Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania major

UniProt:

E9AG00_LEIMA

TriTrypDb:

LmjF.35.5270 , LMJLV39_350060900 , LMJSD75_350060200

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	7
GO:0005840	ribosome	5	5
GO:0032991	protein-containing complex	1	5
GO:0043228	non-membrane-bounded organelle	3	5
GO:0043232	intracellular non-membrane-bounded organelle	4	5
GO:1990904	ribonucleoprotein complex	2	5

Expansion

Sequence features

E9AG00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AG00

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	258	262	PF00656	0.376
CLV_NRD_NRD_1	335	337	PF00675	0.492
CLV_PCSK_KEX2_1	138	140	PF00082	0.452
CLV_PCSK_KEX2_1	335	337	PF00082	0.492
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.462
CLV_PCSK_SKI1_1	138	142	PF00082	0.366
CLV_PCSK_SKI1_1	318	322	PF00082	0.402
DEG_SPOP_SBC_1	344	348	PF00917	0.443
DOC_CKS1_1	21	26	PF01111	0.412
DOC_MAPK_gen_1	49	57	PF00069	0.472
DOC_MAPK_JIP1_4	38	44	PF00069	0.391
DOC_PP1_RVXF_1	239	245	PF00149	0.272
DOC_PP1_RVXF_1	316	323	PF00149	0.479
DOC_PP1_RVXF_1	78	84	PF00149	0.301
DOC_PP4_FxxP_1	149	152	PF00568	0.378
DOC_USP7_MATH_1	152	156	PF00917	0.312
DOC_USP7_MATH_1	167	171	PF00917	0.293
DOC_USP7_MATH_1	200	204	PF00917	0.455
DOC_USP7_MATH_1	212	216	PF00917	0.361
DOC_USP7_MATH_1	43	47	PF00917	0.297
DOC_USP7_MATH_1	87	91	PF00917	0.488
DOC_USP7_UBL2_3	134	138	PF12436	0.448
DOC_WW_Pin1_4	148	153	PF00397	0.452
DOC_WW_Pin1_4	20	25	PF00397	0.543
DOC_WW_Pin1_4	234	239	PF00397	0.383
DOC_WW_Pin1_4	256	261	PF00397	0.501
DOC_WW_Pin1_4	288	293	PF00397	0.463
LIG_14-3-3_CanoR_1	41	51	PF00244	0.318
LIG_14-3-3_CanoR_1	86	94	PF00244	0.474
LIG_BRCT_BRCA1_1	214	218	PF00533	0.507
LIG_CSL_BTD_1	289	292	PF09270	0.448
LIG_FHA_1	172	178	PF00498	0.287
LIG_FHA_1	185	191	PF00498	0.244
LIG_FHA_1	21	27	PF00498	0.352
LIG_FHA_1	231	237	PF00498	0.448
LIG_FHA_1	252	258	PF00498	0.286
LIG_FHA_2	116	122	PF00498	0.645
LIG_FHA_2	152	158	PF00498	0.338
LIG_FHA_2	174	180	PF00498	0.294
LIG_FHA_2	298	304	PF00498	0.427
LIG_FHA_2	93	99	PF00498	0.314
LIG_HCF-1_HBM_1	73	76	PF13415	0.328
LIG_Integrin_RGD_1	119	121	PF01839	0.653
LIG_IRF3_LxIS_1	39	45	PF10401	0.384
LIG_LIR_Apic_2	148	152	PF02991	0.387
LIG_LIR_Apic_2	18	24	PF02991	0.423
LIG_LIR_Gen_1	96	105	PF02991	0.294
LIG_LIR_Nem_3	215	221	PF02991	0.507
LIG_LIR_Nem_3	266	272	PF02991	0.384
LIG_LIR_Nem_3	340	345	PF02991	0.331
LIG_LIR_Nem_3	48	54	PF02991	0.441
LIG_LIR_Nem_3	96	102	PF02991	0.291
LIG_LYPXL_yS_3	269	272	PF13949	0.502
LIG_PDZ_Class_2	351	356	PF00595	0.305
LIG_Pex14_1	72	76	PF04695	0.310
LIG_Pex14_2	247	251	PF04695	0.466
LIG_REV1ctd_RIR_1	216	226	PF16727	0.556
LIG_SH2_NCK_1	197	201	PF00017	0.418
LIG_SH2_PTP2	54	57	PF00017	0.393
LIG_SH2_SRC	197	200	PF00017	0.418
LIG_SH2_SRC	54	57	PF00017	0.393
LIG_SH2_STAP1	197	201	PF00017	0.418
LIG_SH2_STAP1	47	51	PF00017	0.497
LIG_SH2_STAT3	231	234	PF00017	0.457
LIG_SH2_STAT5	250	253	PF00017	0.281
LIG_SH2_STAT5	47	50	PF00017	0.354
LIG_SH2_STAT5	54	57	PF00017	0.299
LIG_SH2_STAT5	99	102	PF00017	0.338
LIG_SH3_2	36	41	PF14604	0.499
LIG_SH3_3	267	273	PF00018	0.366
LIG_SH3_3	33	39	PF00018	0.511
LIG_SH3_3	78	84	PF00018	0.444
LIG_SUMO_SIM_par_1	172	179	PF11976	0.282
LIG_TRAF2_1	7	10	PF00917	0.578
LIG_WRC_WIRS_1	252	257	PF05994	0.286
LIG_WW_3	83	87	PF00397	0.480
MOD_CDK_SPxxK_3	234	241	PF00069	0.348
MOD_CK1_1	133	139	PF00069	0.410
MOD_CK1_1	151	157	PF00069	0.476
MOD_CK1_1	17	23	PF00069	0.365
MOD_CK1_1	170	176	PF00069	0.172
MOD_CK1_1	203	209	PF00069	0.509
MOD_CK1_1	275	281	PF00069	0.436
MOD_CK1_1	45	51	PF00069	0.422
MOD_CK2_1	297	303	PF00069	0.286
MOD_GlcNHglycan	142	145	PF01048	0.411
MOD_GlcNHglycan	202	205	PF01048	0.293
MOD_GSK3_1	13	20	PF00069	0.499
MOD_GSK3_1	148	155	PF00069	0.429
MOD_GSK3_1	167	174	PF00069	0.192
MOD_GSK3_1	230	237	PF00069	0.385
MOD_GSK3_1	268	275	PF00069	0.469
MOD_N-GLC_1	14	19	PF02516	0.546
MOD_N-GLC_1	286	291	PF02516	0.492
MOD_N-GLC_2	297	299	PF02516	0.305
MOD_NEK2_1	230	235	PF00069	0.363
MOD_NEK2_1	251	256	PF00069	0.313
MOD_NEK2_1	343	348	PF00069	0.415
MOD_NEK2_1	42	47	PF00069	0.327
MOD_NEK2_2	212	217	PF00069	0.418
MOD_OFUCOSY	150	156	PF10250	0.325
MOD_PIKK_1	230	236	PF00454	0.458
MOD_PIKK_1	272	278	PF00454	0.482
MOD_PK_1	316	322	PF00069	0.407
MOD_PKA_1	13	19	PF00069	0.481
MOD_Plk_1	14	20	PF00069	0.542
MOD_Plk_1	171	177	PF00069	0.294
MOD_Plk_1	286	292	PF00069	0.378
MOD_Plk_2-3	157	163	PF00069	0.361
MOD_Plk_4	173	179	PF00069	0.313
MOD_Plk_4	225	231	PF00069	0.315
MOD_ProDKin_1	148	154	PF00069	0.444
MOD_ProDKin_1	20	26	PF00069	0.543
MOD_ProDKin_1	234	240	PF00069	0.379
MOD_ProDKin_1	256	262	PF00069	0.495
MOD_ProDKin_1	288	294	PF00069	0.469
MOD_SUMO_for_1	110	113	PF00179	0.632
MOD_SUMO_rev_2	9	16	PF00179	0.517
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.307
TRG_ENDOCYTIC_2	269	272	PF00928	0.502
TRG_ENDOCYTIC_2	54	57	PF00928	0.398
TRG_ENDOCYTIC_2	99	102	PF00928	0.322
TRG_ER_diArg_1	334	336	PF00400	0.469
TRG_Pf-PMV_PEXEL_1	86	91	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4A4	Leptomonas seymouri	85%	100%
A0A0S4JQ50	Bodo saltans	50%	100%
A0A1X0P672	Trypanosomatidae	53%	97%
A0A3R7LPD7	Trypanosoma rangeli	55%	100%
A0A3S7XA48	Leishmania donovani	98%	100%
A4HNI8	Leishmania braziliensis	94%	100%
A4IC45	Leishmania infantum	98%	100%
C9ZYC9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	98%
E9B753	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O74763	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	82%
P61962	Homo sapiens	36%	100%
P61963	Mus musculus	36%	100%
Q12523	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	68%
Q38960	Arabidopsis thaliana	37%	100%
Q552R1	Dictyostelium discoideum	41%	100%
Q9LPV9	Arabidopsis thaliana	38%	100%
Q9XGN1	Arabidopsis thaliana	36%	100%
V5BPC8	Trypanosoma cruzi	54%	99%