c-Myc-binding family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFZ9_LEIMA

TriTrypDb:

LmjF.35.5260 , LMJLV39_350060800 , LMJSD75_350060100

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 4
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0005815	microtubule organizing center	2	2
GO:0005930	axoneme	2	2
GO:0036064	ciliary basal body	3	2
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AFZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFZ9

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003712	transcription coregulator activity	2	9
GO:0003713	transcription coactivator activity	3	9
GO:0140110	transcription regulator activity	1	9
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.462
CLV_PCSK_KEX2_1	48	50	PF00082	0.573
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.573
CLV_PCSK_SKI1_1	48	52	PF00082	0.515
DOC_MAPK_gen_1	68	75	PF00069	0.544
LIG_APCC_ABBA_1	31	36	PF00400	0.485
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_FHA_1	18	24	PF00498	0.533
LIG_FHA_1	25	31	PF00498	0.380
LIG_GBD_Chelix_1	22	30	PF00786	0.550
LIG_LIR_Gen_1	56	67	PF02991	0.514
LIG_LIR_Nem_3	11	16	PF02991	0.487
LIG_LIR_Nem_3	56	62	PF02991	0.531
LIG_SH2_SRC	16	19	PF00017	0.509
LIG_SH2_STAT5	16	19	PF00017	0.475
LIG_SH2_STAT5	46	49	PF00017	0.574
LIG_SH3_3	37	43	PF00018	0.485
LIG_SUMO_SIM_anti_2	72	77	PF11976	0.454
MOD_CK1_1	2	8	PF00069	0.540
MOD_GlcNHglycan	55	58	PF01048	0.567
MOD_GlcNHglycan	80	83	PF01048	0.655
MOD_NEK2_1	17	22	PF00069	0.506
MOD_PIKK_1	17	23	PF00454	0.552
MOD_PKA_2	3	9	PF00069	0.611
MOD_Plk_1	17	23	PF00069	0.511
MOD_SUMO_for_1	8	11	PF00179	0.467
MOD_SUMO_rev_2	35	40	PF00179	0.583
TRG_ENDOCYTIC_2	59	62	PF00928	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P616	Leptomonas seymouri	95%	100%
A0A0S4JQH9	Bodo saltans	73%	97%
A0A3S5H811	Leishmania donovani	99%	100%
A4HNI7	Leishmania braziliensis	98%	100%
A4IC44	Leishmania infantum	99%	100%
C9ZYD0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	100%
E9B752	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q2TBP7	Bos taurus	38%	83%
Q54I57	Dictyostelium discoideum	53%	94%
Q5R7A8	Pongo abelii	39%	83%
Q99417	Homo sapiens	39%	83%
Q9EQS3	Mus musculus	39%	83%