PPM-type phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AG03_LEIMA

TriTrypDb:

LmjF.35.5300 , LMJLV39_350061200 , LMJSD75_350060500

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AG03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG03

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.563
CLV_NRD_NRD_1	232	234	PF00675	0.527
CLV_NRD_NRD_1	253	255	PF00675	0.498
CLV_PCSK_FUR_1	251	255	PF00082	0.532
CLV_PCSK_KEX2_1	114	116	PF00082	0.558
CLV_PCSK_KEX2_1	251	253	PF00082	0.441
CLV_PCSK_KEX2_1	264	266	PF00082	0.420
CLV_PCSK_KEX2_1	63	65	PF00082	0.534
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.577
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.543
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.607
CLV_PCSK_SKI1_1	2	6	PF00082	0.590
CLV_PCSK_SKI1_1	79	83	PF00082	0.401
DEG_Nend_UBRbox_1	1	4	PF02207	0.696
DOC_CKS1_1	109	114	PF01111	0.522
DOC_PP2B_LxvP_1	55	58	PF13499	0.386
DOC_USP7_MATH_1	116	120	PF00917	0.590
DOC_USP7_MATH_1	147	151	PF00917	0.598
DOC_USP7_MATH_1	176	180	PF00917	0.580
DOC_USP7_UBL2_3	287	291	PF12436	0.565
DOC_WW_Pin1_4	108	113	PF00397	0.502
DOC_WW_Pin1_4	245	250	PF00397	0.414
DOC_WW_Pin1_4	311	316	PF00397	0.758
LIG_14-3-3_CanoR_1	115	125	PF00244	0.624
LIG_14-3-3_CanoR_1	238	245	PF00244	0.536
LIG_14-3-3_CanoR_1	251	257	PF00244	0.491
LIG_BRCT_BRCA1_1	25	29	PF00533	0.430
LIG_CSL_BTD_1	246	249	PF09270	0.395
LIG_deltaCOP1_diTrp_1	156	160	PF00928	0.493
LIG_eIF4E_1	220	226	PF01652	0.420
LIG_FHA_1	134	140	PF00498	0.369
LIG_FHA_1	237	243	PF00498	0.627
LIG_FHA_1	305	311	PF00498	0.720
LIG_FHA_2	191	197	PF00498	0.728
LIG_FHA_2	225	231	PF00498	0.533
LIG_FHA_2	257	263	PF00498	0.421
LIG_FHA_2	66	72	PF00498	0.385
LIG_IRF3_LxIS_1	42	49	PF10401	0.377
LIG_LIR_Gen_1	15	24	PF02991	0.342
LIG_LIR_Gen_1	223	231	PF02991	0.530
LIG_LIR_Gen_1	26	33	PF02991	0.396
LIG_LIR_Gen_1	89	99	PF02991	0.421
LIG_LIR_Nem_3	15	19	PF02991	0.338
LIG_LIR_Nem_3	156	161	PF02991	0.411
LIG_LIR_Nem_3	223	229	PF02991	0.518
LIG_LIR_Nem_3	246	250	PF02991	0.392
LIG_LIR_Nem_3	289	293	PF02991	0.505
LIG_LIR_Nem_3	294	299	PF02991	0.502
LIG_LIR_Nem_3	41	47	PF02991	0.369
LIG_LIR_Nem_3	89	94	PF02991	0.421
LIG_NRBOX	224	230	PF00104	0.399
LIG_PDZ_Class_1	311	316	PF00595	0.665
LIG_Pex14_2	91	95	PF04695	0.420
LIG_SH2_CRK	126	130	PF00017	0.477
LIG_SH2_PTP2	128	131	PF00017	0.482
LIG_SH2_SRC	128	131	PF00017	0.361
LIG_SH2_STAP1	135	139	PF00017	0.357
LIG_SH2_STAT3	258	261	PF00017	0.549
LIG_SH2_STAT5	128	131	PF00017	0.389
LIG_SH2_STAT5	135	138	PF00017	0.358
LIG_SH2_STAT5	161	164	PF00017	0.382
LIG_SH2_STAT5	220	223	PF00017	0.404
LIG_SH2_STAT5	258	261	PF00017	0.513
LIG_SH2_STAT5	44	47	PF00017	0.358
LIG_SH2_STAT5	77	80	PF00017	0.530
LIG_SH3_2	58	63	PF14604	0.471
LIG_SH3_3	55	61	PF00018	0.404
LIG_SUMO_SIM_par_1	134	141	PF11976	0.389
LIG_TRAF2_1	259	262	PF00917	0.446
LIG_UBA3_1	105	114	PF00899	0.549
LIG_UBA3_1	225	234	PF00899	0.516
MOD_CDK_SPK_2	108	113	PF00069	0.502
MOD_CDK_SPxK_1	108	114	PF00069	0.516
MOD_CDK_SPxK_1	245	251	PF00069	0.414
MOD_CDK_SPxxK_3	108	115	PF00069	0.530
MOD_CDK_SPxxK_3	245	252	PF00069	0.397
MOD_CK1_1	108	114	PF00069	0.366
MOD_CK1_1	138	144	PF00069	0.391
MOD_CK1_1	165	171	PF00069	0.439
MOD_CK1_1	17	23	PF00069	0.463
MOD_CK1_1	179	185	PF00069	0.427
MOD_CK1_1	200	206	PF00069	0.754
MOD_CK1_1	277	283	PF00069	0.518
MOD_CK1_1	38	44	PF00069	0.453
MOD_CK2_1	190	196	PF00069	0.669
MOD_CK2_1	224	230	PF00069	0.521
MOD_CK2_1	256	262	PF00069	0.435
MOD_GlcNHglycan	131	134	PF01048	0.421
MOD_GlcNHglycan	178	181	PF01048	0.517
MOD_GlcNHglycan	19	22	PF01048	0.425
MOD_GlcNHglycan	202	205	PF01048	0.746
MOD_GlcNHglycan	206	209	PF01048	0.667
MOD_GlcNHglycan	310	313	PF01048	0.666
MOD_GlcNHglycan	48	51	PF01048	0.366
MOD_GSK3_1	129	136	PF00069	0.382
MOD_GSK3_1	165	172	PF00069	0.522
MOD_GSK3_1	200	207	PF00069	0.754
MOD_GSK3_1	220	227	PF00069	0.209
MOD_GSK3_1	252	259	PF00069	0.585
MOD_GSK3_1	300	307	PF00069	0.631
MOD_GSK3_1	31	38	PF00069	0.497
MOD_N-GLC_1	200	205	PF02516	0.735
MOD_N-GLC_2	73	75	PF02516	0.418
MOD_NEK2_1	105	110	PF00069	0.375
MOD_NEK2_1	23	28	PF00069	0.390
MOD_NEK2_1	256	261	PF00069	0.522
MOD_NEK2_1	46	51	PF00069	0.406
MOD_NEK2_2	135	140	PF00069	0.357
MOD_PIKK_1	165	171	PF00454	0.455
MOD_PIKK_1	237	243	PF00454	0.622
MOD_PKA_1	252	258	PF00069	0.571
MOD_PKA_1	286	292	PF00069	0.510
MOD_PKA_2	116	122	PF00069	0.606
MOD_PKA_2	237	243	PF00069	0.589
MOD_PKA_2	252	258	PF00069	0.415
MOD_PKA_2	65	71	PF00069	0.402
MOD_PKB_1	113	121	PF00069	0.658
MOD_Plk_1	133	139	PF00069	0.416
MOD_Plk_1	210	216	PF00069	0.500
MOD_Plk_4	135	141	PF00069	0.346
MOD_Plk_4	220	226	PF00069	0.504
MOD_ProDKin_1	108	114	PF00069	0.516
MOD_ProDKin_1	245	251	PF00069	0.418
MOD_SUMO_rev_2	172	177	PF00179	0.584
MOD_SUMO_rev_2	187	195	PF00179	0.685
TRG_ENDOCYTIC_2	126	129	PF00928	0.447
TRG_ER_diArg_1	112	115	PF00400	0.546
TRG_ER_diArg_1	151	154	PF00400	0.502
TRG_ER_diArg_1	250	253	PF00400	0.429
TRG_ER_diArg_1	64	67	PF00400	0.460
TRG_NLS_MonoExtC_3	112	117	PF00514	0.614
TRG_NLS_MonoExtC_3	62	67	PF00514	0.525
TRG_NLS_MonoExtN_4	112	118	PF00514	0.610
TRG_NLS_MonoExtN_4	61	67	PF00514	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5L9	Leptomonas seymouri	81%	79%
A0A0S4JQD1	Bodo saltans	44%	72%
A0A1X0P4Q6	Trypanosomatidae	55%	78%
A0A3S7XA38	Leishmania donovani	97%	100%
A0A422N5V3	Trypanosoma rangeli	53%	79%
A4HNJ1	Leishmania braziliensis	88%	100%
A4IC48	Leishmania infantum	97%	100%
C9ZYC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	78%
E9B756	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BTX9	Trypanosoma cruzi	53%	71%