Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFZ5_LEIMA

TriTrypDb:

LmjF.35.5220 , LMJLV39_350060400 , LMJSD75_350059700

Length:

318

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFZ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.458
CLV_NRD_NRD_1	276	278	PF00675	0.520
CLV_NRD_NRD_1	38	40	PF00675	0.535
CLV_PCSK_KEX2_1	13	15	PF00082	0.434
CLV_PCSK_KEX2_1	269	271	PF00082	0.562
CLV_PCSK_KEX2_1	38	40	PF00082	0.545
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.520
CLV_PCSK_SKI1_1	196	200	PF00082	0.490
CLV_PCSK_SKI1_1	98	102	PF00082	0.512
DEG_APCC_DBOX_1	97	105	PF00400	0.529
DOC_CKS1_1	119	124	PF01111	0.655
DOC_PP2B_LxvP_1	206	209	PF13499	0.522
DOC_USP7_MATH_1	2	6	PF00917	0.527
DOC_USP7_MATH_1	210	214	PF00917	0.701
DOC_USP7_MATH_2	217	223	PF00917	0.490
DOC_WW_Pin1_4	118	123	PF00397	0.603
DOC_WW_Pin1_4	81	86	PF00397	0.483
LIG_14-3-3_CanoR_1	13	20	PF00244	0.498
LIG_14-3-3_CanoR_1	196	205	PF00244	0.665
LIG_14-3-3_CanoR_1	292	296	PF00244	0.441
LIG_14-3-3_CanoR_1	63	72	PF00244	0.556
LIG_BIR_II_1	1	5	PF00653	0.573
LIG_BIR_III_3	1	5	PF00653	0.456
LIG_EH1_1	146	154	PF00400	0.418
LIG_FHA_1	165	171	PF00498	0.484
LIG_FHA_1	193	199	PF00498	0.601
LIG_FHA_1	260	266	PF00498	0.513
LIG_FHA_1	312	318	PF00498	0.417
LIG_FHA_1	63	69	PF00498	0.499
LIG_FHA_2	65	71	PF00498	0.476
LIG_GBD_Chelix_1	50	58	PF00786	0.452
LIG_LIR_Apic_2	202	208	PF02991	0.502
LIG_LIR_Gen_1	53	61	PF02991	0.504
LIG_LIR_Nem_3	53	58	PF02991	0.507
LIG_PTB_Apo_2	49	56	PF02174	0.371
LIG_RPA_C_Fungi	89	101	PF08784	0.406
LIG_SH2_STAP1	236	240	PF00017	0.483
LIG_SH2_STAP1	64	68	PF00017	0.440
LIG_SH2_STAT5	18	21	PF00017	0.448
LIG_SH2_STAT5	64	67	PF00017	0.388
LIG_SUMO_SIM_anti_2	246	252	PF11976	0.430
LIG_SUMO_SIM_par_1	18	25	PF11976	0.432
MOD_CDC14_SPxK_1	84	87	PF00782	0.388
MOD_CDK_SPK_2	118	123	PF00069	0.588
MOD_CDK_SPxK_1	81	87	PF00069	0.392
MOD_CK1_1	137	143	PF00069	0.535
MOD_CK1_1	200	206	PF00069	0.641
MOD_CK1_1	222	228	PF00069	0.497
MOD_CK2_1	137	143	PF00069	0.446
MOD_CK2_1	39	45	PF00069	0.600
MOD_CK2_1	63	69	PF00069	0.447
MOD_GlcNHglycan	125	128	PF01048	0.732
MOD_GlcNHglycan	139	142	PF01048	0.548
MOD_GlcNHglycan	199	202	PF01048	0.565
MOD_GlcNHglycan	211	215	PF01048	0.717
MOD_GlcNHglycan	222	225	PF01048	0.381
MOD_GlcNHglycan	4	7	PF01048	0.511
MOD_GSK3_1	192	199	PF00069	0.515
MOD_GSK3_1	2	9	PF00069	0.514
MOD_GSK3_1	255	262	PF00069	0.484
MOD_GSK3_1	39	46	PF00069	0.492
MOD_GSK3_1	76	83	PF00069	0.497
MOD_N-GLC_1	2	7	PF02516	0.539
MOD_NEK2_1	12	17	PF00069	0.472
MOD_NEK2_1	125	130	PF00069	0.737
MOD_NEK2_1	76	81	PF00069	0.503
MOD_NEK2_1	90	95	PF00069	0.564
MOD_PIKK_1	12	18	PF00454	0.508
MOD_PIKK_1	39	45	PF00454	0.490
MOD_PK_1	112	118	PF00069	0.569
MOD_PKA_1	38	44	PF00069	0.493
MOD_PKA_2	12	18	PF00069	0.505
MOD_PKA_2	164	170	PF00069	0.490
MOD_PKA_2	291	297	PF00069	0.441
MOD_PKA_2	311	317	PF00069	0.394
MOD_PKA_2	38	44	PF00069	0.493
MOD_PKA_2	62	68	PF00069	0.551
MOD_Plk_1	112	118	PF00069	0.577
MOD_Plk_1	170	176	PF00069	0.404
MOD_Plk_1	192	198	PF00069	0.537
MOD_Plk_1	236	242	PF00069	0.467
MOD_Plk_4	200	206	PF00069	0.477
MOD_Plk_4	46	52	PF00069	0.474
MOD_ProDKin_1	118	124	PF00069	0.602
MOD_ProDKin_1	81	87	PF00069	0.482
TRG_DiLeu_BaEn_1	296	301	PF01217	0.407
TRG_DiLeu_BaLyEn_6	114	119	PF01217	0.488
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.489
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.424
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.466
TRG_ER_diArg_1	12	14	PF00400	0.433
TRG_ER_diArg_1	187	190	PF00400	0.468
TRG_ER_diArg_1	38	40	PF00400	0.500
TRG_NES_CRM1_1	17	30	PF08389	0.389
TRG_Pf-PMV_PEXEL_1	151	156	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	232	237	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXE8	Leptomonas seymouri	50%	96%
A0A1X0P4S8	Trypanosomatidae	29%	83%
A0A3S7XA65	Leishmania donovani	84%	100%
A4HNI4	Leishmania braziliensis	60%	100%
A4IC40	Leishmania infantum	85%	100%
E9B748	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%