Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Secreted protein

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AFZ7_LEIMA

TriTrypDb:

LmjF.35.5240 , LMJLV39_350060600 , LMJSD75_350059900

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AFZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.465
CLV_NRD_NRD_1	144	146	PF00675	0.680
CLV_PCSK_SKI1_1	135	139	PF00082	0.574
CLV_PCSK_SKI1_1	242	246	PF00082	0.718
CLV_PCSK_SKI1_1	58	62	PF00082	0.561
DOC_CDC14_PxL_1	3	11	PF14671	0.524
DOC_CKS1_1	167	172	PF01111	0.492
DOC_CYCLIN_yCln2_LP_2	117	120	PF00134	0.530
DOC_MAPK_HePTP_8	197	209	PF00069	0.509
DOC_MAPK_MEF2A_6	200	209	PF00069	0.503
DOC_MAPK_MEF2A_6	255	264	PF00069	0.343
DOC_PP2B_LxvP_1	117	120	PF13499	0.530
DOC_PP2B_LxvP_1	17	20	PF13499	0.686
DOC_PP2B_LxvP_1	192	195	PF13499	0.499
DOC_PP2B_LxvP_1	92	95	PF13499	0.383
DOC_PP4_FxxP_1	179	182	PF00568	0.501
DOC_PP4_FxxP_1	4	7	PF00568	0.519
DOC_USP7_MATH_1	182	186	PF00917	0.497
DOC_WW_Pin1_4	166	171	PF00397	0.444
DOC_WW_Pin1_4	178	183	PF00397	0.454
DOC_WW_Pin1_4	199	204	PF00397	0.509
DOC_WW_Pin1_4	234	239	PF00397	0.398
DOC_WW_Pin1_4	30	35	PF00397	0.348
LIG_14-3-3_CanoR_1	132	138	PF00244	0.355
LIG_14-3-3_CanoR_1	255	264	PF00244	0.393
LIG_14-3-3_CanoR_1	80	86	PF00244	0.418
LIG_BIR_III_2	31	35	PF00653	0.433
LIG_BRCT_BRCA1_1	195	199	PF00533	0.497
LIG_BRCT_BRCA1_1	24	28	PF00533	0.377
LIG_deltaCOP1_diTrp_1	128	137	PF00928	0.360
LIG_FHA_1	120	126	PF00498	0.477
LIG_FHA_1	128	134	PF00498	0.320
LIG_FHA_1	212	218	PF00498	0.508
LIG_FHA_1	243	249	PF00498	0.323
LIG_FHA_1	31	37	PF00498	0.395
LIG_GBD_Chelix_1	260	268	PF00786	0.348
LIG_LIR_Apic_2	178	182	PF02991	0.504
LIG_LIR_Gen_1	219	225	PF02991	0.433
LIG_LIR_Gen_1	62	69	PF02991	0.532
LIG_LIR_Nem_3	219	223	PF02991	0.441
LIG_LIR_Nem_3	62	67	PF02991	0.533
LIG_NRBOX	261	267	PF00104	0.420
LIG_PDZ_Class_2	263	268	PF00595	0.467
LIG_PDZ_Wminus1_1	266	268	PF00595	0.626
LIG_RPA_C_Fungi	250	262	PF08784	0.302
LIG_SH2_CRK	64	68	PF00017	0.589
LIG_SH2_CRK	82	86	PF00017	0.389
LIG_SH2_STAP1	64	68	PF00017	0.533
LIG_SH2_STAP1	82	86	PF00017	0.547
LIG_SH2_STAT5	82	85	PF00017	0.597
LIG_SH2_STAT5	91	94	PF00017	0.398
LIG_SH3_3	31	37	PF00018	0.453
LIG_SH3_3	92	98	PF00018	0.394
LIG_SH3_5	230	234	PF00018	0.592
LIG_SUMO_SIM_par_1	221	229	PF11976	0.514
MOD_CK1_1	121	127	PF00069	0.603
MOD_CK1_1	165	171	PF00069	0.715
MOD_CK1_1	178	184	PF00069	0.576
MOD_CK1_1	211	217	PF00069	0.623
MOD_GlcNHglycan	249	252	PF01048	0.467
MOD_GlcNHglycan	257	260	PF01048	0.426
MOD_GlcNHglycan	64	67	PF01048	0.594
MOD_GSK3_1	147	154	PF00069	0.634
MOD_GSK3_1	161	168	PF00069	0.585
MOD_GSK3_1	178	185	PF00069	0.422
MOD_GSK3_1	195	202	PF00069	0.476
MOD_GSK3_1	247	254	PF00069	0.524
MOD_N-GLC_1	172	177	PF02516	0.619
MOD_N-GLC_1	225	230	PF02516	0.524
MOD_N-GLC_2	49	51	PF02516	0.534
MOD_NEK2_1	172	177	PF00069	0.623
MOD_NEK2_2	195	200	PF00069	0.704
MOD_OFUCOSY	159	166	PF10250	0.586
MOD_PIKK_1	211	217	PF00454	0.567
MOD_PIKK_1	75	81	PF00454	0.622
MOD_PK_1	104	110	PF00069	0.515
MOD_Plk_1	127	133	PF00069	0.432
MOD_Plk_4	208	214	PF00069	0.541
MOD_Plk_4	7	13	PF00069	0.671
MOD_Plk_4	81	87	PF00069	0.545
MOD_ProDKin_1	166	172	PF00069	0.544
MOD_ProDKin_1	178	184	PF00069	0.560
MOD_ProDKin_1	199	205	PF00069	0.623
MOD_ProDKin_1	234	240	PF00069	0.470
MOD_ProDKin_1	30	36	PF00069	0.410
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.522
TRG_ENDOCYTIC_2	64	67	PF00928	0.594
TRG_ENDOCYTIC_2	82	85	PF00928	0.375
TRG_ENDOCYTIC_2	91	94	PF00928	0.355
TRG_NES_CRM1_1	215	229	PF08389	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBL7	Leptomonas seymouri	73%	100%
A0A0S4JP52	Bodo saltans	41%	96%
A0A3S7XA33	Leishmania donovani	95%	100%
A4IC42	Leishmania infantum	95%	99%
E9B750	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%