153	PF00018	0.432
LIG_SH3_3	281	287	PF00018	0.348
LIG_TYR_ITIM	205	210	PF00017	0.577
LIG_WRC_WIRS_1	56	61	PF05994	0.493
MOD_CDC14_SPxK_1	14	17	PF00782	0.517
MOD_CDK_SPxK_1	11	17	PF00069	0.526
MOD_CK1_1	219	225	PF00069	0.538
MOD_CK1_1	273	279	PF00069	0.475
MOD_CK2_1	186	192	PF00069	0.547
MOD_CK2_1	242	248	PF00069	0.461
MOD_CK2_1	315	321	PF00069	0.504
MOD_GlcNHglycan	146	149	PF01048	0.457
MOD_GlcNHglycan	172	175	PF01048	0.660
MOD_GlcNHglycan	201	204	PF01048	0.540
MOD_GlcNHglycan	245	248	PF01048	0.363
MOD_GlcNHglycan	53	56	PF01048	0.419
MOD_GlcNHglycan	9	12	PF01048	0.507
MOD_GSK3_1	186	193	PF00069	0.553
MOD_GSK3_1	23	30	PF00069	0.483
MOD_GSK3_1	296	303	PF00069	0.376
MOD_GSK3_1	324	331	PF00069	0.489
MOD_GSK3_1	51	58	PF00069	0.514
MOD_GSK3_1	7	14	PF00069	0.622
MOD_N-GLC_1	7	12	PF02516	0.546
MOD_NEK2_1	124	129	PF00069	0.518
MOD_NEK2_1	144	149	PF00069	0.465
MOD_NEK2_1	270	275	PF00069	0.449
MOD_NEK2_2	167	172	PF00069	0.615
MOD_PIKK_1	153	159	PF00454	0.575
MOD_PKA_1	51	57	PF00069	0.466
MOD_PKA_2	151	157	PF00069	0.608
MOD_PKA_2	186	192	PF00069	0.560
MOD_PKA_2	199	205	PF00069	0.539
MOD_PKA_2	287	293	PF00069	0.306
MOD_PKA_2	51	57	PF00069	0.510
MOD_Plk_1	167	173	PF00069	0.583
MOD_Plk_1	216	222	PF00069	0.611
MOD_Plk_2-3	188	194	PF00069	0.549
MOD_Plk_4	167	173	PF00069	0.583
MOD_Plk_4	273	279	PF00069	0.242
MOD_Plk_4	92	98	PF00069	0.455
MOD_ProDKin_1	11	17	PF00069	0.570
MOD_ProDKin_1	257	263	PF00069	0.328
MOD_ProDKin_1	27	33	PF00069	0.276
MOD_SUMO_for_1	224	227	PF00179	0.570
MOD_SUMO_rev_2	340	346	PF00179	0.586
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.390
TRG_ENDOCYTIC_2	105	108	PF00928	0.551
TRG_ENDOCYTIC_2	207	210	PF00928	0.610
TRG_ENDOCYTIC_2	73	76	PF00928	0.419
TRG_ER_diArg_1	115	117	PF00400	0.448
TRG_ER_diArg_1	240	242	PF00400	0.475
TRG_NES_CRM1_1	269	283	PF08389	0.475
TRG_Pf-PMV_PEXEL_1	106	110	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.671
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	307	311	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEG4	Leptomonas seymouri	74%	100%
A0A0S4JP67	Bodo saltans	44%	93%
A0A1X0P5J8	Trypanosomatidae	49%	100%
A0A3Q8IIK7	Leishmania donovani	97%	100%
A0A3R7N649	Trypanosoma rangeli	46%	100%
A4HNJ5	Leishmania braziliensis	84%	100%
A4IC52	Leishmania infantum	97%	100%
C9ZYC2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B760	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BYP5	Trypanosoma cruzi	46%	92%