SAC3_GANP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SAC3/GANP/Nin1/mts3/eIF-3 p25 family, putative

Species:

Leishmania major

UniProt:

E9AG05_LEIMA

TriTrypDb:

LmjF.35.5320 , LMJLV39_350061400 , LMJSD75_350060700

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AG05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG05

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	590	594	PF00656	0.488
CLV_NRD_NRD_1	109	111	PF00675	0.619
CLV_NRD_NRD_1	137	139	PF00675	0.442
CLV_NRD_NRD_1	163	165	PF00675	0.504
CLV_NRD_NRD_1	252	254	PF00675	0.675
CLV_NRD_NRD_1	590	592	PF00675	0.465
CLV_PCSK_KEX2_1	109	111	PF00082	0.619
CLV_PCSK_KEX2_1	137	139	PF00082	0.410
CLV_PCSK_KEX2_1	163	165	PF00082	0.445
CLV_PCSK_KEX2_1	227	229	PF00082	0.599
CLV_PCSK_KEX2_1	241	243	PF00082	0.605
CLV_PCSK_KEX2_1	517	519	PF00082	0.627
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.696
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.709
CLV_PCSK_PC1ET2_1	517	519	PF00082	0.627
CLV_PCSK_SKI1_1	128	132	PF00082	0.413
CLV_PCSK_SKI1_1	137	141	PF00082	0.411
CLV_PCSK_SKI1_1	217	221	PF00082	0.722
CLV_PCSK_SKI1_1	395	399	PF00082	0.445
CLV_PCSK_SKI1_1	461	465	PF00082	0.462
CLV_PCSK_SKI1_1	487	491	PF00082	0.285
CLV_PCSK_SKI1_1	518	522	PF00082	0.495
CLV_PCSK_SKI1_1	65	69	PF00082	0.490
DEG_APCC_DBOX_1	40	48	PF00400	0.493
DEG_APCC_DBOX_1	474	482	PF00400	0.337
DEG_APCC_DBOX_1	64	72	PF00400	0.385
DEG_SCF_FBW7_1	208	214	PF00400	0.512
DEG_SPOP_SBC_1	113	117	PF00917	0.672
DOC_CKS1_1	208	213	PF01111	0.738
DOC_CYCLIN_RxL_1	458	467	PF00134	0.287
DOC_CYCLIN_RxL_1	513	525	PF00134	0.454
DOC_MAPK_gen_1	163	170	PF00069	0.427
DOC_MAPK_gen_1	335	343	PF00069	0.293
DOC_MAPK_MEF2A_6	494	501	PF00069	0.360
DOC_MAPK_NFAT4_5	494	502	PF00069	0.331
DOC_PP1_RVXF_1	44	50	PF00149	0.507
DOC_PP1_RVXF_1	480	486	PF00149	0.281
DOC_PP1_RVXF_1	516	523	PF00149	0.577
DOC_PP4_FxxP_1	220	223	PF00568	0.591
DOC_USP7_MATH_1	113	117	PF00917	0.657
DOC_USP7_MATH_1	249	253	PF00917	0.589
DOC_USP7_MATH_1	53	57	PF00917	0.573
DOC_USP7_MATH_1	87	91	PF00917	0.492
DOC_USP7_UBL2_3	319	323	PF12436	0.308
DOC_USP7_UBL2_3	324	328	PF12436	0.309
DOC_WW_Pin1_4	182	187	PF00397	0.659
DOC_WW_Pin1_4	188	193	PF00397	0.701
DOC_WW_Pin1_4	207	212	PF00397	0.682
DOC_WW_Pin1_4	453	458	PF00397	0.393
DOC_WW_Pin1_4	506	511	PF00397	0.328
DOC_WW_Pin1_4	74	79	PF00397	0.510
DOC_WW_Pin1_4	94	99	PF00397	0.330
LIG_14-3-3_CanoR_1	137	142	PF00244	0.423
LIG_14-3-3_CanoR_1	16	24	PF00244	0.679
LIG_14-3-3_CanoR_1	46	50	PF00244	0.390
LIG_14-3-3_CanoR_1	461	467	PF00244	0.389
LIG_14-3-3_CanoR_1	52	58	PF00244	0.431
LIG_14-3-3_CanoR_1	533	541	PF00244	0.475
LIG_Actin_WH2_2	290	306	PF00022	0.360
LIG_Actin_WH2_2	471	489	PF00022	0.322
LIG_BIR_II_1	1	5	PF00653	0.732
LIG_BRCT_BRCA1_1	504	508	PF00533	0.327
LIG_Clathr_ClatBox_1	463	467	PF01394	0.331
LIG_Clathr_ClatBox_1	520	524	PF01394	0.386
LIG_deltaCOP1_diTrp_1	42	49	PF00928	0.447
LIG_FHA_1	138	144	PF00498	0.517
LIG_FHA_1	210	216	PF00498	0.679
LIG_FHA_1	349	355	PF00498	0.411
LIG_FHA_1	363	369	PF00498	0.411
LIG_FHA_1	414	420	PF00498	0.281
LIG_FHA_1	427	433	PF00498	0.281
LIG_FHA_1	442	448	PF00498	0.221
LIG_FHA_1	454	460	PF00498	0.260
LIG_FHA_1	469	475	PF00498	0.411
LIG_FHA_1	538	544	PF00498	0.465
LIG_FHA_2	264	270	PF00498	0.689
LIG_FHA_2	279	285	PF00498	0.458
LIG_FHA_2	286	292	PF00498	0.363
LIG_FHA_2	313	319	PF00498	0.445
LIG_FHA_2	53	59	PF00498	0.461
LIG_FHA_2	559	565	PF00498	0.643
LIG_FHA_2	588	594	PF00498	0.465
LIG_LIR_Apic_2	218	223	PF02991	0.592
LIG_LIR_Gen_1	169	177	PF02991	0.379
LIG_LIR_Gen_1	204	213	PF02991	0.676
LIG_LIR_Gen_1	305	314	PF02991	0.473
LIG_LIR_Gen_1	348	357	PF02991	0.470
LIG_LIR_Gen_1	408	419	PF02991	0.411
LIG_LIR_Gen_1	535	546	PF02991	0.373
LIG_LIR_Gen_1	583	588	PF02991	0.446
LIG_LIR_Nem_3	204	208	PF02991	0.693
LIG_LIR_Nem_3	257	262	PF02991	0.469
LIG_LIR_Nem_3	284	290	PF02991	0.462
LIG_LIR_Nem_3	305	310	PF02991	0.442
LIG_LIR_Nem_3	408	414	PF02991	0.356
LIG_LIR_Nem_3	505	511	PF02991	0.393
LIG_LIR_Nem_3	535	541	PF02991	0.371
LIG_LIR_Nem_3	583	587	PF02991	0.372
LIG_LYPXL_yS_3	569	572	PF13949	0.411
LIG_NRBOX	458	464	PF00104	0.331
LIG_PCNA_PIPBox_1	375	384	PF02747	0.300
LIG_PCNA_PIPBox_1	391	400	PF02747	0.300
LIG_PCNA_yPIPBox_3	391	401	PF02747	0.484
LIG_Pex14_2	534	538	PF04695	0.445
LIG_REV1ctd_RIR_1	395	405	PF16727	0.281
LIG_SH2_CRK	205	209	PF00017	0.698
LIG_SH2_CRK	400	404	PF00017	0.356
LIG_SH2_CRK	411	415	PF00017	0.276
LIG_SH2_GRB2like	123	126	PF00017	0.550
LIG_SH2_NCK_1	123	127	PF00017	0.493
LIG_SH2_NCK_1	165	169	PF00017	0.398
LIG_SH2_NCK_1	307	311	PF00017	0.481
LIG_SH2_SRC	123	126	PF00017	0.662
LIG_SH2_SRC	307	310	PF00017	0.479
LIG_SH2_STAP1	154	158	PF00017	0.536
LIG_SH2_STAP1	205	209	PF00017	0.517
LIG_SH2_STAP1	355	359	PF00017	0.266
LIG_SH2_STAP1	382	386	PF00017	0.345
LIG_SH2_STAP1	63	67	PF00017	0.350
LIG_SH2_STAT3	3	6	PF00017	0.510
LIG_SH2_STAT5	287	290	PF00017	0.551
LIG_SH2_STAT5	329	332	PF00017	0.269
LIG_SH2_STAT5	404	407	PF00017	0.266
LIG_SH2_STAT5	472	475	PF00017	0.318
LIG_SH2_STAT5	477	480	PF00017	0.281
LIG_SH2_STAT5	584	587	PF00017	0.363
LIG_SH3_3	139	145	PF00018	0.517
LIG_SH3_3	186	192	PF00018	0.706
LIG_SH3_3	194	200	PF00018	0.696
LIG_SH3_3	232	238	PF00018	0.776
LIG_SH3_3	267	273	PF00018	0.622
LIG_SH3_3	540	546	PF00018	0.479
LIG_SH3_3	72	78	PF00018	0.472
LIG_SH3_3	88	94	PF00018	0.315
LIG_SUMO_SIM_par_1	350	356	PF11976	0.380
LIG_TRAF2_1	4	7	PF00917	0.507
LIG_TYR_ITIM	402	407	PF00017	0.281
LIG_UBA3_1	173	178	PF00899	0.510
LIG_UBA3_1	483	487	PF00899	0.346
LIG_UBA3_1	489	494	PF00899	0.376
LIG_UBA3_1	537	542	PF00899	0.416
LIG_WRC_WIRS_1	463	468	PF05994	0.331
LIG_WW_1	202	205	PF00397	0.687
MOD_CK1_1	108	114	PF00069	0.632
MOD_CK1_1	195	201	PF00069	0.708
MOD_CK1_1	413	419	PF00069	0.380
MOD_CK2_1	1	7	PF00069	0.509
MOD_CK2_1	166	172	PF00069	0.418
MOD_CK2_1	263	269	PF00069	0.680
MOD_CK2_1	278	284	PF00069	0.406
MOD_CK2_1	285	291	PF00069	0.388
MOD_CK2_1	312	318	PF00069	0.359
MOD_CK2_1	52	58	PF00069	0.536
MOD_Cter_Amidation	321	324	PF01082	0.331
MOD_Cter_Amidation	513	516	PF01082	0.496
MOD_GlcNHglycan	116	119	PF01048	0.655
MOD_GlcNHglycan	205	208	PF01048	0.716
MOD_GlcNHglycan	407	410	PF01048	0.466
MOD_GSK3_1	108	115	PF00069	0.499
MOD_GSK3_1	188	195	PF00069	0.617
MOD_GSK3_1	203	210	PF00069	0.668
MOD_GSK3_1	211	218	PF00069	0.613
MOD_GSK3_1	308	315	PF00069	0.331
MOD_GSK3_1	502	509	PF00069	0.311
MOD_GSK3_1	94	101	PF00069	0.613
MOD_N-GLC_1	348	353	PF02516	0.331
MOD_N-GLC_1	441	446	PF02516	0.418
MOD_N-GLC_2	12	14	PF02516	0.578
MOD_N-GLC_2	372	374	PF02516	0.266
MOD_NEK2_1	1	6	PF00069	0.779
MOD_NEK2_1	132	137	PF00069	0.532
MOD_NEK2_1	405	410	PF00069	0.331
MOD_NEK2_1	493	498	PF00069	0.389
MOD_NEK2_1	502	507	PF00069	0.333
MOD_NEK2_1	537	542	PF00069	0.449
MOD_NEK2_1	587	592	PF00069	0.459
MOD_NEK2_2	495	500	PF00069	0.300
MOD_NEK2_2	547	552	PF00069	0.572
MOD_PIKK_1	1	7	PF00454	0.596
MOD_PIKK_1	15	21	PF00454	0.738
MOD_PIKK_1	195	201	PF00454	0.739
MOD_PIKK_1	387	393	PF00454	0.287
MOD_PKA_1	137	143	PF00069	0.340
MOD_PKA_2	108	114	PF00069	0.629
MOD_PKA_2	137	143	PF00069	0.379
MOD_PKA_2	15	21	PF00069	0.553
MOD_PKA_2	45	51	PF00069	0.394
MOD_PKA_2	532	538	PF00069	0.473
MOD_Plk_1	254	260	PF00069	0.505
MOD_Plk_1	348	354	PF00069	0.331
MOD_Plk_1	441	447	PF00069	0.331
MOD_Plk_1	468	474	PF00069	0.298
MOD_Plk_1	547	553	PF00069	0.449
MOD_Plk_2-3	166	172	PF00069	0.448
MOD_Plk_4	166	172	PF00069	0.404
MOD_Plk_4	254	260	PF00069	0.568
MOD_Plk_4	45	51	PF00069	0.394
MOD_Plk_4	468	474	PF00069	0.414
MOD_Plk_4	87	93	PF00069	0.483
MOD_ProDKin_1	182	188	PF00069	0.670
MOD_ProDKin_1	192	198	PF00069	0.665
MOD_ProDKin_1	207	213	PF00069	0.684
MOD_ProDKin_1	453	459	PF00069	0.393
MOD_ProDKin_1	506	512	PF00069	0.341
MOD_ProDKin_1	74	80	PF00069	0.505
MOD_ProDKin_1	94	100	PF00069	0.333
MOD_SUMO_for_1	541	544	PF00179	0.487
MOD_SUMO_rev_2	318	325	PF00179	0.331
MOD_SUMO_rev_2	388	397	PF00179	0.428
TRG_DiLeu_BaEn_1	469	474	PF01217	0.411
TRG_DiLeu_BaEn_2	165	171	PF01217	0.531
TRG_DiLeu_BaEn_4	527	533	PF01217	0.391
TRG_DiLeu_BaLyEn_6	458	463	PF01217	0.337
TRG_ENDOCYTIC_2	165	168	PF00928	0.384
TRG_ENDOCYTIC_2	205	208	PF00928	0.608
TRG_ENDOCYTIC_2	290	293	PF00928	0.435
TRG_ENDOCYTIC_2	307	310	PF00928	0.442
TRG_ENDOCYTIC_2	400	403	PF00928	0.396
TRG_ENDOCYTIC_2	404	407	PF00928	0.301
TRG_ENDOCYTIC_2	411	414	PF00928	0.283
TRG_ENDOCYTIC_2	569	572	PF00928	0.508
TRG_ENDOCYTIC_2	584	587	PF00928	0.300
TRG_ER_diArg_1	136	138	PF00400	0.444
TRG_ER_diArg_1	163	165	PF00400	0.481
TRG_NES_CRM1_1	332	344	PF08389	0.266
TRG_NLS_MonoCore_2	514	519	PF00514	0.517
TRG_NLS_MonoExtN_4	512	519	PF00514	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL40	Leptomonas seymouri	58%	98%
A0A0S4JV64	Bodo saltans	34%	100%
A0A1X0P4X7	Trypanosomatidae	39%	96%
A0A3S5IQK8	Trypanosoma rangeli	38%	98%
A0A3S7XA75	Leishmania donovani	96%	100%
A4HNJ3	Leishmania braziliensis	85%	100%
A4IC50	Leishmania infantum	95%	100%
C9ZYC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B758	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5B8T1	Trypanosoma cruzi	37%	98%